Marianna Paykush

Scopus Publications

Mental health of volunteers: Origin of psychosomatic disorders in PTSD conditions
О.М. Kokun, І.М. Vizniuk, M.A. Paikush, S.S. Dolynnyi, A.V. Ordatii, and R.F. Karimulin
Publishing House Zaslavsky
Background. Numerous studies in various scientific areas deal with to the problem of mental health of Ukrainians: the theory and practice of psychological and pedagogical research, psychophysiological concepts and theories, a systematic approach in psychology, the psychophysiological aspect of the emotional background, as well as psychosomatic features of optimal personality functioning. Preservation of mental health has become a priority of the state policy of Ukraine to support the country’s stability and fighting capacity. The study of the impact of psychoemotional factors on the functional state of the body for the restoration and optimization of life support among volunteers who provide free psychological assistance and support the mental health of the population is relevant. The research was aimed at studying the origin of psychosomatic disorders in volunteers with post-traumatic stress disorder (PTSD), as well as determining the impact of these disorders on their mental health and psychosocial status. Materials and methods. The following psychodiagnostic tools were used: emotional burnout diagnosis method according to V. Boyko, NEWS questionnaire, PCL-5 questionnaire and post-traumatic growth questionnaire. According to the results of the study, it was found that emotional burnout in volunteers manifests itself in three phases: tension, resistance, and exhaustion according to indicators of a high level of stress and severe depression in respondents with signs of PTSD (23.9 %). Results. Mental disorders such as asthenic, anxiety-phobic, hysteroform and depressive syndromes are observed in all groups. Conclusions. The psychosomatic mechanism of the relationship between mental activity and behavior in PTSD includes the influence of a traumatic psycho-emotional factor that causes a constant feeling of danger, panic attacks or fear of repeating the situation, a feeling of hopelessness, low mood, apathy, loss of interest in usual activities, aggression, irritability, frequent conflicts and anger outbursts, feelings of detachment, social isolation, relationship problems and guilt for experiencing PTSD symptoms.

Diagnosis of post-traumatic syndrome: functional-vegetative analysis of sensory systems
О.М. Kokun, І.М. Vizniuk, M.A. Paikush, S.S. Dolynnyi, N.М. Ordatii, and R.F. Karimulin
Publishing House Zaslavsky
Background. The article analyzes the relationship between emotional states and the psycho-vegetative status of the respondents using functional-vegetative diagnosis, which is important for medical practice. The study was based on the use of functional-vegetative diagnosis, including the analysis of the parameters of the autonomic nervous system, cardiovascular reactivity and other indicators characterizing the psycho-vegetative status of the individual. The purpose: to justify the functional-vegetative diagnosis of sensory systems in the context of the organization of the psychological health of the individual. Materials and methods. The following theoretical methods were used: comparison of existing psychophysiological concepts, structural and genetic analysis of sensory systems, synthesis of theoretical and methodological approaches of the fields of psychophysiology, inductive-deductive approach to the study of the problem. Empirical methods include: measurements according to the functional-vegetative method of V. Makats on the comparison by quantitative signs of the dynamics of each participant in the experiment and comparison of the relative optimal coefficient of vegetative balance and integrated generalization of data in groups with the same initial level of vegetative balance and surveys to determine emotional psychological background on the Izard’s Differential Emotions Scale, according to the results of which an increase in positive emotions and preservation of a moderate level of positive dynamics due to the influence of a psycho-emotional stimulus was recorded. Conclusions. It is noted that the influence of the psycho-emotional factor is a rehabilitation aspect that has a normalizing effect on the sympathetic and parasympathetic nervous systems and functional-vegetative homeostasis. The obtained results open perspectives for further research on diagnosis and correction of mental and physical health.

Integration Methods as a Means of Improving the Level of Teachers’ Professional Training

SYNTHESIS OF NEW 3-MORPHOLYL-SUBSTITUTED 4-ARYL-2-ARYLIMINO-2,3-DIHYDROTHIAZOLE DERIVATIVES AND THEIR ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY
Iryna Drapak, , Borys Zimenkovsky, Lina Perekhoda, Hanna Yeromina, Zinaida Ieromina, Marianna Paykush, Liliya Logoyda, Vira Lubenets, Tetiana Holubieva,et al.
Lviv Polytechnic National University
New 4-aryl-3-(morpholin-4-yl)-2-arylimino-2,3-dihydrothiazole derivatives 1.1-1.16 were obtained using the Hantzsch reaction by condensation of N-(morpholin-4-yl)-N'-arylthioureas with the corresponding α bromoacetophenones in alcohols. Synthesized hydrobromides 1.1-1.8 were formed as crystalline precipitates during the boiling of the reaction mixture. Bases 1.9-1.16 were obtained by neutralizing the corresponding hydrobromides with NH4OH solution. It has been proposed a possible mechanism of the reaction that is based on the study of the structure of the synthesized compounds. The structures of the synthesized compounds were confirmed by 1H NMR spectroscopy with its special techniques (NOESY and ROESY experiments). It has been shown the formation of the isomer 4-(4'-chlorophenyl)-3-(morpholin-4-yl)-2-(4'-chlorophenylamino)-2.3-dihydrothiazole on the basis of compound 1.14. Pharmacological screening of synthesized derivatives of 4-aryl-2-arylimino-2,3-dihydrothiazole compounds revealed the analgesic effect in the model of visceral pain caused by the introduction of acetic acid to white mice. The anti-inflammatory effect of the synthesized compounds was evaluated in vivo by reducing limb edema in rats with carrageenan-induced inflammation. Thus, the synthesized compounds have analgesic and anti-inflammatory activity.