Zaharadeen Muhammad Yusuf

RESEARCH, TEACHING, or OTHER INTERESTS

Biochemistry, General Biochemistry, Genetics and Molecular Biology, Clinical Biochemistry, Cancer Research

Scopus Publications

Diphtheria outbreak in Nigeria: What do we know so far?
Bashar Gulumbe, Usman Haruna, and Zaharadeen Yusuf
Egypts Presidential Specialized Council for Education and Scientific Research



The role of armed conflict in driving antimicrobial resistance: examining the overlooked links
Bashar Gulumbe, Junaidu Abubakar, Zaharadeen Yusuf, Ibrahim Dalhatu, and Ibrahim Lawal
Egypts Presidential Specialized Council for Education and Scientific Research



Hydroethanolic extract of Piliostigma thonningii leaves extenuates the severity of diarrhoea in female Wistar rats
Quadri Olaide Nurudeen, Zaharadeen Muhammad Yusuf, Saoban Sunkanmi Salimon, Mansurat Bolanle Falana, Abdul’aziz Ayinla, Muhammed Robiu Asinmi, Oghenetega ThankGod Oweh, and Muhammad Ali Dikwa
Walter de Gruyter GmbH
Abstract Objectives Nigeria ranks second in the global prevalence of diarrhoea with most cases concentrated in the Northern-region of the country. This research explored the antidiarrhoeal efficacy of the hydroethanolic extract of Piliostigma thonningii leaves (HEPTL), locally used to manage diarrhoeal conditions in Kebbi State, Nigeria. Methods P. thonningii leaves were screened for their secondary metabolites and mineral constituents. Using 3 standard-diarrhoea models, female Wistar rats completely-randomised into six-groups of six animals each were utilised for probing the antidiarrhoeal activity of HEPTL. Animals in groups I and II served as the negative and positive controls, whereas the rats in groups III, IV and V respectively received 50, 100, and 200 mg/kg body weight-(bw) of HEPTL. Results Six secondary metabolites and eight minerals were found in the extract, with flavonoids and calcium being the most abundant while steroids and zinc were the least prevalent, respectively. High performance liquid chromatographic analysis revealed the presence of 19 bioactive substances. Furthermore, there was a significant (p<0.05) and dose-related reduction in diarrhoea onset, water content, and wet faeces count. Similarly, the amount of intestinal fluid and average distance traversed by the charcoal-meal were decreased dose-dependently by the HEPTL with a commensurate rise in the suppression of intestinal fluid accrual and peristalsis. Acetylcholinesterase, Na+/K+-ATPase, reduced glutathione, intestinal-alkaline phosphatase and protein levels increased significantly (p<0.05) whereas superoxide-dismutase, catalase, intestinal-nitric oxide and malondialdehyde levels all fell significantly (p<0.05). However, the level of intestinal glucose was not significantly altered. Conclusions Overall, the HEPTL exhibited a profound effect in the alleviation of the severity of diarrhoea, notably at 200 mg/kg bw.


Historical Perspectives and Overview of the Value of Herbal Medicine




Harnessing artificial intelligence in the post-COVID-19 era: A global health imperative
Bashar Haruna Gulumbe, Zaharadeen Muhammad Yusuf, and Abubakar Muhammad Hashim
SAGE Publications
Despite the World Health Organization's declaration that the COVID-19 global emergency has ended, the threat of future pandemics remains a significant concern. This paper highlights the potential role of Artificial Intelligence (AI) in strengthening global health systems and mitigating future health crises. We discuss AI's proven utility throughout the COVID-19 pandemic, including disease surveillance, diagnostics, and drug discovery. AI's ability to rapidly analyze vast amounts of data to derive accurate trends and predictions underscores its superiority over traditional computer technology. However, the effective and ethical implementation of AI encounters significant challenges, including a pronounced digital divide, with applications mainly concentrated in high-income countries, thus exacerbating health inequities. We argue for international cooperation to enhance digital infrastructure in low- and middle-income countries, tailoring AI solutions to local needs, and addressing ethical and regulatory issues. The importance of maintaining evidence-based practice, rigorous evaluation of AI's impact, and investment in AI education and innovation are stressed. Ultimately, the potential of AI in global health systems is clear, and tackling these challenges will ensure its robust contribution to global health equity and resilience against future health crises.


The interplay among conflict, water scarcity, and cholera in Northern Nigeria
Bashar Haruna Gulumbe, Zaharadeen Muhammad Yusuf, Abdullahi Adamu Faggo, Tajudeen O. Yahaya, and Sahabi Sule Manga
Wiley
AbstractCholera is a recurring issue in Nigeria, with outbreaks predominantly affecting the Northern states. In 2021, Nigeria experienced its most significant cholera epidemic in a decade, resulting in thousands of fatalities and cases. The spread of cholera and other waterborne diseases in Nigeria is linked to various factors such as flooding, conflict, and water scarcity. The country's poor drinking water quality and lack of equitable access to clean water exacerbate the problem, particularly in the conflict‐affected areas of the North. This paper discusses the interaction of conflict‐related displacement, water shortages, and cholera transmission in Northern Nigeria and provides insights into how these factors impact water resources and public health. This information can inform initiatives and policies to reduce the impact of conflict on water resources and enhance access to clean water in impacted areas. The article suggests that the primary challenges in eliminating cholera in the region include a lack of information due to severe security situations, bureaucratic requirements for delivering essential supplies, and a chronic shortage of water. A successful response to cholera in conflict and displacement situations also requires community engagement and the security and safety of humanitarian personnel. Long‐term solutions to the uprisings in the region are necessary to put an end to the issues related to banditry and insurgency.


Antibiotic resistance and the COVID-19 pandemic: A dual crisis with complex challenges in LMICs
Bashar Haruna Gulumbe, Muhammed Rabiu Sahal, Abdulrakib Abdulrahim, Abdullahi Adamu Faggo, Zaharadeen Muhammad Yusuf, Kabir Hassan Sambo, Nazeef Idris Usman, Musbahu Abdullahi Bagwai, Wada Nafiu Muhammad, Aliyu Adamu,et al.
Wiley
AbstractBackground and AimsAntimicrobial resistance (AMR), a global health crisis of mounting urgency, has been further complicated by the ongoing COVID‐19 pandemic. The intricate relationship between these two phenomena is especially pronounced in low‐ and middle‐income countries (LMICs) due to the distinct obstacles encountered by their healthcare systems and policy structures. This study aims to explore the complex challenges arising from the coexistence of these two crises in LMICs and proffer specific recommendations for holistic management.MethodsAn exhaustive bibliographic survey was executed, employing search queries in specialized databases such as PubMed, SCOPUS, and Web of Science's SCI‐EXPANDED index. The timeframe for the literature search extended from January 2020 to January 2023. The search strategy employed key terms including antibiotic resistance, AMR, COVID‐19 pandemic, low‐ and middle‐income countries, SARS‐CoV‐2, and LMICs.ResultsThe pandemic has aggravated various drivers of AMR in LMICs, including limited capabilities, weak frameworks, and socioeconomic factors. New challenges have emerged, such as disruptions in the antibiotic supply chain and an increased risk of healthcare‐associated infections. The interaction between these drivers presents a complex problem that demands a coordinated response. Specific recommendations include strengthening health systems, funding research and innovation, and enhancing infection prevention control measures.ConclusionThe coexistence of AMR and the COVID‐19 pandemic in LMICs demands an integrated approach involving multiple stakeholders. Emphasis must be placed on constructing aligned regulatory frameworks, nurturing regional collaborations, and focusing on accessible therapeutic options. The study underscores the necessity for actionable strategies to achieve sustainable access to clean water and sanitation and also highlights the importance of long‐term planning, funding, and specialized expertise in emerging modalities like phage therapy.


Beyond the peak: Global health post-COVID-19 and Mpox: Successes, challenges and prospects
Bashar Gulumbe, Zaharadeen Yusuf, and Nazeef Usman
Egypts Presidential Specialized Council for Education and Scientific Research



The World Health Organization's post-pandemic stance: what does it mean for global health
Bashar Haruna Gulumbe and Zaharadeen Muhammad Yusuf
The Sax Institute



Historical Perspectives and Overview of the Value of Herbal Medicine
Sylvester Chibueze Izah, Odangowei Inetiminebi Ogidi, Matthew Chidozie Ogwu, Saoban Sunkanmi Salimon, Zaharadeen Muhammad Yusuf, Muhammad Akram, Morufu Olalekan Raimi, and Austin-Asomeji Iyingiala
Springer International Publishing



Traditional medicinal plants used for treating emerging and re-emerging viral diseases in northern Nigeria
Ibrahim Babangida Abubakar, Sulaiman Sani Kankara, Ibrahim Malami, Jamilu Bala Danjuma, Yusuf Zaharadeen Muhammad, Hafsat Yahaya, Dharmendra Singh, Umar Jaji Usman, Angela Nnenna Ukwuani-Kwaja, Aliyu Muhammad,et al.
Elsevier BV

RECENT SCHOLAR PUBLICATIONS

Preventive effect of hydroethanolic extract of aerva lanata leaf on iron overload-induced oxidative stress
AT Abdulazeez, LO Olayemi, BO Yusuf, IA Moronfolu, ZM Yusuf
Nigerian Journal of Biochemistry and Molecular Biology 39 (3), 146-153 2024



Historical perspectives and overview of the value of herbal medicine
SC Izah, OI Ogidi, MC Ogwu, SS Salimon, ZM Yusuf, M Akram, MO Raimi, ...
Herbal Medicine Phytochemistry: Applications and Trends, 3-35 2024



Peroxisome Proliferator Activated Receptors
AT Abdulazeez, ZM Yusuf, SO Folami
Journal of Biological Research and Reviews 1 (2), 97-97 2024



Diphtheria outbreak in Nigeria: What do we know so far?
BH Gulumbe, UA Haruna, ZM Yusuf
Microbes and Infectious Diseases 5 (2), 676-677 2024



The Role of armed conflict in driving antimicrobial resistance: Examining the overlooked links
BH Gulumbe, J Abubakar, ZM Yusuf, IA Dalhatu, I Lawal
Microbes and Infectious Diseases 5 (2), 577-583 2024



Antioxidant activity and toxicological implications of the aqueous extract of Azanza garckeana fruit pulp in female wistar rats
QO Nurudeen, MR Asinmi, MB Falana, MA Dikwa, ZM Yusuf, MO Lambe
Nigerian Journal of Biochemistry and Molecular Biology 39 (1), 1-7 2024



Hydroethanolic extract of Piliostigma thonningii leaves extenuates the severity of diarrhoea in female Wistar rats
QO Nurudeen, ZM Yusuf, SS Salimon, MB Falana, MR Asinmi, OTG Oweh, ...
Journal of Complementary and Integrative Medicine 21 (1), 26-37 2024



Toxicological Assessment of Chromatographic Fraction obtained From Aqueous extract of Acacia nilotica Seedpod in Experimental Rats
AT Abdulazeez, Z Yusuf, E Balogun
Genomica: Journal of General Biochemistry, Genetics and Molecular Biology 1 2024



Therapeutic potentials of Acarbose and Protocatechuic acid in streptozotocin-induced diabetic rats
AT Abdulazeez, SB Abdulsalam, ZM Yusuf
Dutse Journal of Pure and Applied Sciences 10 (4c), 305-313 2024



Safety Assessment of the Hydroetha
ZM Yusuf, M Muhammad, I Idris
Applied Sciences 1 (3), 61-68 2024



Harnessing artificial intelligence in the post-COVID-19 era: A global health imperative
BH Gulumbe, ZM Yusuf, AM Hashim
Tropical Doctor 53 (4), 414-415 2023



Antibiotic resistance and the COVID‐19 pandemic: A dual crisis with complex challenges in LMICs
BH Gulumbe, MR Sahal, A Abdulrahim, AA Faggo, ZM Yusuf, KH Sambo, ...
Health Science Reports 6 (9), e1566 2023



The interplay among conflict, water scarcity, and cholera in Northern Nigeria
BH Gulumbe, ZM Yusuf, AA Faggo, TO Yahaya, SS Manga
Public Health Challenges 2 (3), e118 2023



Beyond the peak: Global health post-COVID-19 and Mpox: Successes, challenges and prospects
BH Gulumbe, ZM Yusuf, NI Usman
Microbes and Infectious Diseases 4 (3), 762-767 2023



Toxicological Status of the Hydroethanolic Extract of Piliostigma thonningii Leaves in Female Wistar Rats
QO Nurudeen, ZM Yusuf, SS Salimon, MB Falana, MR Asinmi, ...
Nigerian Journal of Biotechnology 40 (1), 92-99 2023



’s post-pandemic stance: what does it mean for global health
BH Gulumbe, ZM Yusuf
Public Health Res Pract 32 (2), e3322318 2023



The World Health Organization's post-pandemic stance: what does it mean for global health.
BH Gulumbe, ZM Yusuf
Public Health Research & Practice 33 (2), 3322318-3322318 2023



The Bandit and Insurgent Attacks on Health and Education Infrastructure Hinder Access to Primary Healthcare and Education in Northern Nigeria
A Abdulrahim, BH Gulumbe, AA Faggo, NI Usman, ZM Yusuf, ...
International Journal of Social Science Research and Review 6 (6), 160-166 2023



Cholera Outbreaks in Conflict-Hit Regions of Northern Nigeria: An Overview
BH Gulumbe, U Aminu, ZM Yusuf, UU Liman, AA Faggo, J Abubakar, ...
Afro-Egyptian Journal of Infectious and Endemic Diseases 13 (2), 134-142 2023



Race Against Time: Experts Rally for Action as Meningitis and Cholera Outbreaks Continue to Spread in Nigeria
BH Gulumbe, ZM Yusuf, AY Bazata
Afro-Egyptian Journal of Infectious and Endemic Diseases 13 (2), 131-133 2023

MOST CITED SCHOLAR PUBLICATIONS

Traditional medicinal plants used for treating emerging and re-emerging viral diseases in northern Nigeria
IB Abubakar, SS Kankara, I Malami, JB Danjuma, YZ Muhammad, ...
European Journal of Integrative Medicine 49, 102094 2022
Citations: 55



Historical perspectives and overview of the value of herbal medicine
SC Izah, OI Ogidi, MC Ogwu, SS Salimon, ZM Yusuf, M Akram, MO Raimi, ...
Herbal Medicine Phytochemistry: Applications and Trends, 3-35 2024
Citations: 31



Harnessing artificial intelligence in the post-COVID-19 era: A global health imperative
BH Gulumbe, ZM Yusuf, AM Hashim
Tropical Doctor 53 (4), 414-415 2023
Citations: 13



Cholera Outbreaks in Conflict-Hit Regions of Northern Nigeria: An Overview
BH Gulumbe, U Aminu, ZM Yusuf, UU Liman, AA Faggo, J Abubakar, ...
Afro-Egyptian Journal of Infectious and Endemic Diseases 13 (2), 134-142 2023
Citations: 10



Antibiotic resistance and the COVID‐19 pandemic: A dual crisis with complex challenges in LMICs
BH Gulumbe, MR Sahal, A Abdulrahim, AA Faggo, ZM Yusuf, KH Sambo, ...
Health Science Reports 6 (9), e1566 2023
Citations: 9



Toxicological Status of the Hydroethanolic Extract of Piliostigma thonningii Leaves in Female Wistar Rats
QO Nurudeen, ZM Yusuf, SS Salimon, MB Falana, MR Asinmi, ...
Nigerian Journal of Biotechnology 40 (1), 92-99 2023
Citations: 4



The interplay among conflict, water scarcity, and cholera in Northern Nigeria
BH Gulumbe, ZM Yusuf, AA Faggo, TO Yahaya, SS Manga
Public Health Challenges 2 (3), e118 2023
Citations: 3



Diphtheria outbreak in Nigeria: What do we know so far?
BH Gulumbe, UA Haruna, ZM Yusuf
Microbes and Infectious Diseases 5 (2), 676-677 2024
Citations: 2



Beyond the peak: Global health post-COVID-19 and Mpox: Successes, challenges and prospects
BH Gulumbe, ZM Yusuf, NI Usman
Microbes and Infectious Diseases 4 (3), 762-767 2023
Citations: 1



The World Health Organization's post-pandemic stance: what does it mean for global health.
BH Gulumbe, ZM Yusuf
Public Health Research & Practice 33 (2), 3322318-3322318 2023
Citations: 1