Selecting optimal imaging modalities for total anomalous pulmonary venous connection visualization Lazzat Bastarbekova, Raushan Rakhimzhanova, Tairkhan Dautov, Kenzhebek Altenov, Zhanar Moldakhanova, et al. Egyptian Journal of Radiology and Nuclear Medicine, 2025 In healthy individuals, pulmonary veins drain oxygenated blood from the lungs into the left atrium. Total anomalous pulmonary venous connection (TAPVC) disrupts this process, causing severe clinical issues. TAPVC is classified into four types based on drainage site: supracardiac, cardiac, infracardiac, and mixed. Untreated, TAPVC is life-threatening with high neonatal mortality, though surgical advances have lowered mortality rates to below 10%. Early diagnosis and intervention are critical for better outcomes, especially in obstructed cases. Transthoracic echocardiography (TTE) is the primary diagnostic tool for TAPVC, identifying the absence of pulmonary venous connection to the left atrium and the presence of a common pulmonary venous trunk. However, TTE’s limitations, such as poor acoustic windows and inadequate spatial resolution, often necessitate advanced imaging like computed tomography angiography (CTA) and magnetic resonance imaging (MRI). CTA offers high spatial and temporal resolution, providing detailed anatomical information crucial for preoperative planning. Although it involves radiation exposure, it outperforms TTE in visualizing extracardiac vascular structures. MRI provides comprehensive anatomical and functional assessments without radiation, making it ideal for younger patients. It evaluates ventricular function, shunt ratios, and vascular anomalies but requires longer acquisition times. Cardiac catheterization remains the reference standard for diagnosing complex TAPVC, offering direct hemodynamic assessment despite being invasive. TTE is the first-line diagnostic tool for neonates, while CTA and MRI are preferred for detailed anatomical and functional assessments in adults. The manuscript reviews and compares these imaging techniques for optimal TAPVC diagnosis and management.
Effects of Intense Physical Training on Left Ventricular Hemodynamic Forces in Endurance Athletes: A Feature-Tracking Cardiac Magnetic Resonance Study YELTAY RAKHMANOV, DINARA JUMADILOVA, BAUYRZHAN TOKTARBAY, ZAUKIYA KHAMITOVA, AIZHAN ZHANKORAZOVA, et al. Medicine and Science in Sports and Exercise, 2025 Purpose We sought to evaluate the effect of intensive physical training on left ventricular (LV) hemodynamic forces (HDF) in athletes. Methods Forty professional endurance athletes were evaluated at the beginning of their training cycle (off-season) and after a period of aerobic isotonic dynamic exercise (peak training period) using cine cardiac magnetic resonance (CMR). Images were analyzed off-line using dedicated software. LV HDF for the whole cardiac cycle and the different cardiac phases were measured. Standard statistics were used to compare off-season and peak training period values. Results The average sport experience was 11 ± 7 yr. There were no differences in LV volumes, stroke volume, LV ejection fraction, and LV mass between off-season and peak training CMR. Similarly, there were no changes induced by physical training in the strain parameters. Physical training induced a significant increase of the longitudinal HDF (18.7 vs 21.2, P = 0.023) and an increase of the transverse HDF (3.4 vs 4.0, P = 0.048) throughout the entire heartbeat. After physical training, the peak values and the hemodynamic work (expressed as area under the curve) of the first part of the systole were significantly higher compared with off-season values (63.9 vs 53.9 (P = 0.034); 4.67 vs 3.79 (P = 0.015), respectively). The difference in the elastic rebound between off-season and peak training (−0.22 vs −0.37) did not reach statistical significance (P = 0.056). Conclusions Intense physical training induces an increase in LV HDF throughout the entire heartbeat, independent from geometric cardiac remodeling. The first part of the systole is the phase of the cardiac cycle that is mostly improved by intense physical training.
A comparative analysis of CT angiography and echocardiography in the evaluation of chest findings in patients with interrupted aortic arch Zhanar Moldakhanova, Raushan Rakhimzhanova, Tairkhan Dautov, Lazzat Bastarbekova, Bauyrzhan Kaliyev, et al. Frontiers in Radiology, 2025 Interrupted aortic arch (IAA) is a rare congenital cardiovascular anomaly characterized by the absence of continuity between the ascending and descending aorta, often accompanied by congenital heart defects such as ventricular septal defects and patent ductus arteriosus. Accurate preoperative imaging is essential for surgical planning and patient management. This study aimed to compare the diagnostic accuracy of echocardiography and computed tomography angiography (CTA) in evaluating thoracic findings in patients with IAA. A retrospective analysis was conducted on 58 patients (median age: 18 days) diagnosed with IAA between September 2020 and January 2023 at the Heart Center, University Medical Center, Astana, Kazakhstan. Conventional echocardiography and multislice CTA were performed using standardized protocols. Sensitivity, specificity, and other diagnostic performance metrics were calculated. Statistical comparisons were made using McNemar's and Wilcoxon signed-rank tests, with p < 0.05 considered significant. Echocardiography correctly identified 91.4% of IAA cases, while CTA achieved 100% sensitivity and specificity. McNemar's test revealed a significant difference in diagnostic performance favoring CTA (p < 0.05). Measurements of the ascending aorta diameter showed no statistically significant difference between the two modalities (p = 0.09). IAA was predominantly type A (48.3%) and type B (46.6%), with hypoplastic ascending aorta identified in 34.5% of patients. Echocardiography remains a practical initial imaging modality for IAA, offering portability and cost-effectiveness. However, CTA demonstrated superior diagnostic accuracy and anatomical resolution, making it the preferred tool for detailed preoperative evaluation and surgical planning. Future studies with larger cohorts and additional modalities could further refine diagnostic strategies for IAA.
Reliability of left ventricular hemodynamic forces derived from feature-tracking cardiac magnetic resonance Temirlan Ismailov, Zaukiya Khamitova, Dinara Jumadilova, Nail Khissamutdinov, Bauyrzhan Toktarbay, et al. Plos One, 2024 Background Hemodynamic forces (HDF) analysis has been proposed as a method to quantify intraventricular pressure gradients, however data on its reliability are still scanty. Thus, the aim of this study is to assess the reliability of HDF parameters derived from cardiac magnetic resonance (CMR). Methods CMR studies of 25 athletes were analysed by two independent observers and then re-analysed by the same observer one week apart. Intraclass Correlation Coefficient (ICC [95% CI]) and Bland-Altman plots were used to assess association, agreement, and bias of the longitudinal (A-B) HDF, transverse (L-S) HDF, and Impulse Angle. The sample size required to detect a relative change in the HDF parameters was also calculated. Results In terms of inter-observer variability, there was a good correlation for the A-B and L-S (ICC 0.85 [0.67–0.93] and 0.86 [0.69–0.94]; p<0.001 for both, respectively) and a moderate correlation for the Impulse Angle (ICC 0.73 [0.39–0.87]; p = 0.001). For intra-observer variability, A-B and L-S showed excellent correlation (ICC 0.91 [0.78–0.93] and 0.93 [0.83–0.97]; p<0.001 for both, respectively). Impulse Angle presented good correlation (ICC 0.80 [0.56–0.90]; p<0.001). Frame selection and aortic valve area measurements were the most vulnerable step in terms of reliability of the method. Sample size calculation to detect relative changes ranged from n = 1 to detect a 15% relative change in Impulse Angle to n = 171 for the detection of 10% relative change in A-B HDF. Conclusions The results of this study showed a low inter- and intra-observer variability of HDF parameters derived from feature-tracking CMR. This provides the fundamental basis for their use both in research and clinical practice, which could eventually lead to the detection of significant changes at follow-up studies.
Eosinophilic Inflammation in COPD: Mechanisms, Diagnostic Markers, Clinical Features and Therapy Guidance Aigerim Aitkazina, Natalya Latypova, Meirzhan Abishev, Aleksey Pak, Nurmakhan Zholshybek, et al. Journal of Clinical Medicine of Kazakhstan, 2024 Chronic obstructive pulmonary disease (COPD) is one of the main causes of morbidity and mortality worldwide. Eosinophilia, which may have a significant role in the inflammation process and obstruction of airways, is present in about one third patients suffering from COPD. The significance of eosinophil counts in COPD is currently debated, but they can potentially serve as biomarkers for treatment selection. Blood eosinophil counts can assist in determining the patients who can benefit from inhaled corticosteroid therapy to prevent or eliminate exacerbations.<br /> The aim of this review is to demonstrate the significance of eosinophilic inflammation COPD and the use of eosinophilic inflammation biomarkers to guide therapy decisions.<br /> To reach this goal, a search of relevant literature on the subject was conducted. Articles were searched in electronic sources: PubMed and Google Scholar. The keywords "COPD and eosinophilia", "COPD exacerbations and eosinophilia", "inhaled corticosteroids, COPD and eosinophilia" were used. One hundred and twenty sources were found, of which 66 were selected.<br /> Results of the review showed high frequency of eosinophilic phenotype detection in COPD. Blood eosinophilia becomes a potential universal marker of eosinophilic COPD. Blood eosinophils level can predict response to inhaled corticosteroids treatment patients with COPD, but increases the likelihood of pneumonia. Overall, the role of eosinophilia in COPD has not been obtained to date, which suggests it needs further study.
Pulmonary artery pseudoaneurysm in a young man with pulmonary hypertension on computed tomography angiography Tairkhan B. Dautov, Bauyrzhan B. Kaliyev, Ruslan Y. Tukinov, Dinara S. Almenova, Zhanar Z. Kozhakhmetova, et al. Digital Diagnostics, 2024 Pulmonary artery aneurysms and pseudoaneurysms are uncommon anomalies; however, their associated morbidity underscores the importance of recognizing them. Herein, we present a clinical case involving a 15-year-old male patient who presented at our clinic with complaints of hemoptysis. Upon diagnosis, a left lung aneurysm was found. Subsequent computed tomography angiography and intervention on the pulmonary arteries confirmed the presence of pulmonary artery aneurysms, elucidating that the hemoptysis was caused by the rupture of the aneurysm. The intervention on the pulmonary artery further confirmed the diagnosis. Early detection and management of pulmonary artery aneurysms are crucial, particularly in young patients, as timely intervention can prevent severe complications and improve patient outcomes. Raising awareness of these vascular abnormalities and promptly addressing them through appropriate diagnostic measures and interventions can help healthcare providers effectively mitigate the potential risks associated with pulmonary artery aneurysms, thereby enhancing patient care and prognosis.
Reliability and diagnostic performance of an automated MRI-based classifier compared with radiologists in Alzheimer’s disease N Zholshybek, E Abdurakhmanova, A Bimakhan, D Jumadilova, ... Frontiers in Neuroinformatics 20, 1821249 , 2026 2026
Structure, mechanical performance and antibacterial behavior of TaCuN coatings deposited by reactive magnetron co-sputtering A Kassymbayev, A Pogrebnjak, R Kimossov, A Myakinin, A Borisov, ... Surface and Coatings Technology, 133529 , 2026 2026
Hemodynamic forces derived from cine cardiac magnetic resonance imaging: technical aspects, applications in various clinical scenarios, and in athlete's heart D Jumadilova, N Zholshybek, T Dautov, G Ayapergenova, G Tonti, ... Frontiers in Cardiovascular Medicine 13, 1778061 , 2026 2026
Harmonizing multicenter quantitative imaging data: sources of variability, statistical solutions, and practical workflows in CT and MRI N Zholshybek, L Bastarbekova Exploration of Digital Health Technologies 4, 101185 , 2026 2026
Agreement between Z-score and an arch-to-ascending aorta ratio derived from CT angiography for detection of aortic arch hypoplasia Ж Молдаханова, Р Рахимжанова, Т Даутов, Л Бастарбекова, ... Астана медициналық журналы, amj002-amj002 , 2025 2025
Selecting optimal imaging modalities for total anomalous pulmonary venous connection visualization L Bastarbekova, R Rakhimzhanova, T Dautov, K Altenov, ... Egyptian Journal of Radiology and Nuclear Medicine 56 (1), 177 , 2025 2025 Citations: 1
Effects of Intense Physical Training on Left Ventricular Hemodynamic Forces in Endurance Athletes: A Feature-Tracking Cardiac Magnetic Resonance Study Y Rakhmanov, D Jumadilova, B Toktarbay, Z Khamitova, A Zhankorazova, ... Medicine & Science in Sports & Exercise 57 (8), 1819-1824 , 2025 2025 Citations: 1
A comparative analysis of CT angiography and echocardiography in the evaluation of chest findings in patients with interrupted aortic arch Z Moldakhanova, R Rakhimzhanova, T Dautov, L Bastarbekova, ... Frontiers in Radiology 5, 1616112 , 2025 2025 Citations: 3
Left ventricular hemodynamic forces: gaining insight into left ventricular function A Salustri, G Tonti, A Zhankorazova, N Zholshybek, B Toktarbay, ... Exploration of Cardiology 2025 (3), 101257 , 2025 2025 Citations: 3
Reliability and Dual Validation of a Deep Learning Model for Anterior Cruciate Ligament Tear Detection Using Magnetic Resonance Imaging N Zholshybek, Z Khorshat, L Bastarbekova, N Assylbek, A Zhankorazova, ... International Conference on AI and Robotics, 362-373 , 2025 2025
Псевдоаневризма лёгочной артерии у молодого человека с лёгочной гипертензией по данным компьютерной томографической ангиографии ТБ Даутов, ББ Калиев, РЯ Тукинов, ДС Альменова, ЖЖ Кожахметова, ... Digital Diagnostics 5 (3), 623-631 , 2024 2024
Pulmonary artery pseudoaneurysm in a young man with pulmonary hypertension on computed tomography angiography TB Dautov, BB Kaliyev, RY Tukinov, DS Almenova, ZZ Kozhakhmetova, ... Digital Diagnostics 5 (3), 623-631 , 2024 2024
Differences in cardiac mechanics assessed by left ventricular hemodynamic forces in athletes and patients with hypertension D Jumadilova, Y Rakhmanov, N Khissamutdinov, A Zhankorazova, ... Scientific Reports 14 (1), 27402 , 2024 2024 Citations: 9
Differences of Left Ventricular Hemodynamic Forces in Athletes and Patients with Hypertension: A Feature-Tracking Cardiac Magnetic Resonance Study D Jumadilova, Y Rakhmanov, N Khissamutdinov, A Zhankorazova, ... Available at SSRN 4888093 , 2024 2024
Reliability of left ventricular hemodynamic forces derived from feature-tracking cardiac magnetic resonance T Ismailov, Z Khamitova, D Jumadilova, N Khissamutdinov, B Toktarbay, ... Plos one 19 (7), e0306481 , 2024 2024 Citations: 10
Radiology loading and coverage hours in Kazakhstan T Dautov, Z Kozhakhmetova, B Kaliyev, N Zholshybek, B Yerekesh Korean Journal of Radiology 25 (6), 508 , 2024 2024 Citations: 2
THE ROLE OF CT AND MRI IN DIAGNOSING COMPLICATIONS AFTER HEART TRANSPLANTATION NZ Zholshybek, TB Dautov, DG Jumadilova, AU Akhmetov МЕДИЦИНАЛЫҚ ОРТАЛЫҒЫНЫҢ ЖАРШЫСЫ, 119 , 2024 2024
Eosinophilic inflammation in COPD: mechanisms, diagnostic markers, clinical features and therapy guidance A Aitkazina, N Latypova, M Abishev, A Pak, N Zholshybek, S Suleimenov, ... Journal of Clinical Medicine of Kazakhstan 21 (3), 4-10 , 2024 2024 Citations: 1
Cardiac imaging in athlete’s heart: current status and future prospects N Zholshybek, Z Khamitova, B Toktarbay, D Jumadilova, ... Cardiovascular Ultrasound 21 (1), 21 , 2023 2023 Citations: 23
The impact of exercise on cardiovascular system: Molecular signaling pathway and cardiac adaptations B Toktarbay, Z Khamitova, N Zholshybek, D Jumadilova, Y Rakhmanov, ... Journal of Clinical Medicine of Kazakhstan 20 (6), 4-11 , 2023 2023 Citations: 3
MOST CITED SCHOLAR PUBLICATIONS
Cardiac imaging in athlete’s heart: current status and future prospects N Zholshybek, Z Khamitova, B Toktarbay, D Jumadilova, ... Cardiovascular Ultrasound 21 (1), 21 , 2023 2023 Citations: 23
Reliability of left ventricular hemodynamic forces derived from feature-tracking cardiac magnetic resonance T Ismailov, Z Khamitova, D Jumadilova, N Khissamutdinov, B Toktarbay, ... Plos one 19 (7), e0306481 , 2024 2024 Citations: 10
Differences in cardiac mechanics assessed by left ventricular hemodynamic forces in athletes and patients with hypertension D Jumadilova, Y Rakhmanov, N Khissamutdinov, A Zhankorazova, ... Scientific Reports 14 (1), 27402 , 2024 2024 Citations: 9
A comparative analysis of CT angiography and echocardiography in the evaluation of chest findings in patients with interrupted aortic arch Z Moldakhanova, R Rakhimzhanova, T Dautov, L Bastarbekova, ... Frontiers in Radiology 5, 1616112 , 2025 2025 Citations: 3
Left ventricular hemodynamic forces: gaining insight into left ventricular function A Salustri, G Tonti, A Zhankorazova, N Zholshybek, B Toktarbay, ... Exploration of Cardiology 2025 (3), 101257 , 2025 2025 Citations: 3
The impact of exercise on cardiovascular system: Molecular signaling pathway and cardiac adaptations B Toktarbay, Z Khamitova, N Zholshybek, D Jumadilova, Y Rakhmanov, ... Journal of Clinical Medicine of Kazakhstan 20 (6), 4-11 , 2023 2023 Citations: 3
Radiology loading and coverage hours in Kazakhstan T Dautov, Z Kozhakhmetova, B Kaliyev, N Zholshybek, B Yerekesh Korean Journal of Radiology 25 (6), 508 , 2024 2024 Citations: 2
Selecting optimal imaging modalities for total anomalous pulmonary venous connection visualization L Bastarbekova, R Rakhimzhanova, T Dautov, K Altenov, ... Egyptian Journal of Radiology and Nuclear Medicine 56 (1), 177 , 2025 2025 Citations: 1
Effects of Intense Physical Training on Left Ventricular Hemodynamic Forces in Endurance Athletes: A Feature-Tracking Cardiac Magnetic Resonance Study Y Rakhmanov, D Jumadilova, B Toktarbay, Z Khamitova, A Zhankorazova, ... Medicine & Science in Sports & Exercise 57 (8), 1819-1824 , 2025 2025 Citations: 1
Eosinophilic inflammation in COPD: mechanisms, diagnostic markers, clinical features and therapy guidance A Aitkazina, N Latypova, M Abishev, A Pak, N Zholshybek, S Suleimenov, ... Journal of Clinical Medicine of Kazakhstan 21 (3), 4-10 , 2024 2024 Citations: 1
Reliability and diagnostic performance of an automated MRI-based classifier compared with radiologists in Alzheimer’s disease N Zholshybek, E Abdurakhmanova, A Bimakhan, D Jumadilova, ... Frontiers in Neuroinformatics 20, 1821249 , 2026 2026
Structure, mechanical performance and antibacterial behavior of TaCuN coatings deposited by reactive magnetron co-sputtering A Kassymbayev, A Pogrebnjak, R Kimossov, A Myakinin, A Borisov, ... Surface and Coatings Technology, 133529 , 2026 2026
Hemodynamic forces derived from cine cardiac magnetic resonance imaging: technical aspects, applications in various clinical scenarios, and in athlete's heart D Jumadilova, N Zholshybek, T Dautov, G Ayapergenova, G Tonti, ... Frontiers in Cardiovascular Medicine 13, 1778061 , 2026 2026
Harmonizing multicenter quantitative imaging data: sources of variability, statistical solutions, and practical workflows in CT and MRI N Zholshybek, L Bastarbekova Exploration of Digital Health Technologies 4, 101185 , 2026 2026
Agreement between Z-score and an arch-to-ascending aorta ratio derived from CT angiography for detection of aortic arch hypoplasia Ж Молдаханова, Р Рахимжанова, Т Даутов, Л Бастарбекова, ... Астана медициналық журналы, amj002-amj002 , 2025 2025
Reliability and Dual Validation of a Deep Learning Model for Anterior Cruciate Ligament Tear Detection Using Magnetic Resonance Imaging N Zholshybek, Z Khorshat, L Bastarbekova, N Assylbek, A Zhankorazova, ... International Conference on AI and Robotics, 362-373 , 2025 2025
Псевдоаневризма лёгочной артерии у молодого человека с лёгочной гипертензией по данным компьютерной томографической ангиографии ТБ Даутов, ББ Калиев, РЯ Тукинов, ДС Альменова, ЖЖ Кожахметова, ... Digital Diagnostics 5 (3), 623-631 , 2024 2024
Pulmonary artery pseudoaneurysm in a young man with pulmonary hypertension on computed tomography angiography TB Dautov, BB Kaliyev, RY Tukinov, DS Almenova, ZZ Kozhakhmetova, ... Digital Diagnostics 5 (3), 623-631 , 2024 2024
Differences of Left Ventricular Hemodynamic Forces in Athletes and Patients with Hypertension: A Feature-Tracking Cardiac Magnetic Resonance Study D Jumadilova, Y Rakhmanov, N Khissamutdinov, A Zhankorazova, ... Available at SSRN 4888093 , 2024 2024
THE ROLE OF CT AND MRI IN DIAGNOSING COMPLICATIONS AFTER HEART TRANSPLANTATION NZ Zholshybek, TB Dautov, DG Jumadilova, AU Akhmetov МЕДИЦИНАЛЫҚ ОРТАЛЫҒЫНЫҢ ЖАРШЫСЫ, 119 , 2024 2024
