Alessandra Mortellaro
@hsr.it
Group Leader
Scopus Publications
- Development and characterization of a model of mucopolysaccharidosis type IVA for evaluating therapies targeting bone disease
Margherita Berti, Selene Ceriotti, Ludovica Santi, Gaia Alberti, Stefano Beretta, Sara Degl'Innocenti, Cristina Ruatti, Evelyn Oliva Savoia, Raisa Jofra-Hernandez, Giada De Ponti, Simona Bolamperti, Isabella Villa, Fabio Galeotti, Alessandro Romano, Ilaria Visigalli, Rossana Norata, Martina Rocchi, Patrizia Cristofori, Matilde Cossutta, Giulia Consiglieri, Francesca Tucci, Lucia Santorelli, Paolo Grumati, Lorenza Ronfani, Patrizia D'Adamo, Andrea Giustina, Marco Angelozzi, Carmine Settembre, Alessandra Mortellaro, Serena Scala, Francesca Sanvito, Nicola Volpi, Alessandro Aiuti, Maria Ester Bernardo, Stefania Crippa
Dmm Disease Models and Mechanisms, 2026
Mucopolysaccharidosis type IVA (MPSIVA) is a lysosomal storage disease (LSD) caused by deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), which causes the accumulation of keratan sulphate (KS) and chondroitin sulphate (CS). Patients with MPSIVA typically present with severe skeletal and joint disorders, which are not addressed by conventional therapies. Currently, no animal model accurately replicates the human disease, hindering the development of novel therapeutic interventions. To overcome this limitation, we established, by CRISPR-Cas9 technology, a Galns−/− mouse model that expresses a non-functional enzyme and accumulates CS and KS in the urine, plasma and distinct tissues, and glycosaminoglycans in the spleen. The mice exhibit shortened long bones, trabecular bone alterations and skeletal abnormalities in the growth plate. Additionally, we observed increased levels of inflammatory and oxidative markers in visceral organs and plasma. Our newly developed model of MPSIVA demonstrates clear and quantifiable signs of skeletal alterations, providing novel means of assessment of the safety and efficacy of innovative therapies, including hematopoietic stem and progenitor cell gene therapy, which has recently been shown to provide a beneficial effect on skeletal alterations in Hurler syndrome. - Gene therapy supports long-term reconstitution of patient hematopoietic stem cells in deficiency of adenosine deaminase 2
Chiara Rigamonti, Dimitri Bulté, Federica Barzaghi, Cristina Mesa-Nuñez, Luca Basso-Ricci, Emanuela Pettinato, Camilla Visconti, Sara Degl’Innocenti, Francesco Gazzo, Fabrizio Benedicenti, Sergio Arévalo, Pamela Quaranta, Francesca Sanvito, Roberta Caorsi, Francesca Schena, Michela Lupia, Silvia Federici, Antonella Insalaco, Fabrizio De Benedetti, Serena Scala, Maurizio Miano, Francesca Conti, Maria Pia Cicalese, Eugenio Montini, Marco Gattorno, Carlo Dufour, Alessandro Aiuti, Alessandra Mortellaro
Molecular Therapy Methods and Clinical Development, 2025
, gene-corrected patient-derived HSPCs sustained long-term engraftment and multilineage reconstitution comparable to healthy controls. Integration site analysis confirmed a polyclonal pattern of hematopoietic reconstitution across all experimental settings, with no evidence of clonal dominance. Together, these findings demonstrate that ADA2 gene therapy with a LV is safe, maintains HSPC functionality, and enables durable hematopoietic reconstitution in a mouse model, providing a strong foundation for clinical translation and as a curative alternative to allogeneic HSCT in DADA2. - IL-1 signaling and inflammasomes in acute myeloid leukemia: mechanisms and therapeutic opportunities
Alessandra Mortellaro, Sara Mastaglio, Marta Muzio
Cellular and Molecular Life Sciences, 2025
Acute myeloid leukemia (AML) is a heterogenous disease characterized by the accumulation of immature myeloid blasts with distinct genetic mutations in the bone marrow and peripheral blood. AML co-evolve with other components of specialized bone marrow niches within a microenvironment enriched in cytokines and inflammatory cells; among these, interleukin-1 (IL-1) may act as a tumor driver. This review examines two complementary aspects of AML biology in relation to IL-1. First, we describe the functional activity of IL-1 and the signaling pathways triggered by the IL-1 receptor in malignant cells, along with preclinical and clinical studies targeting this pathway in AML. Second, we discuss the mechanisms regulating the release of mature IL-1β through the activation of different inflammasomes. Inflammasomes, particularly NLRP3, are emerging as key contributors to AML pathophysiology. Beyond IL-1 release, NLRP3 may interface with cellular stress responses and pyroptosis, thereby influencing both AML cells and their microenvironment through multiple mechanisms. Inflammasome signaling may act as a driver of therapy resistance while also representing a promising therapeutic target. - Early bone marrow alterations in patients with adenosine deaminase 2 deficiency across disease phenotypes and severities
Dimitri Bulté, Federica Barzaghi, Cristina Mesa-Nuñez, Chiara Rigamonti, Luca Basso-Ricci, Camilla Visconti, Stefania Crippa, Emanuela Pettinato, Diego Gilioli, Raffaella Milani, Pamela Quaranta, Roberta Caorsi, Alessia Cafaro, Giuliana Cangemi, Michela Lupia, Francesca Schena, Alice Grossi, Giulia Di Colo, Silvia Federici, Antonella Insalaco, Fabrizio De Benedetti, Sarah Marktel, Raffaella Di Micco, Maria Ester Bernardo, Serena Scala, Maria Pia Cicalese, Francesca Conti, Maurizio Miano, Marco Gattorno, Carlo Dufour, Alessandro Aiuti, Alessandra Mortellaro
Journal of Allergy and Clinical Immunology, 2025 - ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish
Alessia Brix, Laura Belleri, Alex Pezzotta, Emanuela Pettinato, Mara Mazzola, Matteo Zoccolillo, Anna Marozzi, Rui Monteiro, Filippo Del Bene, Alessandra Mortellaro, Anna Pistocchi
Communications Biology, 2024
Deficiency of adenosine deaminase 2 (DADA2) is an inborn error of immunity caused by loss-of-function mutations in the adenosine deaminase 2 (ADA2) gene. Clinical manifestations of DADA2 include vasculopathy and immuno-hematological abnormalities, culminating in bone marrow failure. A major gap exists in our knowledge of the regulatory functions of ADA2 during inflammation and hematopoiesis, mainly due to the absence of an ADA2 orthologue in rodents. Exploring these mechanisms is essential for understanding disease pathology and developing new treatments. Zebrafish possess two ADA2 orthologues, cecr1a and cecr1b, with the latter showing functional conservation with human ADA2. We establish a cecr1b-loss-of-function zebrafish model that recapitulates the immuno-hematological and vascular manifestations observed in humans. Loss of Cecr1b disrupts hematopoietic stem cell specification, resulting in defective hematopoiesis. This defect is caused by induced inflammation in the vascular endothelium. Blocking inflammation, pharmacological modulation of the A2r pathway, or the administration of the recombinant human ADA2 corrects these defects, providing insights into the mechanistic link between ADA2 deficiency, inflammation and immuno-hematological abnormalities. Our findings open up potential therapeutic avenues for DADA2 patients. - The New Frontiers of Gene Therapy and Gene Editing in Inflammatory Diseases
Alessandro Romano, Alessandra Mortellaro
Human Gene Therapy, 2024
Inflammatory diseases are conditions characterized by abnormal and often excessive immune responses, leading to tissue and organ inflammation. The complexity of these disorders arises from the intricate interplay of genetic factors and immune responses, which challenges conventional therapeutic approaches. However, the field of genetic manipulation has sparked unprecedented optimism in addressing these complex disorders. This review aims to comprehensively explore the application of gene therapy and gene editing in the context of inflammatory diseases, offering solutions that range from correcting genetic defects to precise immune modulation. These therapies have exhibited remarkable potential in ameliorating symptoms, improving quality of life, and even achieving disease remission. As we delve into recent breakthroughs and therapeutic applications, we illustrate how these advancements offer novel and transformative solutions for conditions that have traditionally eluded conventional treatments. By examining successful case studies and pre-clinical research, we emphasize the favorable results and substantial transformative impacts that gene-based interventions have demonstrated in patients and animal models of inflammatory diseases such as chronic granulomatous disease, cryopyrin-associated syndromes, and adenosine deaminase 2 deficiency, as well as those of multifactorial origins like arthropathies (osteoarthritis, rheumatoid arthritis) and inflammatory bowel disease. In conclusion, gene therapy and gene editing offer transformative opportunities to address the underlying causes of inflammatory diseases, ushering in a new era of precision medicine and providing hope for personalized, targeted treatments. - Anaphylactic degranulation by mast cells requires the mobilization of inflammasome components
Andrea Mencarelli, Pradeep Bist, Hae Woong Choi, Hanif Javanmard Khameneh, Alessandra Mortellaro, Soman N. Abraham
Nature Immunology, 2024 - IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer
Nicoletta Caronni, Federica La Terza, Francesco M. Vittoria, Giulia Barbiera, Luca Mezzanzanica, Vincenzo Cuzzola, Simona Barresi, Marta Pellegatta, Paolo Canevazzi, Garett Dunsmore, Carlo Leonardi, Elisa Montaldo, Eleonora Lusito, Erica Dugnani, Antonio Citro, Melissa S. F. Ng, Marco Schiavo Lena, Denise Drago, Annapaola Andolfo, Silvia Brugiapaglia, Alessandro Scagliotti, Alessandra Mortellaro, Vincenzo Corbo, Zhaoyuan Liu, Anna Mondino, Paolo Dellabona, Lorenzo Piemonti, Carla Taveggia, Claudio Doglioni, Paola Cappello, Francesco Novelli, Matteo Iannacone, Lai Guan Ng, Florent Ginhoux, Stefano Crippa, Massimo Falconi, Chiara Bonini, Luigi Naldini, Marco Genua, Renato Ostuni
Nature, 2023 - Inflammasomes: Mechanisms of Action and Involvement in Human Diseases
Dimitri Bulté, Chiara Rigamonti, Alessandro Romano, Alessandra Mortellaro
Cells, 2023
Inflammasome complexes and their integral receptor proteins have essential roles in regulating the innate immune response and inflammation at the post-translational level. Yet despite their protective role, aberrant activation of inflammasome proteins and gain of function mutations in inflammasome component genes seem to contribute to the development and progression of human autoimmune and autoinflammatory diseases. In the past decade, our understanding of inflammasome biology and activation mechanisms has greatly progressed. We therefore provide an up-to-date overview of the various inflammasomes and their known mechanisms of action. In addition, we highlight the involvement of various inflammasomes and their pathogenic mechanisms in common autoinflammatory, autoimmune and neurodegenerative diseases, including atherosclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. We conclude by speculating on the future avenues of research needed to better understand the roles of inflammasomes in health and disease. - Constitutive IL-1RA production by modified immune cells protects against IL-1–mediated inflammatory disorders
Mariasilvia Colantuoni, Raisa Jofra Hernandez, Emanuela Pettinato, Luca Basso-Ricci, Laura Magnani, Grazia Andolfi, Chiara Rigamonti, Annamaria Finardi, Valentina Romeo, Monica Soldi, Lucia Sergi Sergi, Martina Rocchi, Serena Scala, Hal M. Hoffman, Silvia Gregori, Anna Kajaste-Rudnitski, Francesca Sanvito, Luca Muzio, Luigi Naldini, Alessandro Aiuti, Alessandra Mortellaro
Science Translational Medicine, 2023
Dysregulation of the interleukin-1 (IL-1) pathway leads to immune diseases that can result in chronic tissue and organ inflammation. Although IL-1 blockade has shown promise in ameliorating these symptoms and improving patients’ quality of life, there is an urgent need for more effective, long-lasting treatments. We developed a lentivirus (LV)–mediated gene transfer strategy using transplanted autologous hematopoietic stem/progenitor cells (HSPCs) as a source of IL-1 receptor antagonist (IL-1RA) for systemic delivery to tissues and organs. Transplantation of mouse and human HSPCs transduced with an IL-1RA–encoding LV ensured stable IL-1RA production while maintaining the clonogenic and differentiation capacities of HSPCs in vivo. We examined the efficacy of cell-mediated IL-1RA delivery in three models of IL-1–dependent inflammation, for which treatment hindered neutrophil recruitment in an inducible model of gout, prevented systemic and multi-tissue inflammation in a genetic model of cryopyrin-associated periodic syndromes, and reduced disease severity in an experimental autoimmune encephalomyelitis model of multiple sclerosis. Our findings demonstrate HSPC-mediated IL-1RA delivery as a potential therapeutic modality that can be exploited to suppress tissue and organ inflammation in diverse immune-related diseases involving IL-1–driven inflammation. - Editorial: NLRP3 activation and regulation in innate immune responses
Alessandra Mortellaro
Frontiers in Immunology, 2023 - Case Report: Consistent disease manifestations with a staggered time course in two identical twins affected by adenosine deaminase 2 deficiency
Federica Barzaghi, Maria Pia Cicalese, Matteo Zoccolillo, Immacolata Brigida, Matteo Barcella, Ivan Merelli, Claudia Sartirana, Monica Zanussi, Valeria Calbi, Maria Ester Bernardo, Francesca Tucci, Maddalena Migliavacca, Fabio Giglio, Matteo Doglio, Daniele Canarutto, Francesca Ferrua, Giulia Consiglieri, Giulia Prunotto, Francesco Saettini, Sonia Bonanomi, Patrizia Rovere-Querini, Giulia Di Colo, Tatiana Jofra, Georgia Fousteri, Federica Penco, Marco Gattorno, Michael S. Hershfield, Lucia Bongiovanni, Maurilio Ponzoni, Sarah Marktel, Raffaella Milani, Jacopo Peccatori, Fabio Ciceri, Alessandra Mortellaro, Alessandro Aiuti
Frontiers in Immunology, 2022 - Gasdermins: New Therapeutic Targets in Host Defense, Inflammatory Diseases, and Cancer
Laura Magnani, Mariasilvia Colantuoni, Alessandra Mortellaro
Frontiers in Immunology, 2022 - T cells and monocytes: A dangerous liaison in adenosine deaminase 2 deficiency
Cristina Mesa‐Nuñez, Alessandra Mortellaro
Journal of Leukocyte Biology, 2022 - Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency
Matteo Zoccolillo, Immacolata Brigida, Federica Barzaghi, Serena Scala, Raisa Jofra Hernández, Luca Basso-Ricci, Mariasilvia Colantuoni, Emanuela Pettinato, Lucia Sergi Sergi, Giulia Milardi, Paola Capasso, Angelo Lombardo, Silvia Gregori, Francesca Sanvito, Francesca Schena, Simone Cesaro, Francesca Conti, Andrea Pession, Fabio Benedetti, Marco Gattorno, Pui Y. Lee, Luigi Naldini, Maria Pia Cicalese, Alessandro Aiuti, Alessandra Mortellaro
Blood Advances, 2021 - Targeting glycolysis in macrophages confers protection against pancreatic ductal adenocarcinoma
Hweixian Leong Penny, Je Lin Sieow, Sin Yee Gun, Mai Chan Lau, Bernett Lee, Jasmine Tan, Cindy Phua, Florida Toh, Yvonne Nga, Wei Hseun Yeap, Baptiste Janela, Dilip Kumar, Hao Chen, Joe Yeong, Justin A. Kenkel, Angela Pang, Diana Lim, Han Chong Toh, Tony Lim Kiat Hon, Christopher I. Johnson, Hanif Javanmard Khameneh, Alessandra Mortellaro, Edgar G. Engleman, Olaf Rotzschke, Florent Ginhoux, Jean-Pierre Abastado, Jinmiao Chen, Siew Cheng Wong
International Journal of Molecular Sciences, 2021 - Update on Clinical Ex Vivo Hematopoietic Stem Cell Gene Therapy for Inherited Monogenic Diseases
Francesca Tucci, Samantha Scaramuzza, Alessandro Aiuti, Alessandra Mortellaro
Molecular Therapy, 2021 - Hematopoietic Tumors in a Mouse Model of X-linked Chronic Granulomatous Disease after Lentiviral Vector-Mediated Gene Therapy
Raisa Jofra Hernández, Andrea Calabria, Francesca Sanvito, Fabiola De Mattia, Giada Farinelli, Serena Scala, Ilaria Visigalli, Nicola Carriglio, Maura De Simone, Michela Vezzoli, Francesca Cecere, Maddalena Migliavacca, Luca Basso-Ricci, Maryam Omrani, Fabrizio Benedicenti, Rossana Norata, Paola Maria Vittoria Rancoita, Clelia Di Serio, Paola Albertini, Patrizia Cristofori, Luigi Naldini, Bernhard Gentner, Eugenio Montini, Alessandro Aiuti, Alessandra Mortellaro
Molecular Therapy, 2021 - Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides
Arumay Pal, Kurt Neo, Lakshminarayanan Rajamani, Fernando Jose Ferrer, David P. Lane, Chandra S. Verma, Alessandra Mortellaro
Scientific Reports, 2019 - Tyrosine dephosphorylation of ASC modulates the activation of the NLRP3 and AIM2 inflammasomes
Bezaleel Mambwe, Kurt Neo, Hanif Javanmard Khameneh, Keith Weng Kit Leong, Mariasilvia Colantuoni, Maurizio Vacca, Richmond Muimo, Alessandra Mortellaro
Frontiers in Immunology, 2019 - The inflammasome adaptor ASC intrinsically limits CD4+ T-cell proliferation to help maintain intestinal homeostasis
Hanif Javanmard Khameneh, Keith Weng Kit Leong, Andrea Mencarelli, Maurizio Vacca, Bezaleel Mambwe, Kurt Neo, Alice Tay, Francesca Zolezzi, Bernett Lee, Alessandra Mortellaro
Frontiers in Immunology, 2019 - Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis
Andrea Mencarelli, Hanif Javanmard Khameneh, Jan Fric, Maurizio Vacca, Sary El Daker, Baptiste Janela, Jing Ping Tang, Sabrina Nabti, Akhila Balachander, Tong Seng Lim, Florent Ginhoux, Paola Ricciardi-Castagnoli, Alessandra Mortellaro
Nature Communications, 2018 - The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy
Shyam S. Chaurasia, Rayne R. Lim, Bhav H. Parikh, Yeo Sia Wey, Bo Bo Tun, Tien Yin Wong, Chi D. Luu, Rupesh Agrawal, Arkasubhra Ghosh, Alessandra Mortellaro, Elizabeth Rackoczy, Rajiv R. Mohan, Veluchamy A. Barathi
Scientific Reports, 2018 - Calcineurin B in CD4+ T Cells prevents autoimmune colitis by negatively regulating the JAK/STAT pathway
Andrea Mencarelli, Maurizio Vacca, Hanif Javanmard Khameneh, Enzo Acerbi, Alicia Tay, Francesca Zolezzi, Michael Poidinger, Alessandra Mortellaro
Frontiers in Immunology, 2018 - NLRP3 inflammasome pathway has a critical role in the host immunity against clinically relevant Acinetobacter baumannii pulmonary infection
N Dikshit, S D Kale, H J Khameneh, V Balamuralidhar, C Y Tang, P Kumar, T P Lim, T T Tan, A L Kwa, A Mortellaro, B Sukumaran
Mucosal Immunology, 2018 - Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis
Catherine E. Diamond, Keith Weng Kit Leong, Maurizio Vacca, Jack Rivers-Auty, David Brough, Alessandra Mortellaro
Scientific Reports, 2017 - Nod2 is required for the early innate immune clearance of Acinetobacter baumannii from the lungs
Sandeep D. Kale, Neha Dikshit, Pankaj Kumar, Vanniarajan Balamuralidhar, Hanif Javanmard Khameneh, Najib Bin Abdul Malik, Tse Hsien Koh, Gladys Gek Yen Tan, Thuan Tong Tan, Alessandra Mortellaro, Bindu Sukumaran
Scientific Reports, 2017 - NLRP10 enhances CD4+ T-cell-mediated IFNγ response via regulation of dendritic cell-derived IL-12 release
Maurizio Vacca, Julia Böhme, Lia Paola Zambetti, Hanif Javanmard Khameneh, Bhairav S. Paleja, Federica Laudisi, Adrian W. S. Ho, Kurt Neo, Keith Weng Kit Leong, Mardiana Marzuki, Bernett Lee, Michael Poidinger, Laura Santambrogio, Liana Tsenova, Francesca Zolezzi, Gennaro De Libero, Amit Singhal, Alessandra Mortellaro
Frontiers in Immunology, 2017 - Erratum: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP
Pradeep Bist, Wan Shoo Cheong, Aylwin Ng, Neha Dikshit, Bae Hoon Kim, Niyas Kudukkil Pulloor, Hanif Javanmard Khameneh, Matija Hedl, Avinash R. Shenoy, Vanniarajan Balamuralidhar, Najib Bin Abdul Malik, Michelle Hong, Albert Neutzner, Keh-Chuang Chin, Koichi S. Kobayashi, Antonio Bertoletti, Alessandra Mortellaro, Clara Abraham, John D. MacMicking, Ramnik J. Xavier, Bindu Sukumaran
Nature Communications, 2017 - E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP
Pradeep Bist, Wan Shoo Cheong, Aylwin Ng, Neha Dikshit, Bae-Hoon Kim, Niyas Kudukkil Pulloor, Hanif Javanmard Khameneh, Matija Hedl, Avinash R. Shenoy, Vanniarajan Balamuralidhar, Najib Bin Abdul Malik, Michelle Hong, Albert Neutzner, Keh-Chuang Chin, Koichi S. Kobayashi, Antonio Bertoletti, Alessandra Mortellaro, Clara Abraham, John D. MacMicking, Ramnik J. Xavier, Bindu Sukumaran
Nature Communications, 2017 - C5a regulates IL-1β production and leukocyte recruitment in a murine model of monosodium urate crystal-induced peritonitis
Hanif J. Khameneh, Adrian W. S. Ho, Federica Laudisi, Heidi Derks, Matheswaran Kandasamy, Baalasubramanian Sivasankar, Gim Gee Teng, Alessandra Mortellaro
Frontiers in Pharmacology, 2017 - The Syk-NFAT-IL-2 pathway in dendritic cells is required for optimal sterile immunity elicited by alum adjuvants
Hanif Javanmard Khameneh, Adrian W. S. Ho, Roberto Spreafico, Heidi Derks, Hazel Q. Y. Quek, Alessandra Mortellaro
Journal of Immunology, 2017 - Inflammasome-dependent IL-1β release depends upon membrane permeabilisation
F Martín-Sánchez, C Diamond, M Zeitler, A I Gomez, A Baroja-Mazo, J Bagnall, D Spiller, M White, M J D Daniels, A Mortellaro, M Peñalver, P Paszek, J P Steringer, W Nickel, D Brough, P Pelegrín
Cell Death and Differentiation, 2016 - Continuous time Bayesian networks identify Prdm1 as a negative regulator of TH17 cell differentiation in humans
Enzo Acerbi, Elena Viganò, Michael Poidinger, Alessandra Mortellaro, Teresa Zelante, Fabio Stella
Scientific Reports, 2016 - Investigating IL-1β secretion using real-time single-cell imaging
Catherine Diamond, James Bagnall, David G. Spiller, Michael R. White, Alessandra Mortellaro, Pawel Paszek, David Brough
Methods in Molecular Biology, 2016 - Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes
Elena Viganò, Catherine Emma Diamond, Roberto Spreafico, Akhila Balachander, Radoslaw M. Sobota, Alessandra Mortellaro
Nature Communications, 2015 - CD103+ Dendritic Cells Control Th17 Cell Function in the Lung
Teresa Zelante, Alicia Yoke Wei Wong, Tang Jing Ping, Jinmiao Chen, Hermi R. Sumatoh, Elena Viganò, Yu Hong Bing, Bernett Lee, Francesca Zolezzi, Jan Fric, Evan W. Newell, Alessandra Mortellaro, Michael Poidinger, Paolo Puccetti, Paola Ricciardi-Castagnoli
Cell Reports, 2015 - Genome-wide analysis of the genetic regulation of gene expression in human neutrophils
Anand Kumar Andiappan, Rossella Melchiotti, Tuang Yeow Poh, Michelle Nah, Kia Joo Puan, Elena Vigano, Doreen Haase, Nurhashikin Yusof, Boris San Luis, Josephine Lum, Dilip Kumar, Shihui Foo, Li Zhuang, Anusha Vasudev, Astrid Irwanto, Bernett Lee, Alessandra Nardin, Hong Liu, Furen Zhang, John Connolly, Jianjun Liu, Alessandra Mortellaro, De Yun Wang, Michael Poidinger, Anis Larbi, Francesca Zolezzi, Olaf Rotzschke
Nature Communications, 2015 - A unique role for p53 in the regulation of M2 macrophage polarization
L Li, D S W Ng, W-C Mah, F F Almeida, S A Rahmat, V K Rao, S C Leow, F Laudisi, M T Peh, A M Goh, J S Y Lim, G D Wright, A Mortellaro, R Taneja, F Ginhoux, C G Lee, P K Moore, D P Lane
Cell Death and Differentiation, 2015 - NLRC4 gets out of control
Hanif Javanmard Khameneh, Alessandra Mortellaro
Nature Genetics, 2014 - GM-CSF-licensed CD11b+ lung dendritic cells orchestrate Th2 immunity to Blomia tropicalis
Qian Zhou, Adrian W S Ho, Andreas Schlitzer, Yafang Tang, Kenneth H S Wong, Fiona H S Wong, Yen Leong Chua, Veronique Angeli, Alessandra Mortellaro, Florent Ginhoux, David M Kemeny
Journal of Immunology, 2014 - Dendritic cells and their tissue microenvironment during exposure to pathogens
Phagocyte Pathogen Interactions Macrophages and the Host Response to Infection, 2014 - The Nod1, Nod2, and Rip2 axis contributes to host immune defense against intracellular Acinetobacter baumannii infection
Pradeep Bist, Neha Dikshit, Tse Hsien Koh, Alessandra Mortellaro, Thuan Tong Tan, Bindu Sukumaran
Infection and Immunity, 2014 - NLRPs, microbiota, and gut homeostasis: Unravelling the connection
Lia Paola Zambetti, Alessandra Mortellaro
Journal of Pathology, 2014 - Tyrosine kinases: the molecular switch for inflammasome activation
Federica Laudisi, Elena Viganò, Alessandra Mortellaro
Cellular and Molecular Immunology, 2014 - A novel human anti-interleukin-1β neutralizing monoclonal antibody showing in vivo efficacy
Angeline XH Goh, Sebastien Bertin-Maghit, Siok Ping Yeo, Adrian Ho, Heidi Derks, Alessandra Mortellaro, Cheng-I Wang
Mabs, 2014 - Caspase-11: The driving factor for noncanonical inflammasomes
Elena Viganò, Alessandra Mortellaro
European Journal of Immunology, 2013 - Cutting edge: The NLRP3 inflammasome links complement-mediated inflammation and IL-1β release
Federica Laudisi, Roberto Spreafico, Maximilien Evrard, Timothy R Hughes, Barbara Mandriani, Matheswaran Kandasamy, B Paul Morgan, Baalasubramanian Sivasankar, Alessandra Mortellaro
Journal of Immunology, 2013 - The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells
Ginevra Licandro, Hwei Ling Khor, Ottavio Beretta, Junyun Lai, Heidi Derks, Federica Laudisi, Cristina Conforti‐Andreoni, Hong Liang Qian, Gim Gee Teng, Paola Ricciardi‐Castagnoli, Alessandra Mortellaro
European Journal of Immunology, 2013 - CD80 and CD86 Differentially Regulate Mechanical Interactions of T-Cells with Antigen-Presenting Dendritic Cells and B-Cells
Tong Seng Lim, James Kang Hao Goh, Alessandra Mortellaro, Chwee Teck Lim, Günter J. Hämmerling, Paola Ricciardi-Castagnoli
Plos One, 2012 - The rhapsody of NLRPs: Master players of inflammation ... and a lot more
Lia Paola Zambetti, Federica Laudisi, Ginevra Licandro, Paola Ricciardi-Castagnoli, Alessandra Mortellaro
Immunologic Research, 2012 - Calcineurin/NFAT signalling inhibits myeloid haematopoiesis
Jan Fric, Clarice X. F. Lim, Esther G. L. Koh, Benjamin Hofmann, Jinmiao Chen, Hock Soon Tay, Siti Aminah Bte Mohammad Isa, Alessandra Mortellaro, Christiane Ruedl, Paola Ricciardi‐Castagnoli
EMBO Molecular Medicine, 2012 - Synergism between curdlan and GM-CSF confers a strong inflammatory signature to dendritic cells
Lin Min, Siti Aminah Bte Mohammad Isa, Wee Nih Fam, Siu Kwan Sze, Ottavio Beretta, Alessandra Mortellaro, Christiane Ruedl
Journal of Immunology, 2012 - Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18
Cristina Conforti-Andreoni, Roberto Spreafico, Hong Liang Qian, Nicolas Riteau, Bernhard Ryffel, Paola Ricciardi-Castagnoli, Alessandra Mortellaro
Journal of Immunology, 2011 - Mechanical interactions between dendritic cells and T cells correlate with T cell responsiveness
Tong Seng Lim, Alessandra Mortellaro, Chwee Teck Lim, Günter J Hämmerling, Paola Ricciardi-Castagnoli
Journal of Immunology, 2011 - From vaccine practice to vaccine science: The contribution of human immunology to the prevention of infectious disease
Alessandra Mortellaro, Paola Ricciardi‐Castagnoli
Immunology and Cell Biology, 2011 - The inflammasomes in health and disease: From genetics to molecular mechanisms of autoinflammation and beyond
Cristina Conforti-Andreoni, Paola Ricciardi-Castagnoli, Alessandra Mortellaro
Cellular and Molecular Immunology, 2011 - Synergism of NOD2 and NLRP3 activators promotes a unique transcriptional profile in murine dendritic cells
Cristina Conforti-Andreoni, Ottavio Beretta, Ginevra Licandro, Hong Liang Qian, Matteo Urbano, Federico Vitulli, Paola Ricciardi-Castagnoli, Alessandra Mortellaro
Journal of Leukocyte Biology, 2010 - The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants
Roberto Spreafico, Paola Ricciardi‐Castagnoli, Alessandra Mortellaro
European Journal of Immunology, 2010 - The need to identify myeloid dendritic cell progenitors in human blood
Alessandra Mortellaro, Siew Cheng Wong, Jan Fric, Paola Ricciardi-Castagnoli
Trends in Immunology, 2010 - Generation of murine growth factor-dependent long-term dendritic cell lines to investigate host-parasite interactions
Alessandra Mortellaro, Matteo Urbano, Stefania Citterio, Maria Foti, Francesca Granucci, Paola Ricciardi-Castagnoli
Methods in Molecular Biology, 2009 - Spotlight on mycobacteria and dendritic cells: will novel targets to fight tuberculosis emerge?
Alessandra Mortellaro, Lucy Robinson, Paola Ricciardi‐Castagnoli
EMBO Molecular Medicine, 2009 - Dendritic cells as sensors of environmental perturbations
Alessandra Mortellaro, Cristina Conforti-Andreoni, Jan Fric, Paola Ricciardi-Castagnoli
Microbes and Infection, 2008 - Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages
Ludovic Tailleux, Simon J. Waddell, Mattia Pelizzola, Alessandra Mortellaro, Michael Withers, Antoine Tanne, Paola Ricciardi Castagnoli, Brigitte Gicquel, Neil G. Stoker, Philip D. Butcher, Maria Foti, Olivier Neyrolles
Plos One, 2008 - Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects
Alessandra Mortellaro, Raisa Jofra Hernandez, Matteo M. Guerrini, Filippo Carlucci, Antonella Tabucchi, Maurilio Ponzoni, Francesca Sanvito, Claudio Doglioni, Clelia Di Serio, Luca Biasco, Antonia Follenzi, Luigi Naldini, Claudio Bordignon, Maria Grazia Roncarolo, Alessandro Aiuti
Blood, 2006 - Assessment of thymic output in common variable immunodeficiency patients by evaluation of T cell receptor excision circles
V GUAZZI, F AIUTI, I MEZZAROMA, F MAZZETTA, G ANDOLFI, A Mortellaro, M Pierdominici, R FANTINI, M MARZIALI, A AIUTI
Clinical and Experimental Immunology, 2002 - Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning
Alessandro Aiuti, Shimon Slavin, Memet Aker, Francesca Ficara, Sara Deola, Alessandra Mortellaro, Shoshana Morecki, Grazia Andolfi, Antonella Tabucchi, Filippo Carlucci, Enrico Marinello, Federica Cattaneo, Sergio Vai, Paolo Servida, Roberto Miniero, Maria Grazia Roncarolo, Claudio Bordignon
Science, 2002 - Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement
Alessandro Aiuti, Sergio Vai, Alessandra Mortellaro, Giulia Casorati, Francesca Ficara, Grazia Andolfi, Giuliana Ferrari, Antonella Tabucchi, Filippo Carlucci, Hans D. Ochs, Luigi D. Notarangelo, Maria Grazia Roncarolo, Claudio Bordignon
Nature Medicine, 2002 - New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-κB and AP-1 activation
Alessandra Mortellaro, Simona Songia, Paola Gnocchi, Mario Ferrari, Chiara Fornasiero, Roberto D’Alessio, Anna Isetta, Francesco Colotta, Josée Golay
Journal of Immunology, 1999 - Characterization of the New Immunosuppressive Drug Undecylprodigiosin in Human Lymphocytes: Retinoblastoma Protein, Cyclin-Dependent Kinase-2, and Cyclin-Dependent Kinase-4 as Molecular Targets
S Songia, A Mortellaro, S Taverna, C Fornasiero, E A Scheiber, E Erba, F Colotta, A Mantovani, A M Isetta, J Golay
Journal of Immunology, 1997
