Dr NARKHEDE HEMANT P.
@pkkotecha.org
Associate Professor Chemistry Department
SSVPMS SMT.P.K.KOTECHA MAHILA MAHAVIDYALAYA BHUSAWAL MAHARASHTRA INDIA
EDUCATION
Ph.D M. M.
RESEARCH, TEACHING, or OTHER INTERESTS
Chemistry, Organic Chemistry, Agricultural and Biological Sciences, Analytical Chemistry
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Vilas K. Patil, Jayant G. Chandorkar, Devender T. Seshadri, Jitendra G. Patil, Narendra H. Petha, Tanaji S. Bhagat, and Hemant P. Narkhede
Springer Science and Business Media LLC
Vilas K Patil, Jayant G Chandorkar, Yogesh B Wagh, Yogesh B More, and Hemant P Narkhede
Oxford University Press (OUP)
Abstract Background The advantage of simultaneous separation and quantification is the reduction of analysis time and consumption of solvents and reagents. Objective The objective of the present investigation was to optimize and validate a novel, rapid, and simple reverse-phase high-performance liquid chromatographic method for the simultaneous determination of acephate, dinotefuran, and emamectin benzoate in a pesticide formulation. Method The chromatographic separation and quantification were accomplished by using Kromasil CN column (250 mm × 4.6 mm; 5 μm) with a mobile phase consisting of acetonitrile and water [0.1% (v/v) triethylamine, pH 2.7 with 10% (v/v) orthophosphoric acid] in the ratio of 50:50 (v/v) with a flow rate of 1.0 mL/min and diode array detection at the wavelength of (215 nm and 245 nm). Results The HPLC method was able to separate and quantify all the actives in the formulation by isocratic elution within 10 min. The method was fully validated in accordance with the SANCO and Collaborative International Pesticide Analytical Council guidelines concerning system suitability, specificity, linearity, precision, accuracy, and robustness. All the analytical parameters are within the range of acceptable limits in the guidelines. Conclusions The validated method was successfully applied to a pesticide formulation. Highlights The novelty of the current research work lies in the development of the simple and rapid HPLC method for simultaneous determination of acephate, dinotefuran, and emamectin benzoate in wettable granular formulation.
Jayashri D. Bhirud, Gaurav R. Gupta, and Hemant P. Narkhede
Bentham Science Publishers Ltd.
Objectives: the synthesis of 4-((1-phenyl-3-(substitutedphenyl)-1h-pyrazol-4-yl) methylene)- 4h-pyrazol-3,5-diamine and 3-amino-4-((1-phenyl-3-(substitutedphenyl)-1h-pyrazol-4-yl) methylene)-1h-pyrazol-5(4h)-one was designed and performed very aptly in deep eutectic solvent system. Methods: the utilization of deep eutectic solvent (des) system chcl/gly (1:2) in the absence of hazardous organic co-solvents, an efficient multicomponent one-pot synthetic strategy has been advanced. In addition to that, from the perspectives of sustainable developments in organic synthesis, the deep eutectic solvent system was recovered and very efficiently reused up to four cycles. Results: it has been observed that the efficacy of the deep eutectic solvent was decreased after the second cycle, which has a measurable impact on the yield of the reaction. Conclusion: furthermore, the synthesized aminopyrazole and aminopyrazolone compounds were screened as antibacterial and antifungal agents.
Vilas K. Patil, Ujwala B. Wagh, Raju P. Phalak, Jayashri D. Bhirud, and Hemant P. Narkhede
Royal Society of Chemistry (RSC)
A novel, rapid and simple reverse-phase high performance liquid chromatography (RP-HPLC) method for the simultaneous determination of three pesticides – mancozeb, azoxystrobin and difenoconazole by derivatization with ethyl iodide is presented.
Vilas Patil, Dipak Dalal, Kishor Phatangare, Suresh Bagul, and Hemant Narkhede
Informa UK Limited
Vilas K. Patil, Nilesh D. Dhande, Narendra H. Petha, and Hemant P. Narkhede
Royal Society of Chemistry (RSC)
A simple derivatization reverse-phase high performance liquid chromatographic method for the simultaneous analysis (separation and quantification) of zineb and hexaconazole has been optimized and validated.
Jayashri D. Bhirud, Rajendra D. Patil, and Hemant P. Narkhede
Elsevier BV
J. D. Bhirud, G. R. Gupta, and H. P. Narkhede
Pleiades Publishing Ltd
H. P. Narkhede, U. B. More, D. S. Dalal, and P. P. Mahulikar
Informa UK Limited
Abstract The most abundant and potent natural products having a broad spectrum of biological activity against various pests are terpenoids, especially monoterpenoids. The chemical modification of natural monoterpenoids has been reported to result in modified biological activity. The present work emphasizes the structural modification of carvacrol, a phenolic monoterpenoid, through the synthesis of different ether and ester derivatives that are useful for structure–activity relationship studies to exploit the potent molecules. The carvacrol was reacted with alkyl halides and acid chlorides under microwaves using solid supports such as silica gel, alumina, and fly ash to give ethers and esters, respectively. The synthesis of dimeric ether and ester compounds using dihalides and acid dichlorides was conducted with novel reactions. Additional features of the methodology include very fast reactions, higher yields and purities of the products, and an ecofriendly approach.
U. B. More, H. P. Narkhede, D. S. Dalal, and P. P. Mahulikar
Informa UK Limited
Abstract Natural monoterpenoids have been documented for their acute toxicity and repellent, antifeedent, reproduction inhibitory, and insecticidal actions. The present work aims to derive a variety of ether and ester compounds using polymer‐supported reactions from the polymer‐supported carvacrol anion was reacted with alkyl halides and acid chlorides to afford carvacryl ethers and esters, respectively. Furthermore, a special study on the effect of different solvents and supports revealed that Amberlite IRA 400 (chloride form) was found to be the best polymer support and acetone among the solvents.
Hemant P. Narkhede, Uttam B. More, Dipak S. Dalal, Nilesh S. Pawar, Dhananjay H. More, and Pramod P. Mahulikar
Informa UK Limited
Abstract Microwave‐assisted, solvent‐free alkylation and acylation of 2‐mercaptobenzothiazole has been attempted using silica gel, alumina, and a new solid support, fly ash. Fly ash, a waste generated at thermal power stations, could be used as solid support just as efficiently as commercial supports. The additional features of methodology include a much faster reaction, easy workup, higher yields, higher purity of the products, and an ecofriendly approach.