Goncharova Natalia

@blood.by

laboratory of biology and genetics of stem cells
Republican Scientific and Practical Center of Transfusiology and Medical Biotechnology

Goncharova Natalia


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https://researchid.co/n.goncharova

RESEARCH, TEACHING, or OTHER INTERESTS

Immunology, Biotechnology, Cell Biology, Multidisciplinary
30

Scopus Publications

429

Scholar Citations

11

Scholar h-index

11

Scholar i10-index

Scopus Publications

  • Comparison the impact of mesenchymal stromal cells, their microvesicles and plasma enriched with soluble platelet factors on survival and apoptosis of rat spleen lymphocytes in vitro
    Oksana V. Klimenkova, Michael P. Potapnev, Natalia V. Goncharova, Oleg A. Kudelich, Gennady G. Kondratenko
    Genes and Cells, 2024
    BACKGROUND: The trophic function is one of the important but insufficiently studied features of mesenchymal stromal cells (MSCs), their microvesicles (MVs), and plasma enriched with soluble platelet factors (PRPs), which ensure the viability of target cells.AIM: To analyze the capability of MSCs, MVs, and PRP to affect the viability and spontaneous and activation-induced apoptosis of rat spleen lymphocytes during culturing in vitro.MATERIALS AND METHODS: MSCs were isolated from the mononuclear cell fraction of the femoral bone marrow of Wistar rats using the plastic adhesion method. MVs were obtained from the conditioned medium of MSCs by centrifugation at 14,500 g. PRP was prepared by freezing/thawing rat peripheral blood platelet concentrate. Rat spleen lymphocytes were isolated on a density gradient of 1.077 g/cm3. The viability and degree of lymphocyte apoptosis in vitro were assessed by flow cytometry for 7-AAD incorporation and binding to annexin V.RESULTS: The presence of MSCs at 10 and 20% concentrations caused an increase in the number of living intact and PMA-activated lymphocytes by the end of 3-day in vitro cultivation. Compared with controls, the amount of necrotic cells decreased 8.3–13.5 times, and the number of apoptotic cells decreased 2.3–4.0 times, mainly due to lymphocytes at the late stage of apoptosis. MVs of MSCs at the indicated concentrations did not significantly affect the viability of lymphocytes cultured in vitro but reduced the level of apoptosis of intact and PMA-activated lymphocytes by 3.6 (р=0.03) and 4.8–5.2 (р=0.048; р=0.03) times respectively. Studies have shown that 1.25% rat PRP has a growth-stimulatory activity against MSCs but not against lymphocytes cultured in vitro. In the culture of intact lymphocytes, PRPs did not significantly affect cell viability with a slight decrease (2.7–2.9 fold, p 0.05) in the number of necrotic cells. In the culture of PMA-activated lymphocytes, 1.25–2.50% PRP increased the number of living cells by 1.6–2.2 times (р=0.002; р=0.01) and the number of necrotic cells by two times (р=0.02).CONCLUSION: MSCs, MVs of MSCs, and PRP, in decreasing order, enhanced the viability of rat spleen lymphocytes and suppressed late apoptosis during in vitro cultivation. Lymphocytes activated by phorbol myristate acetate are more sensitive to their vital action compared with resting cells.
  • Regional use of extracellular microvesicles of mesenchymal stromal cells in acute necrotizing pancreatitis in an experiment
    O. A. Kudelich, G. G. Kondratenko, M. P. Potapnev, O. V. Klimenkova, N. V. Goncharova
    Transplantologiya the Russian Journal of Transplantation, 2024
    Background. The significance of the problem of treatment of acute pancreatitis is due to an increase in the incidence with an increase in the number of necrotizing forms, accompanied by a high incidence of severe complications and high mortality.Objective. To identify the impact of regionally used extracellular microvesicles of mesenchymal stromal cells on the endogenous intoxication markers in acute necrotizing pancreatitis in the experiment.Material and methods. Acute pancreatitis was induced by the introduction of a 0.3 ml of 5% solution of non-ionic polyethylene glycol octylphenol ether detergent into the caudal part of the rat pancreas. The study was conducted on 42 adult Wistar rats, which were randomly divided into 4 groups. Group I (n=6) included intact animals, Group II (control group) (n=12) included rats with pancreatitis without treatment, Group III (n=12) consisted of rats with pancreatitis treated with analgesia + infusions of 0.9% sodium chloride solution (saline), Group IV (n=12) included rats with pancreatitis treated with analgesia+ saline infusions + regional application of extracellular microvesicles of mesenchymal stromal cells. Cells were obtained from the bone marrow of healthy animals. Microvesicles were obtained by differential centrifugation under sterile conditions. Microvesicles were administered one day after the pancreatitis induction through the catheter installed into the pathologically altered part of the pancreas. The dose of microvesicles was calculated as equivalent to (derived from) 1 million mesenchymal stromal cells. The hematological parameters, markers of the systemic manifestation of the pathological process (alpha-amylase, aspartate aminotransferase, alanine aminotransferase), the endogenous intoxication markers (lipid peroxidation activity, nitric oxide level), the systemic inflammatory response markers (tumor necrosis factor-alpha, interleukin-6) were studied on the 3rd and 7th day from the start of disease modeling.Results. Regional use of extracellular microvesicles of mesenchymal stromal cells in the treatment of acute experimental necrotizing pancreatitis at an early stage helped to normalize the level of blood platelets, reduce enzymeemia, elements of endogenous intoxication (interleukin-6, tumor necrosis factor-alpha), and the nitric oxide level.Conclusion. The early application of extracellular microvesicles of mesenchymal stromal cells in the treatment of acute necrotizing pancreatitis in an experiment has a positive effect on parameters, which are key links of pathogenesis and leading markers of this disease severity.
  • Comparative Evaluation of Cellular Origin Bioproducts Effects on the Course of Acute Necrotizing Pancreatitis in Experiment
    О. А. Куделич, Г. Г. Кондратенко, Михаил Петрович Потапнев, Татьяна Сергеевна Колесникова, О. В. Клименкова, et al.
    Surgery Eastern Europe, 2024
    Цель. Обосновать возможность коррекции системной патологической реакции при экспериментальном остром некротизирующем панкреатите с помощью локального применения мезенхимальных стромальных клеток (МСК), их микровезикул (МВ) или плазмы, обогащенной растворимыми факторами тромбоцитов (ПОРФТ). Материалы и методы. Изучено влияние МСК, МВ МСК и ПОРФТ на гематологические и биохимические показатели при остром экспериментальном некротизирующем панкреатите. Исследование проведено на 54 половозрелых крысах-самцах линии Wistar. Модель острого некротизирующего панкреатита создавали стандартно введением 0,3 мл 5% неионного детергента полиэтиленгликоль-октилфенолового эфира в хвостовую часть поджелудочной железы крыс. На 3-и и 7-е сутки от начала моделирования заболевания оценивали гематологические показатели, маркеры системного проявления патологического процесса (альфа-амилаза, глюкоза, аспартатаминотрансфераза, аланинаминотрансфераза), маркеры эндогенной интоксикации (малоновый диальдегид, уровень оксида азота), маркеры системного воспалительного ответа (фактор некроза опухоли α, интерлейкин-6, СРБ). Результаты. Применение МСК и их микровезикул на ранней стадии острого некротизирующего панкреатита положительно влияет на количество тромбоцитов в периферической крови экспериментальных животных. В эти же сроки МСК предотвращали гипергликемию, что может свидетельствовать о цитопрототекторном их действии в отношении гормонпродуцирующих клеток поджелудочной железы. Использование МСК и ПОРФТ способствует нормализации активности α-амилазы в сыворотке крови, что также может косвенно свидетельствовать о системном антиферментном, опосредованном через цитопротекторное действие в отношении экзокринных клеточных структур поджелудочной железы. Использование ПОРФТ, МСК и МВ МСК при остром экспериментальном некротизирующем панкреатите уменьшает системный воспалительный ответ, что продемонстрировала динамика значений ФНО-α и ИЛ-6. В сыворотке крови животных, которым проводилось лечение МСК, уровень СРБ на протяжении всего эксперимента не повышался. Регионарное использование МСК препятствует росту уровня оксида азота и малонового диальдегида в сыворотке крови экспериментальных животных. Заключение. Раннее регионарное применение биопродуктов клеточного происхождения при экспериментальном остром некротизирующем панкреатите оказывает системный положительный эффект, что позволяет рассматривать их в качестве перспективных средств для патогенетического лечения данного заболевания. Purpose. To substantiate a possibility of correcting a systemic pathological reaction in experimental acute necrotizing pancreatitis by local application of mesenchymal stromal cells (MSCs), their microvesicles (MV MSCs), or plasma enriched with platelet factors (PRP). Materials and methods. The effect of MSCs, MB MSCs and PORFT on hematological and biochemical parameters in acute experimental necrotizing pancreatitis was studied. The study was carried out on 54 adults Wistar rats. Acute pancreatitis was induced by introducing 0.3 ml of 5% solution of non-ionic polyethylene glycol octylphenol ether detergent into the caudal part of rats’ pancreas. Hematological parameters, markers of systemic manifestation of the pathological process (alpha-amylase, glucose, AST, ALT), markers of endogenous intoxication (malondialdehyde, nitric oxide), and markers of systemic inflammatory response (tumor necrosis factor-alpha, interleukin-6, CRP) were evaluated on the 3rd and 7th day from the beginning of disease modeling. Results. MSCs and their microvesicles used at early stages of acute necrotizing positively affect the number of platelets in the peripheral blood of experimental animals. At the same time, MSCs prevented hyperglycemia, indicating their cytoprotective effect on hormone-producing pancreatic cells. The use of MSCs and PRP promotes normalization of α-amylase activity in serum, which may also indirectly indicate systemic anti-enzyme action, mediated through cytoprotective one, against exocrine cellular structures of the pancreas. MSCs, MB MSCs and PRP application in acute experimental necrotizing pancreatitis reduced the systemic inflammatory response, as demonstrated by TNF-α and IL-6 values changes. CRP blood serum levels in animals treated with MSCs did not increase throughout the experiment. A regional use of MSCs prevents increasing nitric oxide and malondialdehyde levels in blood serum of experimental animals. Conclusion. A regional use of cell origin bioproducts at early stages of experimental acute necrotizing pancreatitis provides a positive systemic effect, which allows considering them as promising agents for pathogenetic treatment of this disease.
  • Dual Effect of Amino Acid Compositions on Antibacterial Activity of Human Neutrophilic Granulocytes
    M. P. Potapnev, S. V. Andreyev, N. V. Goncharova, O. I. Viatkina, E. L. Berdina, et al.
    Biochemistry Moscow Supplement Series B Biomedical Chemistry, 2023
  • Dual effect of amino acid compositions upon antibacterial activity of human neutrophilic granulocytes
    M.P. Potapnev, S.V. Andreyev, N.V. Goncharova, O.I. Viatkina, E.L. Berdina, et al.
    Immunologiya, 2023
  • Clinical benefits of single vs repeated courses of mesenchymal stem cell therapy in epilepsy patients
    Fedor Hlebokazov, Tatiana Dakukina, Michael Potapnev, Svetlana Kosmacheva, Lubov Moroz, et al.
    Clinical Neurology and Neurosurgery, 2021
  • Treatment of refractory epilepsy patients with autologous mesenchymal stem cells reduces seizure frequency: An open label study
    Fedor Hlebokazov, Tatiana Dakukina, Svetlana Ihnatsenko, Svetlana Kosmacheva, Michael Potapnev, et al.
    Advances in Medical Sciences, 2017
  • The Use of Autologous Mesenchymal Stem Cells for Cell Therapy of Patients with Amyotrophic Lateral Sclerosis in Belarus
    Yu. N. Rushkevich, S. M. Kosmacheva, G. V. Zabrodets, S. I. Ignatenko, N. V. Goncharova, et al.
    Bulletin of Experimental Biology and Medicine, 2015
  • In vitro expansion and lineage commitment of the human umbilical cord blood myeloid progenitors
    Cellular Transplantation and Tissue Engineering, 2012
  • Non-viral engineering of skin precursor-derived Schwann cells for enhanced NT-3 production in adherent and microcarrier culture
    A. Shakhbazau, D. Shcharbin, M. Bryszewska, R. Kumar, H. M. Wobma, et al.
    Current Medicinal Chemistry, 2012
    Genetic engineering of stem cells and their derivatives has the potential to enhance their regenerative capabilities. Here, dendrimer- and lipofection-based approaches were used for non-viral neurotrophin-3 (NT-3) over-expression in Schwann cells differentiated from skin precursors (SKP-SCs). A variety of dendrimers were first tested for transfection efficiency on HEK 293T cells, with PAMAMNH2 G4 found most effective and used subsequently for SKP-SCs transfection. Plasmid-based expression resulted in increased NT-3 release from SKP-SCs in both adherent and microcarrier-based culture. In a proof-of-concept study, the microcarrier/SKP-SCs were implanted into the injured nerve, and transfected cells were shown to detach, integrate into the nerve tissue and associate with regenerating axons. Virus-free systems for transient neurotrophin expression are a feasible and biologically safe option to increase the therapeutic value of stem cells and stem cell-derived cells in nerve repair strategies. Further work to develop bioprocesses for expansion of SKP-SCs on microcarriers in bioreactors is still needed.
  • Dendrimer-driven neurotrophin expression differs in temporal patterns between rodent and human stem cells
    Antos Shakhbazau, Dzmitry Shcharbin, Ihar Seviaryn, Natalya Goncharova, Svetlana Kosmacheva, et al.
    Molecular Pharmaceutics, 2012
  • Non-virally modified human mesenchymal stem cells produce ciliary neurotrophic factor in biodegradable fibrin-based 3D scaffolds
    Antos Shakhbazau, Dzmitry Shcharbin, Natalya Petyovka, Natalya Goncharova, Ihar Seviaryn, et al.
    Journal of Pharmaceutical Sciences, 2012
  • Fourth generation phosphorus-containing dendrimers: Prospective drug and gene delivery carrier
    D. Shcharbin, V. Dzmitruk, A. Shakhbazau, N. Goncharova, I. Seviaryn, et al.
    Pharmaceutics, 2011
  • Effect of cholesterol on the functional activity of proteins responsible for the resistance of human lymphocytes to xenobiotics
    A. V. Tamashevski, N. M. Kozlova, N. V. Goncharova, G. P. Zubritskaya, E. I. Slobozhanina
    Biophysics, 2011
  • [Effect of cholesterol on the functional activity of proteins responsible for the resistance of human lymphocytes to xenobiotics].
    Biofizika, 2011
  • Hepatogenic potential of human bone marrow and umbilical cord blood mesenchymal stem cells
    S. M. Kosmacheva, I. N. Seviaryn, N. V. Goncharova, N. V. Petyovka, M. P. Potapnev
    Bulletin of Experimental Biology and Medicine, 2011
  • Neurons and stromal stem cells as targets for polycation-mediated transfection
    A. V. Shakhbazau, D. G. Shcharbin, N. V. Goncharova, I. N. Seviaryn, S. M. Kosmacheva, et al.
    Bulletin of Experimental Biology and Medicine, 2011
  • Revealing some virus infections by lymphocyte laser scattering
    Gennady I. Ruban, Vladimir V. Berdnik, Dmitry V. Marinitch, Natalia V. Goncharova, Valery A. Loiko
    Proceedings of SPIE the International Society for Optical Engineering, 2011
  • Light scattering and morphology of the lymphocyte as applied to flow cytometry for distinguishing healthy and infected individuals
    Gennady I. Ruban, Vladimir V. Berdnik, Dmitry V. Marinitch, Natalia V. Goncharova, Valery A. Loiko
    Journal of Biomedical Optics, 2010
  • Use of polyamidoamine dendrimers to engineer BDNF-producing human mesenchymal stem cells
    Antos Shakhbazau, Dzmitry Shcharbin, Ihar Seviaryn, Natalya Goncharova, Svetlana Kosmacheva, et al.
    Molecular Biology Reports, 2010
  • Transfection efficiencies of PAMAM dendrimers correlate inversely with their hydrophobicity
    Antos Shakhbazau, Iauhenia Isayenka, Nikolai Kartel, Natalya Goncharova, Ihar Seviaryn, et al.
    International Journal of Pharmaceutics, 2010
  • Erratum: "Plasticity of human mesenchymal stem cell phenotype and expression profile under neurogenic conditions" (Bulletin of Experimental Biology and Medicine (2009) vol. 147(4) (513-516))
    A. V. Shakhbazau, N. V. Goncharova, S. M. Kosmacheva, N. A. Kartel’, M. P. Potapnev
    Bulletin of Experimental Biology and Medicine, 2009
  • Plasticity of human mesenchymal stem cell phenotype and expression profile under neurogenic conditions
    A. V. Shakhbazov, N. V. Goncharova, S. M. Kosmacheva, N. A. Kartel’, M. P. Potapnev
    Bulletin of Experimental Biology and Medicine, 2009
  • Viral vectors for stable transduction of human mesenchymal stem cells: Systems based on adeno-associated viruses and lentiviruses
    A. V. Shakhbazau, I. N. Sevyaryn, N. V. Goncharova, V. V. Grinev, S. M. Kosmacheva, et al.
    Bulletin of Experimental Biology and Medicine, 2008
  • Development of human granulocyte morphometric model for scanning flow cytometry
    Gennady I. Ruban, Svetlana M. Kosmacheva, Natalia V. Goncharova, Valery A. Loiko
    Proceedings of SPIE the International Society for Optical Engineering, 2007
  • Investigation of morphometric parameters for granulocytes and lymphocytes as applied to a solution of direct and inverse light-scattering problems
    Gennady I. Ruban, Svetlana M. Kosmacheva, Natalia V. Goncharova, Dirk Van Bockstaele, Valery A. Loiko
    Journal of Biomedical Optics, 2007
  • Investigation of human white blood cells: Application to scanning flow cytometry
    Valery A. Loiko, Gennady I. Ruban, Olga A. Gritsai, Alexander A. Miskevich, Svetlana M. Kosmacheva, et al.
    Proceedings of SPIE the International Society for Optical Engineering, 2006
  • Morphometric model of lymphocyte as applied to scanning flow cytometry
    Valery A. Loiko, Gennady I. Ruban, Olga A. Gritsai, Alexey D. Gruzdev, Svetlana M. Kosmacheva, et al.
    Journal of Quantitative Spectroscopy and Radiative Transfer, 2006
  • Modeling long-haul WDM transmission in nonlinear optical fibers using a fast split-step wavelet collocation method
    Piers 2004 Progress in Electromagnetics Research Symposium Extended Papers Proceedings, 2004
  • Discrepancy between direct and antibody-dependent cytotoxic activities of human LAK cells
    Michael P. Potapnev, Tatyana S. Garbuzenco, Natalia V. Goncharova, Vladimir D. Zobnin, Oleg V. Shadrin, et al.
    Immunology Letters, 1994

RECENT SCHOLAR PUBLICATIONS

  • Comparison the impact of mesenchymal stromal cells, their microvesicles and plasma enriched with soluble platelet factors on survival and apoptosis of rat spleen lymphocytes in …
    OV Klimenkova, MP Potapnev, NV Goncharova, OA Kudelich, ...
    Genes & Cells 19 (3), 387-399 , 2024
    2024
  • Dual Effect of Amino Acid Compositions on Antibacterial Activity of Human Neutrophilic Granulocytes
    MP Potapnev, SV Andreyev, NV Goncharova, OI Viatkina, EL Berdina, ...
    Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry 17 (1), 17-25 , 2023
    2023
    Citations: 1
  • Sistemnoe vs lokal'noe vvedenie mezenkhimal'nykh stromal'nykh kletok dlya terapii neyrodegenerativnykh zabolevaniy cheloveka
    MP Potapnev, SM Kosmacheva, LA Repina, AG Ionova, NV Goncharova, ...
    Genes & Cells 17 (3), 189-190 , 2022
    2022
  • Experimental search for new means of Pathogenetic therapy COVID-19: Inhibitor of H2-receptors famotidine increases the effect of oseltamivir on survival and immune status of …
    NV Goncharov, KA Vasilyev, IV Kudryavtsev, PP Avdonin, DA Belinskaia, ...
    Journal of Evolutionary Biochemistry and Physiology 58 (1), 230-246 , 2022
    2022
    Citations: 2
  • MARKERS OF PLATELET DYSFUNCTION IN THE FIRST 48 HOURS OF LACUNAR STROKE RESULTING FROM CEREBRAL SMALL VESSEL DISEASE
    L Anatskaia, N Goncharova, L Matusevich, N Shcharbina, V Zabarovski, ...
    INTERNATIONAL JOURNAL OF STROKE 16 (2_ SUPPL), 50-50 , 2021
    2021
  • Clinical benefits of single vs repeated courses of mesenchymal stem cell therapy in epilepsy patients
    F Hlebokazov, T Dakukina, M Potapnev, S Kosmacheva, L Moroz, ...
    Clinical neurology and neurosurgery 207, 106736 , 2021
    2021
    Citations: 37
  • Circulating cytological markers of endothelial dysfunction in acute lacunar stroke resulting from cerebral small vessels disease
    L Anatskaia, N Goncharova, N Shcharbina
    Journal of the Neurological Sciences 381, 393 , 2017
    2017
  • Mezenkhimnye stromal'nye kletki platsenty cheloveka podderzhivayut differentsirovku gemopoeticheskikh CD34+ kletok pupovinnoy krovi v granulotsitarno-monotsitarnom napravlenii
    EV Vasina, VS Kostyunina, NV Goncharova, IN Severin, NV Petevka
    Genes & Cells 12 (3), 60-60 , 2017
    2017
  • The features of cellular immunity in patients with treatment-resistant asthma
    Z Antanovich, N Goncharova
    European Respiratory Journal 50 (suppl 61) , 2017
    2017
  • Treatment of refractory epilepsy patients with autologous mesenchymal stem cells reduces seizure frequency: an open label study
    F Hlebokazov, T Dakukina, S Ihnatsenko, S Kosmacheva, M Potapnev, ...
    Advances in medical sciences 62 (2), 273-279 , 2017
    2017
    Citations: 69
  • P-GLYCOPROTEIN TRANSPORT ACTIVITY UNDER REDOX BALANCE CHANGES IN LYMPHOCYTES OF PATIENTS WITH B-CHRONIC LYMPHOCYTIC LEUKEMIA
    Y Harmaza, A Tamashevski, N Goncharova, E Slobozhanina, ...
    HAEMATOLOGICA 101, 721-721 , 2016
    2016
  • Our experience in application of autologous bone-marrow-derived mesenchymal stem cells for therapy of patients with symptomatic epilepsy
    FP Hlebokazov, TV Dоkukina, SI Ighnatenko, SM Кosmacheva, ...
    Epilepsy and paroxysmal conditions 6 (1), 6-14 , 2016
    2016
    Citations: 2
  • Growth-stimulating activity of platelet preparations in relation to mesenchymal stem cells in vitro
    SI Ihnatsenko, SM Kasmachova, MP Potapnev, EA Kahno, ...
    Proceedings of the National Academy of Sciences of Belarus, Medical series … , 2016
    2016
    Citations: 2
  • Clinical phenotype of destructive-regenerative endothelial response in the first 48 hours of lacunar stroke resulting from cerebral small vessels disease
    L Anatskain, N Goncharova, G Khulup
    CEREBROVASCULAR DISEASES 41, 198-198 , 2016
    2016
  • EFFICIENCY OF MONTELUKAST TREATMENT OF THE CHILDREN, SUFFERING FROM BRONCHIAL ASTHMA
    II Balabolkin, IE Smirnov, AV Liapunov, OF Lukina, NV Goncharova, ...
    Current Pediatrics 5 (5), 35-38 , 2015
    2015
  • The content of natural killer cells in the blood of patients with asthma in combination with depression
    Z Antanovich, N Goncharova
    European Respiratory Journal 46 (suppl 59) , 2015
    2015
  • The use of autologous mesenchymal stem cells for cell therapy of patients with amyotrophic lateral sclerosis in Belarus
    YN Rushkevich, SM Kosmacheva, GV Zabrodets, SI Ignatenko, ...
    Bulletin of experimental biology and medicine 159 (4), 576-581 , 2015
    2015
    Citations: 60
  • Effect of intravenous low intensity laser irradiation of blood on the level of angiogenic T-cells in acute lacunar stroke
    L Anatskaia, N Goncharova, I Seviaryn, GG Khulup, SS Marchenko, ...
    EUROPEAN JOURNAL OF NEUROLOGY 22, 808-808 , 2015
    2015
  • Mononuclears size-distribution as marker of acute leukemia
    GI Ruban, NV Goncharova, DV Marinitch, VA Loiko
    International Journal of Advance in Medical Science 3, 1-12 , 2015
    2015
    Citations: 1
  • Influence of intravenous low-intensity laser irradiation of blood on the level of circulating endothelial progenitor cells in acute lacunar stroke
    L Anatskaia, N Goncharova, I Seviaryn, G Khulup
    INTERNATIONAL JOURNAL OF STROKE 10, 367-367 , 2015
    2015

MOST CITED SCHOLAR PUBLICATIONS

  • Treatment of refractory epilepsy patients with autologous mesenchymal stem cells reduces seizure frequency: an open label study
    F Hlebokazov, T Dakukina, S Ihnatsenko, S Kosmacheva, M Potapnev, ...
    Advances in medical sciences 62 (2), 273-279 , 2017
    2017
    Citations: 69
  • Investigation of morphometric parameters<? xpp qa?> for granulocytes and lymphocytes as applied<? xpp qa?> to a solution of direct and inverse light-scattering problems
    GI Ruban, SM Kosmacheva, NV Goncharova, DV Bockstaele, VA Loiko
    Journal of biomedical optics 12 (4), 044017-044017-11 , 2007
    2007
    Citations: 61
  • The use of autologous mesenchymal stem cells for cell therapy of patients with amyotrophic lateral sclerosis in Belarus
    YN Rushkevich, SM Kosmacheva, GV Zabrodets, SI Ignatenko, ...
    Bulletin of experimental biology and medicine 159 (4), 576-581 , 2015
    2015
    Citations: 60
  • Morphometric model of lymphocyte as applied to scanning flow cytometry
    VA Loiko, GI Ruban, OA Gritsai, AD Gruzdev, SM Kosmacheva, ...
    Journal of Quantitative Spectroscopy and Radiative Transfer 102 (1), 73-84 , 2006
    2006
    Citations: 48
  • Clinical benefits of single vs repeated courses of mesenchymal stem cell therapy in epilepsy patients
    F Hlebokazov, T Dakukina, M Potapnev, S Kosmacheva, L Moroz, ...
    Clinical neurology and neurosurgery 207, 106736 , 2021
    2021
    Citations: 37
  • Plasticity of human mesenchymal stem cell phenotype and expression profile under neurogenic conditions
    AV Shakhbazov, NV Goncharova, SM Kosmacheva, NA Kartel’, ...
    Bulletin of experimental biology and medicine 147 (4), 513-516 , 2009
    2009
    Citations: 30
  • Neurons and stromal stem cells as targets for polycation-mediated transfection
    AV Shakhbazau, DG Shcharbin, NV Goncharova, IN Seviaryn, ...
    Bulletin of experimental biology and medicine 151 (1), 126-129 , 2011
    2011
    Citations: 25
  • Light scattering and morphology of the lymphocyte as applied to flow cytometry for distinguishing healthy and infected individuals
    GI Ruban, VV Berdnik, DV Marinitch, NV Goncharova, VA Loiko
    Journal of biomedical optics 15 (5), 057008-057008-9 , 2010
    2010
    Citations: 23
  • Hepatogenic potential of human bone marrow and umbilical cord blood mesenchymal stem cells
    SM Kosmacheva, IN Seviaryn, NV Goncharova, NV Petyovka, ...
    Bulletin of experimental biology and medicine 151 (1), 142 , 2011
    2011
    Citations: 22
  • Viral vectors for stable transduction of human mesenchymal stem cells: systems based on adeno-associated viruses and lentiviruses
    AV Shakhbazau, IN Sevyaryn, NV Goncharova, VV Grinev, ...
    Bulletin of Experimental Biology & Medicine 146 (4), 531-533 , 2008
    2008
    Citations: 18
  • Mononuclear cells morphology for cells discrimination by the angular structure of scattered light
    VA Loiko, GI Ruban, OA Gritsai, VV Berdnik, NV Goncharova
    Tenth Conference on Electromagnetic and Light Scattering , 2007
    2007
    Citations: 12
  • Clinical functional criteria of bronchial asthma severity in children and efficacy of basic therapy
    II Balabolkin, OF Lukina, NV Goncharova, N Yukhtina
    Pediatra 5, 4-9 , 2001
    2001
    Citations: 5
  • In vitro expansion and lineage commitment of the human umbilical cord blood myeloid progenitors
    NV Petyovka, NV Goncharova, IM Seviaryn, SM Kosmacheva, ...
    Genes & Cells 7 (1), 40-48 , 2012
    2012
    Citations: 4
  • Experimental search for new means of Pathogenetic therapy COVID-19: Inhibitor of H2-receptors famotidine increases the effect of oseltamivir on survival and immune status of …
    NV Goncharov, KA Vasilyev, IV Kudryavtsev, PP Avdonin, DA Belinskaia, ...
    Journal of Evolutionary Biochemistry and Physiology 58 (1), 230-246 , 2022
    2022
    Citations: 2
  • Our experience in application of autologous bone-marrow-derived mesenchymal stem cells for therapy of patients with symptomatic epilepsy
    FP Hlebokazov, TV Dоkukina, SI Ighnatenko, SM Кosmacheva, ...
    Epilepsy and paroxysmal conditions 6 (1), 6-14 , 2016
    2016
    Citations: 2
  • Growth-stimulating activity of platelet preparations in relation to mesenchymal stem cells in vitro
    SI Ihnatsenko, SM Kasmachova, MP Potapnev, EA Kahno, ...
    Proceedings of the National Academy of Sciences of Belarus, Medical series … , 2016
    2016
    Citations: 2
  • Investigation of human white blood cells: application to scanning flow cytometry
    VA Loiko, GI Ruban, OA Gritsai, AA Miskevich, SM Kosmacheva, ...
    International Conference on Lasers, Applications, and Technologies 2005 … , 2006
    2006
    Citations: 2
  • Discrepancy between direct and antibody-dependent cytotoxic activities of human LAK cells
    MP Potapnev, TS Garbuzenco, NV Goncharova, VD Zobnin, OV Shadrin, ...
    Immunology letters 41 (1), 13-17 , 1994
    1994
    Citations: 2
  • Dual Effect of Amino Acid Compositions on Antibacterial Activity of Human Neutrophilic Granulocytes
    MP Potapnev, SV Andreyev, NV Goncharova, OI Viatkina, EL Berdina, ...
    Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry 17 (1), 17-25 , 2023
    2023
    Citations: 1
  • Mononuclears size-distribution as marker of acute leukemia
    GI Ruban, NV Goncharova, DV Marinitch, VA Loiko
    International Journal of Advance in Medical Science 3, 1-12 , 2015
    2015
    Citations: 1