Prof. Dr. Nadhir Najim Abdullah Jafar
@alzahraa.edu.iq
Pharmacy College/ Dept. of Pharmaceutical Chemistry
University of Al-zahraa for Women
EDUCATION
Dr. organic chemistry synthesis, study Anti-cancer and Anti-Viral activity for synthetic compounds. Aim of our research is get the advantage of the molecular modeling advanced studies to define the pharmacophore core of the anticancer active analogs that are essential for designing the new analogs based on the prediction of the ligand-receptor recognition. Synthesis, structural function analysis and QSAR studies are essential for targeting the viral, cancer, bacteria and fungus.
RESEARCH INTERESTS
Synthesis Organic Compounds, Docking study, Drug development, Synthesis Fluorsences compounds.
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Amer Alhaj Zen, Matheel D. Al-Sabti, Zaman Abdalhussein Ibadi Alaridhee, Mohammed B. Alqaraguly, Nadhir N.A. Jafar, Majid Jabir, Hasan Majdi, Elyor Berdimurodov, Maryam hussein abdulameer, Aiham O. Altayeh,et al.
Elsevier BV
Guang Yang, Nadhir N.A. Jafar, Rafid Jihad Albadr, Mariem Alwan, Zainab Sadeq Yousif, Suhair Mohammad Husein Kamona, Safaa Mohammed Ibrahim, Usama S. Altimari, Ashwaq Talib Kareem, Raghu Jettie,et al.
Elsevier BV
Basim K. Nile, Ahmed M. Faris, Hasan F. Alesary, Nadhir N. A. Jafar, Hani K. Ismail, Muhammad Abdulredha, Maad F. Al Juboury, Waqed H. Hassan, Luma M. Ahmed, Hussein Rasool Abid,et al.
Springer Science and Business Media LLC
AbstractThe fate of cadmium at the Muharram Aisha wastewater treatment plant in Karbala governorate, Iraq was studied using the TOXCHEM model. Cadmium, a known carcinogen, and is considered one of the most dangerous heavy metals and high concentrations, greater than permissible limits, were found in the treated wastewater. The plant operates using an activated sludge system and this was modeled via TOXCHEM with a sensitivity analysis carried out on the extended aeration system. Prior to analysis, the model was calibrated and validated for cadmium, with the adjustments leading to a mean square error (RMSE) and correlation coefficient (R) of 0.0001 and 0.81, respectively. The mass balance of cadmium in the Muharram Aisha treatment plant was found to be 4832.44 g/day (37.1726%) in the treated wastewater and 8164.52 g/day (62.804%) in the sludge, which indicated that the mix liquor suspended solid (MLSS) was the most sensitive factor. The sensitivity to cadmium was analyzed via MLSS in the extended aeration system and the results o indicated that the higher the MLSS concentration (mg/L), the greater the removal of cadmium in the treated wastewater. It was found that increasing the MLSS through a biological treatment method reduced the concentration of cadmium without the need for additional of any (potentially harmful) chemical treatments. The plant was subsequently operated for a period of 5 months with the MLSS increased from 1500 to 4500 mg/L, and this reduced the concentration of cadmium in the wastewater from 0.36 to 0.01 mg/L as a consequence. This research demonstrates how the novel application of TOXCHEM can be a useful tool in the reduction of heavy metal contamination in the environment.
Ali Altharawi, Nadhir N.A. Jafar, Taibah Aldakhil, and Tareq Jwad Kazem
Elsevier BV
Irshad Ahmad, R. Bousbih, Ahmed Mahal, Waheed Qamar Khan, Mohammed Aljohani, Mohammed A. Amin, Nadhir N.A. Jafar, Majid S. Jabir, Hasan Majdi, Ali S. Alshomrany,et al.
Elsevier BV
Sidra Moeed, R. Bousbih, Ali Raza Ayub, Nadhir N.A. Jafar, Mohammed Aljohani, Majid S. Jabir, Mohammed A. Amin, Hira Zubair, Hasan Majdi, Muhammad Waqas,et al.
Elsevier BV
Mohamed J. Saadh, Nadhir N.A. Jafar, Farag M. A. Altalbawy, Pawan Sharma, Abhishek Kumar, Hassan Thoulfikar A. Alamir, Hameed Ghazy, Maha Noori Shakir, Saad khudhur Mohammed, Khursheed Muzammil,et al.
Royal Society of Chemistry (RSC)
Novel Mo/BPDA nanocomposite with crystalline structure, high thermal stability and specific surface area was synthesized. The Mo/BPDA nanocomposite was effective against a wide range of microbial species, bone cancer cells and breast cancer cells.
Tan Wang, Nadhir N.A. Jafar, Afrah Majeed Ahmed Al-Rihaymee, Dheyaa Yahaia Alhameedi, Fadhil A. Rasen, Furqan S. Hashim, Talib Kh Hussein, Montather F. Ramadan, Kasim Kadhim Alasedi, Muath Suliman,et al.
Elsevier BV
Zaman Abdalhussein Ibadi Alaridhee, Dheyaa J. Jasim, Ikromjon Mamadoliyev, Moayad Jasim Mohammed, Abdul-Jabbar A. Ali, Ayat H. Athab, Salim S. Al-Rejaie, Mohamed Mohany, Majid Jabir, Hasan Majdi,et al.
Springer Science and Business Media LLC
Ameer H. Al-Rubaye, Salim S. Al-Rejaie, Zaman Abdalhussein Ibadi Alaridhee, Mohamed Mohany, Hawzhen Fateh M. Ameen, Nadhir N.A. Jafar, Dheyaa J. Jasim, Hasan Majdi, Abhinav Kumar, Mohammed A. Al-Anber,et al.
Elsevier BV
Aqeel A. Hussein, Nadhir N. A. Jafar, and Yumiao Ma
American Chemical Society (ACS)
A computational study is reported here on the mechanism of tetrahydrofuran (THF)-diol formation from the Os(VI)-catalyzed oxidative cyclization of 5,6-dihydroxyalkene ligated with citric acid and in the presence of Bro̷nsted acid. Initiated by Os(VI) dioxo citrate formation, coordination of co-oxidant pyridine-N-oxide (PNO) and protonation of its oxo group generate the active catalyst. The catalytic cycle commences through successive steps, including dihydroxyalkene addition to the active catalyst in a concerted mechanism to form hexacoordinated alkoxy-protonated PNO-complexed Os(VI) bisglycolate as a turnover-limiting step (TLS), cyclization to Os(IV) THF-diolate, reoxidation to Os(VI) THF-diolate, and hydrolysis via a dissociative mechanism to furnish the THF-diol and regenerate the active species, sustaining the catalytic cycle through an Os(VI)/Os(IV) cycle. Despite the overall exergonic nature of catalytic cycle (ΔGrcycle = -45.0 kcal/mol), the TLS is accelerated by the formation of an open-valence 16-electron Os(VI) intermediate but decelerated by the undesired formation of a saturated/hexacoordinate 18-electron Os(VI) intermediate. Bro̷nsted acid plays crucial roles in the formation of Os(VI) citrate and the active catalyst, impediment of the second cycle, and the cyclization step. Additionally, besides its role as a co-oxidant, and in the presence of acid, PNO is found to assist the insertion of dihydroxyalkene and, importantly, in releasing the THF-diol to regenerate the active intermediate.
Ali Basem, Shomansur Sh. Sagdullaev, Zaman Abdalhussein Ibadi Alaridhee, Aiham O. Altayeh, Nadhir N. A. Jafar, Majid S. Jabir, Hasan Majdi, Ameer H. Al‐Rubaye, Moamel Dheyaa Jumaah, Lola M. Usmonova,et al.
Wiley
ABSTRACTMeticulous electrode design is pivotal in advancing greener and more sustainable electro‐organic synthesis practices. In this research, our team designed and synthesized a copper‐doped electrode on multiwalled carbon nanotubes (MWCNTs) and characterized it using Fourier transform infrared spectroscopy (FT‐IR), scanning electron microscopy (SEM), energy‐dispersive X‐ray spectroscopy (EDS), thermogravimetric analysis (TGA), Brunauer–Emmett–Teller (BET) analysis, X‐ray diffraction (XRD) analysis, X‐ray photoelectron spectroscopy (XPS), and cyclic voltammetry (CV) analysis. Subsequently, this electrode was utilized as a catalyst at the electrode surface, serving as a cathode in electro‐oxidation reactions in the presence of phenylacetylene, sodium azide (NaN3), and benzyl halide for the production of 1,2,3‐triazole derivatives under ambient temperature, within a 30‐min reaction time, and at atmospheric pressure, achieving an efficiency level ranging from good to excellent, specifically between 88% and 96%. The synthesized 1,2,3‐triazole derivatives were identified using proton nuclear magnetic resonance (1H NMR) spectroscopy, CHN elemental analysis, and melting point. In this paper, choline chloride/urea deep eutectic solvents (DES) serve multiple roles in the reaction mechanism. They function as solvents and co‐catalysts, generate weak bases, and provide numerous advantages in green chemistry. These advantages include low toxicity, reduced environmental risks, improved atom economy, and non‐volatility, making them safer alternatives to traditional organic solvents.
R. Bousbih, M. S. Soliman, N. N. A. Jafar, M. S. Jabir, H. Majdi, A. S. Alshomrany, N. M. A. Hadia, M. Shaban, Y. A. El-Badry, and M. Iftikhar
Springer Science and Business Media LLC
R.H. Zaooli, F.A. Hussein, N.N.A. Jafar, and S.N.K. Al-Thamir
Asian Journal of Chemistry
Many derivatives of 4-chloro-3,5-dimethylphenol have been synthesized using Suzuki reaction and characterized by IR, 1H NMR and micro elemental analysis. These compounds also tested in terms of their antibacterial properties against Staphylococcus aureus, Escherichia coli and Proteus mirabilis.
Nadhir N.A. Jafar, Ibtihial M Abdul Mahdi, Mahmoud Hussein Hadwan, and Ameer A Alameri
EManuscript Technologies
Objective: 4-methoxy-N, N-dimethyl-6-(phenylthio) pyrimidin-2-amine, 4-(benzo[d]thiazol-2-ylthio)-6-methoxy-N,N-dimethylpyrimidin-2-amine, 4-(4-(1,2,3-selenadiazol-4-yl)phenoxy)-6-methoxy-N,N 2-amine and 4-(4-(1,2,3-thiadiazol-4-yl)phenoxy)-6-methoxy-N,N 2-amine have been synthesized. Method: The prepared compounds were synthesized by nucleophilic displacement of chloride substituted in pyrimidine heterocyclic ring. Results: The synthesized compounds were being identified by different methods included TLC technique, IR, 1H-NMR and 13C-NMR spectrophotometers. All compounds confirmed by elemental analysis. The biological activity of these new compounds investigated against some fungi like Aspergillus terreus and Aspergillus niger, the results was Aspergillus terreus more effected by antifungal compare with Aspergillus niger, the effect ration 0.98, 1.32 with 200μM respectively and the compound number (2) has more effect than other compounds. Conclusion: It is concluded that synthesized dimethylpyrimidin-derivatives are biologically active and developed into useful Antifungal agents. Key words: Pyrimidine, Dimethylpyrimidin-derivatives, Heterocyclic compound, Aspergillus terreus, Aspergillus niger.
Nadhir NA Jafar, Najim A Al-Masoudi, Sadiq J Baqir, Pieter Leyssen, and Christophe Pannecouque
SAGE Publications
Background: In continuation of our search for new anti-HIV and anti-HCV agents, the suggestion, synthesis and structure elucidation of a new series of 2,6-diamino-4-alkylthio- or (2-benzylhydrazinyl)-5- p-chlorophenylazopyrimidines), 2,6-diamino-4-(2-benzylhydrazinyl)-5-(aryl-[1,1′-biphenyl]-4-yl)pyrimidines, 2,6-diamino-4-(aryl)-5-(aryl[1,1′-biphenyl]-4-yl) pyrimidines), 6-(aryl)-1,3-dimethyl-5-nitro pyrimidine-2,4-dione and 6-amino-4-methoxy- N,N-dimethyl-6-arylpyrimidines were described. Methods: The anti-HIV-1 (strain IIIB) and HIV-2 (strain ROD) activity of the newly synthesized pyrimidine analogues was evaluated in vitro in human MT-4 cells using the MT-4/MTT assay. Similarly, the same compounds were evaluated in vitro for their selective antiviral activity against HCV in the Huh 5–2 replicon system (type 1b, Con1 strain). Results: None of the tested compounds exhibited inhibition of HIV-1 and HIV-2 replication in cell culture. Even though many compounds yielded a 50% effective concentration in the HCV replicon system with selectivity indexes up to 6.9, none of the compounds matched the selection criteria of a selective inhibitor of virus replication in this assay (that is, >70% inhibition at concentrations that do not elicit an anti-metabolic effect on the host cells). Conclusions: Structural modification of these compounds might optimize their anti-HCV activity by introducing diverse and potent functional groups at the pyrimidine backbone, like nitrile residue. Because of the nature of the molecules, these new derivatives will also be evaluated for their potential anti-HIV activity.
Nadhir Najimabdullah Jafar, Hussein Oleiwi Muttaleb Al-Dahmoshi, Ayad Mohammed JeburAlmamoori, Noor Salman Kadhim Al-Khafajii, and NajimAbod Al-Masoudi
Oriental Scientific Publishing Company
6-chloro-5-((4-chlorophenyl) diazenyl) pyrimidine-2, 4-diamine and 4-chloro-6-methoxy-N,Ndimethylpyrimidin-2-amine has been used as precursors for the synthesis of new pyrimidine derivatives, employing Suzuki cross-coupling reaction. Thus, treatment of pyrimidine derivative with various arylboronic acids in the presence of palladium tetraacetate, PhP3 and Na2CO3 in refluxing n-propanol afforded the target compounds. The synthesis was supported by spectroanalytical techniques. The synthesized compounds have been screened for their inhibitory activity against some microbial, the results were showed that among gram positive isolates only (1/10) isolates of S. aureus and (3/10) isolates of S. saprophyticaus were sensitive for compound 13, while (1/10) isolates of S. aureus and (1/10) isolates of S.saprophyticaus were sensitive for compound 4. All isolates of S. pyogenes were resisting to all compounds, among gram negative bacterial isolates only (2/10) isolates of E. coli and (1/10) isolates of K. pneumoniae were sensitive to compound 4. Concerning the antifungal effects of compounds 3, 4, 5, 13, 14, 15 the results revealed that, all C. albicans and C. glabrata isolate were resist these compounds.
Najim A. Al-Masoudi, Nadhir N. A. Jafar, Layla J. Abbas, Sadiq J. Baqir, and Christophe Pannecouque
Walter de Gruyter GmbH
There is an urgent need for the design and development of new and safer drugs for the treatment of HIV infection, active against the currently resistant viral strains. New derivatives of the non-steroidal anti-inflammatory drug indomethacin bearing benzimidazoles, benzothiazole, purine and pyridine residues 8 - 13 were synthesized with the aim of developing new non-nucleoside reverse transcriptase inhibitors (NNRTIs).Alternatively, new imine analogs 16 - 20 were synthesized from condensation of indomethacinyl hydrazide 15, prepared from the ester 14, with various ketone precursors. Treatment of 15 with phenyl isothiocyanate or triethyl orthoformate afforded the phenylcarbonothioyl and the oxadiazole derivatives 21 and 22, respectively. The new compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. Compounds 9 and 10 were the most active in inhibiting HIV-2 and HIV-1, respectively, with EC50 ≥ 17.60 μgmL−1 and > 1.15 μgmL−1 (therapeutic indexes (SI) of ≥ 3 and < 1, respectively), and are leading candidates for further development.