@unimib.it
Assistant Professor (Human Anatomy)
University of Milano-Bicocca
The project investigates mechanisms leading to peripheral neuropathies (PN), with a specific interest for axonal damage. PN have many different causes: genetic, metabolic, toxic, dysimmune(Scuteri and Cavaletti, 2016). Patients affected by PN can experience impaired strength, sensation and involuntary functions (e.g. control of the gastrointestinal tract). Unfortunately, in the majority of cases there are only symptomatic treatments; this is partly due to the incomplete knowledge of axonal damage mechanisms. The project investigates a possible pathogenetic cascade, shared by different PN, with the aim of shedding light on the chronological and causative sequence of events leading to peripheral nerve axon damage. Goals Verifying the role of a particular molecular family, the sodium/calcium exchangers (NCX) family, as downstream pivotal elements leading to axonal damage.
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