Dr Nithya Mohan

@scmsgroup.org

Assistant Professor in Chemistry
SCMS SCHOOL OF ENGINEERING AND TECHNOLOGY, KERALA

https://researchid.co/nithyanedumpilly

EDUCATION

Postdoc in materials chemistry
PhD in Inorganic CHemistry

RESEARCH, TEACHING, or OTHER INTERESTS

Multidisciplinary, Materials Chemistry, Inorganic Chemistry, General Chemistry

Scopus Publications

211

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

Multi-faceted investigation of copper(II) chelates based on ONS donor thiosemicarbazone: Crystal structures, spectral aspects, DNA binding, cytotoxicity and computational studies
Jinsa Mary Jacob, Nithya Mohan, Sreejith S．S．, M. Sithambaresan, E. Manoj, and M.R. Prathapachandra Kurup
Elsevier BV

Pyrazolyl-derived zinc(II) and cadmium(II) complexes: Synthesis, spectral characterization, single crystal insights, Hirshfeld surface analysis, and in silico DNA interaction studies
Lakshmi Krishnaa Suresh, Pramod Kumar Maniyampara, Nithya Mohan, M. Simi, K. Gopal, M.R. Prathapachandra Kurup, and A. Santhy
Elsevier BV

Mononuclear and binuclear dioxidomolybdenum(VI) chelates derived from a tridentate ONO donor aroylhydrazone: Spectral, structural, DFT and in silico biological investigations
A. Ambili Aravindakshan, Nithya Mohan, M.R. Prathapachandra Kurup, Sultan Erkan, Savaş Kaya, and E. Manoj
Elsevier BV

A novel Salen-based dual channel sensor for easy and selective nanomolar detection of l-cysteine
Nithya Mohan, S. S. Sreejith, and M. R. Prathapachandra Kurup
Royal Society of Chemistry (RSC)
A Salen-type Schiff base sensor, characterized by XRD, efficiently detects l-cysteine through static and dynamic fluorescence quenching, employing a FRET mechanism. It exhibits remarkable stability, with a low detection limit of 1.52 × 10−9 M.

Bioactivity Modulation: Anionic Influence on Cu(II) Schiff Base Complexes
Jesna K. Sebastian, S. R. Amrutha, N. R. Suja, Nithya Mohan, S. S. Sreejith, Maheswaran Sithambaresan, M. Priya, and M. K. Muraleedharan Nair
Wiley
ABSTRACTThis article explains the synthesis of three Schiff base Cu(II) complexes derived from 3‐hydroxybenzaldehyde and ethylenediamine using three distinct copper anionic salts, and it explores the effects of those salts on the properties of the complexes. Elemental analysis, electronic spectra, FT‐IR, ESR, molar conductance, magnetic measurement, thermogravimetric analysis and PXRD were used to characterize the compounds. The anionic salt has been demonstrated to exhibit distinctive characteristics on Gram‐positive and Gram‐negative bacteria in terms of structure, DNA binding, cell viability, DNA breakage and activity. Furthermore, this ligand L1 and its derivatives indicated positive antifungal efficacy against Aspergillus niger and Trichophyton tonsurans. The study elucidates the manner in which distinct anion salts impacted the properties of complexes and their antifungal, anticancer and antibacterial outcomes.

Structural tuning effect to enhance the nonlinear optical response of salen type compounds
Nithya Mohan, S. S. Sreejith, P. V. Mohanan, and M. R. Prathapachandra Kurup
AIP Publishing

Copper(ii) salen-based complexes as potential anticancer agents
Nithya Mohan, C. V. Vidhya, V. Suni, Jimna Mohamed Ameer, Naresh Kasoju, P. V. Mohanan, S. S. Sreejith, and M. R. Prathapachandra Kurup
Royal Society of Chemistry (RSC)
The systematic design and synthesis of four Cu(ii) salen compounds and their potential as excellent anticancer agents is discussed using biological studies.

Emergent Catalytic Materials Towards CO<inf>2</inf> Reduction
S. S. Sreejith, Nithya Mohan, and M. R. P. Kurup
Springer Nature Singapore

Synthesis, crystal structure and ligand based catalytic activity of octahedral salen Schiff base Co(III) compounds
Nithya Mohan, S.S. Sreejith, Reni George, P.V. Mohanan, and M.R. Prathapachandra Kurup
Elsevier BV

Facile synthesis, X-ray diffraction studies, photophysical properties and DFT-D based conformational analysis of octa and dodecacyanomethoxycalix[4]resorcinarenes
A.M. Shebitha, S.S. Sreejith, P.B. Sherly Mole, Nithya Mohan, G. Avudaiappan, K. Hiba, K.S. Priya, and K. Sreekumar
Elsevier BV

Investigation on catecholase activity of salen Co(III) octahedral complexes
Nithya Mohan, S.S. Sreejith, and M.R. Prathapachandra Kurup
Elsevier BV

A study of structural effects on linear and nonlinear response of bicompartmental Ni (II) Schiff base complexes
Nithya Mohan, Sreejith S. S., Vasudevan Kuttippurath, Chandrasekharan Keloth, and M.R. Prathapachandra Kurup
Wiley
Herein we investigate imaginary third order NLO activity, optical limiting capability and first hyperpolarizabilities of five Ni (II) salen complexes using experimental and theoretical methods. The complexes are tuned to have different NLO response by changing mainly the diimine spacer group. Out of the compounds reported, the one with o‐phenylene spacer group exhibits the highest NLO activity comparable with that of polymers and semiconductors which is followed by the compound with ethylene spacer unit. The order of activity is a direct function of the degree of π‐delocalization. Further all the tested compounds returned outstanding optical limiting capabilities making them excellent materials for fabrication of such devices. The experimental results were substantiated with frontier orbital calculations carried out using DFT at M06/6‐31G* level of theory and complex with aromatic spacer group exhibits least energy gap and highest activity. The total dipole moment, polarizability and first hyperpolarizability were also calculated at the same level of theory which are also in line with the experimentally observed results.

A modern approach for the sensing of aqueous Al(III) ion by Ni(II) Salen-type Schiff base complexes
Nithya Mohan, Sreejith S. S., P.M. Sabura Begum, and M.R. Prathapachandra Kurup
Wiley
In this work, we explore a modern concept of transmetalation (metal exchange) for the effective recognition of aqueous Al(III) ion. Three different Ni(II) salen‐type Schiff base complexes with different spacer diimine groups were prepared for the metal exchange reaction. These probes recognize Al(III) both colorimetically as well as fluorimetrically. The efficiency in sensing is mainly due to the low emission characteristics of the respective Ni(II) complexes which results in enhanced emission on the formation of Al(III) complex. The geometry of the central Ni(II) metal ion in the probe plays a pivotal role in the sensing action with the highest sensitivity being shown by the Ni(II) metal center with distorted square pyramidal geometry. Further DFT calculations and the energetics involved in the sensing mechanism via the formation of Al(III) complexes substantiates the experimental results.

Experimental and theoretical analysis of a rare nitrato bridged 3d-4f complex containing LaZn<inf>2</inf> core synthesized from a Zn(II) metalloligand
S.S. Sreejith, Nithya Mohan, and M.R. Prathapachandra Kurup
Elsevier BV

Dual responsive salen-type Schiff bases for the effective detection of l-arginine: Via a static quenching mechanism
Nithya Mohan, S. S. Sreejith, P. M. Sabura Begum, and M. R. Prathapachandra Kurup
Royal Society of Chemistry (RSC)
The effect of substituents of salen Schiff bases on the detection of l-arginine via a static quenching mechanism is discussed.

Experimental and theoretical investigations on Pd(II) host-guest compound: Deciphering the structural and electronic features of a potential bioactive complex
S.S. Sreejith, Nithya Mohan, and M.R. Prathapachandra Kurup
Elsevier BV

Water-Encapsulated Ni(II) Salphen-Type Host Complexes: Experimental and Theoretical Analysis of Potentially Bioactive Quasi-Isostructural Polymorphs
Sreejith S. Sreekumar, Nithya Mohan, and Maliyeckal R. Prathapachandra Kurup
Wiley
AbstractIn this study, we report the formation of two quasi‐isostructural polymorphs (α and β) of a Ni(II) salphen‐type Schiff base complex using solvent evaporation technique. The polymorphs are inclusion compounds with guest water molecules exhibiting similar spectroscopic and thermal characteristics. Single crystal XRD (X‐ray Diffraction) analyses reveal the subtle differences in packing and supramolecular interactions which are quantified using Hirshfeld and 2D finger print analyses. Electrostatic potential analysis shows significant difference in potential distribution in the two molecules. The compositional analysis of the frontier orbitals and differences among the atomic charge distribution of the polymorphs are established using DFT (Density Functional Theory) calculations. Apart from highlighting the strength of encapsulation, DFT study substantiates the formation of inclusion compounds through single point energy calculations. Effects of inherent differences in the polymorphs on potential biological activity are probed using in silico molecular docking with B‐DNA and Human Serum Albumin (HSA). The α form shows superior bioactivity while β form excels in water encapsulation.

Experimental and theoretical studies on photoluminescent Zn(II) host complex with an open book structure: Implication on potential bioactivity and comparison with its ligand and Zn(II), Pd(II) siblings
S.S. Sreejith, Nithya Mohan, and M.R. Prathapachandra Kurup
Elsevier BV

Inclusion, pseudo-inclusion compounds and coordination polymer of Pd(II), Zn(II) and Cd(II) from salen-type Schiff base ligand with a 1,3-diimino spacer group: Crystal structures, spectroscopic and thermal studies
S.S. Sreejith, Nithya Mohan, N. Aiswarya, and M.R. Prathapachandra Kurup
Elsevier BV

(±)-trans-6,6′-Diethoxy-2,2′-[cyclohexane-1, 2-diylbis(nitrilomethanylylidene)]diphenol monohydrate
Nithya Mohan, S. S. Sreejith, M. Sithambaresan, and M. R. Prathapachandra Kurup
International Union of Crystallography (IUCr)
In the title hydrate, C24H30N2O4·H2O, the organic molecule adopts anEconformation with respect to the azomethine double bonds. The cyclohexane ring is in a chair conformation. The dihedral angle between benzene rings is 79.6 (2)°. Two intramolecular O—H...N hydrogen bonds are present. In the crystal, the components are linked by O–H...O hydrogen bonds and weak C—H...π interactions, generating a three-dimensional supramolecular architecture.

RECENT SCHOLAR PUBLICATIONS

Bioactivity Modulation: Anionic Influence on Cu (II) Schiff Base Complexes
JK Sebastian, SR Amrutha, NR Suja, N Mohan, SS Sreejith, ...
Applied Organometallic Chemistry 39 (3), e7853 2025

Multi-faceted investigation of copper (II) chelates based on ONS donor thiosemicarbazone: Crystal structures, spectral aspects, DNA binding, cytotoxicity and computational studies
JM Jacob, N Mohan, SS Sreejith, M Sithambaresan, E Manoj, MRP Kurup
Journal of Molecular Structure 1319, 139463 2025

Pyrazolyl-derived zinc (II) and cadmium (II) complexes: Synthesis, spectral characterization, single crystal insights, Hirshfeld surface analysis, and in silico DNA interaction
LK Suresh, PK Maniyampara, N Mohan, M Simi, K Gopal, MRP Kurup, ...
Inorganic Chemistry Communications 168, 112811 2024

Mononuclear and binuclear dioxidomolybdenum (VI) chelates derived from a tridentate ONO donor aroylhydrazone: Spectral, structural, DFT and in silico biological investigations
AA Aravindakshan, N Mohan, MRP Kurup, S Erkan, S Kaya, E Manoj
Polyhedron 256, 116998 2024

A novel Salen-based dual channel sensor for easy and selective nanomolar detection of l-cysteine
N Mohan, SS Sreejith, MRP Kurup
New Journal of Chemistry 48 (6), 2584-2593 2024

Structural tuning effect to enhance the nonlinear optical response of salen type compounds
N Mohan, SS Sreejith, PV Mohanan, MR Kurup
AIP Conference Proceedings 2783 (1) 2023

Emergent Catalytic Materials Towards CO₂ Reduction
SS Sreejith, N Mohan, MRP Kurup
Emerging Materials: Design, Characterization and Applications, 315-360 2022

Copper (II) salen-based complexes as potential anticancer agents
N Mohan, CV Vidhya, V Suni, JM Ameer, N Kasoju, PV Mohanan, ...
New Journal of Chemistry 46 (26), 12540-12550 2022

Synthesis, crystal structure and ligand based catalytic activity of octahedral salen Schiff base Co (III) compounds
N Mohan, SS Sreejith, R George, PV Mohanan, MRP Kurup
Journal of Molecular Structure, 129779 2021

Facile synthesis, X-ray diffraction studies, photophysical properties and DFT-D based conformational analysis of octa and dodecacyanomethoxycalix [4] resorcinarenes
AM Shebitha, SS Sreejith, PBS Mole, N Mohan, G Avudaiappan, K Hiba, ...
Journal of Molecular Structure 1214, 128215 2020

Investigation on catecholase activity of salen Co (III) octahedral complexes
N Mohan, SS Sreejith, MRP Kurup
Polyhedron 173, 114129 2019

A modern approach for the sensing of aqueous Al (III) ion by Ni (II) Salen‐type Schiff base complexes
N Mohan, S SS, PMS Begum, MRP Kurup
Applied Organometallic Chemistry 33 (9), e5064 2019

A study of structural effects on linear and nonlinear response of bicompartmental Ni (II) Schiff base complexes
N Mohan, S SS, V Kuttippurath, C Keloth, MRP Kurup
Applied Organometallic Chemistry 33 (5), e4900 2019

Experimental and theoretical analysis of a rare nitrato bridged 3d-4f complex containing LaZn2 core synthesized from a Zn (II) metalloligand
SS Sreejith, N Mohan, MRP Kurup
Journal of Molecular Structure 1153, 85-95 2018

Dual responsive salen-type Schiff bases for the effective detection of L-arginine via a static quenching mechanism
N Mohan, SS Sreejith, PMS Begum, MRP Kurup
New Journal of Chemistry 42 (15), 13114-13121 2018

Experimental and theoretical studies on photoluminescent Zn (II) host complex with an open book structure: Implication on potential bioactivity and comparison with its ligand
SS Sreejith, N Mohan, MRP Kurup
Polyhedron 135, 278-295 2017

Experimental and theoretical investigations on Pd (II) host-guest compound: Deciphering the structural and electronic features of a potential bioactive complex
SS Sreejith, N Mohan, MRP Kurup
Journal of Molecular Structure 1145, 170-183 2017

Water‐Encapsulated Ni (II) Salphen‐Type Host Complexes: Experimental and Theoretical Analysis of Potentially Bioactive Quasi‐Isostructural Polymorphs
SS Sreekumar, N Mohan, MRP Kurup
ChemistrySelect 2 (22), 6493-6502 2017

Inclusion, pseudo-inclusion compounds and coordination polymer of Pd (II), Zn (II) and Cd (II) from salen-type Schiff base ligand with a 1, 3-diimino spacer group: Crystal
SS Sreejith, N Mohan, N Aiswarya, MRP Kurup
Polyhedron 115, 180-192 2016

()-trans-6, 6′-Diethoxy-2, 2′-[cyclohexane-1, 2-diylbis (nitrilomethanylylidene)] diphenol monohydrate
N Mohan, SS Sreejith, M Sithambaresan, MRP Kurup
Structure Reports 70 (2), o182-o183 2014

MOST CITED SCHOLAR PUBLICATIONS

Experimental and theoretical studies on photoluminescent Zn (II) host complex with an open book structure: Implication on potential bioactivity and comparison with its ligand
SS Sreejith, N Mohan, MRP Kurup
Polyhedron 135, 278-295 2017
Citations: 24

Copper (II) salen-based complexes as potential anticancer agents
N Mohan, CV Vidhya, V Suni, JM Ameer, N Kasoju, PV Mohanan, ...
New Journal of Chemistry 46 (26), 12540-12550 2022
Citations: 17

Investigation on catecholase activity of salen Co (III) octahedral complexes
N Mohan, SS Sreejith, MRP Kurup
Polyhedron 173, 114129 2019
Citations: 12

A modern approach for the sensing of aqueous Al (III) ion by Ni (II) Salen‐type Schiff base complexes
N Mohan, S SS, PMS Begum, MRP Kurup
Applied Organometallic Chemistry 33 (9), e5064 2019
Citations: 9

()-trans-6, 6′-Diethoxy-2, 2′-[cyclohexane-1, 2-diylbis (nitrilomethanylylidene)] diphenol monohydrate
N Mohan, SS Sreejith, M Sithambaresan, MRP Kurup
Structure Reports 70 (2), o182-o183 2014
Citations: 6

Mononuclear and binuclear dioxidomolybdenum (VI) chelates derived from a tridentate ONO donor aroylhydrazone: Spectral, structural, DFT and in silico biological investigations
AA Aravindakshan, N Mohan, MRP Kurup, S Erkan, S Kaya, E Manoj
Polyhedron 256, 116998 2024
Citations: 3

Multi-faceted investigation of copper (II) chelates based on ONS donor thiosemicarbazone: Crystal structures, spectral aspects, DNA binding, cytotoxicity and computational studies
JM Jacob, N Mohan, SS Sreejith, M Sithambaresan, E Manoj, MRP Kurup
Journal of Molecular Structure 1319, 139463 2025
Citations: 1