Paolo D'Angelo
@arnascivico.it
Pediatric Hematology and Oncology Unit, Pediatric Department
ARNAS Civico, Di Cristina and Benfratelli, Palermo, Italy
D’ANGELO, Paolo Fiscal Code DNGPLA59L30G273F
Palermo, Italy, 1959 July 30th
A.R.N.A.S. – Pediatric Hematology and Oncology Unit, Piazza Nicola Leotta n. 4, 90127 Palermo.
Medical doctor in Pediatric Hematology and Oncology since 2001 November 1th
Head of the staff since 2011 September 1th
1988 Febbruary - 1988 October fellowship “L. Marangoni”
Division of Pediatric Hematology, S. Gerardo Hospital, Monza, Italy
1989 April - 1991 March, fellowship “Fondazione Tettamanti”
Division of Pediatric Hematology, S. Gerardo Hospital, Monza, Italy
1991 March 18th - 2001 October 31th
Azienda Ospedaliera “Villa via Fattori 61, Palermo.
Assistant of Pediatric Division from 1991 March 18th to 1993 December 31th
Hospital Aid of Pediatric Division from 1994 Jannuary to 2001 October 31th
2001 November 1th to 2009 March 31th
Azienda ARNAS Civico, Di Cristina e Benfratelli, Palermo. Piazza Nicola Leotta, 4 - 90127 Palermo, Italy.
Medical director of first level – Pediatric Hematology
EDUCATION
1985 November 7th
Faculty of Medicine and Surgery of the University of Palermo, Italy
Degree in Medicine and Surgery
1989 November 15th
Faculty of Medicine and Surgery, University of Palermo, Italy.
Pediatrics
1995 November 9th
Catholic University of the Sacred Hearth – Rome, Italy
Pediatric Hematology and Oncology
RESEARCH INTERESTS
Pediatric Oncology and Hematology. Palliative Care. Rare Tumors.
Scopus Publications
Scopus Publications
Monica Terenziani, Francesco Barretta, Giovanna Gattuso, Gianni Bisogno, Massimo Conte, Alessandro Crocoli, Maria Debora De Pasquale, Davide Biasoni, Filippo Spreafico, and Paolo D'Angelo
Wiley
This paper retrospectively investigated the site and the detection method of relapses in children and adolescents with malignant germ cell tumors enrolled in the TCGM‐AIEOP‐2004 Study and subsequently developed a relapse, in order to evaluate a possible reduction in radiological exposure during follow‐up. Including all malignant cases, serum tumor markers identified a relapse in more than 70% and, according to the selection criteria published by Children Oncology Group in 2018, in more than 90% of cases. These results confirm the importance of serum tumor markers as a relapse detection method, with possible reduction of radiology exams in specific subgroups.
Gianni Bisogno, Giovanna Congiu, Maria Carmen Affinita, Giuseppe Maria Milano, Ilaria Zanetti, Beatrice Coppadoro, Carla Manzitti, Eleonora Basso, Angela Tamburini, Fraia Melchionda,et al.
Wiley
The survival of children with rhabdomyosarcoma (RMS) has gradually improved as a result of the adoption of multidisciplinary treatments. Dedicated skills and facilities are indispensable and more readily available at reference centers. In this study, we examined the role of centers’ experience (based on the number of patients treated) in their management of patients with RMS.
Ilaria Pirrone, Piero Farruggia, Francesca Cacciatore, Antonino Giambona, Angela Guarina, Anna Paola Marcello, Clara Mosa, Simona Scalzo, and Paolo D’Angelo
Ovid Technologies (Wolters Kluwer Health)
Rasburicase is a recombinant urate oxidase enzyme indicated for tumor lysis syndrome, a potential life-threatening oncologic emergency that occurs most commonly during initial chemotherapy for hematological malignancies. As a result of the defects in the physiological antioxidant pathway, erythrocytes of patients with glucose-6-phosphate dehydrogenase deficiency are not protected against the oxidizing stress exerted by hydrogen peroxide generated with the administration of rasburicase. The authors report a 14-year-old patient, diagnosed with T-cell acute lymphoblastic leukemia, who developed methemoglobinemia and hemolytic anemia with low oxygen saturation after starting steroids, hyperhydratation, and rasburicase administration. The complications resolved with supportive therapy only.
Calogero Virgone, Andrea Ferrari, Stefano Chiaravalli, Maria Debora De Pasquale, Alessandro Inserra, Paolo D'Angelo, Martina Funmilayo Ogunleye, Alessandro Crocoli, Stefano Vallero, Simone Cesaro,et al.
Wiley
Extra‐appendicular neuroendocrine tumors (NETs) are very rare tumors. While diagnostic and therapeutic guidelines are well established for adults, data on children and adolescents are lacking.
Paolo D'Angelo, Maria Debora De Pasquale, Francesco Barretta, Maria Carmen Affinita, Massimo Conte, Patrizia Dall'Igna, Andrea Di Cataldo, Alessandro Inserra, Massimo Provenzi, Lucia Quaglietta,et al.
Wiley
To evaluate clinical features at diagnosis, prognostic factors, and outcomes of malignant sacrococcygeal germ cell tumors (SC‐GCTs) in patients enrolled in the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) TCG 2004 protocol.
Calogero Virgone, Marina Andreetta, Stefano Avanzini, Stefano Chiaravalli, Maria Debora De Pasquale, Alessandro Crocoli, Alessandro Inserra, Paolo D'Angelo, Rita Alaggio, Giuseppe Opocher,et al.
Wiley
Pheochromocytomas (PCs) are neuroendocrine tumors arising from the chromaffin cells of the adrenal gland, and paragangliomas (PGLs) are their extra‐adrenal counterparts arising from ganglia along the sympathetic/parasympathetic chain. Surgery is the cornerstone of treatment. A sporatic or inherited germline mutation is commonly associated.
Loredana Amoroso, Marzia Ognibene, Martina Morini, Massimo Conte, Andrea Di Cataldo, Annalisa Tondo, Paolo D'Angelo, Aurora Castellano, Alberto Garaventa, Vito A. Lasorsa,et al.
Wiley
Neuroblastoma (NB) is the most common extracranial malignant tumor of childhood and is characterized by a broad heterogeneity in clinical presentation and evolution. Recent advances in pangenomic analysis of NB have revealed different recurrent chromosomal aberrations. Indeed, it is now well established that the overall genomic profile is important for treatment stratification. In previous studies, 11 genes were shown to be recurrently amplified (ODC1, ALK, GREB1, NTSR2, LIN28B, MDM2, CDK4, MYEOV, CCND1, TERT, and MYC) besides MYCN, with poor survival of NB patients harboring these amplifications being suggested. Genomic profiles of 628 NB samples analyzed by array‐comparative genome hybridization (a‐CGH) were re‐examined to identify gene amplifications other them MYCN amplification. Clinical data were retrospectively collected. We additionally evaluated the association of FRS2 gene expression with NB patient outcome using the public R2 Platform. We found eight NB samples with high grade amplification of one or two loci on chromosome arm 12q. The regional amplifications were located on bands 12q13.3‐q14.1 and 12q15‐q21.1 involving the genes CDK4, MDM2, and the potential oncogenic gene FRS2. The CDK4, MDM2, and FRS2 loci were coamplified in 8/8 samples. The 12q amplifications were associated with very poor prognosis and atypical clinical features of NB patients. Further functional and clinical investigations are needed to confirm or refute these associations.
Maria Debora De Pasquale, Paolo D'Angelo, Alessandro Crocoli, Renata Boldrini, Massimo Conte, Gianni Bisogno, Filippo Spreafico, Alessandro Inserra, Davide Biasoni, Patrizia Dall'Igna,et al.
Wiley
Malignant germ cell tumors (GCTs) are a heterogeneous group of rare neoplasms in children. Optimal outcome is achieved with multimodal therapies for patients with both localized and advanced disease, especially after the introduction of platinum‐based chemotherapy regimens. In this respect, data on salvage treatment for children with relapsed or platinum‐refractory disease are still limited.
Concetta Polizzi, Giovanna Perricone, Valentina Fontana, Paolo D'Angelo, Momcilo Jankovic, Francesca Nichelli, Calogero Taormina, and Sofia Burgio
MDPI AG
The present study focuses on the relation between coping strategies of children with leukemia during treatment and locus of control of their mothers. In particular, the study aims to determine whether maternal locus of control can influence sick children’s coping styles, and if this relation can be used to predict maladjustments. The study analyzed a cohort of 60 pediatric leukemia patients undergoing treatment and a group formed by their mothers. The participants were recruited from two Pediatric Onco- Hematology Units in Italy. The Child Behavioral Style Scale (CBSS) was used to assess children’s coping strategies, whereas the Parental Health Locus of Control Scale (PHLCS) was employed to analyze maternal locus of control. A linear regression model was applied to verify a possible interdependent relationship between children’s coping styles and maternal locus of control. The differences in mean CBSS scores were analyzed by K-S test. Multivariate analysis of variance was performed to assess any potential effect of child’s gender, hospital context and maternal socio-cultural status on children’s coping strategies. Our results show a significant relationship between children’s coping strategies and maternal locus of control. In particular, the scales mass media, fate and healthcare professionals display a predictive effect on children’s monitoring coping style, given the positive correlation observed (F=3.28, P=0.008). In contrast, the same scales negatively correlate with blunting coping style (F=3.5, P=0.005). Our results reveal several interesting resources having a profound impact on the psychological functioning of children with leukemia undergoing treatment as well as their mothers. Furthermore, with regard to the central hypothesis of the study, our findings show both positive and negative correlations between specific scales of maternal locus of control and children’s coping style, which could be used to predict children at risk of emotional maladjustment.
Francesca Bagnasco, Silvia Caruso, Anita Andreano, Maria Grazia Valsecchi, Momcilo Jankovic, Andrea Biondi, Lucia Miligi, Claudia Casella, Monica Terenziani, Maura Massimino,et al.
Elsevier BV
Bruno De Bernardi, Andrea Di Cataldo, Alberto Garaventa, Paolo Massirio, Elisabetta Viscardi, Marta Giorgia Podda, Aurora Castellano, Paolo D’Angelo, Elisa Tirtei, Fraia Melchionda,et al.
Springer Science and Business Media LLC
Gloria Pelizzo, Veronica Veschi, Melissa Mantelli, Stefania Croce, Vincenzo Di Benedetto, Paolo D’Angelo, Alice Maltese, Laura Catenacci, Tiziana Apuzzo, Emanuela Scavo,et al.
Springer Science and Business Media LLC
Monica Terenziani, Maria D. De Pasquale, Gianni Bisogno, Davide Biasoni, Renata Boldrini, Paola Collini, Massimo Conte, Patrizia Dall'Igna, Alessandro Inserra, Fraia Melchionda,et al.
Elsevier BV
Luca Bergamaschi, Gianni Bisogno, Carla Manzitti, Paolo D'Angelo, Giuseppe Maria Milano, Angela Scagnellato, Mirko Cappelletti, Stefano Chiaravalli, Patrizia Dall'Igna, Rita Alaggio,et al.
Wiley
Malignant peripheral nerve sheath tumor (MPNST) is one of the most common nonrhabdomyosarcoma soft tissue sarcomas encountered in pediatric age, and it is generally characterized by poor outcome, particularly for relapsing patients.
Roberto Luksch, Giovanni Grignani, Paolo D'Angelo, Arcangelo Prete, Nadia Puma, Marta Podda, Michela Casanova, Andrea Ferrari, Carlo Morosi, Franca Fagioli,et al.
Wiley
The aim was to assess the activity of cisplatin (CDDP) in Ewing sarcoma (ES). The study consisted of front‐line window therapy with CDDP 120 mg/sqm every 3 weeks for two courses in children and young adults with primary disseminated ES. Response was assessed using the Response Evaluation Criteria in Solid Tumours criteria, and Simon's two‐stage design was applied. Twelve consecutive patients were enrolled in stage 1. Only one objective response was observed. Since the target response rate was not achieved, accrual was stopped and CDDP as a single agent in ES was judged unworthy of further assessment.
Paolo D'Angelo, Andrea Di Cataldo, Monica Terenziani, Gianni Bisogno, Paola Collini, Martina Di Martino, Fraia Melchionda, Clara Mosa, Marilina Nantron, Daniela Perotti,et al.
Wiley
Children with Wilms’ tumor (WT) aged under 24 months (infants) have a better prognosis than older patients. Our aim was to study the epidemiology of this age group, with focus on the modality of diagnosis, tumor size, and association with malformations/syndromes, seeking to understand if any of these factors might be related to prognosis.
Alice Indini, Gianni Bisogno, Giovanni Cecchetto, Marco Vitellaro, Stefano Signoroni, Maura Massimino, Giovanna Riccipetitoni, Marco Zecca, Patrizia Dall'Igna, Maria Debora De Pasquale,et al.
Wiley
Gastrointestinal (GI) carcinomas are very rare in the pediatric and adolescent age range. We report the clinical features, treatment, and outcome of a series of children and adolescents with GI carcinoma prospectively registered in the Italian Tumori Rari in Età Pediatrica (TREP) project.
Filippo Spreafico, Davide Biasoni, Salvatore Lo Vullo, Lorenza Gandola, Paolo D’Angelo, Monica Terenziani, Maurizio Bianchi, Massimo Provenzi, Paolo Indolfi, Andrea Pession,et al.
Ovid Technologies (Wolters Kluwer Health)
M. Terenziani, G. Bisogno, R. Boldrini, G. Cecchetto, M. Conte, L. Boschetti, M.D. De Pasquale, D. Biasoni, A. Inserra, F. Siracusa,et al.
Wiley
Malignant ovarian germ cell tumors (MOGCT) carry an excellent prognosis, and the treatment aims to achieve results with the least possible treatment‐related morbidity. The aim of this study was to assess the outcomes of pediatric patients with MOGCT.
Luca Pio, Stefano Avanzini, Girolamo Mattioli, Giuseppe Martucciello, Angela Rita Sementa, Massimo Conte, Annarita Gigliotti, Claudio Granata, Ernesto Leva, Anna Maria Fagnani,et al.
Elsevier BV
Roberta Angelico, Annalisa Passariello, Michele Pilato, Tommaso Cozzolino, Marcello Piazza, Roberto Miraglia, Paolo D’Angelo, Mariella Capasso, Maria Cristina Saffioti, Daniele Alberti,et al.
Elsevier BV
Lorenzo Angelini, Gianni Bisogno, Rita Alaggio, Giovanni Scarzello, Luisa Santoro, Ilaria Zanetti, Angela Scagnellato, Eleonora Basso, Paolo D'Angelo, Andrea Ferrari,et al.
Elsevier BV
Tullio Proserpio, Laura Veneroni, Matteo Silva, Alvaro Lassaletta, Rosalia Lorenzo, Chiara Magni, Marina Bertolotti, Elena Barisone, Maurizio Mascarin, Momcilo Jankovic,et al.
SAGE Publications
Introduction Spirituality is a fundamental aspect of the psychological well-being of adolescents with cancer. This study reports on a survey conducted at pediatric oncology centers in Italy and Spain to examine the situation concerning the provision of spiritual support. Methods An ad hoc questionnaire was distributed including multiple-choice questions on whether or not spiritual support was available; the spiritual counselor's role; how often the spiritual counselor visited the unit; and the type of training this person had received. Results A spiritual support service was available at 24 of the 26 responding centers in Italy and 34/36 in Spain. The training received by the spiritual counselor was exclusively theological in most cases (with medical or psychological training in a few cases). In both countries the spiritual counselor was mainly involved in providing religious services and support at the terminal stage of the disease or in talking with patients and families. Cooperation with caregivers was reported by 27.3% and 46.7% of the Italian and Spanish centers, respectively, while the daily presence of the chaplain on the ward was reported by 18.2% and 26.7%. Conclusions The role of the spiritual counselor in pediatric oncology – in Italy and Spain at least – is still neither well-established nor based on standardized operating methods or training requirements. A model that implies the constant presence of a spiritual counselor in hospital wards may be proposed to provide appropriate spiritual support to adolescents with cancer.
RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)
Coordinator of Italian Protocol for Germ Cell Tumors
Industry, Institute, or Organisation Collaboration
A.R.N.A.S. Civico, Di Cristina e Benfratelli Hospitals