Dr. NARENDER REDDY

EDUCATION

California Institute of Technology, Pasadena, California, USA
University of Regensburg, Germany
Indian Institute of Technology Hyderabad, Telangana, India.

RESEARCH INTERESTS

Organic Chemistry, Transition-metal Catalysis, Visible-Light Photocatalysis, Organic Synthesis

Scopus Publications

Merging Cu(I) and Cu(II) Photocatalysis: Development of a Versatile Oxohalogenation Protocol for the Sequential Cu(II)/Cu(I)-Catalyzed Oxoallylation of Vinylarenes
Tirtha Mandal, Narenderreddy Katta, Hendrik Paps, Oliver Reiser
ACS Organic and Inorganic Au, 2023
A sequential photocatalytic strategy is developed via the merger of Cu(II)/Cu(I)-catalytic cycles for the oxoallylation of vinyl arenes via α-haloketones. The initial Cu(II)-photocatalyzed oxohalogenation exploits ligand-to-metal charge transfer (LMCT) to generate halide radicals from acyl halides utilizing air as a terminal oxidant and can be employed for the late-stage modification of pharmaceuticals and agrochemicals. α-Bromoketones obtained this way can be subsequently subjected to a one-pot Cu(I)-photocatalyzed allylation. This sequential photocatalysis proceeds in a highly regio- and chemoselective fashion and is inconsequential to the electronic nature of styrenes.
Divergent and Synergistic Photocatalysis: Hydro- and Oxoalkylation of Vinyl Arenes for the Stereoselective Synthesis of Cyclopentanols via a Formal [4+1]-Annulation of 1,3-Dicarbonyls
Narenderreddy Katta, Quan-Qing Zhao, Tirtha Mandal, Oliver Reiser
ACS Catalysis, 2022
The controllable divergent reactivity of 1,3-dicarbonyls is described, which enables the efficient hydro- and oxoalkylation of vinyl arenes. Both reaction pathways are initiated through the formation of polarity-reversed C-centered-radical intermediates at the active methylene center of 1,3-dicarbonyls via direct photocatalytic C–H bond transformations. The oxoalkylation of alkenes is achieved under aerobic conditions via a Cu(II)-photomediated rebound mechanism, while the corresponding hydroalkylation becomes possible under a nitrogen atmosphere by the combination of 4CzIPN and a Brønsted base. The breadth of these divergent protocols is demonstrated in the late-stage modification of drugs and natural products and by the transformation of the products to a variety of heterocycles such as pyridines, pyrroles, or furans. Moreover, the two catalytic modes can be combined synergistically for the stereoselective construction of cyclopentanol derivatives in a formal [4+1]-annulation process.
Visible-Light-Mediated Photocatalytic Oxidative C-C Bond Cleavage of Geminal Diazides: An Approach to Oxamates
Duddu S. Sharada, Narenderreddy Katta, Arumugavel Murugan, Sonika Sharma
Synopen, 2021
Photoredox catalysis has received great attention in both academia and industry and remarkable progress has been made over the past decade. Now, it has been shown that a visible-light-mediated oxidative C–C bond cleavage of geminal diazides can be induced by organic dye catalysis for the synthesis of oxamates. A mechanistic study, confirmed by control experiments, indicates that this proceeds through single-electron transfer (SET). This methodology can be applied to convert a wide array of geminal diazides into oxamates.
Visible light-mediated photocatalytic oxidative cleavage of activated alkynes: Via hydroamination: A direct approach to oxamates
Narenderreddy Katta, Mamata Ojha, Arumugavel Murugan, Sagar Arepally, Duddu S. Sharada
Rsc Advances, 2020
The direct oxidative cleavage of activated alkynes via hydroamination has been described using organic photocatalyst under visible-light irradiation at room temperature.
Exocyclic N-Acyliminium Ion (NAI) Cyclization: Access to Fully Substituted Oxazoles and Furocoumarins
Venkata Nagarjuna Babu, Arumugavel Murugan, Narenderreddy Katta, Suman Devatha, Duddu S. Sharada
Journal of Organic Chemistry, 2019
A concise, one-pot route to oxazoles and furocoumarins has been reported. The key step in this transformation involves in situ generation of N-acyliminium ion (NAI) precursor under catalyst and solvent-free conditions and their further transformations promoted by superacid in the same pot. We have also presented the experimental evidence for the involvement of proto-solvated novel exocyclic N-acyliminium ion. Further, the UV-visible and fluorescence studies revealed that few of the compounds reported here exhibited emission of blue light upon irradiation in EtOH in the region of 404-422 nm.
Stereoselective Aminoiodination of Activated Alkynes with Organoiodine(III) Reagents and Amines via Multiple-Site Functionalization: Access to Iodinated Enamines and N-Aryl Indoles
Sagar Arepally, Ajoy Chamuah, Narenderreddy Katta, Duddu S. Sharada
European Journal of Organic Chemistry, 2019
A stereoselective aminoiodination of activated alkynes with PhI(OAc)2 and amines via multiple-site functionalization to afford (Z)diethyl 2-(diphenylamino)-3-iodomaleate derivatives with superior yields has been described. The key feature of this reaction is the incorporation of iodide and aryl group concurrently in the same molecule in a stereoselective manner by employing PhI(OAc)2 as electrophilic reagent as well as iodide and aryl group source. The high stereoselectivity of the reaction can be explained based on the structure of the possible intermediates, the conformations of which controlled by the hydrogen bonding, steric hindrance and electrostatic attractions. This reaction proceeds under mild conditions, providing various dialkyl 2-(diphenylamino)-3-iodomaleates by a single operation starting from activated alkynes. The robustness of our strategy is revealed by making of bis (dialkyl 2-(diphenylamino)-3-iodomaleate) derivatives involving formation of four new C-N bonds and two C-I bonds with a single step. The synthesized inactive 3° enamines (dialkyl 2-(diphenylamino)-3-iodomaleates) could be further transformed into highly substituted indoles via Pd catalyzed C-H and C-I activation under non-acidic conditions.

RECENT SCHOLAR PUBLICATIONS

Shining a Light on Copper: Harnessing Light for Efficient & Sustainable Chemical Transformation
NR Katta
2025
Merging Cu (I) and Cu (II) photocatalysis: Development of a versatile oxohalogenation protocol for the sequential Cu (II)/Cu (I)-catalyzed oxoallylation of vinylarenes
T Mandal, N Katta, H Paps, O Reiser
ACS Organic & Inorganic Au 3 (4), 171-176 , 2023
2023
Citations: 22
Divergent and synergistic photocatalysis: Hydro-and oxoalkylation of Vinyl Arenes for the stereoselective synthesis of Cyclopentanols via a formal [4+ 1]-Annulation of 1, 3 …
N Katta, QQ Zhao, T Mandal, O Reiser
ACS catalysis 12 (22), 14398-14407 , 2022
2022
Citations: 37
Visible-Light-Mediated Photocatalytic Oxidative C–C Bond Cleavage of Geminal Diazides: An Approach to Oxamates
N Katta, A Murugan, S Sharma, DS Sharada
SynOpen 5 (02), 152-157 , 2021
2021
Citations: 1
Obesity and coronary heart disease: epidemiology, pathology, and coronary artery imaging
N Katta, T Loethen, CJ Lavie, MA Alpert
Current problems in cardiology 46 (3), 100655 , 2021
2021
Citations: 401
Visible light-mediated photocatalytic oxidative cleavage of activated alkynes via hydroamination: a direct approach to oxamates
N Katta, M Ojha, A Murugan, S Arepally, DS Sharada
RSC advances 10 (21), 12599-12603 , 2020
2020
Citations: 14
Exocyclic N -Acyliminium Ion (NAI) Cyclization: Access to Fully Substituted Oxazoles and Furocoumarins
VN Babu, A Murugan, N Katta, S Devatha, DS Sharada
The Journal of Organic Chemistry 84 (11), 6631-6641 , 2019
2019
Citations: 20
Stereoselective Aminoiodination of Activated Alkynes with Organoiodine (III) Reagents and Amines via Multiple‐Site Functionalization: Access to Iodinated Enamines and N‐Aryl …
S Arepally, A Chamuah, N Katta, DS Sharada
European Journal of Organic Chemistry 2019 (7), 1542-1547 , 2019
2019
Citations: 5
Hula: Scalable load balancing using programmable data planes
N Katta, M Hira, C Kim, A Sivaraman, J Rexford
Proceedings of the Symposium on SDN Research, 1-12 , 2016
2016
Citations: 586

MOST CITED SCHOLAR PUBLICATIONS

Hula: Scalable load balancing using programmable data planes
N Katta, M Hira, C Kim, A Sivaraman, J Rexford
Proceedings of the Symposium on SDN Research, 1-12 , 2016
2016
Citations: 586
Obesity and coronary heart disease: epidemiology, pathology, and coronary artery imaging
N Katta, T Loethen, CJ Lavie, MA Alpert
Current problems in cardiology 46 (3), 100655 , 2021
2021
Citations: 401
Divergent and synergistic photocatalysis: Hydro-and oxoalkylation of Vinyl Arenes for the stereoselective synthesis of Cyclopentanols via a formal [4+ 1]-Annulation of 1, 3 …
N Katta, QQ Zhao, T Mandal, O Reiser
ACS catalysis 12 (22), 14398-14407 , 2022
2022
Citations: 37
Merging Cu (I) and Cu (II) photocatalysis: Development of a versatile oxohalogenation protocol for the sequential Cu (II)/Cu (I)-catalyzed oxoallylation of vinylarenes
T Mandal, N Katta, H Paps, O Reiser
ACS Organic & Inorganic Au 3 (4), 171-176 , 2023
2023
Citations: 22
Exocyclic N -Acyliminium Ion (NAI) Cyclization: Access to Fully Substituted Oxazoles and Furocoumarins
VN Babu, A Murugan, N Katta, S Devatha, DS Sharada
The Journal of Organic Chemistry 84 (11), 6631-6641 , 2019
2019
Citations: 20
Visible light-mediated photocatalytic oxidative cleavage of activated alkynes via hydroamination: a direct approach to oxamates
N Katta, M Ojha, A Murugan, S Arepally, DS Sharada
RSC advances 10 (21), 12599-12603 , 2020
2020
Citations: 14
Stereoselective Aminoiodination of Activated Alkynes with Organoiodine (III) Reagents and Amines via Multiple‐Site Functionalization: Access to Iodinated Enamines and N‐Aryl …
S Arepally, A Chamuah, N Katta, DS Sharada
European Journal of Organic Chemistry 2019 (7), 1542-1547 , 2019
2019
Citations: 5
Visible-Light-Mediated Photocatalytic Oxidative C–C Bond Cleavage of Geminal Diazides: An Approach to Oxamates
N Katta, A Murugan, S Sharma, DS Sharada
SynOpen 5 (02), 152-157 , 2021
2021
Citations: 1
Shining a Light on Copper: Harnessing Light for Efficient & Sustainable Chemical Transformation
NR Katta
2025