Murugan Arumugavel
@iitgn.ac.in
Research Associate
Indian Institute of Technology Gandhinagar
EDUCATION
Doctor of Philosophy
(Organic Chemistry) Indian Institute of Technology Hyderabad, Telangana, India.
Thesis Title: Sustainable approaches for the site-selective C-H functionalization of 2H-Indazoles. 8.2 CPI 2014‒2019
Master of Science
(Chemistry) Madurai Kamaraj University, Madurai, Tamil Nadu, India. 6.5 CPI 2011‒2013
Bachelor of Science
(Chemistry) St. Xavier’s College, Palayamkottai, Tirunelveli,
Tamil Nadu, India. 60.8% 2008‒2011
RESEARCH INTERESTS
Synthesis of heterocycle molecules and nitrogen-enriched molecules
Metal and Photoredox catalyzed selective C-H functionalization
Iodine catalyzed C-H functionalization
Design and synthesis of organic fluorescent dyes
Biological sensing and Imaging applications
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Rahul Dahiwadkar, Arumugavel Murugan, Delna Johnson, Rik Chakraborty, Vijay Thiruvenkatam, and Sriram Kanvah
Elsevier BV
Duddu S. Sharada, Narenderreddy Katta, Arumugavel Murugan, and Sonika Sharma
Georg Thieme Verlag KG
AbstractPhotoredox catalysis has received great attention in both academia and industry and remarkable progress has been made over the past decade. Now, it has been shown that a visible-light-mediated oxidative C–C bond cleavage of geminal diazides can be induced by organic dye catalysis for the synthesis of oxamates. A mechanistic study, confirmed by control experiments, indicates that this proceeds through single-electron transfer (SET). This methodology can be applied to convert a wide array of geminal diazides into oxamates.
Narenderreddy Katta, Mamata Ojha, Arumugavel Murugan, Sagar Arepally, and Duddu S. Sharada
Royal Society of Chemistry (RSC)
The direct oxidative cleavage of activated alkynes via hydroamination has been described using organic photocatalyst under visible-light irradiation at room temperature.
Arumugavel Murugan, Venkata Nagarjuna Babu, Ashok Polu, Nagaraj Sabarinathan, Manickam Bakthadoss, and Duddu S. Sharada
American Chemical Society (ACS)
Trifluoromethyl-substituted heteroarenes are biologically active compounds and useful building blocks. In this sequence, we have developed a visible-light-promoted regioselective C3-H trifluoromethylation of 2 H-indazole under metal-free conditions, which proceeds via a radical mechanism. The combination of photocatalysis and hypervalent iodine reagent provides a practical approach to a library of trifluoromethylated indazoles in 35-83% yields.
Venkata Nagarjuna Babu, Arumugavel Murugan, Narenderreddy Katta, Suman Devatha, and Duddu S. Sharada
American Chemical Society (ACS)
A concise, one-pot route to oxazoles and furocoumarins has been reported. The key step in this transformation involves in situ generation of N-acyliminium ion (NAI) precursor under catalyst and solvent-free conditions and their further transformations promoted by superacid in the same pot. We have also presented the experimental evidence for the involvement of proto-solvated novel exocyclic N-acyliminium ion. Further, the UV-visible and fluorescence studies revealed that few of the compounds reported here exhibited emission of blue light upon irradiation in EtOH in the region of 404-422 nm.
Arumugavel Murugan, Koteswar Rao Gorantla, Bhabani S. Mallik, and Duddu S. Sharada
Royal Society of Chemistry (RSC)
An efficient C3–H functionalization of indazole has been demonstrated. Notably, this method involves chelation-free radical C–H nitration on 2H-indazole. The radical mechanism was confirmed by control experiments and quantum chemical calculations. The synthetic utility has been proven by the synthesis of bio-relevant benzimidazoindazoles via reductive cyclization.
Arumugavel Murugan, Shinde Vidyacharan, Ruma Ghosh, and Duddu S. Sharada
Wiley
A metal-free regioselective approach to annulated indazoles is presented via dual C−H functionalization of indazole and benzylamine in a cascade fashion. The salient features of the present protocol are regioselective C3-functionalization, one-pot synthesis of annulated scaffolds, metal-free, peroxide-free, operationally simple and wide substrate scope.
Shinde Vidyacharan, Arumugavel Murugan, and Duddu S. Sharada
American Chemical Society (ACS)
Herein, we have reported an efficient Pd-catalyzed C-H functionalization of 2H-indazole at C3-position via an isocyanide insertion strategy for the synthesis of unprecedented benzoxazinoindazoles, indazoloquinaoxalines and benzoxazinoindazolones for the first time. Our new method provides an operationally simple and versatile route for a selective synthesis of 2-(2H-indazol-2-yl)phenols. Furthermore, we developed a sequential one-pot strategy for the synthesis of benzoxazinoindazolone under metal-oxidant-free conditions. We also achieved the isocyanide insertion between C(sp(2))-H and oxygen heteroatom for the first time. The key features of the present protocol are construction of 4 bonds in one-pot, synthesis of new skeletally diverse scaffolds, broad substrate scope, high yields and environmentally benign conditions.