Zaharadeen Muhammad Yusuf

@auk.edu.ng

Department of Biochemistry, College of Natural and Applied Sciences
Al-Qalam University Katsina

Zaharadeen Muhammad Yusuf


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https://researchid.co/mzyusuf

RESEARCH, TEACHING, or OTHER INTERESTS

Biochemistry, General Biochemistry, Genetics and Molecular Biology, Clinical Biochemistry, Cancer Research
13

Scopus Publications

345

Scholar Citations

8

Scholar h-index

7

Scholar i10-index

Scopus Publications

  • Nutritional evaluation and effects of pretreatment methods on Arachis hypogaea cultivars for Ready-to-Use Therapeutic Food (RUTF)
    Nigerian Journal of Nutritional Sciences, 2026
  • Prevalence of Cataract and Its Association with Sociodemographic Factors, Health-Related Conditions, and ABO Blood Groups in Birnin Kebbi, Nigeria
    Tajudeen Olanrewaju Yahaya, Rasheed Adebayo Yinusa, Zaharadeen Muhammad Yusuf, Sa'adat Haliru, Priscilla Oluwaseyi Obi, et al.
    Epidemiology and Health System Journal, 2025
    Background and aims: The increaing prevalence of cataracts in Nigeria necessitates improved preventive strategies. Accordingly, this study assessed the prevalence of cataracts and their association with sociodemographic factors, comorbidities, and ABO blood groups in Birnin Kebbi. Methods: A structured checklist was used to collect data from the medical records of 233 patients who attended the ophthalmology unit of two medical facilities between June 5, 2023, and June 5, 2024. Descriptive statistics were utilized to present data as frequencies and percentages. Moreover, chi-square tests and binary logistic regression were employed to test associations between cataract and explanatory variables at the 5% significance level. Results: The overall prevalence of cataract was 23% (54 participants). In addition, binary logistic regression revealed that age was the strongest predictor of cataracts. Individuals aged 55–64 were nearly six times more likely to have cataracts than those aged≤44 (OR=5.82, 95% CI: 2.10–16.14, P<0.001). Furthermore, male gender was significantly associated with increased risk (OR=1.88, 95% CI: 1.01–3.51, P=0.042). Comorbidities, including diabetes (OR=3.49), hypertension (OR=2.86), and glaucoma (OR=2.64), were significant predictors (P<0.05). Moreover, family history of cataract demonstrated the strongest effect, increasing the odds nearly 18-fold (OR=17.6, 95% CI: 4.44–69.9, P<0.001). Finally, ABO blood group, education, ethnicity, and religion were not significantly associated with cataracts. Conclusion: Age, male gender, family history, and comorbidities are independent predictors of cataracts, highlighting the need for targeted prevention and early intervention strategies.
  • Diphtheria outbreak in Nigeria: What do we know so far?
    Bashar Gulumbe, Usman Haruna, Zaharadeen Yusuf
    Microbes and Infectious Diseases, 2024
  • The role of armed conflict in driving antimicrobial resistance: examining the overlooked links
    Bashar Gulumbe, Junaidu Abubakar, Zaharadeen Yusuf, Ibrahim Dalhatu, Ibrahim Lawal
    Microbes and Infectious Diseases, 2024
  • Hydroethanolic extract of Piliostigma thonningii leaves extenuates the severity of diarrhoea in female Wistar rats
    Quadri Olaide Nurudeen, Zaharadeen Muhammad Yusuf, Saoban Sunkanmi Salimon, Mansurat Bolanle Falana, Abdul’aziz Ayinla, et al.
    Journal of Complementary and Integrative Medicine, 2024
    Objectives Nigeria ranks second in the global prevalence of diarrhoea with most cases concentrated in the Northern-region of the country. This research explored the antidiarrhoeal efficacy of the hydroethanolic extract of Piliostigma thonningii leaves (HEPTL), locally used to manage diarrhoeal conditions in Kebbi State, Nigeria. Methods P. thonningii leaves were screened for their secondary metabolites and mineral constituents. Using 3 standard-diarrhoea models, female Wistar rats completely-randomised into six-groups of six animals each were utilised for probing the antidiarrhoeal activity of HEPTL. Animals in groups I and II served as the negative and positive controls, whereas the rats in groups III, IV and V respectively received 50, 100, and 200 mg/kg body weight-(bw) of HEPTL. Results Six secondary metabolites and eight minerals were found in the extract, with flavonoids and calcium being the most abundant while steroids and zinc were the least prevalent, respectively. High performance liquid chromatographic analysis revealed the presence of 19 bioactive substances. Furthermore, there was a significant (p<0.05) and dose-related reduction in diarrhoea onset, water content, and wet faeces count. Similarly, the amount of intestinal fluid and average distance traversed by the charcoal-meal were decreased dose-dependently by the HEPTL with a commensurate rise in the suppression of intestinal fluid accrual and peristalsis. Acetylcholinesterase, Na+/K+-ATPase, reduced glutathione, intestinal-alkaline phosphatase and protein levels increased significantly (p<0.05) whereas superoxide-dismutase, catalase, intestinal-nitric oxide and malondialdehyde levels all fell significantly (p<0.05). However, the level of intestinal glucose was not significantly altered. Conclusions Overall, the HEPTL exhibited a profound effect in the alleviation of the severity of diarrhoea, notably at 200 mg/kg bw.
  • Historical Perspectives and Overview of the Value of Herbal Medicine
    Reference Series in Phytochemistry, 2024
  • Harnessing artificial intelligence in the post-COVID-19 era: A global health imperative
    Bashar Haruna Gulumbe, Zaharadeen Muhammad Yusuf, Abubakar Muhammad Hashim
    Tropical Doctor, 2023
    Despite the World Health Organization's declaration that the COVID-19 global emergency has ended, the threat of future pandemics remains a significant concern. This paper highlights the potential role of Artificial Intelligence (AI) in strengthening global health systems and mitigating future health crises. We discuss AI's proven utility throughout the COVID-19 pandemic, including disease surveillance, diagnostics, and drug discovery. AI's ability to rapidly analyze vast amounts of data to derive accurate trends and predictions underscores its superiority over traditional computer technology. However, the effective and ethical implementation of AI encounters significant challenges, including a pronounced digital divide, with applications mainly concentrated in high-income countries, thus exacerbating health inequities. We argue for international cooperation to enhance digital infrastructure in low- and middle-income countries, tailoring AI solutions to local needs, and addressing ethical and regulatory issues. The importance of maintaining evidence-based practice, rigorous evaluation of AI's impact, and investment in AI education and innovation are stressed. Ultimately, the potential of AI in global health systems is clear, and tackling these challenges will ensure its robust contribution to global health equity and resilience against future health crises.
  • The interplay among conflict, water scarcity, and cholera in Northern Nigeria
    Bashar Haruna Gulumbe, Zaharadeen Muhammad Yusuf, Abdullahi Adamu Faggo, Tajudeen O. Yahaya, Sahabi Sule Manga
    Public Health Challenges, 2023
    Cholera is a recurring issue in Nigeria, with outbreaks predominantly affecting the Northern states. In 2021, Nigeria experienced its most significant cholera epidemic in a decade, resulting in thousands of fatalities and cases. The spread of cholera and other waterborne diseases in Nigeria is linked to various factors such as flooding, conflict, and water scarcity. The country's poor drinking water quality and lack of equitable access to clean water exacerbate the problem, particularly in the conflict‐affected areas of the North. This paper discusses the interaction of conflict‐related displacement, water shortages, and cholera transmission in Northern Nigeria and provides insights into how these factors impact water resources and public health. This information can inform initiatives and policies to reduce the impact of conflict on water resources and enhance access to clean water in impacted areas. The article suggests that the primary challenges in eliminating cholera in the region include a lack of information due to severe security situations, bureaucratic requirements for delivering essential supplies, and a chronic shortage of water. A successful response to cholera in conflict and displacement situations also requires community engagement and the security and safety of humanitarian personnel. Long‐term solutions to the uprisings in the region are necessary to put an end to the issues related to banditry and insurgency.
  • Antibiotic resistance and the COVID-19 pandemic: A dual crisis with complex challenges in LMICs
    Bashar Haruna Gulumbe, Muhammed Rabiu Sahal, Abdulrakib Abdulrahim, Abdullahi Adamu Faggo, Zaharadeen Muhammad Yusuf, et al.
    Health Science Reports, 2023
    Background and AimsAntimicrobial resistance (AMR), a global health crisis of mounting urgency, has been further complicated by the ongoing COVID‐19 pandemic. The intricate relationship between these two phenomena is especially pronounced in low‐ and middle‐income countries (LMICs) due to the distinct obstacles encountered by their healthcare systems and policy structures. This study aims to explore the complex challenges arising from the coexistence of these two crises in LMICs and proffer specific recommendations for holistic management.MethodsAn exhaustive bibliographic survey was executed, employing search queries in specialized databases such as PubMed, SCOPUS, and Web of Science's SCI‐EXPANDED index. The timeframe for the literature search extended from January 2020 to January 2023. The search strategy employed key terms including antibiotic resistance, AMR, COVID‐19 pandemic, low‐ and middle‐income countries, SARS‐CoV‐2, and LMICs.ResultsThe pandemic has aggravated various drivers of AMR in LMICs, including limited capabilities, weak frameworks, and socioeconomic factors. New challenges have emerged, such as disruptions in the antibiotic supply chain and an increased risk of healthcare‐associated infections. The interaction between these drivers presents a complex problem that demands a coordinated response. Specific recommendations include strengthening health systems, funding research and innovation, and enhancing infection prevention control measures.ConclusionThe coexistence of AMR and the COVID‐19 pandemic in LMICs demands an integrated approach involving multiple stakeholders. Emphasis must be placed on constructing aligned regulatory frameworks, nurturing regional collaborations, and focusing on accessible therapeutic options. The study underscores the necessity for actionable strategies to achieve sustainable access to clean water and sanitation and also highlights the importance of long‐term planning, funding, and specialized expertise in emerging modalities like phage therapy.
  • Beyond the peak: Global health post-COVID-19 and Mpox: Successes, challenges and prospects
    Bashar Gulumbe, Zaharadeen Yusuf, Nazeef Usman
    Microbes and Infectious Diseases, 2023
  • The World Health Organization's post-pandemic stance: what does it mean for global health
    Bashar Haruna Gulumbe, Zaharadeen Muhammad Yusuf
    Public Health Research Practice, 2023
  • Historical Perspectives and Overview of the Value of Herbal Medicine
    Sylvester Chibueze Izah, Odangowei Inetiminebi Ogidi, Matthew Chidozie Ogwu, Saoban Sunkanmi Salimon, Zaharadeen Muhammad Yusuf, et al.
    Reference Series in Phytochemistry, 2023
  • Traditional medicinal plants used for treating emerging and re-emerging viral diseases in northern Nigeria
    Ibrahim Babangida Abubakar, Sulaiman Sani Kankara, Ibrahim Malami, Jamilu Bala Danjuma, Yusuf Zaharadeen Muhammad, et al.
    European Journal of Integrative Medicine, 2022

RECENT SCHOLAR PUBLICATIONS

  • Nutritional evaluation and effects of pretreatment methods on Arachis hypogaea cultivars for ready-to-use therapeutic food (RUTF)
    URA Yusuf Z.M., Ibrahim S.G., Yahaya T.O., Razak A.A., Isah S.A.
    Nigerian Journal of Nutritional Sciences 47 (1), 10 , 2026
    2026
  • Prevalence of Cataract and Its Association with Sociodemographic Factors, Health-Related Conditions, and ABO Blood Groups in Birnin Kebbi, Nigeria
    TO Yahaya, RA Yinusa, ZM Yusuf, S Haliru, PO Obi, JW Adamu
    Epidemiology 12 (3) , 2025
    2025
  • Nutritional Quality Assessment and Functional Properties of Textured Vegetable Protein
    ZM Yusuf, GO Shaibu, SG Ibrahim, MY Sani
    Nigerian Society of Biochemistry and Molecular Biology, 41st Scientific … , 2025
    2025
  • Preventive effect of hydroethanolic extract of aerva lanata leaf on iron overload-induced oxidative stress
    AT Abdulazeez, LO Olayemi, BO Yusuf, IA Moronfolu, ZM Yusuf
    Nigerian Journal of Biochemistry and Molecular Biology 39 (3), 146-153 , 2024
    2024
    Citations: 2
  • Historical perspectives and overview of the value of herbal medicine
    SC Izah, OI Ogidi, MC Ogwu, SS Salimon, ZM Yusuf, M Akram, MO Raimi, ...
    Herbal Medicine Phytochemistry: Applications and Trends, 3-35 , 2024
    2024
    Citations: 104
  • Peroxisome Proliferator Activated Receptors
    AT Abdulazeez, ZM Yusuf, SO Folami
    Journal of Biological Research and Reviews 1 (2), 97-97 , 2024
    2024
    Citations: 2
  • Diphtheria outbreak in Nigeria: What do we know so far?
    BH Gulumbe, UA Haruna, ZM Yusuf
    Microbes and Infectious Diseases 5 (2), 680-681 , 2024
    2024
    Citations: 2
  • The Role of armed conflict in driving antimicrobial resistance: examining the overlooked links
    BH Gulumbe, J Abubakar, ZM Yusuf, IA Dalhatu, I Lawal
    Microbes and Infectious Diseases 5 (2), 581-587 , 2024
    2024
    Citations: 6
  • Pharmacological mechanism of antiulcer activity of chromatographic Fraction B obtained from Acacia nilotica seedpods in experimental rats
    AT Abdulazeez, EA Balogun, ZM Yusuf
    Dutse Journal of Pure and Applied Sciences 10 (1a), 231-240 , 2024
    2024
  • Antioxidant activity and toxicological implications of the aqueous extract of Azanza garckeana fruit pulp in female wistar rats
    QO Nurudeen, MR Asinmi, MB Falana, MA Dikwa, ZM Yusuf, MO Lambe
    Nigerian Journal of Biochemistry and Molecular Biology 39 (1), 1-7 , 2024
    2024
    Citations: 4
  • Hydroethanolic extract of Piliostigma thonningii leaves extenuates the severity of diarrhoea in female Wistar rats
    QO Nurudeen, ZM Yusuf, SS Salimon, MB Falana, A Ayinla, MR Asinmi, ...
    Journal of Complementary and Integrative Medicine 21 (1), 26-37 , 2024
    2024
    Citations: 2
  • Genomica: Journal of General Biochemistry, Genetics and Molecular Biology
    AT Abdulazeez, ZM Yusuf, E Abidemi
    Molecular Biology 1 (1) , 2024
    2024
  • Toxicological Assessment of Chromatographic Fraction obtained From Aqueous extract of Acacia nilotica Seedpod in Experimental Rats
    AT Abdulazeez, Z Yusuf, E Balogun
    Genomica: Journal of General Biochemistry, Genetics and Molecular Biology 1 … , 2024
    2024
  • Therapeutic potentials of Acarbose and Protocatechuic acid in streptozotocin-induced diabetic rats
    AT Abdulazeez, SB Abdulsalam, ZM Yusuf
    Dutse Journal of Pure and Applied Sciences 10 (4c), 305-313 , 2024
    2024
  • Safety Assessment of the Hydroetha
    ZM Yusuf, M Muhammad, I Idris
    Applied Sciences 1 (3), 61-68 , 2024
    2024
  • Harnessing artificial intelligence in the post-COVID-19 era: A global health imperative
    BH Gulumbe, ZM Yusuf, AM Hashim
    Tropical Doctor 53 (4), 414-415 , 2023
    2023
    Citations: 23
  • Antibiotic resistance and the COVID‐19 pandemic: A dual crisis with complex challenges in LMICs
    BH Gulumbe, MR Sahal, A Abdulrahim, AA Faggo, ZM Yusuf, KH Sambo, ...
    Health Science Reports 6 (9), e1566 , 2023
    2023
    Citations: 23
  • The interplay among conflict, water scarcity, and cholera in Northern Nigeria
    BH Gulumbe, ZM Yusuf, AA Faggo, TO Yahaya, SS Manga
    Public Health Challenges 2 (3), e118 , 2023
    2023
    Citations: 12
  • Beyond the peak: Global health post-COVID-19 and Mpox: Successes, challenges and prospects
    BH Gulumbe, ZM Yusuf, NI Usman
    Microbes and Infectious Diseases 4 (3), 762-767 , 2023
    2023
    Citations: 4
  • Toxicological Status of the Hydroethanolic Extract of Piliostigma thonningii Leaves in Female Wistar Rats
    QO Nurudeen, ZM Yusuf, SS Salimon, MB Falana, MR Asinmi, ...
    Nigerian Journal of Biotechnology 40 (1), 92-99 , 2023
    2023
    Citations: 10

MOST CITED SCHOLAR PUBLICATIONS

  • Historical perspectives and overview of the value of herbal medicine
    SC Izah, OI Ogidi, MC Ogwu, SS Salimon, ZM Yusuf, M Akram, MO Raimi, ...
    Herbal Medicine Phytochemistry: Applications and Trends, 3-35 , 2024
    2024.0
    Citations: 104
  • Traditional medicinal plants used for treating emerging and re-emerging viral diseases in northern Nigeria
    IB Abubakar, SS Kankara, I Malami, JB Danjuma, YZ Muhammad, ...
    European Journal of Integrative Medicine 49, 102094 , 2022
    2022.0
    Citations: 98
  • Cholera Outbreaks in Conflict-Hit Regions of Northern Nigeria: An Overview
    BH Gulumbe, U Aminu, ZM Yusuf, UU Liman, AA Faggo, J Abubakar, ...
    Afro-Egyptian Journal of Infectious and Endemic Diseases 13 (2), 134-142 , 2023
    2023.0
    Citations: 31
  • Harnessing artificial intelligence in the post-COVID-19 era: A global health imperative
    BH Gulumbe, ZM Yusuf, AM Hashim
    Tropical Doctor 53 (4), 414-415 , 2023
    2023.0
    Citations: 23
  • Antibiotic resistance and the COVID‐19 pandemic: A dual crisis with complex challenges in LMICs
    BH Gulumbe, MR Sahal, A Abdulrahim, AA Faggo, ZM Yusuf, KH Sambo, ...
    Health Science Reports 6 (9), e1566 , 2023
    2023.0
    Citations: 23
  • The interplay among conflict, water scarcity, and cholera in Northern Nigeria
    BH Gulumbe, ZM Yusuf, AA Faggo, TO Yahaya, SS Manga
    Public Health Challenges 2 (3), e118 , 2023
    2023.0
    Citations: 12
  • Toxicological Status of the Hydroethanolic Extract of Piliostigma thonningii Leaves in Female Wistar Rats
    QO Nurudeen, ZM Yusuf, SS Salimon, MB Falana, MR Asinmi, ...
    Nigerian Journal of Biotechnology 40 (1), 92-99 , 2023
    2023.0
    Citations: 10
  • The bandit and insurgent attacks on health and education infrastructure hinder access to primary healthcare and education in Northern Nigeria
    A Abdulrahim, BH Gulumbe, AA Faggo, NI Usman, ZM Yusuf, ...
    Int J Social Sci Res Rev 6 (6), 160-6 , 2023
    2023.0
    Citations: 9
  • The Role of armed conflict in driving antimicrobial resistance: examining the overlooked links
    BH Gulumbe, J Abubakar, ZM Yusuf, IA Dalhatu, I Lawal
    Microbes and Infectious Diseases 5 (2), 581-587 , 2024
    2024.0
    Citations: 6
  • & Iyingiala, AA (2024). Historical Perspectives and Overview of the Value of Herbal Medicine
    SC Izah, OI Ogidi, MC Ogwu, SS Salimon, ZM Yusuf, M Akram
    Herbal Medicine Phytochemistry: Applications and Trends, 3-35 , 0
    Citations: 6
  • Antibiotic resistance and the COVID‐19 pandemic: A dual crisis with complex challenges in LMICs. Health Science Reports, 6 (9)
    BH Gulumbe, MR Sahal, A Abdulrahim, AA Faggo, ZM Yusuf, KH Sambo
    2023.0
    Citations: 5
  • Antioxidant activity and toxicological implications of the aqueous extract of Azanza garckeana fruit pulp in female wistar rats
    QO Nurudeen, MR Asinmi, MB Falana, MA Dikwa, ZM Yusuf, MO Lambe
    Nigerian Journal of Biochemistry and Molecular Biology 39 (1), 1-7 , 2024
    2024.0
    Citations: 4
  • Beyond the peak: Global health post-COVID-19 and Mpox: Successes, challenges and prospects
    BH Gulumbe, ZM Yusuf, NI Usman
    Microbes and Infectious Diseases 4 (3), 762-767 , 2023
    2023.0
    Citations: 4
  • Preventive effect of hydroethanolic extract of aerva lanata leaf on iron overload-induced oxidative stress
    AT Abdulazeez, LO Olayemi, BO Yusuf, IA Moronfolu, ZM Yusuf
    Nigerian Journal of Biochemistry and Molecular Biology 39 (3), 146-153 , 2024
    2024.0
    Citations: 2
  • Peroxisome Proliferator Activated Receptors
    AT Abdulazeez, ZM Yusuf, SO Folami
    Journal of Biological Research and Reviews 1 (2), 97-97 , 2024
    2024.0
    Citations: 2
  • Diphtheria outbreak in Nigeria: What do we know so far?
    BH Gulumbe, UA Haruna, ZM Yusuf
    Microbes and Infectious Diseases 5 (2), 680-681 , 2024
    2024.0
    Citations: 2
  • Hydroethanolic extract of Piliostigma thonningii leaves extenuates the severity of diarrhoea in female Wistar rats
    QO Nurudeen, ZM Yusuf, SS Salimon, MB Falana, A Ayinla, MR Asinmi, ...
    Journal of Complementary and Integrative Medicine 21 (1), 26-37 , 2024
    2024.0
    Citations: 2
  • The World Health Organization’s post-pandemic stance: What does it mean for global health?
    BH Gulumbe, ZM Yusuf
    Public Health Research and Practice 33 (2), e3322318 , 2023
    2023.0
    Citations: 1
  • Race Against Time: Experts Rally for Action as Meningitis and Cholera Outbreaks Continue to Spread in Nigeria‎
    BH Gulumbe, ZM Yusuf, AY Bazata
    Afro-Egyptian Journal of Infectious and Endemic Diseases 13 (2), 131-133 , 2023
    2023.0
    Citations: 1
  • Nutritional evaluation and effects of pretreatment methods on Arachis hypogaea cultivars for ready-to-use therapeutic food (RUTF)
    URA Yusuf Z.M., Ibrahim S.G., Yahaya T.O., Razak A.A., Isah S.A.
    Nigerian Journal of Nutritional Sciences 47 (1), 10 , 2026
    2026.0