Pawan Ganesh Nayak

Scopus Publications

Network pharmacology and in vitro studies demonstrate modulation of fibrotic pathways by Swertia chirayita in pulmonary fibrosis
Bharath H. B., Farmiza Begum, Gautam Kumar, Jyothi Giridhar, Usha Y. Nayak, Fayaz S. M., Pawan Ganesh Nayak, Yogendra Nayak
Scientific Reports, 2026
Various biological processes contribute to pulmonary fibrosis, which results in fibrotic foci that impede the exchange of gases between alveoli and capillaries. This study investigates the therapeutic mechanism in fibrotic foci reconfiguring via the TNF signaling pathway by potential Swertia chirayita (SC) components to treat pulmonary fibrosis by network pharmacology, in silico, and in vitro studies. The targets of LC-MS/MS analyzed SC components were used to build a protein-protein interaction network in Cytoscape and predicted key targets and signalings. The molecular docking, dynamics (MD) simulation, and principal component analysis (PCA) were performed to predict the potential interactions between components and their targets. In vitro studies, such as cell migration, E-cadherin immune fluorescence assay, and western blot analysis were performed in NIH3T3 and A549 cells with or without TGFβ1 stimulation. The network pharmacology of SC revealed nine key targets, and the pathway analysis found that these targets are implicated in TNF-α signaling. The main components of SC have substantial binding affinities, as shown by molecular docking. Furthermore, MD simulation and PCA predict that bellidifolin, gentiopicroside, and mangiferin will substantiate the anti-fibrotic effect. SC inhibited fibroblast migration and differentiation, epithelial to mesenchymal transition, and TNF-α downstream markers like NF-κB/p-NF-κB. In vitro studies confirmed the network pharmacology and docking predictions that SC can modulate fibrotic foci by acting through the TNF-α signaling pathway.
Preclinical evidence for digoxin's anti-tumor activity through HIF-1α pathways: Systematic review and meta-analysis
Dhanya Bolar, Gollapalle Lakshminarayanashastry Viswanatha, Chamallamudi Mallikarjuna Rao, Shylaja Hanumanthappa, Krishnadas Nandakumar, Pawan Ganesh Nayak
Pharmacological Research Natural Products, 2026
This systematic review and meta-analysis was aimed to synthesize existing preclinical evidence on digoxin's anti-tumor effects via HIF-1α inhibition. This study was conducted as per PRISMA 2020 guidelines. A systematic literature search was conducted using PubMed/Medline, EMBASE, and Google Scholar, and based on the inclusion and exclusion criteria, a total of 13 studies were selected. The meta-analysis performed on the included studies revealed that the digoxin treatment decreased the tumor volume (IV:-1.40(-1.89 to -0.91) at 95% CI, p<0.00001, I 2 =42%), H I F-1α (IV:-2.43(-4.07 to -0.78) at 95% CI, p=0.004, I 2 = 62%), VEGF (IV:-1.14(-1.91 to -0.36) at 95% CI, p=0.004, I 2 = 0%), and GLUT-1 (IV: 1.57(-2.57 to -0.57) at 95% CI, p=0.002 I 2 = 0%), but had no statistically significant reduction in the tumor weight (IV:-0.31(-0.69 to 0.07), 95% CI, p=0.11, I 2 =98%), and CD31 marker (IV:-1.15(-3.10 to 0.79) at 95% CI, p=0.25, I 2 =71%) and has no effect on the animal survival rate (IV:6.46(-0.93 to 13.86) at 95% CI, p=0.09, I 2 =86%) compared to the control. Conclusions: In summary, the available moderate weight of evidence suggests that digoxin possesses potential anti-tumor effects via HIF-1α pathways. However, considering the pitfalls associated with the existing studies, there is a scope for conducting more robust pre-clinical studies. Further, randomized controlled trials in humans are essential to evaluate and validate the antitumor effect of digoxin. • Meta-analysis shows digoxin reduces tumor growth in preclinical models • Digoxin targets hypoxia inducible factor (HIF-1α) driving tumor growth pathways • Associated with reduced tumor size and key signals linked to growth • No consistent effect on survival or tumor weight across studies • Further preclinical studies and human trials are needed for validation
Diethylaminoethyl dextran as a multifunctional polycationic system: From molecular design to therapeutic advancement
Raagul Seenivasan, Praveen Halagali, Jey Kumar Pachiyappan, Aniket Navale, Kuljeet Kaur, Parashuram Bugadannavar, Anitha Marimuthu, Pawan Ganesh Nayak, Vamshi Krishna Tippavajhala
Carbohydrate Polymer Technologies and Applications, 2026
Drug discovery and development with special reference to molecular modeling: A bibliometric approach (2005–2024)
Pawan Nayak, Virendra S. Ligade
Journal of Applied Pharmaceutical Science, 2026
There is growing evidence demonstrating the use of computer modeling in biomedicine as new technologies emerge in every discipline. Computational, translational, experimental, and clinical methods are all combined in current drug development to find possible novel potential medications. However, limited attention has been given to summarizing global publication trends in this field. The aim of the current study is to describe and assess global trends in applying the bibliometric approach to drug development and discovery regarding the importance of molecular modeling. A literature search was conducted to extract all relevant papers on molecular modeling in drug discovery and development using the Scopus database. The data were gathered for the year 2005–2024. Insights are classified based on authors, title of publication sources, countries, type of documents, research domains, and so on. A total of 3,489 papers were retrieved, demonstrating a surge of interest in molecular modeling within drug discovery and development, with a significant rise in recent years. The top countries contributing were the United States, India, and China. Journal articles constituted the highest percentage of papers, and the most productive source was the Journal of Chemical Information and Modeling. The study highlights the tools and software used in modern drug development and discovery-related analysis that were developed using machine learning techniques. There has been an upsurge of interest in molecular modeling in drug discovery and development, as shown by a growing trend in research publications in recent years. This study is the first extensive bibliometric evaluation between 2005 and 2024 with specific emphasis on molecular modeling in drug development and discovery. The results serve as a useful guide for academicians, researchers, and policy-makers to identify global trends and future research directions in this new field.
Gut microbiota shifts in spaceflight: a case study evidence and countermeasures for microbial homeostasis
Raagul Seenivasan, Jey Kumar Pachiyappan, Anitha Marimuthu, Praveen Halagali, Gowthamarajan Kuppusamy, Pawan Ganesh Nayak, Vamshi Krishna Tippavajhala
3 Biotech, 2026
The gut microbiota is a crucial component in maintaining overall human health since it has been found to influence not only metabolism but also neurobehavioral function and immunity. The extreme conditions of space, for example, cosmic radiation, microgravity, and confinement, can severely disrupt the functioning and alter the composition of gut microbiota. In fact, this will predispose the immune system to be dysfunctional, lead to psychological and metabolic disorders that are accompanied by a decrease in the diversity of beneficial microbes and change in the pattern of metabolite production. The spaceflight analog and ground, based studies have produced important findings concerning the mechanisms and reasons for gut microbial dysbiosis in extreme conditions. Different research works have been carried out, such as dietary intervention and high fiber to support the growth of healthy microbes. Further, advanced microbial monitoring using wearable sensors to identify the microbial and proinflammatory biomarkers will mitigate dysbiosis and safeguard the crew’s health for longer-duration missions. This wearable sensor will not only help monitor astronauts’ microbial status continuously, but it will also provide a significant feature for designing personalized dietary plans and probiotic supplements. This article provides a comprehensive understanding of astronaut health, including disturbances to the gut microbiome during space travel, space-analogue studies conducted by many researchers to unravel mechanisms, countermeasures to stabilize the gut microbiome, and its prospects.
Reverse Phase High Performance Liquid Chromatography Method for the Estimation of Mangiferin in Nano Formulations: Development and Optimization by Analytical Quality-by-Design
Akshatha P. Kamath, Lalit Kumar, Srinivas Mutalik, Pawan Ganesh Nayak, Krishnadas Nandakumar
ACS Omega, 2026
A novel reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed and optimized for the estimation of Mangiferin (MGF) by employing a Quality by Design (QbD) approach. Preliminary method screening was done by the Taguchi OA, followed by using a Box-Behnken Design (BBD), enabling systematic evaluation of critical factors with a reduced number of experimental runs. The model efficiently established significant correlations between selected variables and analytical responses, thereby enhancing the method's robustness and reliability. Chromatographic separation was achieved on a Hyperclone C18 column (4.6 × 250 mm, 5 μm) using an isocratic mobile phase consisting of phosphate buffer (pH 3.2) and acetonitrile (30%) + methanol (70%) in a 78:22% v/v ratio, at a flow rate of 1.0 mL/min. Detection was performed using a photodiode array detector at 258 nm. The method was validated in accordance with ICH Q2-(R2) guidelines. Validation parameters, including system suitability, linearity, accuracy, precision, robustness, sensitivity, and solution stability, were found within acceptable limits. The proposed method was successfully applied for the analysis of the stability study of MGF and to analyze the release kinetics of MGF SLNs, formulated via high-pressure homogenization and the sonication technique. The results confirm the applicability of the developed RP-HPLC method for routine quality control of combination nanocarrier systems.
Network pharmacology and in vitro studies demonstrate modulation of fibrotic pathways by Swertia chirayita in pulmonary fibrosis
Bharath H. B., Farmiza Begum, Gautam Kumar, Jyothi Giridhar, Usha Y. Nayak, Fayaz S. M., Pawan Ganesh Nayak, Yogendra Nayak
Scientific Reports, 2025
Various biological processes contribute to pulmonary fibrosis, which results in fibrotic foci that impede the exchange of gases between alveoli and capillaries. This study investigates the therapeutic mechanism in fibrotic foci reconfiguring via the TNF signaling pathway by potential Swertia chirayita (SC) components to treat pulmonary fibrosis by network pharmacology, in silico, and in vitro studies. The targets of LC-MS/MS analyzed SC components were used to build a protein-protein interaction network in Cytoscape and predicted key targets and signalings. The molecular docking, dynamics (MD) simulation, and principal component analysis (PCA) were performed to predict the potential interactions between components and their targets. In vitro studies, such as cell migration, E-cadherin immune fluorescence assay, and western blot analysis were performed in NIH3T3 and A549 cells with or without TGFβ1 stimulation. The network pharmacology of SC revealed nine key targets, and the pathway analysis found that these targets are implicated in TNF-α signaling. The main components of SC have substantial binding affinities, as shown by molecular docking. Furthermore, MD simulation and PCA predict that bellidifolin, gentiopicroside, and mangiferin will substantiate the anti-fibrotic effect. SC inhibited fibroblast migration and differentiation, epithelial to mesenchymal transition, and TNF-α downstream markers like NF-κB/p-NF-κB. In vitro studies confirmed the network pharmacology and docking predictions that SC can modulate fibrotic foci by acting through the TNF-α signaling pathway.
Formulation, Characterization, and Pharmacological Evaluation of Quercetin-Loaded Phytosomes for Enhanced Bioavailability.
Rajeev Garg, Aditi Raval, Mohit Kumar, Brijesh Shivhare, Julliyan Dilleban A, et al.
International Journal of Drug Delivery Technology, 2025
Quercetin is a potent dietary flavonoid with multifaceted therapeutic potential which is severely restricted by the fact it is poorly aqueously soluble, extensively first-pass metabolised and therefore has negligible oral bioavailability (<2%). In order to address these pharmacokinetic barriers, this investigation sought to design, optimize, and assess quercetin-loaded phytosomes as a novel type of delivery system, which will improve bioavailability. The solvent evaporation method was used to prepare phytosomes through the complexation of quercetin and soy phosphatidylcholine ( Phospholipon(r) 90G). A Box-Behnken Design (BBD) was used to solve the critical variables of formulation: drug to phospholipid molar ratio, reaction temperature, and solvent volume wavelength and entrapment efficiency (EE%), particle size (PS), and in vitro drug release were one of the responses. The optimized phytosomes had good physicochemical characteristics, namely: nanoscaled particle size of 194 +- 8 nm, a high negative zeta potential of -32.5 +- 1.8 mV and EE of an amazing 86.2 +- 1.1%. Characterization of solid-state (XRD, DSC, FTIR) was used to verify the conversion of crystalline quercetin to an amorphous form in the phospholipid complex by hydrogen bonding. Following the Higuchi diffusion laws, in vitro release experiments showed that phytosomes released phytosomes contained 87.8 +- 1.5% of the phytosomes into solution after 8 hours, compared to less than 25% of the phytosomes released by the pure quercetin suspension. Lyophilized formulation demonstrated a high degree of physical stability at accelerated conditions. More importantly, these in vitro antioxidant studies (DPPH and FRAP) demonstrated that the process of complexation did not only maintain the antioxidant activity of quercetin but also in the FRAP assay, the antioxidant activity was significantly improved as a consequence of a better solubilization. In summation, quercetin-encased phytosomes are a very promising, stable, and effective nanocarrier system, which has already overcome the fundamental solubility and dissolution shortcomings of quercetin, which sets the basis of the expected improvement in the bioavailability and therapeutic performance of this compound in vivo.
Development And Evaluation of a Controlled-Release Combination Tablet of Glimepiride and Metformin for Type 2 Diabetes Mellitus.
Akash Verma, Payal N. Vaja, Umesh Kumar, Jalpa R. Patel, Pawan G. Nayak, et al.
International Journal of Drug Delivery Technology, 2025
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that requires sustained glycemic control to prevent long-term complications. Combination therapy with metformin hydrochloride and glimepiride is widely used due to their complementary mechanisms of action; however, conventional immediate-release formulations often require multiple daily dosing, leading to poor patient compliance and fluctuating plasma drug levels. The present study aimed to develop and evaluate a controlled-release bilayer tablet containing metformin hydrochloride as a sustained-release layer and glimepiride as an immediate-release layer for effective management of T2DM. Bilayer tablets were prepared by direct compression. The sustained-release layer of metformin hydrochloride was formulated using hydroxypropyl methylcellulose (HPMC K100M) and Carbopol 940, while croscarmellose sodium was employed as a super-disintegrant in the immediate-release layer of glimepiride. The prepared formulations were evaluated for pre- and post-compression parameters, drug content uniformity, in-vitro dissolution, release kinetics, and stability under accelerated conditions in accordance with ICH guidelines. The optimized formulation exhibited satisfactory physicochemical characteristics, including acceptable hardness, low friability, uniform weight variation, and high drug content. In-vitro dissolution studies demonstrated rapid release of glimepiride within 30 minutes and sustained release of metformin hydrochloride for up to 12 hours. Release kinetic analysis indicated a good fit with the Korsmeyer– Peppas model, suggesting an anomalous diffusion mechanism. Stability studies showed no significant changes in physical properties, drug content, or dissolution profile. The developed bilayer tablet successfully achieved a dual-release profile and represents a promising approach for improving patient compliance and therapeutic efficacy in the management of T2DM.
Formulation and Characterization of Floating Microspheres for Sustained Gastric Delivery of Anti-Diabetic Drugs
Pawan G. Nayak, Dhara N. Patel, Prabhat Kumar Upadhyay, D Anand, Dilnawaz Pathan, et al.
International Journal of Drug Delivery Technology, 2025
The present study focuses on the formulation and characterization of floating microspheres for sustained gastric delivery of anti-diabetic drugs. Oral administration of anti-diabetic agents is often associated with variable bioavailability, short half-life, and frequent dosing, leading to reduced patient compliance. Floating microspheres, a gastroretentive drug delivery system, were developed to overcome these limitations by prolonging gastric residence time and achieving sustained drug release. Microspheres were prepared using the solvent evaporation method employing polymers such as hydroxypropyl methylcellulose (HPMC), ethyl cellulose (EC), and Eudragit RS100 in varying ratios. The prepared microspheres were evaluated for particle size, percentage yield, buoyancy, drug entrapment efficiency, in vitro drug release, and surface morphology using scanning electron microscopy. Results demonstrated good buoyancy (>12 hours), satisfactory drug entrapment efficiency, and a sustained release pattern over 12 hours following non-Fickian diffusion kinetics. This approach offers a promising platform for improving the therapeutic efficacy and patient compliance of anti-diabetic drug therapy
UNIVERSAL AND ADAPTIVE THRESHOLDING METHODS FOR MULTILEVEL DENOISING OF ECG SIGNALS USING ORTHOGONAL WAVELETS
Global and Stochastic Analysis, 2025
Nanomedicine A Promising Way to Manage Alzheimer's Disease
Saish Pawar, Pawan Ganesh Nayak, Sarika Sharma, Surabhi Singh, Nidhi Puranik, Arun Sharma
Nanomedicine in the Treatment and Management of Alzheimer S Disease, 2025
Revolutionizing neurotherapeutics: Nanocarriers unveiling the potential of phytochemicals in Alzheimer's disease
Akshatha P. Kamath, Pawan Ganesh Nayak, Jeena John, Srinivas Mutalik, Ashok Kumar Balaraman, Nandakumar Krishnadas
Neuropharmacology, 2024
AN ASSESSMENT OF THE ORTHOGONAL AND BIORTHOGONAL DISCRETE WAVELET TRANSFORM BASED DENOISING OF BIOLOGICAL SIGNALS − A STUDY BASED ON ECG
Global and Stochastic Analysis, 2024
Docosahexaenoic Acid and Pregnancy: A Systematic Review and Meta-Analysis of the Association with Improved Maternal and Fetal Health
Kiran Bilgundi, Gollapalle Lakshminarayanashastry Viswanatha, Kowshik Muttur Purushottam, Jeena John, Akshatha P. Kamath, Anoop Kishore, Pawan Ganesh Nayak, Krishnadas Nandakumar
Nutrition Research, 2024
Recent Progress in the Oral Delivery of Therapeutic Peptides and Proteins: Overview of Pharmaceutical Strategies to Overcome Absorption Hurdles
Sonal Mehrotra, Pavan Kalyan BG, Pawan G Nayak, Alex Joseph, Jyothsna Manikkath
Advanced Pharmaceutical Bulletin, 2024
Sesamol combats diabetogenic effects of atorvastatin through GLUT-4 expression and improved pancreatic viability
Raghuvir Keni, Pawan Ganesh Nayak, Nitesh Kumar, Anoop Kishore, Sulaiman Mohammed Alnasser, Farmiza Begum, Karthik Gourishetti, Krishnadas Nandakumar
3 Biotech, 2023
Protective effect of β-glucan on Poly(I:C)-induced acute lung injury/inflammation: Therapeutic implications of viral infections in the respiratory system
Satya Krishna Tirunavalli, Shashidhar Pramatha, Abhisheik Chowdary Eedara, Komal Paresh Walvekar, Christiana Immanuel, Pooja Potdar, Pawan G. Nayak, Mallikarjuna Rao Chamallamudi, Ramakrishna Sistla, Sabarinadh Chilaka, Sai Balaji Andugulapati
Life Sciences, 2023
Diabetic wound healing approaches: an update
Raghuvir Keni, Farmiza Begum, Karthik Gourishetti, Gollapalle Lakshminarayanashastry Viswanatha, Pawan Ganesh Nayak, Krishnadas Nandakumar, Rekha R Shenoy
Journal of Basic and Clinical Physiology and Pharmacology, 2023
Amelioration of Doxorubicin-Induced Cognitive Impairment by Quercetin in a Rat Model of Breast Cancer
Grandhi Venkata Ramalingayya, Jeena John, Karthik Gourishetti, Pawan Ganesh Nayak, C. Mallikarjuna Rao, Anoop Kishore, Sulaiman M. Alnasser, Shalam M. Hussain, Nandakumar Krishnadas
Revista Brasileira De Farmacognosia, 2023
Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
P.V. Anuranjana, Fathima Beegum, Divya K.P, Krupa Thankam George, G.L. Viswanatha, Pawan G. Nayak, Abhinav Kanwal, Anoop Kishore, Rekha R. Shenoy, K. Nandakumar
F1000research, 2023
Neuroprotective effect of Mulmina Mango against chemotherapy-induced cognitive decline in mouse model of mammary carcinoma
Jeena John, Manas Kinra, Niraja Ranadive, Raghuvir Keni, Pawan Ganesh Nayak, Rajesh N. Jagdale, Syed M. Ahmed, Kaggundi V. Raghavendra, Jayesh Mudgal, K. Nandakumar
Scientific Reports, 2022
Mitochondria–lysosome crosstalk in GBA1-associated Parkinson’s disease
M. Sahyadri, Abhishek P. R. Nadiga, Seema Mehdi, K. Mruthunjaya, Pawan G. Nayak, Vipan K. Parihar, S. N. Manjula
3 Biotech, 2022
Beta-Caryophyllene, a CB2R Selective Agonist, Protects Against Cognitive Impairment Caused by Neuro-inflammation and Not in Dementia Due to Ageing Induced by Mitochondrial Dysfunction
Urja Kanojia, Shrikant Gyaneshwar Chaturbhuj, Runali Sankhe, Maushami Das, Raviteja Surubhotla, Nandakumar Krishnadas, Karthik Gourishetti, Pawan Ganesh Nayak, Anoop Kishore
CNS and Neurological Disorders Drug Targets, 2021
Role of Statins in New-onset Diabetes Mellitus: The Underlying Cause, Mechanisms Involved, and Strategies to Combat
Raghuvir Keni, Abinitha Sekhar, Karthik Gourishetti, Pawan G. Nayak, Manas Kinra, Nitesh Kumar, Rekha R. Shenoy, Anoop Kishore, Krishnadas Nandakumar
Current Drug Targets, 2021
The prophylactic approach of sesamol and 3′,4′-(Methylenedioxy)acetophenone to prevent associated cardiotoxicity of doxorubicin at high dose in prostate cancer rat model
A. Shah, A. A. Shah, K. Nandakumar, D. S. Rekunge, G. U. Chaturbhuj, A. Kishore, P. G. Nayak, R. Lobo
Rasayan Journal of Chemistry, 2021
Erratum: Neuroprotective effect of mulmina™ against chemotherapy-induced cognitive decline in normal mice (Biomed Rep, (2021) 14, 1, 10.3892/br.2020.1377)
Manas Kinra, Niraja Ranadive, Karthik Gourishetti, Pawan Nayak, Rajesh Jagdale, Syed Ahmed, Kaggundi Raghavendra, Jayesh Mudgal, Krishnadas Nandakumar
Biomedical Reports, 2021
Botrops derived hemocoagulase formulation a probable agent for diabetic wound healing
Raghuvir Keni, Karthik Gourishetti, Manas Kinra, Pawan G. Nayak, Rekha Shenoy, Krishnadas Nandakumar, Rajesh N. Jagdale, K. V. Raghavendra, Syed Mushtaq Ahmed
3 Biotech, 2020
COVID-19: Emergence, Spread, Possible Treatments, and Global Burden
Raghuvir Keni, Anila Alexander, Pawan Ganesh Nayak, Jayesh Mudgal, Krishnadas Nandakumar
Frontiers in Public Health, 2020
Sesamol-loaded plga nanosuspension for accelerating wound healing in diabetic foot ulcer in rats
Karthik Gourishetti, Raghuvir Keni, Pawan Ganesh Nayak, Srinivas Reddy Jitta, Navya Ajitkumar Bhaskaran, Lalit Kumar, Nitesh Kumar, Krishnadas Nandakumar, Rekha Shenoy
International Journal of Nanomedicine, 2020
Neuroprotective effect of mulmina™ against chemotherapy-induced cognitive decline in normal rats
Manas Kinra, Niraja Ranadive, Karthik Gourishetti, Pawan Nayak, Rajesh Jagdale, Syed Ahmed, Kaggundi Raghavendra, Jayesh Mudgal, Krishnadas Nandakumar
Biomedical Reports, 2020
Medhya rasayana restores memory function against doxorubicin-induced cognitive decline: Possibly by its neuroprotective effect
Karthik Gourishetti, Sawan Ghetia, Ligin Jacob, Sanchari Basu Mallik, Pawan Ganesh Nayak, Anoop Kishore, Krishnadas Nandakumar, Sulaiman Mohammed Alnaseer, Shalam Mohamed Hussain
Indian Journal of Pharmaceutical Education and Research, 2019
Rutin protects against doxorubicin-induced cognitive dysfunction while retaining the anticancer potential of dox in a murine model of N-methyl-N-nitrosourea– induced mammary carcinoma
Grandhi Venkata Ramalingayya, Karthik Gourishetti, Pawan G. Nayak, Chamallamudi Mallikarjuna Rao, Anoop Kishore, Sulaiman M. Alnaseer, Shalam M. Hussain, Krishnadas Nandakumar
Journal of Environmental Pathology Toxicology and Oncology, 2019
Naringin ameliorates doxorubicin-induced neurotoxicity in vitro and cognitive dysfunction in vivo
Krishnadas Nandakumar, GrandhiVenkata Ramalingayya, PawanG Nayak, RekhaR Shenoy, SanchariBasu Mallik, Karthik Gourishetti, ShalamM Hussain, ChamallamudiMallikarjuna Rao
Pharmacognosy Magazine, 2018
Combined administration of monosodium glutamate and high sucrose diet accelerates the induction of type 2 diabetes, vascular dysfunction, and memory impairment in rats
Kaja Saikrishna, Ringu Kumari, Kantamaneni Chaitanya, Subhankar Biswas, Pawan G. Nayak, Jayesh Mudgal, Anoop Kishore, Krishnadas Nandakumar
Journal of Environmental Pathology Toxicology and Oncology, 2018
Sodium valproate enhances doxorubicin-induced cognitive dysfunction in Wistar rats
Thaneshwar Verma, Sanchari Basu Mallik, G.V. Ramalingayya, Pawan G. Nayak, Anoop Kishore, K. Sreedhara R. Pai, Krishnadas Nandakumar
Biomedicine and Pharmacotherapy, 2017
Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats
Grandhi V Ramalingayya, Sri Pragnya Cheruku, Pawan Nayak, Anoop Kishore, Rekha Shenoy, Chamallamudi Mallikarjuna Rao, Nandakumar Krishnadas
Drug Design Development and Therapy, 2017
Insulin protects against brain oxidative stress with an apparent effect on episodic memory in doxorubicin-induced cognitive dysfunction in wistar rats
Grandhi Venkata Ramalingayya, Vishwajeet Sonawane, Sri Pragnya Cheruku, Anoop Kishore, Pawan G. Nayak, Nitesh Kumar, Rekha S. Shenoy, Krishnadas Nandakumar
Journal of Environmental Pathology Toxicology and Oncology, 2017
Bulbophyllum sterile petroleum ether fraction induces apoptosis in vitro and ameliorates tumor progression in vivo
Subhankar Biswas, Rashmi Pardeshi, Neetinkumar D. Reddy, Muhammed Haneefa Shoja, Pawan G. Nayak, M. Manjunath Setty, K. Sreedhara R. Pai
Biomedicine and Pharmacotherapy, 2016
In vivo evaluation of two thiazolidin-4-one derivatives in high sucrose diet fed pre-diabetic mice and their modulatory effect on AMPK, akt and p38 MAP kinase in L6 cells
Jayesh Mudgal, Priya Shetty, Neetinkumar D. Reddy, H. S. Akhila, Karthik Gourishetti, Geetha Mathew, Pawan G. Nayak, Nitesh Kumar, Anoop Kishore, Nampurath G. Kutty, Krishnadas Nandakumar, Rekha R. Shenoy, Chamallamudi M. Rao, Alex Joseph
Frontiers in Pharmacology, 2016
Female rats induced with mammary cancer as a relevant animal model for doxorubicin-induced chemobrain in vivo
Grandhi Venkata Ramalingayya, Pawan G Nayak, Rekha R Shenoy, Chamallamudi Mallikarjuna Rao, Krishnadas Nandakumar
Clinical and Experimental Pharmacology and Physiology, 2016
Preclinical efficacy of a gastro-sparing novel thiazolidin-4-one in alleviating secondary lesions of polyarthritis: A multi-parametric approach
Jayesh Mudgal, Vasantharaju S. Gowdra, Piya P. Mudgal, Pawan G. Nayak, Nitesh Kumar, Zenab Attari, C. Mallikarjuna Rao, Gopalan K. Nampurath
European Journal of Pharmaceutical Sciences, 2016
Assessment of the in vitro cytotoxicity and in vivo anti-tumor activity of the alcoholic stem bark extract/fractions of Mimusops elengi Linn.
Harish Kumar, Mihir Savaliya, Subhankar Biswas, Pawan G. Nayak, Naseer Maliyakkal, M. Manjunath Setty, Karthik Gourishetti, K. Sreedhara Ranganath Pai
Cytotechnology, 2016
An appraisal of cinnamyl sulfonamide hydroxamate derivatives (HDAC inhibitors) for anti-cancer, anti-angiogenic and anti-metastatic activities in human cancer cells
Neetinkumar D. Reddy, M.H. Shoja, Subhankar Biswas, Pawan G. Nayak, Nitesh Kumar, C. Mallikarjuna Rao
Chemico Biological Interactions, 2016
In vitro mechanistic and in vivo anti-tumor studies of Glycosmis pentaphylla (Retz.) DC against breast cancer
M.H. Shoja, Neetinkumar D. Reddy, Pawan G. Nayak, Subhankar Biswas, K.K. Srinivasan, C. Mallikarjuna Rao
Journal of Ethnopharmacology, 2016
Endothelium dependent and independent mechanisms of vasorelaxant activity of synthesized 2,5-disubstituted-1,3,4-oxadiazole derivatives in rat thoracic aorta-ex vivo and molecular docking studies
Zenab Attari, Jayesh Mudgal, Pawan G Nayak, Nandakumar Krishnadas, Revathi Rajappan, N. Gopalan Kutty
Letters in Drug Design and Discovery, 2016
Novel Indole-Quinazolinone Based Amides as Cytotoxic Agents
Nikhila Gokhale, Naveen Panathur, Udayakumar Dalimba, Pawan G. Nayak, K. Sreedhar Ranganath Pai
Journal of Heterocyclic Chemistry, 2016
Naringin and rutin alleviates episodic memory deficits in two differentially challenged object recognition tasks
Krishnadas Nandakumar, GrandhiVenkata Ramalingayya, Madhavan Nampoothiri, PawanG Nayak, Anoop Kishore, RekhaR Shenoy, ChamallamudiMallikarjuna Rao
Pharmacognosy Magazine, 2016
Sambar, an Indian dish prevents the development of dimethyl hydrazine-induced colon cancer: A preclinical study
Krishnadas Nandakumar, VutturuGanga Prasad, Neetinkumar Reddy, Albi Francis, PawanG Nayak, Anoop Kishore, MallikarjunaC Rao, Rekha Shenoy
Pharmacognosy Magazine, 2016
Glycosmis pentaphylla (Retz.) DC arrests cell cycle and induces apoptosis via caspase-3/7 activation in breast cancer cells
M.H. Shoja, Neetinkumar D. Reddy, Pawan G. Nayak, K.K. Srinivasan, C. Mallikarjuna Rao
Journal of Ethnopharmacology, 2015
In vitro and in vivo evaluation of novel cinnamyl sulfonamide hydroxamate derivative against colon adenocarcinoma
Neetinkumar D. Reddy, M.H. Shoja, B.S. Jayashree, Pawan G. Nayak, Nitesh Kumar, V. Ganga Prasad, K. Sreedhara R. Pai, C. Mallikarjuna Rao
Chemico Biological Interactions, 2015
Curcumin half analog modulates Interleukin-6 and tumor necrosis factor-alpha in inflammatory bowel disease
RekhaRaghuveer Shenoy, PhaniKrishna Kondamudi, Hemalatha Kovelamudi, PawanG Nayak, MallikarjunaChamallamudi Rao
Pharmacognosy Magazine, 2015
Remedial effects of novel 2,3-disubstituted thiazolidin-4-ones in chemical mediated inflammation
Jayesh Mudgal, Vasantharaju S. Gowdra, Geetha Mathew, Pawan G. Nayak, Nitin D. Reddy, Neelesh Namdeo, Ravilla R. Kumar, Chaitanya Kantamaneni, Mallikarjuna R. Chamallamudi, Gopalan K. Nampurath
Chemico Biological Interactions, 2014
Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-Induced inflammatory bowel disorder in albino rats
Phani Krishna Kondamudi, Hemalatha Kovelamudi, Geetha Mathew, Pawan G. Nayak, Mallikarjuna C. Rao, Rekha R. Shenoy
Scientific World Journal, 2014
Erratum: Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-induced inflammatory bowel disorder in albino rats
Phani Krishna Kondamudi, Hemalatha Kovelamudi, Geetha Mathew, Pawan G. Nayak, Mallikarjuna C. Rao, Rekha R. Shenoy
Scientific World Journal, 2014
Synthesis, characterization, and preclinical evaluation of new thiazolidin-4-ones substituted with p-chlorophenoxy acetic acid and clofibric acid against insulin resistance and metabolic disorder
Vasantharaju S. Gowdra, Jayesh Mudgal, Punit Bansal, Pawan G. Nayak, Seethappa A. Manohara Reddy, Gautham G. Shenoy, Manna Valiathan, Mallikarjuna R. Chamallamudi, Gopalan K. Nampurath
Biomed Research International, 2014
Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer
V. Ganga Prasad, Shishir Kawade, B. S. Jayashree, Neetinkumar D. Reddy, Albi Francis, Pawan G. Nayak, Anoop Kishore, K. Nandakumar, C. Mallikarjuna Rao, Rekha R. Shenoy
Biomed Research International, 2014
Evaluation of in vitro antioxidant and in Vivo analgesic potential of Terminalia paniculata aqueous bark extract
Sahil Talwar, Pawan G. Nayak, Jayesh Mudgal, Piya Paul, Punit Bansal, Krishnadas Nandakumar
Journal of Medicinal Food, 2013
Impact of caffeic acid on aluminium chloride-induced dementia in rats
Kafeel A Khan, Nitesh Kumar, Pawan G Nayak, Madhavan Nampoothiri, Rekha R Shenoy, Nandakumar Krishnadas, C Mallikarjuna Rao, Jayesh Mudgal
Journal of Pharmacy and Pharmacology, 2013
Sesamol prevents doxorubicin-induced oxidative damage and toxicity on H9c2 cardiomyoblasts
Pawan G Nayak, Piya Paul, Punit Bansal, Nampurath Gopalan Kutty, Karkala Sreedhara Ranganath Pai
Journal of Pharmacy and Pharmacology, 2013
Toxicological evaluation of Terminalia paniculata bark extract and its protective effect against CCl4-induced liver injury in rodents
Sahil Talwar, Hitesh V Jagani, Pawan G Nayak, Nitesh Kumar, Anoop Kishore, Punit Bansal, Rekha R Shenoy, Krishnadas Nandakumar
BMC Complementary and Alternative Medicine, 2013
Sesamol treatment reduces plasma cholesterol and triacylglycerol levels in mouse models of acute and chronic hyperlipidemia
Nitesh Kumar, Jayesh Mudgal, Vipan K. Parihar, Pawan G. Nayak, N. Gopalan Kutty, C. Mallikarjuna Rao
Lipids, 2013
Corrigendum to In vivo anticancer and histopathology studies of Schiff bases on Ehrlich ascitic carcinoma cells [Arabian Journal of Chemistry 6(1) (2013) 25-33]
Dhanya Sunil, Arun M. Isloor, Prakash Shetty, Pawan G. Nayak, K.S.R. Pai, Hoong-Kun Fun
Arabian Journal of Chemistry, 2013
In vivo anticancer and histopathology studies of Schiff bases on Ehrlich ascitic carcinoma cells. 1st Cancer Update.
Dhanya Sunil, Arun M. Isloor, Prakash Shetty, Pawan G. Nayak, K.S.R. Pai
Arabian Journal of Chemistry, 2013
Modulatory effects of sesamol in dinitrochlorobenzene-induced inflammatory bowel disorder in albino rats
Phani Krishna Kondamudi, Hemalatha Kovelamudi, Geetha Mathew, Pawan G. Nayak, C. Mallikarjuna Rao, Rekha R. Shenoy
Pharmacological Reports, 2013
Click Chemistry Approach for Bis-Chromenyl Triazole Hybrids and Their Antitubercular Activity
Reshma J. Naik, Manohar V. Kulkarni, K. Sreedhara Ranganath Pai, Pawan G. Nayak
Chemical Biology and Drug Design, 2012
Radioprotection by quercetin-3-O-rutinoside, a flavonoid glycoside - A cellular and mechanistic approach
Punit Bansal, Piya Paul, Amit Kunwar, S. Jayakumar, Pawan G. Nayak, K.I. Priyadarsini, M.K. Unnikrishnan
Journal of Functional Foods, 2012
Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice
Punit Bansal, Piya Paul, Jayesh Mudgal, Pawan G. Nayak, Steve Thomas Pannakal, K.I. Priyadarsini, M.K. Unnikrishnan
Experimental and Toxicologic Pathology, 2012
Anticancer activity of Berberis aristata in Ehrlich ascites carcinoma-bearing mice: A preliminary study
K.S.R. Pai, P. Srilatha, Kumar Suryakant, M. Manjunath Setty, Pawan G. Nayak, C. Mallikarjuna Rao, M.S. Baliga
Pharmaceutical Biology, 2012
Polyphenolic fraction of Pilea microphylla (L.) protects Chinese hamster lung fibroblasts against γ-radiation-induced cytotoxicity and genotoxicity
Piya Paul, Punit Bansal, Pawan G. Nayak, Steve Thomas Pannakal, K.I. Priyadarsini, M.K. Unnikrishnan
Environmental Toxicology and Pharmacology, 2012
Pro-healing effects of morin, a natural antioxidant, on normal and dexamethasone-impaired wounds
Rekha Raghuveer Shenoy, Arun Theerthahalli Sudheendra, Pawan Ganesh Nayak, Piya Paul, Nampurath Gopalan Kutty, Chamallamudi Mallikarjuna Rao
Journal of Basic and Clinical Physiology and Pharmacology, 2011
Flavonoid rich fraction of Pilea microphylla (L.) attenuates metabolic abnormalities and improves pancreatic function in C57BL/KsJ-db/db mice
P. Bansal, P. Paul, G. Shankar, D. Munjal, P.G. Nayak, K.I. Priyadarsini, M.K. Unnikrishnan
Biomedicine and Preventive Nutrition, 2011
Effect of Dehydrozingerone, a half analog of curcumin on dexamethasone-delayed wound healing in albino rats
Mallikarjuna C. Rao, Arun T. Sudheendra, Pawan G. Nayak, Piya Paul, Gopalan N. Kutty, Rekha R. Shenoy
Molecular and Cellular Biochemistry, 2011
Anti-inflammatory activity of Terminalia paniculata bark extract against acute and chronic inflammation in rats
Sahil Talwar, K. Nandakumar, Pawan G. Nayak, Punit Bansal, Jayesh Mudgal, Vijay Mor, Chamallamudi Mallikarjuna Rao, Richard Lobo
Journal of Ethnopharmacology, 2011
Vasorelaxant and antihypertensive effect of Cocos nucifera Linn. endocarp on isolated rat thoracic aorta and DOCA salt-induced hypertensive rats
Girish R. Bankar, Pawan G. Nayak, Punit Bansal, Piya Paul, K.S.R. Pai, Rajeev K. Singla, Varadaraj G. Bhat
Journal of Ethnopharmacology, 2011
Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats
Rekha R. Shenoy, Arun T. Sudheendra, Pawan G. Nayak, Piya Paul, N. Gopalan Kutty, C. Mallikarjuna Rao
Journal of Ethnopharmacology, 2011
A possible correlation between the correction of endothelial dysfunction and normalization of high blood pressure levels by 1,3,4-oxadiazole derivative, an L-type Ca2+ channel blocker in deoxycorticosterone acetate and NG-nitro-l-arginine hypertensive rats
Girish R. Bankar, Gopalan Kutty Nampurath, Pawan G. Nayak, Shoumyo Bhattacharya
Chemico Biological Interactions, 2010
Antitumor and antioxidant activity of Polyalthia longifolia stem bark ethanol extract
Santhepete N. Manjula, Mruthunjaya Kenganora, Vipan K. Parihar, Suryakant Kumar, Pawan G. Nayak, Nitesh Kumar, Karkala Sreedhara Ranganath Pai, Chamallamudi Mallikarjuna Rao
Pharmaceutical Biology, 2010
Vasorelaxant effect in rat aortic rings through calcium channel blockage: A preliminary in vitro assessment of a 1,3,4-oxadiazole derivative
Girish R. Bankar, K. Nandakumar, Pawan G. Nayak, Anjali Thakur, Mallikarjuna Rao Chamallamudi, Gopalan Kutty Nampurath
Chemico Biological Interactions, 2009
Evaluation of the healing potential of schrebera swietenioides in the dexamethasone-suppressed wound healing in rodents
Amol S. Rasal, Pawan G. Nayak, K. Baburao, Rekha R. Shenoy, C. Mallikarjuna Rao
International Journal of Lower Extremity Wounds, 2009

Pawan Ganesh Nayak

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