Paola Alberti

@unimib.it

Assistant Professor (Human Anatomy)
University of Milano-Bicocca

Paola Alberti
Her main expertise is related to peripheral nervous system diseases, especially Chemotherapy-Induced Peripheral Neurotoxicity (CIPN). She is an active member of the Toxic Neuropathy Consortium (TNC), part of the Peripheral Nervous System (PNS) society. During the Residency in Neurology, she was a visiting fellow at Johns Hopkins University (Prof. D.R. Cornblath, MD) to refine her knowledge of neurophysiological techniques. Since 2015 she has been pursuing an interest for preclinical research and joined the Experimental Neurology Unit (ENU, University of Milano-Bicocca) team, where she completed the PhD program in Neuroscience (2019). Her PhD project was focused on Oxaliplatin Induced Peripheral Neurotoxicity in preclinical models: she introduced advanced neurophysiological techniques, nerve excitability testing, to ENU after having learnt them from Prof H. Bostock, (UCL, London). She was a visiting fellow at University of Baltimore (Prof. S.G. Dorsey and Prof C. Renn) where learned DRG

EDUCATION

EDUCATION AND TRAINING

July 2010: Degree: MD – 110/110 cum laude – University of Milano-Bicocca (Monza, Italy)

June 2016 – Degree: Board in Neurology – 70/70 cum laude – University of Milano-Bicocca (Monza, Italy)

February 2019 – Degree: PhD in Neuroscience – University of Milano-Bicocca (Monza, Italy)

RESEARCH, TEACHING, or OTHER INTERESTS

Medicine, Anatomy, Neurology (clinical)

FUTURE PROJECTS

Sodium-calcium exchanger (NCX) and ion channels: pivotal elements leading to axonal damage in peripheral nerves?

The project investigates mechanisms leading to peripheral neuropathies (PN), with a specific interest for axonal damage. PN have many different causes: genetic, metabolic, toxic, dysimmune(Scuteri and Cavaletti, 2016). Patients affected by PN can experience impaired strength, sensation and involuntary functions (e.g. control of the gastrointestinal tract). Unfortunately, in the majority of cases there are only symptomatic treatments; this is partly due to the incomplete knowledge of axonal damage mechanisms. The project investigates a possible pathogenetic cascade, shared by different PN, with the aim of shedding light on the chronological and causative sequence of events leading to peripheral nerve axon damage. Goals Verifying the role of a particular molecular family, the sodium/calcium exchangers (NCX) family, as downstream pivotal elements leading to axonal damage.


Applications Invited
PhD students, postdoc. technicians
104

Scopus Publications

6070

Scholar Citations

42

Scholar h-index

77

Scholar i10-index

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

  • Serum neurofilament light chain (sNFL) as a predictive biomarker for Chemotherapy-induced peripheral neurotoxicity (CIPN): consideration of current evidence, validation steps …
    P Alberti, S Faithfull, AA Argyriou, D Balayssac, DL Hertz, M Lustberg, ...
    Supportive Care in Cancer 34 (6), 508 , 2026
    2026
  • Interleukin-6 as a keystone cytokine in experimental rat models of chemotherapy-induced peripheral neurotoxicity
    O Tarasiuk, A Chiorazzi, A Argentini, E Ballarini, A Canta, VA Carozzi, ...
    Scientific Reports , 2026
    2026
    Citations: 2
  • Neuromuscular complications of oncologic immunotherapies. NEUROPATHIES
    P Alberti
    Abstract book , 2026
    2026
  • Molecular Characterization of Oxaliplatin‐Induced Peripheral Neurotoxicity: The Complex Spectrum of Painful Manifestations
    E Pozzi, MP Serra, M Boi, A Canta, A Chiorazzi, C Capelli, C Invernizzi, ...
    Journal of the Peripheral Nervous System 30 (4), e70078 , 2025
    2025
    Citations: 1
  • Peripheral Nerve Society Training Grant Program: An Exciting Opportunity Not to Be Missed
    P Alberti, L Querol
    Journal of the Peripheral Nervous System 30 (4), e70076 , 2025
    2025
  • CANVAS causing AAGGG repeat expansions cause tissue-specific reduction in RFC1 expression and increase sensitivity to DNA damage
    R Curro, N Dominik, S Facchini, RP Schnekenberg, C Perini, R Ronco, ...
    bioRxiv, 2025.11. 18.688292 , 2025
    2025
  • Sodium channel modulation as a therapeutic strategy for chemotherapy-induced peripheral neurotoxicity
    S Di Girolamo, G Terribile, P Alberti, G Cavaletti
    Expert Opinion on Investigational Drugs 34 (11), 887-903 , 2025
    2025
    Citations: 2
  • ITF6475, a new histone deacetylase 6 inhibitor, prevents painful neuropathy induced by paclitaxel
    G Cavaletti, A Canta, A Chiorazzi, E Pozzi, V Carozzi, C Meregalli, ...
    Toxics 13 (9), 767 , 2025
    2025
    Citations: 1
  • Chemotherapy-Induced Peripheral Neurotoxicity: Patient's Perception of Socio-Economic Burden-A Pilot Study
    P Alberti, E Lucchese
    JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 30 (3), 106-106 , 2025
    2025
  • INSIGHTS INTO MORPHO-FUNCTIONAL FEATURES OF CORTICAL NEURONS IN NEUROPATHIC PAIN ANIMAL MODELS
    L Fantoni, A Sacchini, L Cherchi, A Canta, VR Menendez, C Meregalli, ...
    JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 30 , 2025
    2025
  • CENTRAL AND PERIPHERAL NEUROTOXICITY OF OXALIPLATIN IN A MICE MODEL
    G Cavaletti, G Iezzi, A Canta, V Carozzi, E Pozzi, P Alberti, P Marmiroli, ...
    JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 30 , 2025
    2025
  • A PILOT STUDY ON HEALTH-ECONOMICS BURDEN DUE TO CHEMOTHERAPY-INDUCED NEUROTOXICITY
    P Alberti, MF Kraus, E Lucchese
    JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 30 (S2), 1-1 , 2025
    2025
  • Patient-reported strategies for prevention and treatment of chemotherapy-induced peripheral neuropathy
    DL Hertz, M Tanay, C Tofthagen, E Rossi, DP Bernasconi, KE Sheffield, ...
    Supportive Care in Cancer 33 (2), 142 , 2025
    2025
    Citations: 3
  • MECHANISTIC IMPLICATIONS OF TUBULIN POST-TRANSLATIONAL MODIFICATIONS IN A PRECLINICAL MODEL OF PROTEASOME INHIBITOR-INDUCED PERIPHERAL NEUROPATHY
    F Iseppon, A Malacrida, A Chiorazzi, P Alberti, V Carozzi, E Pozzi, ...
    Abstracts of the Fifteenth Annual Meeting of the Associazione italiana per … , 2025
    2025
  • Overtime Characterization of Vascular Network in the Peripheral Nervous System of Rats With Paclitaxel-Induced Painful Peripheral Neuropathy
    A Zippo, A Sacchini, C D'Aprile, A Canta, E Pozzi, A Chiorazzi, E Ballarini, ...
    JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 105-106 , 2025
    2025
  • THERAPEUTIC VERSUS PREVENTIVE ADMINISTRATION OF NEUROACTIVE STEROIDS TO TREAT BORTEZOMIB-INDUCED PAINFUL NEUROPATHY
    F Iseppon, E Tonelli, V Fabbro, A Chiorazzi, P Alberti, V Carozzi, E Pozzi, ...
    EUROPEAN JOURNAL OF HISTOCHEMISTRY 69 (S3), 20-20 , 2025
    2025
  • Molecular Mechanisms of Proteasome Inhibitor-Induced Peripheral Neuropathy
    F Iseppon, A Malacrida, V Fabbro, A Chiorazzi, A Canta, P Alberti, ...
    JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 30 (S3), 113-113 , 2025
    2025
  • THYMOQUINONE AS A POSSIBLE NEUROPROTECTIVE AGENT AGAINST PACLITAXEL-INDUCED PERIPHERAL NEUROTOXICITY
    I Segmani, L Cherchi, E Pozzi, A Chiorazzi, A Canta, P Alberti, ...
    Abstracts of the Fifteenth Annual Meeting of the Associazione italiana per … , 2025
    2025
  • SODIUM-CALCIUM EXCHANGER PIVOTAL ROLE IN OXALIPLATIN-INDUCED ALTERATIONS LEADING TO PERIPHERAL NEUROTOXICITY, AXONAL DAMAGE AND NECROPTOSIS
    S Di Girolamo, C Invernizzi, M Kraus, E Ballarini, P Alberti
    2025
  • Implementation of gami# cation,! ipped-classroom approach and 3D virtual tools in neuroanatomy teachings: a pilot phase
    P Alberti
    ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY 129 (1), 1-114 , 2025
    2025

MOST CITED SCHOLAR PUBLICATIONS

  • Guillain-Barré syndrome related to COVID-19 infection
    P Alberti, S Beretta, M Piatti, A Karantzoulis, ML Piatti, P Santoro, ...
    Neurology: Neuroimmunology & Neuroinflammation 7 (4), e741 , 2020
    2020
    Citations: 457
  • The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findings
    G Cavaletti, DR Cornblath, ISJ Merkies, TJ Postma, E Rossi, B Frigeni, ...
    Annals of Oncology 24 (2), 454-462 , 2013
    2013
    Citations: 398
  • Chemotherapy-induced peripheral neurotoxicity assessment: a critical revision of the currently available tools
    G Cavaletti, B Frigeni, F Lanzani, L Mattavelli, E Susani, P Alberti, ...
    European journal of cancer 46 (3), 479-494 , 2010
    2010
    Citations: 362
  • Understanding the quality of life (QOL) issues in survivors of cancer: towards the development of an EORTC QOL cancer survivorship questionnaire
    M Van Leeuwen, O Husson, P Alberti, JI Arraras, OL Chinot, A Costantini, ...
    Health and quality of life outcomes 16 (1), 114 , 2018
    2018
    Citations: 319
  • Clinical pattern and associations of oxaliplatin acute neurotoxicity: a prospective study in 170 patients with colorectal cancer
    AA Argyriou, G Cavaletti, C Briani, R Velasco, J Bruna, M Campagnolo, ...
    Cancer 119 (2), 438-444 , 2013
    2013
    Citations: 282
  • Physician-assessed and patient-reported outcome measures in chemotherapy-induced sensory peripheral neurotoxicity: two sides of the same coin
    P Alberti, E Rossi, DR Cornblath, ISJ Merkies, TJ Postma, B Frigeni, ...
    Annals of oncology 25 (1), 257-264 , 2014
    2014
    Citations: 220
  • Early predictors of oxaliplatin-induced cumulative neuropathy in colorectal cancer patients
    R Velasco, J Bruna, C Briani, AA Argyriou, G Cavaletti, P Alberti, B Frigeni, ...
    Journal of Neurology, Neurosurgery & Psychiatry 85 (4), 392-398 , 2014
    2014
    Citations: 186
  • Chemotherapy-induced peripheral neurotoxicity in the era of pharmacogenomics
    G Cavaletti, P Alberti, P Marmiroli
    The lancet oncology 12 (12), 1151-1161 , 2011
    2011
    Citations: 156
  • Voltage‐gated sodium channel polymorphisms play a pivotal role in the development of oxaliplatin‐induced peripheral neurotoxicity: results from a prospective multicenter study
    AA Argyriou, G Cavaletti, A Antonacopoulou, AA Genazzani, C Briani, ...
    Cancer 119 (19), 3570-3577 , 2013
    2013
    Citations: 150
  • Chemotherapy-induced neuropathy
    G Cavaletti, P Alberti, B Frigeni, M Piatti, E Susani
    Current treatment options in neurology 13 (2), 180-190 , 2011
    2011
    Citations: 142
  • Efficacy of a novel sigma-1 receptor antagonist for oxaliplatin-induced neuropathy: a randomized, double-blind, placebo-controlled phase IIa clinical trial
    J Bruna, S Videla, AA Argyriou, R Velasco, J Villoria, C Santos, C Nadal, ...
    Neurotherapeutics 15 (1), 178-189 , 2018
    2018
    Citations: 140
  • Peripheral neurotoxicity of oxaliplatin in combination with 5-fluorouracil (FOLFOX) or capecitabine (XELOX): a prospective evaluation of 150 colorectal cancer patients
    AA Argyriou, R Velasco, C Briani, G Cavaletti, J Bruna, P Alberti, ...
    Annals of Oncology 23 (12), 3116-3122 , 2012
    2012
    Citations: 132
  • Long‐term course of oxaliplatin‐induced polyneuropathy: a prospective 2‐year follow‐up study
    C Briani, AA Argyriou, C Izquierdo, R Velasco, M Campagnolo, P Alberti, ...
    Journal of the Peripheral Nervous System 19 (4), 299-306 , 2014
    2014
    Citations: 126
  • Neurophysiological, nerve imaging and other techniques to assess chemotherapy-induced peripheral neurotoxicity in the clinical and research settings
    AA Argyriou, SB Park, B Islam, S Tamburin, R Velasco, P Alberti, J Bruna, ...
    Journal of Neurology, Neurosurgery & Psychiatry 90 (12), 1361-1369 , 2019
    2019
    Citations: 119
  • Chemotherapy‐induced peripheral neurotoxicity: a multifaceted, still unsolved issue
    G Cavaletti, P Alberti, AA Argyriou, M Lustberg, NP Staff, S Tamburin, ...
    Journal of the Peripheral Nervous System 24, S6-S12 , 2019
    2019
    Citations: 108
  • Bortezomib and other proteosome inhibitors—induced peripheral neurotoxicity: From pathogenesis to treatment
    R Velasco, P Alberti, J Bruna, D Psimaras, AA Argyriou
    Journal of the Peripheral Nervous System 24, S52-S62 , 2019
    2019
    Citations: 103
  • Overview and critical revision of clinical assessment tools in chemotherapy‐induced peripheral neurotoxicity
    SB Park, P Alberti, NA Kolb, JS Gewandter, A Schenone, AA Argyriou
    Journal of the Peripheral Nervous System 24, S13-S25 , 2019
    2019
    Citations: 101
  • Chemotherapy‐induced peripheral neurotoxicity can be misdiagnosed by the National Cancer Institute Common Toxicity scale
    B Frigeni, M Piatti, F Lanzani, P Alberti, P Villa, C Zanna, M Ceracchi, ...
    Journal of the peripheral nervous system 16 (3), 228-236 , 2011
    2011
    Citations: 101
  • Neurofilament light chain as disease biomarker in a rodent model of chemotherapy induced peripheral neuropathy
    C Meregalli, G Fumagalli, P Alberti, A Canta, VA Carozzi, A Chiorazzi, ...
    Experimental neurology 307, 129-132 , 2018
    2018
    Citations: 93
  • Neurofilament light chain: a specific serum biomarker of axonal damage severity in rat models of chemotherapy-induced peripheral neurotoxicity
    C Meregalli, G Fumagalli, P Alberti, A Canta, A Chiorazzi, L Monza, ...
    Archives of Toxicology 94 (7), 2517-2522 , 2020
    2020
    Citations: 88