Malik Nurbekov

Scopus Publications

Relative Telomere Length Is Associated with the Risk of Development and Severity of the Course of Age-Related Macular Degeneration in the Russian Population
Olga P. Dmitrenko, Olga I. Abramova, Nataliia S. Karpova, Malik K. Nurbekov, and Ekaterina S. Arshinova
MDPI AG
One of the most significant factors for age-related macular degeneration (AMD) development is considered to be aging, the processes of which are closely associated with telomere shortening. The different forms, indicators of aggressiveness, and intensities of AMD can be observed in the same age group, confirming the need to find a biomarker for early diagnosis and be capable of monitoring the progression of the pathological process. Therefore, we investigated whether the relative telomere length (RTL) has any connection with the risk of development of disease and its progression. RTL was measured using RT-PCR in 166 people, including 96 patients with AMD. RTL was significantly lower in patients with AMD. Women were more likely to develop AMD than men (odds ratio (OR) = 9.53 × 106 vs. OR = 1.04 × 108, respectively). The decrease in RTL in patients reliably correlated with the progression of AMD, and the smallest RTL was observed in late-stage patients. RTL < 0.8 is a significant risk factor for disease progression. The results of our research showed that RTL may be considered as a potential biomarker and a promising predictor of disease progression in patients with early AMD.

Review: Influence of 25(OH)D Blood Concentration and Supplementation during Pregnancy on Preeclampsia Development and Neonatal Outcomes
Nataliia Karpova, Olga Dmitrenko, Ekaterina Arshinova, and Malik Nurbekov
MDPI AG
Briefly, 25-hydroxyvitamin D (25(OH)D) plays an essential role in embryogenesis and the course of intra- and postnatal periods and is crucially involved in the functioning of the mother–placenta–fetus system. The low quantity of 25(OH)D during pregnancy can lead to an elevated risk for preeclampsia occurrence. Despite the numerous studies on the association of 25(OH)D deficiency and preeclampsia development, the current research on this theme is contradictory. In this review, we summarize and analyze study data on the effects of 25(OH)D deficiency and supplementation on pregnancy, labor, and fetal and neonatal outcomes.

Severe types of fetopathy are associated with changes in the serological proteome of diabetic mothers
Arthur T. Kopylov, Olga Papysheva, Iveta Gribova, Anna L. Kaysheva, Galina Kotaysch, Lubov Kharitonova, Tatiana Mayatskaya, Malik K. Nurbekov, Ekaterina Schipkova, Olga Terekhina,et al.
Ovid Technologies (Wolters Kluwer Health)
Abstract Pregestational or gestational diabetes are the main risk factors for diabetic fetopathy. There are no generalized signs of fetopathy before the late gestational age due to insufficient sensitivity of currently employed instrumental methods. In this cross-sectional observational study, we investigated several types of severe diabetic fetopathy (cardiomyopathy, central nervous system defects, and hepatomegaly) established in type 2 diabetic mothers during 30 to 35 gestational weeks and confirmed upon delivery. We examined peripheral blood plasma and determined a small proportion of proteins strongly associated with a specific type of fetopathy or anatomical malfunction. Most of the examined markers participate in critical processes at different stages of embryogenesis and regulate various phases of morphogenesis. Alterations in CDCL5 had a significant impact on mRNA splicing and DNA repair. Patients with central nervous system defects were characterized by the greatest depletion (ca. 7% of the basal level) of DFP3, a neurotrophic factor needed for the proper specialization of oligodendrocytes. Dysregulation of noncanonical wingless-related integration site signaling pathway (Wnt) signaling guided by pigment epithelium-derived factor (PEDF) and disheveled-associated activator of morphogenesis 2 (DAAM2) was also profound. In addition, deficiency in retinoic acid and thyroxine transport was exhibited by the dramatic increase of transthyretin (TTHY). The molecular interplay between the identified serological markers leads to pathologies in fetal development on the background of a diabetic condition. These warning serological markers can be quantitatively examined, and their profile may reflect different severe types of diabetic fetopathy, producing a beneficial effect on the current standard care for pregnant women and infants.

Analysis of Paradoxical Neurophysiological Reactions at Different Stages of the Perception of Negative Emotional Stimuli in Schizophrenia Patients
V. B. Strelets, G. I. Rodionov, M. K. Nurbekov, V. L. Ushakov, and A. Yu. Arkhipov
Springer Science and Business Media LLC

I/D Polymorphism Gene ACE and Risk of Preeclampsia in Women with Gestational Diabetes Mellitus
O. P. Dmitrenko, N. S. Karpova, M. K. Nurbekov, and O. V. Papysheva
Hindawi Limited
Preeclampsia (PE) and gestational diabetes mellitus (GDM) are the most common complications of pregnancy, which result in adverse outcomes for the mother and the fetus. GDM is regarded as a separate independent risk factor for PE development, as evidenced by a higher preeclampsia rate in gestational diabetes mellitus than in the general population. The role the endothelial cell dysfunction plays is considered to be the most reasonable one in the origin of these diseases. The activity of plasma and tissue angiotensin converting enzyme (ACE) is believed to be genetically controlled. The available data suggests that increased ACE activity due to deletion (D)/insertion (I) in the 16th intron of ACE gene, which is called ACE gene I/D polymorphism, is associated with preeclampsia and varies depending on the studied population and the geography. We did not find any literature data that estimates the influence of ACE gene I/D polymorphism on PE rate in pregnant women with GDM. Therefore, the present study aimed to investigate a relationship between ACE gene I/D polymorphism and preeclampsia development in the case of GDM in the Russian population. The study used the genomic DNA derived by phenol-chloroform extraction method from venous blood samples in 137 pregnant women, including samples of 74 women with GDM accompanied with PE and the blood samples of 63 women with GDM w/o preeclampsia. Genotyping of insertion/deletion in the I/D region (16 intron of АСЕ gene) was conducted by real-time PCR using the TaqMan competing probe technology. The particular features in the frequency array of alleles and genotypes of the ACE gen I/D polymorphism under review, as associated with preeclampsia development risk in pregnant women with GDM, were identified. The acquired data testify to the need to further study of ACE gene I/D region polymorphism association in a large patient sample taking into account the PE and GDM risk factors estimated in the clinical practice.

Sirtuins and their role in the aging eye (review)
L. K. Moshetova, O. I. Abramova, K. I. Turkina, M. K. Nurbekov, O. P. Dmitrenko, I. N. Saburina, and S. A. Kochergin
PE Polunina Elizareta Gennadievna
Visual impairment in elderly people is a serious problem that significantly affects the quality of life of millions people around the world. The magnitude of this problem is becoming increasingly apparent as the population ages and the number of older people increases. Age-related macular degeneration (AMD) is the third leading cause of blindness worldwide and the main cause of vision loss in people over 60 years. It is expected that AMD will affect about 288 million people by 2040. AMD is a multifactorial disease with a progressive course. The arised dystrophic changes in the retina cannot be reversed by any of the known treatment methods. A lot of research and effort has already been invested in identifying various biomarkers for predicting the incidence rate, identifying people at risk, finding out the pathogenetic mechanisms of this disease, and finding effective methods of treatment and prevention.Aging is the basis of pathological changes that occur during AMD. Aging biomarkers are measurable vital signs that qualitatively and quantitatively change with the age of the body. DNA methylation is a molecular mechanism that is a potential biomarker of aging. Sirtuins indirectly participate in this process, regulating the activity of the DNMT1 enzyme. The article discusses current knowledge of the mechanisms underlying the action of sirtuins (Sirtuins / SIRT), with an emphasis on SIRT1. Analysis of the pathophysiological action of sirtuins can affect the prevention and treatment of pathological eye changes associated with AMD. The article provides literature sources containing the results of studies of the effect of SIRT1 as a marker of aging in body tissues. SIRT1 is an attractive candidate for developing therapeutic strategies preventing early eye aging, in particular, age-associated diseases such as AMD The impact on the genetic mechanisms of this disease is a promising direction in treatment.

Influence of the pgc1α, АСЕ and drd<inf>2</inf> gene polymorphisms on the development and the course of gestational diabetes
O.V. Papysheva, , M.K. Nurbekov, T.A. Mayatskaya, G.A. Kotaysh, E.N. Kozhevnikova, E.S. Shchipkova, S.G. Morozov, , ,et al.
Dynasty Publishing House

The influence of negative emotional stimuli on the late perception stages (P300 & N400 components) in patients with paranoid schizophrenia in implicite situation
А.Ю. Архипов, В.Ю. Новотоцкий-Власов, М. К. Нурбеков, and В.Б. Стрелец
Akademizdatcenter Nauka

Central and peripheral pathogenetic forms of type 2 diabetes: A proof-of-concept study
Dmitry M Davydov and Malik K Nurbekov
Bioscientifica
Hypothesis Previous studies provide evidence that glycated haemoglobin (HbA1c) and fasting plasma glucose (FPG) should not be considered as interchangeable alternatives in the diagnosis of the same type 2 diabetes, but as indicators of its different pathogenetic subtypes. This study was conducted to determine whether a particularly high amount of glucose in either HbA1c form or in fasting plasma would be found in diabetic patients genetically predisposed for either intensive cognitive or intensive muscle metabolic activity, respectively. Methods HbA1c and FPG levels, polymorphisms of genes indicating the predisposition to different cognitive activity (the dopamine D2 receptor (DRD2/ANKK1)), muscle activity (peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC1A(PPARGC1A))), and vascular regulation of general metabolic activity (the angiotensin 1 converting enzyme (ACE)) were assessed in diabetic patients and nondiabetic controls. Results DRD2/ANKK1 polymorphism that affects baseline central arousal determined HbA1c variations uncorrelated with FPG in total and clinical groups. The mutation of PGC1A mainly affecting peripheral glucose metabolism had an effect on FPG correlated or uncorrelated with HbA1c depending on the effect assessment in the total sample or in the nondiabetic group, respectively. ACE insertion/deletion (I/D) gene polymorphism was associated with both HbA1c and FPG fluctuations, but only in diabetic patients. Conclusion The findings provide evidence that the HbA1c and FPG may predict the risks for different subtypes of type 2 diabetes associated with either brain or muscle metabolic activity in genetically vulnerable people.

Tryptophanyl-tRNA synthase gene expression as genetic marker of the athletes' overtraining

Trecrezan: Inhibitor of acid cholesterol esterase synthesis in platelets and monocytes
M. M. Rasulov, S. N. Bobkova, O. A. Belikova, M. K. Nurbekov, N. P. Shimanovskaya, L. K. Karaulova, and M. G. Voronkov
Springer Science and Business Media LLC

The complex of zinc bis-(2-methylphenoxyacetate) with tris-2(hydroxyethyl) amine as an activator of synthesis of total tryptophanyl-tRNA synthetase
M. M. Rasulov, M. G. Voronkov, M. K. Nurbekov, M. V. Zvereva, A. N. Mirskova, S. N. Adamovich, and R. G. Mirskov
Pleiades Publishing Ltd

Tris-2(hydroxyethyl)ammonium (2-methylphenoxy)acetate as an inhibitor of synthesis of acid phospholipase A2 of mononuclear cells
M. M. Rasulov, S. N. Bobkova, O. A. Belikova, M. K. Nurbekov, and M. G. Voronkov
Pleiades Publishing Ltd

Tris-2(hydroxyethyl)ammonium (2-methylphenoxy)acetate as an inhibitor of synthesis of acid cholesterol esterase of platelets and mononuclear cells
M. M. Rasulov, S. N. Bobkova, O. A. Belikova, M. K. Nurbekov, N. P. Shimanovskaya, and M. G. Voronkov
Pleiades Publishing Ltd

Tris-2(hydroxyethyl) ammonium 2-methylphenoxyacetate as an inhibitor of synthesis of liver phospholipase A1
S. N. Bobkova, M. M. Rasulov, M. K. Nurbekov, O. A. Belikova, N. P. Shimanovskaya, and M. G. Voronkov
Pleiades Publishing Ltd

Tris-2(hydroxyethyl) ammonium 2-methylphenoxyacetate as an activator of aorta intima acid lipase
M. G. Voronkov, S. N. Bobkova, M. M. Rasulov, M. K. Nurbekov, and O. A. Belikova
Pleiades Publishing Ltd

Trecrezan as an activator of aminoacyl-tRNA synthase mRNA
M. M. Rasulov, M. K. Nurbekov, S. N. Bobkova, O. A. Belikova, and M. G. Voronkov
Springer Science and Business Media LLC

Tris-2(hydroxyethyl)ammonium 2-methylphenoxyacetate activates the synthesis of mRNA aminoacyl-tRNA synthetase
M. K. Nurbekov, M. M. Rasulov, M. G. Voronkov, S. N. Bobkova, and O. A. Belikova
Pleiades Publishing Ltd

The hypolipidemic action of trecrezan and its possible molecular mechanisms
M. M. Rasulov, M. K. Nurbekov, S. N. Bobkova, V. V. Bulanova, E. S. Antonova, M. I. Susova, and M. G. Voronkov
Springer Science and Business Media LLC

Antisclerotic effect of Trekrezan and its possible mechanisms
M. G. Voronkov, M. K. Nurbekov, S. N. Bobkova, L. K. Karaulova, M. I. Susova, and M. M. Rasulov
Pleiades Publishing Ltd

Silicon in Organic and Bioorganic Chemistry: Possible Mechanisms of the Stimulating Effects of Isopropoxygermatran and 1-Ethoxysilatran in Regenerated Liver
Wiley

Long-term group isolation is a factor of dysregulation of reproductive function in rats

Hepatoprotective activity of 1-ethoxysilatrane and 1-isopropoxygermatrane
M. G. Voronkov, M. K. Nurbekov, and M. M. Rasulov
Springer Science and Business Media LLC

SK18 diphasmid for constructing genomic libraries with blue/white selection, multiple cloning sites, and with the M13 and λ ori
E.R. Zabarovsky, O.V. Turina, M.K. Nurbekov, and L.L. Kisselev
Oxford University Press (OUP)

λSK3 and λSK5, vectors for constructing genomic libraries derived from λEMBL3 and λEMBL4 by insertion of lac gene
E.R. Zabarovsky, O.V. Turina, R.L. Allikmets, M.K. Nurbekov, S.A. Filippov, V.N. Dobrynin, and L.L. Kisselev
Oxford University Press (OUP)

Malik Nurbekov

EDUCATION

RESEARCH, TEACHING, or OTHER INTERESTS

Scopus Publications

Publications