Nagwa Abdelkader Shoeib
@tanta.edu.eg
Tanta pharmacy
RESEARCH, TEACHING, or OTHER INTERESTS
Plant Science
Scopus Publications
- Bioprospecting of hyoscyamine alkaloid and other secondary metabolites production by some fungal endophytes isolated from hyoscyamus muticus
Samah A. El-Debaiky, Aml A. El-Somany, Nagwa A. Shoeib, Ghada I. El-Shahat, Abdel-Rahim S. Ibrahim
Egyptian Journal of Botany, 2023 - LC-MS/MS metabolomics profiling of Glechoma hederacea L. methanolic extract; in vitro antimicrobial and in vivo with in silico wound healing studies on Staphylococcus aureus infected rat skin wound
Mona El-Aasr, Toshihiro Nohara, Tsuyushi Ikeda, Sally E. Abu-Risha, Engy Elekhnawy, et al.
Natural Product Research, 2023
LC-MS/MS analysis of Glechoma hederacea L. methanolic extract (GHME), revealed the identification of 25 metabolites. Ursolic acid (1), 2α-hydroxyursolic acid or corosolic acid (2), 2β-hydroxyursolic acid or epi-corosolic (3), luteolin 7-O-β-D-glucopyranoside (4) and rosmarinic acid (5) were isolated and identified using spectroscopy. Antibacterial activity of GHME against multi drug resistance Staphylococcus aureus clinical isolates was measured. Minimum inhibitory concentrations (MICs) were ranged from 62.5 to 500 µg/ml. In vivo wound healing potential of 2%, and 5% GHME prepared hydrogels were criticized on Staphylococcus aureus infected wound rat model. 5% GHME prepared hydrogel treated group showed significant (p < 0.05) shrinkage of their colony forming unit/ml (CFU/ml) values in comparison with standard Fucidin. Meanwhile, wound closure associated with full re-epithelization and hair follicles proliferation was noticed after ten days of treatment. Finally, among the GHME isolated compounds, luteolin 7-O-β-D-glucopyranoside (4) exhibited the highest molecular docking score (–9.6 kcal/mol) against matrix metalloproteinase-8 target (MMP-8). Graphical Abstract - Phytochemical Profile of the Ethanol Extract of Malvaviscus arboreus Red Flower and Investigation of the Antioxidant, Antimicrobial, and Cytotoxic Activities
Hanaa S. S. Gazwi, Nagwa A. Shoeib, Magda E. Mahmoud, Osama I. A. Soltan, Moaz M. Hamed, et al.
Antibiotics, 2022
Flowers are rich sources of bioactive antimicrobial, antioxidant, and anticancer components. This study aimed to determine the constituents of the ethanol extract of Malvaviscus arboreus red flower (ERF) by GC-MS analysis and HPLC identification of phenolic compounds and flavonoids, in addition to the 1HNMR fingerprint. The antimicrobial, antioxidant, and cytotoxic activities of the ERF were investigated. The GC-MS analysis revealed twenty-one components, while HPLC analysis revealed the presence of phenolic and flavonoid compounds. The ERF showed antifungal and antibacterial activity. The highest antibacterial activity was found against Vibrio damsela where a time-kill assay revealed a decline in the amount of viable V. damsela. For fungi, the highest activity was observed against Aspergillus terreus. Using the SRB test on HepG2, the anti-proliferative efficacy of the ERF was evaluated. Cell cycle analysis was utilized to determine autophagic cell death. The ERF prevented the proliferation of the HepG2 cell line with an IC50 of 67.182 µg/µL. The extract primarily promoted apoptosis in HepG2 cells by accumulating hypodiploid cells in the sub-G0/G1 phase, increased caspase 3/7 activity, and caused considerable autophagic cell death in apoptosis-deficient cells. Finally, the observed elevation of cancer cell death indicated that ERF had substantial anticancer potential against HepG2 cells. - Antibacterial activity and wound healing potential of Cycas thouarsii R.Br n-butanol fraction in diabetic rats supported with phytochemical profiling
Reem Binsuwaidan, Engy Elekhnawy, Walaa S. Elseady, Walaa A. Keshk, Nagwa A. Shoeib, et al.
Biomedicine and Pharmacotherapy, 2022 - In vitro and in silico β-lactamase inhibitory properties and phytochemical profile of Ocimum basilicum cultivated in central delta of Egypt
Nagwa A. Shoeib, Lamiaa A. Al-Madboly, Amany E. Ragab
Pharmaceutical Biology, 2022
Context Some studies reported the chemical content and antimicrobial properties of Ocimum basilicum L. (Lamiaceae), relevant to the ecological variations in some areas of Egypt and other countries, yet no research was conducted on the plant cultivated in the central delta region of Egypt. Also, no previous data reported on inhibition of β-lactamases by O. basilicum. Objective To assess β-lactamases inhibition by O. basilicum extracts and the individual constituents. Materials and methods Dried aerial parts of O. basilicum were extracted by hydrodistillation for preparation of essential oil and by methanol for non-volatile constituents. Essential oil content and the methanol extract were analysed by GC–MS and UPLC-PDA-MS/MS, respectively. Methyl cinnamate was isolated and analysed by NMR. Broth microdilution method was used to investigate the antimicrobial against resistant clinical isolates of Escherichia coli identified by double disc synergy, combination disc tests and PCR. The most active oil content was further tested with a nitrocefin kit for β-lactamase inhibition and investigated by docking. Results O. basilicum was found to contain methyl cinnamate as the major content of the essential oil. More interestingly, methyl cinnamate inhibited ESBL β-lactamases of the type CTX-M. The in vitro IC50 using nitrocefin kit was 11.6 µg/mL vs. 8.1 µg/mL for clavulanic acid as a standard β-lactamase inhibitor. Discussion and conclusions This is the first study to report the inhibitory activity of O. basilicum oil and methyl cinnamate against β-lactamase-producing bacteria. The results indicate that methyl cinnamate could be a potential alternative for β-lactamase inhibition. - PVA nanocomposite hydrogel loaded with silver nanoparticles enriched Nigella sativa oil
Eram Sharmin, Afnan S. Batubara, Bushra Abdulrahman Tamboosi, Elaf Bander Al Khozay, Maha Khalid Alamoudi, et al.
Inorganic and Nano Metal Chemistry, 2022
Nigella sativa oil [NSO] was enriched with biosynthesized silver nanoparticles [NP] by simple, cost-effective, and less time-consuming “Green Chemistry” protocol. This combination [NSO/NP], on blending with PVA, produced transparent and foldable hydrogel film. The structure, morphology, hydrophilicity and thermal stability of hydrogel film confirmed the incorporation of inorganic NP in organic PVA matrix. FTIR spectrum of nanocomposite film revealed good interactions between PVA matrix, NP and NSO. SEM of PVA and NSO combination film exhibited lipidic NSO cloud-like phase (light grey) dispersed in PVA matrix (dark contrast), while in nanocomposite hydrogel film these lipidic clouds disappeared completely, and PVA matrix appeared donning a grey sheath. The nanocomposite film showed good folding endurance (> 300 folds) and antimicrobial behavior against Staphylococcus aureus (ATCC 25923), Enterococcus faecalis (ATTC 29212), Escherichia coli (ATCC 26922), Pseudomonas aeruginosa (ATCC 27853), Proteus mirabilis (ATCC 29906), Klebsiella pneumonia (MTCC109), Acinetobacter baumannii (NCTC 12156), and Candida albicans (ATCC90028) with prospective applications in antimicrobial packaging and wound dressings. - Synthesis and characterization of polyvinyl alcohol/corn starch/linseed polyol-based hydrogel loaded with biosynthesized silver nanoparticles
Eram Sharmin, Maram Talal Kafyah, Aljohara Abdulrahman Alzaydi, Anan Abdulrahman Fatani, Fatima Ali Hazazzi, et al.
International Journal of Biological Macromolecules, 2020 - Flavonoidal constituents, antioxidant, antimicrobial, and cytotoxic activities of Dipterygium glaucum grown in Kingdom of Saudi Arabia
NagwaAbdelkader Shoeib, Usama Shaheen, Abeer Temraz, MohamedI. S. Abdelhady
Pharmacognosy Magazine, 2017
Background: Dipterygium glaucum Decne. herb is one of the common traditional plants with multiple medicinal uses. Objective: To isolate the major constituents and to investigate the antioxidant, antimicrobial, and cytotoxic activities of this herb. Materials and Methods: Methanolic extract of D. glaucum herb was fractionated using n-hexane, dichloromethane, and n-butanol. Butanol fraction was chromatographed using column chromatography and preparative thin layer chromatography to isolate the major constituents. Isolated compounds were elucidated by means of spectroscopic methods, including 1D, 2D NMR (1H, 13C, DEPT, COSY, HSQC, HMBC, NEOSY) and MS analysis. Total phenolic content using Folin–Ciocalteu reagent and antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay of the total methanolic extract were evaluated. Cytotoxic potential of both methanolic extract and butanol fraction was tested using a crystal violet viability assay. Antimicrobial activities of both extracts were investigated using diffusion agar technique. Results: Apigenin 6, 8-di-C-glucopyranoside (vicenin-2), quercetin-3'-O-methyl-3-O-glucopyranoside, quercetin-3'-O-methyl-3-O-galactopyranoside, quercetin-3-O-β-D-glucopyranoside, and quercetin-3-O-β-D-galactopyranoside were isolated and elucidated. Total phenolic content was (83.89 mg gallic acid equivalent/g extract). The EC50value of scavenging DPPH radical was 152.0 ± 2 μ g/mL. Butanol fraction showed the highest cytotoxic activity against cervical and breast carcinoma cells (IC50 3.6 and 6.1 μ g/mL, respectively). Both methanolic extract and butanol fraction showed wide spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria and some fungi. The highest activity was from methanolic extract against Enterococcus faecalis (83.25%) and against Candida tropicalis (77.03%) as compared to reference antibiotics. Conclusion: Data obtained from this study demonstrate that D. glaucum possesses significant antioxidant, cytotoxic, and antimicrobial activities which could be ascribed to its flavonoidal content. Abbreviations used: KSA: Kingdom of Saudi Arabia; TLC: Thin Layer Chromatography; DPPH: 2,2'-diphenyl-1-picrylhydrazyl; EC50: Half maximal effective concentration; IC50: Half maximal inhibitory concentration; DMSO: dimethyl sulfoxide; NMR: Nuclear Magnetic Resonance; ESIMS: Electrospray ionization mass spectrometry; MeOH: Methyl alcohol. - Pharmacognostic investigation of Tribulus bimucronatus (Zygophyllaceae) grown in Saudi Arabia
Journal of Pharmaceutical Sciences and Research, 2016 - Pharmacological evaluation of the methanolic extract of Tribulus bimucronatus growing in Saudi Arabia in rats
International Journal of Pharmacognosy and Phytochemical Research, 2014 - Chemical and biological investigation of some secondary metabolites in Atriplex halimus growing in Egypt
Amal Kabbash, Nagwa Shoeib
Natural Product Communications, 2012 - Supercritical carbon dioxide extraction of aloe emodin and barbaloin from Aloe vera L. leaves and their in-vitro cytotoxic activity
Saudi Pharmaceutical Journal, 2008 - Seasonal variation in bromophenol content of Polysiphonia lanosa
Nagwa A. Shoeib, Michael C. Bibby, Gerald Blunden, Peter A. Linley, David J. Swaine, et al.
Natural Product Communications, 2006 - In-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers
Nagwa A. Shoeib, Michael C. Bibby, Gerald Blunden, Peter A. Linley, David J. Swaine, et al.
Journal of Natural Products, 2004 - Evaluation of Some Egyptian Plant Species for in vitro Antimycobacterial and Cytotoxic Activities
Kamilia A.E.H. Abou El Seoud, Michael C. Bibby, Nagwa Shoeib, Colin W. Wright
Pharmaceutical Biology, 2003 - In-vitro antiplasmodial and cytotoxic activities of some British species of marine algae
Journal of Pharmacy and Pharmacology, 2000
RECENT SCHOLAR PUBLICATIONS
- Anti-ulcer and Antibiofilm Activities of Abelmoschus esculentus L. Leaves: Biological and In-Silico Insights
HI Ghanem, SA El-Sherbeni, AR Azzam, E Elekhnawy, HO Tawfik, ...
Journal of Advanced Medical and Pharmaceutical Research, 26-37 , 2026
2026 - Cultivation and Preliminary Screening of Some Microalgae and Cyanobacteria for Biotransformation of Coumarins and Flavonoids
N Samir, AE Ragab, N Shoeib, MH Hussein, A Ibrahim
Journal of Advanced Medical and Pharmaceutical Research, 8-14 , 2025
2025 - GC-MS Analysis and Antimicrobial Activity of Typha domingensis Pers. Aerial Parts.
E Elfar, NA Shoeib, G Attia
Journal of Advanced Medical and Pharmaceutical Research 6 (1), 10-21 , 2025
2025
Citations: 3 - Antimicrobial importance of essential oils
NA Shoeib, LA Al-Madboly
Vegetable Oil-Based Polymers and their Surface Applications, 259-276 , 2024
2024
Citations: 4 - Muco-bioadhesive gel containing basil extract (Ocimum basilicum) in the management of recurrent aphthous stomatitis: a randomized clinical and immunological study
MYM Shoukheba, AE Eagab, NA Shoeib, DH Abdelkader, ...
Tanta Dental Journal 21 (1), 74-81 , 2024
2024 - Bioprospecting of Hyoscyamine alkaloid and other secondary metabolites production by some fungal endophytes isolated from Hyoscyamus muticus
SA El-Debaiky, AA El-Somany, NA Shoeib, GI El-Shahat, ARS Ibrahim
Egyptian Journal of Botany 63 (3), 1031-1047 , 2023
2023
Citations: 5 - LC-MS/MS metabolomics profiling of Glechoma hederacea L. methanolic extract; in vitro antimicrobial and in vivo with in silico wound healing studies on Staphylococcus aureus …
M El-Aasr, T Nohara, T Ikeda, SE Abu-Risha, E Elekhnawy, HO Tawfik, ...
Natural Product Research 37 (10), 1730-1734 , 2023
2023
Citations: 14 - In vitro and in silico β-lactamase inhibitory properties and phytochemical profile of Ocimum basilicum cultivated in central delta of Egypt
NA Shoeib, LA Al-Madboly, AE Ragab
Pharmaceutical Biology 60 (1), 1969-1980 , 2022
2022
Citations: 17 - Phytochemical Profile of the Ethanol Extract of Malvaviscus arboreus Red Flower and Investigation of the Antioxidant, Antimicrobial, and Cytotoxic Activities
HSS Gazwi, NA Shoeib, ME Mahmoud, OIA Soltan, MM Hamed, ...
Antibiotics 11 (11), 1652 , 2022
2022
Citations: 30 - Antibacterial activity and wound healing potential of Cycas thouarsii R. Br n-butanol fraction in diabetic rats supported with phytochemical profiling
R Binsuwaidan, E Elekhnawy, WS Elseady, WA Keshk, NA Shoeib, ...
Biomedicine & Pharmacotherapy 155, 113763 , 2022
2022
Citations: 30 - Pharmacognostical and biological investigation of Dioon holmgrenii De Luca, Sabato & Vázq. Torres, Dioon mejiae Standl. & LO Williams, and Dioon meorlae De Luca, Sabato & Vázq …
H El Gendy, SM Mostafa, A Kabbash, NA Shoeib
Journal of Advanced Medical and Pharmaceutical Research 3 (2), 45-52 , 2022
2022
Citations: 3 - PVA nanocomposite hydrogel loaded with silver nanoparticles enriched Nigella sativa oil
E Sharmin, AS Batubara, BA Tamboosi, EB Al Khozay, MK Alamoudi, ...
Inorganic and Nano-Metal Chemistry 52 (8), 1134-1142 , 2022
2022
Citations: 12 - Synthesis and characterization of polyvinyl alcohol/corn starch/linseed polyol-based hydrogel loaded with biosynthesized silver nanoparticles
E Sharmin, MT Kafyah, AA Alzaydi, AA Fatani, FA Hazazzi, SK Babgi, ...
International Journal of Biological Macromolecules 163, 2236-2247 , 2020
2020
Citations: 42 - Flavonoidal constituents, antioxidant, antimicrobial, and cytotoxic activities of Dipterygium glaucum grown in Kingdom of Saudi Arabia
U Shaheen, NA Shoeib, A Temraz, MIS Abdelhady
Pharmacognosy Magazine 13 (Suppl 3), S484 , 2017
2017
Citations: 23 - Flavonoidal constituents, antioxidant, antimicrobial, and cytotoxic activities of Dipterygium glaucum grown in Kingdom of Saudi Arabia.
US Usama Shaheen, NA Shoeib, A Temraz, MIS Abdelhady
2017 - Antiviral, antibacterial activities and chemical composition of the essential oil of nepeta deflersiana schweinf growing in KSA
M Hassan, N Shoeib, A Temraz, AK Kadry
International Research Journal of Pharmacy 7 (6), 29-33 , 2016
2016
Citations: 9 - Pharmacognostic investigation of Tribulus bimucronatus (Zygophyllaceae) grown in Saudi Arabia
NA Shoeib
Pharmainfo Publications 8, 939-946 , 2016
2016 - Chemical and Biological Investigation of Some Secondary Metabolites in Atriplex Halimus Growing in Egypt
A Kabbash, N Shoeib
Natural product communications 7 (11), 1934578X1200701114 , 2012
2012
Citations: 31 - Supercritical carbon dioxide extraction of aloe emodin and barbaloin from Aloe vera L. leaves and their in-vitro cytotoxic activity.
A Kabbash, KA El-Se'oud, E Zalat, N Shoeib, A Yagi
2008
Citations: 11 - Seasonal Variation in Bromophenol Content of Polysiphonia lanosa
NA Shoeib, MC Bibby, G Blunden, PA Linley, DJ Swaine, CW Wright
Natural Product Communications 1 (1), 1934578X0600100109 , 2006
2006
Citations: 8
MOST CITED SCHOLAR PUBLICATIONS
- In - vitro Cytotoxic Activities of the Major Bromophenols of the Red Alga Polysiphonia l anosa and Some Novel Synthetic Isomers
NA Shoeib, MC Bibby, G Blunden, PA Linley, DJ Swaine, RT Wheelhouse, ...
Journal of Natural Products 67 (9), 1445-1449 , 2004
2004
Citations: 90 - Synthesis and characterization of polyvinyl alcohol/corn starch/linseed polyol-based hydrogel loaded with biosynthesized silver nanoparticles
E Sharmin, MT Kafyah, AA Alzaydi, AA Fatani, FA Hazazzi, SK Babgi, ...
International Journal of Biological Macromolecules 163, 2236-2247 , 2020
2020
Citations: 42 - Chemical and Biological Investigation of Some Secondary Metabolites in Atriplex Halimus Growing in Egypt
A Kabbash, N Shoeib
Natural product communications 7 (11), 1934578X1200701114 , 2012
2012
Citations: 31 - Phytochemical Profile of the Ethanol Extract of Malvaviscus arboreus Red Flower and Investigation of the Antioxidant, Antimicrobial, and Cytotoxic Activities
HSS Gazwi, NA Shoeib, ME Mahmoud, OIA Soltan, MM Hamed, ...
Antibiotics 11 (11), 1652 , 2022
2022
Citations: 30 - Antibacterial activity and wound healing potential of Cycas thouarsii R. Br n-butanol fraction in diabetic rats supported with phytochemical profiling
R Binsuwaidan, E Elekhnawy, WS Elseady, WA Keshk, NA Shoeib, ...
Biomedicine & Pharmacotherapy 155, 113763 , 2022
2022
Citations: 30 - Flavonoidal constituents, antioxidant, antimicrobial, and cytotoxic activities of Dipterygium glaucum grown in Kingdom of Saudi Arabia
U Shaheen, NA Shoeib, A Temraz, MIS Abdelhady
Pharmacognosy Magazine 13 (Suppl 3), S484 , 2017
2017
Citations: 23 - In vitro and in silico β-lactamase inhibitory properties and phytochemical profile of Ocimum basilicum cultivated in central delta of Egypt
NA Shoeib, LA Al-Madboly, AE Ragab
Pharmaceutical Biology 60 (1), 1969-1980 , 2022
2022
Citations: 17 - Evaluation of some Egyptian plant species for in vitro antimycobacterial and cytotoxic activities
KAEH Abou El Seoud, MC Bibby, N Shoeib, CW Wright
Pharmaceutical biology 41 (6), 463-465 , 2003
2003
Citations: 15 - LC-MS/MS metabolomics profiling of Glechoma hederacea L. methanolic extract; in vitro antimicrobial and in vivo with in silico wound healing studies on Staphylococcus aureus …
M El-Aasr, T Nohara, T Ikeda, SE Abu-Risha, E Elekhnawy, HO Tawfik, ...
Natural Product Research 37 (10), 1730-1734 , 2023
2023
Citations: 14 - PVA nanocomposite hydrogel loaded with silver nanoparticles enriched Nigella sativa oil
E Sharmin, AS Batubara, BA Tamboosi, EB Al Khozay, MK Alamoudi, ...
Inorganic and Nano-Metal Chemistry 52 (8), 1134-1142 , 2022
2022
Citations: 12 - Supercritical carbon dioxide extraction of aloe emodin and barbaloin from Aloe vera L. leaves and their in-vitro cytotoxic activity.
A Kabbash, KA El-Se'oud, E Zalat, N Shoeib, A Yagi
2008
Citations: 11 - Antiviral, antibacterial activities and chemical composition of the essential oil of nepeta deflersiana schweinf growing in KSA
M Hassan, N Shoeib, A Temraz, AK Kadry
International Research Journal of Pharmacy 7 (6), 29-33 , 2016
2016
Citations: 9 - Seasonal Variation in Bromophenol Content of Polysiphonia lanosa
NA Shoeib, MC Bibby, G Blunden, PA Linley, DJ Swaine, CW Wright
Natural Product Communications 1 (1), 1934578X0600100109 , 2006
2006
Citations: 8 - Bioprospecting of Hyoscyamine alkaloid and other secondary metabolites production by some fungal endophytes isolated from Hyoscyamus muticus
SA El-Debaiky, AA El-Somany, NA Shoeib, GI El-Shahat, ARS Ibrahim
Egyptian Journal of Botany 63 (3), 1031-1047 , 2023
2023
Citations: 5 - Antimicrobial importance of essential oils
NA Shoeib, LA Al-Madboly
Vegetable Oil-Based Polymers and their Surface Applications, 259-276 , 2024
2024
Citations: 4 - GC-MS Analysis and Antimicrobial Activity of Typha domingensis Pers. Aerial Parts.
E Elfar, NA Shoeib, G Attia
Journal of Advanced Medical and Pharmaceutical Research 6 (1), 10-21 , 2025
2025
Citations: 3 - Pharmacognostical and biological investigation of Dioon holmgrenii De Luca, Sabato & Vázq. Torres, Dioon mejiae Standl. & LO Williams, and Dioon meorlae De Luca, Sabato & Vázq …
H El Gendy, SM Mostafa, A Kabbash, NA Shoeib
Journal of Advanced Medical and Pharmaceutical Research 3 (2), 45-52 , 2022
2022
Citations: 3 - In-vitro cytotoxic activities of the major bromophenols present in the British alga, Polysiphonia lanosa
NA Shoeib, MC Bibby, G Blunden, PA Linley, CW Wright
Journal of Pharmacy and Pharmacology 55, 2-2 , 2003
2003
Citations: 1 - In-vitro antiplasmodial and cytotoxic activities of some British species of marine algae
NA Shoeib, MC Bibby, PA Cooper, G Blunden, CW Wright
JOURNAL OF PHARMACY AND PHARMACOLOGY 52 (9; SUPP/1), 311-311 , 2000
2000
Citations: 1 - Anti-ulcer and Antibiofilm Activities of Abelmoschus esculentus L. Leaves: Biological and In-Silico Insights
HI Ghanem, SA El-Sherbeni, AR Azzam, E Elekhnawy, HO Tawfik, ...
Journal of Advanced Medical and Pharmaceutical Research, 26-37 , 2026
2026