Zaharadeen Muhammad Yusuf
@auk.edu.ng
Department of Biochemistry, College of Natural and Applied Sciences
Al-Qalam University Katsina
RESEARCH, TEACHING, or OTHER INTERESTS
Biochemistry, General Biochemistry, Genetics and Molecular Biology, Clinical Biochemistry, Cancer Research
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Quadri Olaide Nurudeen, Zaharadeen Muhammad Yusuf, Saoban Sunkanmi Salimon, Mansurat Bolanle Falana, Abdul’aziz Ayinla, Muhammed Robiu Asinmi, Oghenetega ThankGod Oweh, and Muhammad Ali Dikwa
Walter de Gruyter GmbH
Abstract Objectives Nigeria ranks second in the global prevalence of diarrhoea with most cases concentrated in the Northern-region of the country. This research explored the antidiarrhoeal efficacy of the hydroethanolic extract of Piliostigma thonningii leaves (HEPTL), locally used to manage diarrhoeal conditions in Kebbi State, Nigeria. Methods P. thonningii leaves were screened for their secondary metabolites and mineral constituents. Using 3 standard-diarrhoea models, female Wistar rats completely-randomised into six-groups of six animals each were utilised for probing the antidiarrhoeal activity of HEPTL. Animals in groups I and II served as the negative and positive controls, whereas the rats in groups III, IV and V respectively received 50, 100, and 200 mg/kg body weight-(bw) of HEPTL. Results Six secondary metabolites and eight minerals were found in the extract, with flavonoids and calcium being the most abundant while steroids and zinc were the least prevalent, respectively. High performance liquid chromatographic analysis revealed the presence of 19 bioactive substances. Furthermore, there was a significant (p<0.05) and dose-related reduction in diarrhoea onset, water content, and wet faeces count. Similarly, the amount of intestinal fluid and average distance traversed by the charcoal-meal were decreased dose-dependently by the HEPTL with a commensurate rise in the suppression of intestinal fluid accrual and peristalsis. Acetylcholinesterase, Na+/K+-ATPase, reduced glutathione, intestinal-alkaline phosphatase and protein levels increased significantly (p<0.05) whereas superoxide-dismutase, catalase, intestinal-nitric oxide and malondialdehyde levels all fell significantly (p<0.05). However, the level of intestinal glucose was not significantly altered. Conclusions Overall, the HEPTL exhibited a profound effect in the alleviation of the severity of diarrhoea, notably at 200 mg/kg bw.
Bashar Haruna Gulumbe, Zaharadeen Muhammad Yusuf, and Abubakar Muhammad Hashim
SAGE Publications
Despite the World Health Organization's declaration that the COVID-19 global emergency has ended, the threat of future pandemics remains a significant concern. This paper highlights the potential role of Artificial Intelligence (AI) in strengthening global health systems and mitigating future health crises. We discuss AI's proven utility throughout the COVID-19 pandemic, including disease surveillance, diagnostics, and drug discovery. AI's ability to rapidly analyze vast amounts of data to derive accurate trends and predictions underscores its superiority over traditional computer technology. However, the effective and ethical implementation of AI encounters significant challenges, including a pronounced digital divide, with applications mainly concentrated in high-income countries, thus exacerbating health inequities. We argue for international cooperation to enhance digital infrastructure in low- and middle-income countries, tailoring AI solutions to local needs, and addressing ethical and regulatory issues. The importance of maintaining evidence-based practice, rigorous evaluation of AI's impact, and investment in AI education and innovation are stressed. Ultimately, the potential of AI in global health systems is clear, and tackling these challenges will ensure its robust contribution to global health equity and resilience against future health crises.
Bashar Haruna Gulumbe, Muhammed Rabiu Sahal, Abdulrakib Abdulrahim, Abdullahi Adamu Faggo, Zaharadeen Muhammad Yusuf, Kabir Hassan Sambo, Nazeef Idris Usman, Musbahu Abdullahi Bagwai, Wada Nafiu Muhammad, Aliyu Adamu,et al.
Wiley
AbstractBackground and AimsAntimicrobial resistance (AMR), a global health crisis of mounting urgency, has been further complicated by the ongoing COVID‐19 pandemic. The intricate relationship between these two phenomena is especially pronounced in low‐ and middle‐income countries (LMICs) due to the distinct obstacles encountered by their healthcare systems and policy structures. This study aims to explore the complex challenges arising from the coexistence of these two crises in LMICs and proffer specific recommendations for holistic management.MethodsAn exhaustive bibliographic survey was executed, employing search queries in specialized databases such as PubMed, SCOPUS, and Web of Science's SCI‐EXPANDED index. The timeframe for the literature search extended from January 2020 to January 2023. The search strategy employed key terms including antibiotic resistance, AMR, COVID‐19 pandemic, low‐ and middle‐income countries, SARS‐CoV‐2, and LMICs.ResultsThe pandemic has aggravated various drivers of AMR in LMICs, including limited capabilities, weak frameworks, and socioeconomic factors. New challenges have emerged, such as disruptions in the antibiotic supply chain and an increased risk of healthcare‐associated infections. The interaction between these drivers presents a complex problem that demands a coordinated response. Specific recommendations include strengthening health systems, funding research and innovation, and enhancing infection prevention control measures.ConclusionThe coexistence of AMR and the COVID‐19 pandemic in LMICs demands an integrated approach involving multiple stakeholders. Emphasis must be placed on constructing aligned regulatory frameworks, nurturing regional collaborations, and focusing on accessible therapeutic options. The study underscores the necessity for actionable strategies to achieve sustainable access to clean water and sanitation and also highlights the importance of long‐term planning, funding, and specialized expertise in emerging modalities like phage therapy.
Bashar Gulumbe, Zaharadeen Yusuf, and Nazeef Usman
Egypts Presidential Specialized Council for Education and Scientific Research
Bashar Haruna Gulumbe and Zaharadeen Muhammad Yusuf
The Sax Institute
Sylvester Chibueze Izah, Odangowei Inetiminebi Ogidi, Matthew Chidozie Ogwu, Saoban Sunkanmi Salimon, Zaharadeen Muhammad Yusuf, Muhammad Akram, Morufu Olalekan Raimi, and Austin-Asomeji Iyingiala
Springer International Publishing
Ibrahim Babangida Abubakar, Sulaiman Sani Kankara, Ibrahim Malami, Jamilu Bala Danjuma, Yusuf Zaharadeen Muhammad, Hafsat Yahaya, Dharmendra Singh, Umar Jaji Usman, Angela Nnenna Ukwuani-Kwaja, Aliyu Muhammad,et al.
Elsevier BV