Pabyton Goncalves Cadena

Associate Professor of the Federal Rural University of Pernambuco (UFRPE) working in the Department of Animal Morphology and Physiology - DMFA in the area of Physiology and Pharmacology.
Coordinator of the Nucleus of Technological Innovation - UFRPE (2014 to 2020).
Coordinator of the Animal Bioscience Graduate Program - UFRPE (2021 - 2023).
Member of the Brazilian Society of Physiology - SBFIS (2013 to present).
Leader of the research group "Nanobiotechnology, Toxicology and Animal Behavior".
Research areas: Biochemistry and Molecular Pharmacology, Animal Physiology and Toxicology, Pharmaceutical Nanotechnology and Development of Analytical Methods.
Advisor in Graduate Programs: Animal Bioscience, and Biology Applied to Health.
Advisor of undergraduate students and high school students.

EDUCATION

Bachelor and Licentiate in Biological Sciences, Master of Science in Biochemistry and Physiology and Doctor in Biological Sciences.

RESEARCH, TEACHING, or OTHER INTERESTS

Physiology, Pharmacology (medical), Biochemistry, Toxicology

Scopus Publications

Single essential oils and their binary mixtures protect against ethanol-induced defects in a zebrafish fetal alcohol spectrum disorder model at the same level as folic acid
Andressa Raphaely de Lima Silva, Maria Letícia Santos Carnaúba da Silva, Jadson Freitas da Silva, Katarine Evelyn Falcão e Falcão, James A. Marrs, Marilia Ribeiro Sales Cadena, and Pabyton Gonçalves Cadena
Elsevier BV



Nanoemulsions with cannabidiol reduced autistic-like behaviors and reversed decreased hippocampus viable cells and cerebral cortex neuronal death in a prenatal valproic acid rat model
MARIANA DE F.O. DA SILVA, AMANDA R. SANTOS-MAGNABOSCO, CLÁUDIA KATHARINY DA S. FARIAS, SANDRA MARIA DE TORRES, ANTÔNIO JOSÉ ALVES, PABYTON G. CADENA, and VALDEMIRO A. DA SILVA JÚNIOR
FapUNIFESP (SciELO)
Abstract The highly lipophilic nature and low aqueous solubility of cannabidiol (CBD) limit its oral bioavailability, resulting in poor intestinal absorption. To overcome these limitations, we proposed the production of a nanoemulsion with CBD to be included in the therapeutic treatment of autism spectrum disorder. The current study aimed to evaluate the effect of CBD-rich corn oil nanoemulsion treatment in male rats born to females exposed to valproic acid (VPA) during pregnancy on autistic-like behaviors and hippocampal histology. Offspring rats were treated orally twice daily with CBD nanoemulsions at different doses (1 and 2 mg/animal). The endpoints evaluated were anxiety, grooming time, exploratory activity, sociability, the social preference index, and hippocampal and cerebral cortex histology. All formulations were characterized as nanoemulsions and showed a reduced vesicle size (107.6 - 72.6 nm), low PDI (0.290-0.432), negative zeta potential (-40.6 mv), and good stability. Prenatal exposure to VPA increased anxiety and grooming time, and reduced exploratory activity, sociability, and the social preference index in the animals. Furthermore, VPA-exposed animals exhibited elevated neuronal death and a reduction in viable cells in the hippocampus. In conclusion, CBD nanoemulsion treatment reversed autistic-like behaviors, potentially by protecting against hippocampal neuronal death. The highly lipophilic nature and low aqueous solubility of cannabidiol (CBD) limit its oral bioavailability, resulting in poor intestinal absorption. To overcome these limitations, we proposed the production of a nanoemulsion with CBD to be included in the therapeutic treatment of autism spectrum disorder. The current study aimed to evaluate the effect of CBD-rich corn oil nanoemulsion treatment in male rats born to females exposed to valproic acid (VPA) during pregnancy on autistic-like behaviors and hippocampal histology. Offspring rats were treated orally twice daily with CBD nanoemulsions at different doses (1 and 2 mg/animal). The endpoints evaluated were anxiety, grooming time, exploratory activity, sociability, the social preference index, and hippocampal and cerebral cortex histology. All formulations were characterized as nanoemulsions and showed a reduced vesicle size (107.6 - 72.6 nm), low PDI (0.290-0.432), negative zeta potential (-40.6 mv), and good stability. Prenatal exposure to VPA increased anxiety and grooming time, and reduced exploratory activity, sociability, and the social preference index in the animals. Furthermore, VPA-exposed animals exhibited elevated neuronal death and a reduction in viable cells in the hippocampus. In conclusion, CBD nanoemulsion treatment reversed autistic-like behaviors, potentially by protecting against hippocampal neuronal death.


Use of phytocanabinoids in animal models of Parkinson's disease: Systematic review
Amanda de Deus Ferreira Alves, Fernanda Carolina Ribeiro Dias, Pabyton Gonçalves Cadena, and Valdemiro Amaro Silva-Jr
Elsevier BV



Speckle statistics as a tool to distinguish collective behaviors of Zebrafish shoals
Adauto J. F. de Souza, Antonio. R. de C. Romaguera, João V. A. Vasconcelos, Luis G. Negreiros-Neto, Viviane M. de Oliveira, Pabyton G. Cadena, Anderson L. R. Barbosa, and Marcelo L. Lyra
Springer Science and Business Media LLC
AbstractZebrafish have become an important model animal for studying the emergence of collective behavior in nature. Here, we show how to properly analyze the polarization statistics to distinguish shoal regimes. In analogy with the statistical properties of optical speckles, we show that exponential and Rayleigh distributions emerge in shoals with many fish with uncorrelated velocity directions. In the opposite limit of just two fish, the polarization distribution peaks at high polarity, with the average value being a decreasing function of the shoal’s size, even in the absence of correlations. We also perform a set of experiments unveiling two shoaling regimes. Large shoals behave as small domains with strong intra-domain and weak inter-domain correlations. A strongly correlated regime develops for small shoals. The reported polarization statistical features shall guide future automated neuroscience, pharmacological, toxicological, and embryogenesis-motivated experiments aiming to explore the collective behavior of fish shoals.


Behavioral Effects of the Mixture and the Single Compounds Carbendazim, Fipronil, and Sulfentrazone on Zebrafish (Danio rerio) Larvae
Samara da Silva Gomes, Jadson Freitas da Silva, Renata Meireles Oliveira Padilha, João Victor Alves de Vasconcelos, Luís Gomes de Negreiros Neto, James A. Marrs, and Pabyton Gonçalves Cadena
MDPI AG
Pesticides are often detected in freshwater, but their impact on the aquatic environment is commonly studied based on single compounds, underestimating the potential additive effects of these mixtures. Even at low concentrations, pesticides can negatively affect organisms, altering important behaviors that can have repercussions at the population level. This study used a multi-behavioral approach to evaluate the effects of zebrafish larvae exposure to carbendazim (C), fipronil (F), and sulfentrazone (S), individually and mixed. Five behavioral tests, thigmotaxis, touch sensitivity, optomotor response, bouncing ball test, and larval exploratory behavior, were performed to assess potential effects on anxiety, fear, and spatial and social interaction. Significant changes were observed in the performance of larvae exposed to all compounds and their mixtures. Among the single pesticides, exposure to S produced the most behavioral alterations, followed by F and C, respectively. A synergistic effect between the compounds was observed in the C + F group, which showed more behavioral effects than the groups exposed to pesticides individually. The use of behavioral tests to evaluate pesticide mixtures is important to standardize methods and associate behavioral changes with ecologically relevant events, thus creating a more realistic scenario for investigating the potential environmental impacts of these compounds.


Assessment of toxicity of pyriproxyfen, Bacillus thuringiensis, and malathion and their mixtures used for mosquito control on embryo-larval development and behavior of zebrafish
Renata Meireles Oliveira Padilha, Samara da Silva Gomes, Jadson Freitas da Silva, Renatta Priscilla Ferreira Silva, André Lucas Corrêa de Andrade, Amanda Rodrigues dos Santos Magnabosco, Thamiris Pinheiro Santos, Andressa Raphaely de Lima Silva, Maria Leticia Santos Carnaúba da Silva, Marilia Ribeiro Sales Cadena,et al.
Springer Science and Business Media LLC



Multifractal fluctuations in zebrafish (Danio rerio) polarization time series
Antonio R. de C. Romaguera, João V. A. Vasconcelos, Luis G. Negreiros-Neto, Nathan L. Pessoa, Jadson F. da Silva, Pabyton G. Cadena, Adauto J. F. de Souza, Viviane M. de Oliveira, and Anderson L. R. Barbosa
Springer Science and Business Media LLC



Use of a fast toxicity test to determine whether carbendazim, fipronil, and sulfentrazone and their mixtures affect early zebrafish embryonic development
Samara da Silva Gomes, Bruno Andre Fernandes de Jesus da Silva Nunes, and Pabyton Gonçalves Cadena
Instituto de Pesquisas Ambientais em Bacias Hidrograficas (IPABHi)
Because of the exacerbated use of pesticides and their mixtures, and the difficulty of evaluating their toxicity, it is necessary to identify sensitive tools for the early detection of potential environmental risks related to the use of these chemicals. Our objective was therefore to evaluate the effects of these chemicals using a rapid 24 h toxicity test in zebrafish embryos. After exposure of individual and mixtures of the pesticides carbendazim (carb), fipronil (fipr), and sulfentrazone (sulf), the lethality and sublethally at 24 hpf, the effects of the mixtures on epiboly and on coagulation of the embryos at 8 hpf were evaluated. This model can be extrapolated to several vertebrate groups, including humans. All three pesticides were toxic in both exposure periods, at 24 hpf, all concentrations used affected the embryos, with lethal and sublethal effects occurring. At 8 hpf, epiboly analysis indicated that the mixtures did not potentiate the effects compared to the pesticides alone, being toxic in the order: carb > sulf > fipr > fipr + sulf > carb + sulf > carb + fipr + sulf > carb + fipr + sulf > carb + fipr. We conclude that the most toxic pesticide was sulfentrazone, since it was highly toxic to embryonic development at 24 hpf and caused both delayed epiboly and high percent clotting at 8 hpf. Thus, we see that the rapid toxicity test was effective in assessing the toxicity of pesticides and was sensitive in assessing the effects of pesticides at low concentrations.Keywords: epiboly, pesticides, teratogenicity.


Essential Oils Produce Developmental Toxicity in Zebrafish Embryos and Cause Behavior Changes in Zebrafish Larvae
Ivanildo Inacio da Silva, Niely Priscila Correia da Silva, James A. Marrs, and Pabyton Gonçalves Cadena
MDPI AG
Essential oils have gained significant popularity in various industries due to their biological properties, but their potential toxic effects on living organisms have been poorly investigated. This study aimed to evaluate the effects of lemongrass, thyme, and oregano essential oils on zebrafish embryos and larvae as animal models. Embryos were exposed to different concentrations of essential oils, and various endpoints were assessed, including epiboly, mortality (LC50), morphometry, and behavioral changes. All three essential oils reduced epiboly, affecting embryonic development. LC50 values were calculated for lemongrass (3.7 µg/mL), thyme (14.4 µg/mL), and oregano (5.3 µg/mL) oils. Larvae exposed to these oils displayed morphological defects, including growth reduction, spinal deformation, pericardial edema, eye size reduction, and reduced swim-bladder inflation. Morphometric analysis confirmed reduced larval length at higher oil concentrations. Essential-oil exposure altered zebrafish larval swimming behavior, with lemongrass oil reducing dark-cycle activity and oregano oil increasing light-cycle activity, suggesting neurodevelopmental toxicity. These findings illustrate the adverse effects of these oils on zebrafish embryos and larvae and reveal essential-oil toxicity, indicating careful use should be considered, particularly during pregnancy.


Efficacy and non-toxicity of ciclopirox olamine-loaded liposomes against Cryptococcus neoformans clinical isolates
Patrícia de Oliveira Kocerginsky, Pedro Henrique dos Santos Soares, Hannah Ferreira Soares Lyra, Pabyton Gonçalves Cadena, Reginaldo Gonçalves de Lima-Neto, Nicodemos Teles Pontes-Filho, José Vitor Moreira Lima-Filho, Sérgio Dias Costa-Júnior, Rejane Pereira Neves, Isabella Macário Ferro Cavalcanti,et al.
Springer Science and Business Media LLC



Single and joint toxic effects of thyroid hormone, levothyroxine, and amiodarone on embryo-larval stages of zebrafish (Danio rerio)
Thamiris Pinheiro Santos, Paulo Eduardo da Silva Bastos, Jadson Freitas da Silva, Stefânia Maria de Medeiros Vieira, Marília Cordeiro Galvão da Silva, André Lucas Corrêa de Andrade, Renata Meireles Oliveira Padilha, Amanda Rodrigues dos Santos Magnabosco, Marilia Ribeiro Sales Cadena, and Pabyton Gonçalves Cadena
Springer Science and Business Media LLC



Testosterone nanoemulsion produced masculinized Nile tilapia (Oreochromis niloticus)
Amanda Rodrigues dos Santos Magnabosco, Ester Inácio Damião Quinova, Matheus Victor Viana de Melo, Paulo Eduardo da Silva Bastos, Thamiris Pinheiro Santos, Ivanildo Inácio da Silva Júnior, André Lucas Corrêa de Andrade, Renata Meireles Oliveira Padilha, Jadson Freitas da Silva, Fabrício Bezerra de Sá,et al.
Springer Science and Business Media LLC



Aqueous extract of fresh leaves from Alternanthera brasiliana (L.) Kuntze: chemical evaluation and antimycobacterial and anticandidal activities
Amanda Dias de Araújo, Maria do Carmo de Barros Pimentel, Camila da Silva Santos, Roberto Afonso da Silva, Pabyton Gonçalves Cadena, Nicácio Henrique da Silva, Norma Buarque Gusmão, Bruno Alonso Sleifer, Maria da Paz Carvalho da Silva, and Amélia Teresinha Henriques
Springer Science and Business Media LLC



Zebrafish (Danio rerio) larvae show behavioral and embryonic development defects when exposed to opioids at embryo stage
Marilia R. Sales Cadena, Pabyton G. Cadena, Meredith R. Watson, Swapnalee Sarmah, Stephen L. Boehm II, and James A. Marrs
Elsevier BV



Protective effects of quercetin, polydatin, and folic acid and their mixtures in a zebrafish (Danio rerio) fetal alcohol spectrum disorder model
Pabyton Gonçalves Cadena, Marilia Ribeiro Sales Cadena, Swapnalee Sarmah, and James A. Marrs
Elsevier BV



Folic acid reduces the ethanol-induced morphological and behavioral defects in embryonic and larval zebrafish (Danio rerio) as a model for fetal alcohol spectrum disorder (FASD)
Pabyton Gonçalves Cadena, Marilia Ribeiro Sales Cadena, Swapnalee Sarmah, and James A. Marrs
Elsevier BV



Marijuana and opioid use during pregnancy: Using zebrafish to gain understanding of congenital anomalies caused by drug exposure during development
Swapnalee Sarmah, Marilia Ribeiro Sales Cadena, Pabyton Gonçalves Cadena, and James A. Marrs
MDPI AG
Marijuana and opioid addictions have increased alarmingly in recent decades, especially in the United States, posing threats to society. When the drug user is a pregnant mother, there is a serious risk to the developing baby. Congenital anomalies are associated with prenatal exposure to marijuana and opioids. Here, we summarize the current data on the prevalence of marijuana and opioid use among the people of the United States, particularly pregnant mothers. We also summarize the current zebrafish studies used to model and understand the effects of these drug exposures during development and to understand the behavioral changes after exposure. Zebrafish experiments recapitulate the drug effects seen in human addicts and the birth defects seen in human babies prenatally exposed to marijuana and opioids. Zebrafish show great potential as an easy and inexpensive model for screening compounds for their ability to mitigate the drug effects, which could lead to new therapeutics.


Toxic effects of sediments of the Capibaribe estuary on zebrafish embryos (Danio rerio)
S.S. Gomes, A.C.C. Carvalho, C.M.V.A. Castro, and P.G. Cadena
FapUNIFESP (SciELO)
RESUMO O presente estudo utilizou embriões de Danio rerio expostos aos elutriatos dos sedimentos estuarinos do rio Capibaribe, dos períodos chuvoso e seco, e analisou os efeitos letais, teratogênicos, bem como a frequência cardíaca. Os testes de toxicidade com os embriões seguiram as diretrizes da OECD 236. Mediante os resultados obtidos, a frequência cardíaca e a teratogenicidade foram os efeitos mais observados nos animais quando submetidos às amostras. Entre os efeitos teratogênicos, o retardo geral no desenvolvimento dos embriões foi o mais frequente durante as análises. Tais efeitos tóxicos se modificaram entre os pontos e entre os períodos de coleta. Essa variação de toxicidade pode estar relacionada à diversidade de atividades realizadas no entorno desse estuário, a influência do regime de chuvas, marés e correntes, indicando que a análise dos efeitos subletais e da teratogenicidade em embriões de D. rerio constitui bom parâmetro para avaliações de toxicidade de amostras ambientais.


Values of plasma total proteins of free-living marmosets (Callithrix jacchus) in an urban forest
Juliana Ribeiro de Albuquerque, Fernanda Danielle Gomes da Silva, Pedro Ivo Aragão Rocha, Dênisson da Silva e Souza, Maria Adélia Borstelmann de Oliveira, Pabyton Gonçalves Cadena, and Anísio Francisco Soares
Wiley
AbstractBackgroundCallithrix jacchus is a small primate widely used in experimentation, but data on plasma total protein (PTP) values of free‐living animals inhabiting its own endemism region are non‐existent.MethodsMarmosets belonging to two free‐living groups were captured for marking and obtaining biological material. The collected blood was centrifuged to obtain the plasma and thus to determine the concentration of PTP.Results and conclusionsFemales and adults had the highest mean PTP. Mean found were higher than other values described for other neotropical primates, and the high PTP values presented by the animals indicate dehydration. Due to the importance of total plasma proteins for health and management, obtaining these values as a reference is relevant for the free‐living Callithrix genus and other neotropical primates


Thyroxine, levothyroxine, and thyroxine complexed into cyclodextrin changed animal behavior, oxygen consumption, and photopic electroretinogram of Colossoma macropomum
Thamiris Pinheiro Santos, Priscila Rafaela Leão Soares, Marília Cordeiro Galvão da Silva, Stephannie Caroline Barros Lucas da Silva, André Lucas Correa de Andrade, Amanda Rodrigues dos Santos, Jadson Freitas da Silva, Elyda Grazyelle da Silva Oliveira, Elton Hugo Lima da Silva Souza, Fabrício Bezerra de Sá,et al.
Springer Science and Business Media LLC



Chronic exposure to metformin chloridrate and glibenclamide causes behavioral, blood glucose and mortality changes of Hemigrammus caudovittatus and Danio rerio
E.Q. Souza, T.Q.M. Bittencourt, R.C.B. Ferreira, E.G.S. Oliveira, N.P.C. Silva, S.C.B.L. Silva, M.R.S. Cadena, and P.G. Cadena
FapUNIFESP (SciELO)
RESUMO Hemigrammus caudovittatus e Danio rerio foram expostos aos hipoglicemiantes orais (HOs) cloridrato de metformina a 40µg/L e 120µg/L e glibenclamida a 0,13µg/L e 0,39µg/L durante 100 dias. Foram avaliados os efeitos tóxicos dos fármacos em relação ao peso, ao comportamento animal, à glicemia e à mortalidade. H. caudovittatus expostos à menor concentração dos fármacos apresentaram aumento significativo (P<0,05) no evento Respiração Aérea. Ainda, foi observado aumento no comportamento Descansar quando os animais foram expostos à glibenclamida a 0,39µg/L. Em D. rerio expostos ao cloridrato de metformina a 120µg/L, foi observado aumento (P<0,05) no comportamento Descansar. A glibenclamida provocou redução (P<0,05) na glicemia de H. caudovittatus. Ambos os fármacos causaram efeito letal na espécie D. rerio, contudo a glibenclamida foi mais tóxica, causando 100% de mortalidade em 30 dias de exposição. Os animais que vieram a óbito apresentaram congestão nos arcos branquiais e hemorragia. Os HOs foram desenvolvidos para apresentarem efeitos fisiológicos em mamíferos, entretanto efeitos tóxicos foram encontrados nas duas espécies de peixe estudadas. Isso levanta a preocupação sobre possíveis efeitos tóxicos de HOs e sobre quais métodos serão utilizados para a sua degradação no ambiente aquático.


The complexation of steroid hormones into cyclodextrin alters the toxic effects on the biological parameters of zebrafish (Danio rerio)
Marília Cordeiro Galvão da Silva, Jadson Freitas da Silva, Thamiris Pinheiro Santos, Niely Priscila Correia da Silva, Amanda Rodrigues dos Santos, André Lucas Corrêa de Andrade, Elton Hugo Lima da Silva Souza, Marilia Ribeiro Sales Cadena, Fabrício Bezerra de Sá, Valdemiro Amaro da Silva Junior,et al.
Elsevier BV



Toxic effects of vanadium compounds on biological parameters of embryos and adults of zebrafish (Danio rerio)
T.Q.M. Bittencourt, A.R. Santos, M.C.G. Silva, J.F. Silva, N.P.C. Silva, W.E. Silva, P.G. Cadena, and M.J.A.A.L. Amorim
FapUNIFESP (SciELO)
RESUMO Foram avaliados os efeitos tóxicos do metavanadato de sódio (MV), pentóxido de vanádio (PV) e sulfato de oxovanádio (SV), potenciais fármacos antidiabéticos, em embriões e adultos de zebrafish (Danio rerio). Os embriões foram expostos a concentrações de 10-1000µg/mL para avaliação da CL50 96h e seus efeitos teratogênicos. Os adultos foram expostos a 10 e 20µg/mL dos mesmos compostos para se avaliarem alterações comportamentais relacionadas à exposição química e à mortalidade. A CL50 96h foi de 22,48, 53,62 e 74,14µg/mL para MV, SV e PV, respectivamente. Houve 100% de mortalidade nas concentrações de 400-1000µg/mL dos três compostos. Os efeitos teratogênicos mais observados (P<0,05) nos embriões foram edemas de pericárdio e saco vitelínico. Foram constatados, nos animais adultos expostos aos compostos de vanádio, maior batimento opercular e congestão nos arcos branquiais. A exibição dos comportamentos Flutuar e Descansar nos adultos expostos foi significativa (P<0,05), como também a exibição do comportamento Respiração Aérea. Pode-se concluir que a exposição química aos compostos de vanádio causou efeitos tóxicos em embriões e adultos de zebrafish com alta mortalidade. Diante disso, o seu uso como potencial fármaco antidiabético deve ser mais bem estudado em razão do efeito tóxico dessas substâncias.


Impact evaluation caused by disponibility of free and complexed 17β-estradiol into cyclodextrin in the aquatic environment in tilapia (Oreochromis niloticus)
M.C.G. Silva, S.C.B.L. Silva, T.P. Santos, P.R.L. Soares, A.L.C. Andrade, M.R.S. Cadena, and P.G. Cadena
FapUNIFESP (SciELO)
RESUMO Foram avaliados os efeitos tóxicos do hormônio 17β-estradiol (E2) livre e complexado à β-ciclodextrina (CD) sobre o comportamento e a fisiologia de tilápia (Oreochromis niloticus). Os peixes foram observados por 30 dias, em dois estágios do desenvolvimento (alevino e juvenil), pelo método ad libitum, para a confecção de um etograma. Posteriormente, juvenis foram divididos em três grupos: controle e expostos ao E2 (10ng/L) livre e complexado à β-ciclodextrina (β-CD:E2) por 90 dias. Foram avaliados o comportamento pelo método de varredura instantânea, o consumo de ração, o ganho de peso e a mortalidade em diferentes intervalos. Os alevinos e os juvenis apresentaram frequências de exibição comportamentais diferentes (P<0,05) nos eventos: Afastar (4,7±1,3 e 3,6±0,6%) e Ondulação de repulsão (2,3±0,9 e 1,3±1,0%). Os juvenis expostos ao complexo β-CD:E2 apresentaram aumento (P<0,05) na exibição dos comportamentos agressivos, como Afastar, Ataque caudal, Confronto prolongado, Perseguição, Fuga, e menor mortalidade, quando comparados ao grupo exposto ao E2 livre e controle. Pode-se concluir que a complexação do E2 com a β-CD alterou a toxicidade do E2, pois promoveu um aumento na frequência de exibição dos comportamentos agressivos e interferiu na mortalidade dos animais.


Evaluation of the toxic effect of endocrine disruptor Bisphenol A (BPA) in the acute and chronic toxicity tests with Pomacea lineata gastropod
André Lucas Correa de Andrade, Priscila Rafaela Leão Soares, Stephannie Caroline Barros Lucas da Silva, Marília Cordeiro Galvão da Silva, Thamiris Pinheiro Santos, Marilia Ribeiro Sales Cadena, Pierre Castro Soares, and Pabyton Gonçalves Cadena
Elsevier BV

RECENT SCHOLAR PUBLICATIONS

Single essential oils and their binary mixtures protect against ethanol-induced defects in a zebrafish fetal alcohol spectrum disorder model at the same level as folic acid
AR de Lima Silva, MLSC da Silva, JF da Silva, KEF e Falco, JA Marrs, ...
Alcohol 123, 77-86 2025



Nanoemulsions with cannabidiol reduced autistic-like behaviors and reversed decreased hippocampus viable cells and cerebral cortex neuronal death in a prenatal valproic acid
MDEFODA Silva, AR Santos-Magnabosco, CKDAS Farias, SMDE Torres, ...
Anais da Academia Brasileira de Cincias 97 (1), e20240607 2025



Prospeco tecnolgica das teraputicas veterinrias em mamites subclnicas por meio de busca em base de patentes
ES do Amaral Alves, MLA de Moraes, ES de Medeiros, PG Cadena
OBSERVATRIO DE LA ECONOMA LATINOAMERICANA 23 (1), e8651-e8651 2025



Prospeco tecnolgica dos mtodos de diagnstico da sndrome alcolica fetal em indivduos afetados
MLA de Moraes, MLSC da Silva, PG Cadena
Revista Eletrnica Acervo Sade 25, e18114-e18114 2025



Technological monitoring perspective: zebrafish as a model in alcohol-related disease research
AR dos Santos Magnabosco, PG Cadena
Revista Eletrnica Acervo Sade 24 (12), e19046-e19046 2024



A Nanotoxicological Approach to the Effects of Metformin and Sodium Metavanadate Co-encapsulated in Polycaprolactone Nanoparticles under the Biological Parameters of Zebrafish
TQM Bittencourt, TP Santos, PES Bastos, MJAAL Amorim, SS Gomes, ...
Archives of Current Research International 24 (12), 174-184 2024



Modelo didtico de embrio do Zebrafish (Danio rerio): uma proposta para introduo ao ensino de Medicina Translacional
EVL da Silva, PG Cadena, MRS Cadena
Revista Prxis 16 (30) 2024



Presena de coliformes em carne bovina moda comercializada em mercado pblico
ES do Amaral Alves, AK de Araujo Medeiros, DM da Silva, ...
Brazilian Journal of Animal and Environmental Research 7 (3), e73230-e73230 2024



Contaminao por coliformes em carne de frango comercializadas em pequenos mercados varejistas
ES do Amaral Alves, KDA Soares, DD da Silva, AC Alves, MEL da Costa, ...
Brazilian Journal of Animal and Environmental Research 7 (3), e73229-e73229 2024



Avaliao de contaminao por coliformes em casca, gema e clara de ovos de Gallus Gallus domesticus
ES do Amaral Alves, M da Silva Mesquita, KDA Soares, DD da Silva, ...
Brazilian Journal of Animal and Environmental Research 7 (3), e73232-e73232 2024



Anlise de mesfilos e coliformes em produtos embutidos porcionados como indicadores das condies higinico-sanitrias
ES do Amaral Alves, BB Volpato, MF da Silva Souza, MLB Barreto, ...
Brazilian Journal of Animal and Environmental Research 7 (3), e73231-e73231 2024



Use of phytocanabinoids in animal models of parkinson's disease: systematic review
ADF Alves, FCR Dias, PG Cadena, VA da Silva Junior
NeuroToxicology 2024



Uso de um teste rpido de toxicidade para determinar carbendazim, fipronil e sulfentrazona e suas misturas afetaram o desenvolvimento embrionrio inicial do peixe-zebra
SS Gomes, BAFJS Nunes, PG Cadena
Revista Ambiente & gua 19, e2990 2024



Use of a fast toxicity test to determine whether carbendazim, fipronil, and sulfentrazone and their mixtures affect early zebrafish embryonic development
SS Gomes, BAFJS Nunes, PG Cadena
Revista Ambiente & gua 19, e2990 2024



Speckle statistics as a tool to distinguish collective behaviors of Zebrafish shoals
AJF de Souza, ARC Romaguera, JVA Vasconcelos, LG Negreiros-Neto, ...
Scientific Reports 14 (1), 15835 2024



Cannabidiol como um potencial tratamento anti-inflamatrio na infeco respiratria (reviso integrativa)
AGC Marinho, IA de Souza, PG Cadena, JV Lima Filho, AJ Alves, ...
Cuadernos de Educacin y Desarrollo 16 (6), e4642-e4642 2024



Modelo didtico de zigoto e perodo de clivagem de peixe-zebra (Danio rerio) que atende estudantes normovisuais e com deficincia visual
EVL da Silva, PG Cadena, MRS Cadena
Revista Eletrnica Acervo Sade 24 (6), e15472-e15472 2024



Assessment of toxicity of pyriproxyfen, Bacillus thuringiensis, and malathion and their mixtures used for mosquito control on embryo-larval development and
RMO Padilha, S da Silva Gomes, JF da Silva, RPF Silva, ALC de Andrade, ...
Environmental Science and Pollution Research 31 (30), 42672-42685 2024



Behavioral Effects of the Mixture and the Single Compounds Carbendazim, Fipronil, and Sulfentrazone on Zebrafish (Danio rerio) Larvae
SS Gomes, JF da Silva, RMO Padilha, JVA de Vasconcelos, ...
Biomedicines 12 (6), 1176 2024



Multifractal fluctuations in zebrafish (Danio rerio) polarization time series
ARC Romaguera, JVA Vasconcelos, LG Negreiros-Neto, NL Pessoa, ...
The European Physical Journal E 47 (5), 29 2024

MOST CITED SCHOLAR PUBLICATIONS

Nanoencapsulation of quercetin and resveratrol into elastic liposomes
PG Cadena, MA Pereira, RBS Cordeiro, IMF Cavalcanti, BB Neto, ...
Biochimica et Biophysica Acta (BBA)-Biomembranes 1828 (2), 309-316 2013
Citations: 171



Covalent immobilization of invertase on polyurethane, plast-film and ferromagnetic Dacron
PG Cadena, RAS Jeronimo, JM Melo, RA Silva, JL Lima Filho, ...
Bioresource technology 101 (6), 1595-1602 2010
Citations: 58



Acute and chronic toxicity of the benzoylurea pesticide, lufenuron, in the fish, Colossoma macropomum
PRL Soares, ALC de Andrade, TP Santos, SCBL da Silva, JF da Silva, ...
Chemosphere 161, 412-421 2016
Citations: 53



Folic acid reduces the ethanol-induced morphological and behavioral defects in embryonic and larval zebrafish (Danio rerio) as a model for fetal alcohol spectrum disorder (FASD)
PG Cadena, MRS Cadena, S Sarmah, JA Marrs
Reproductive Toxicology 96, 249-257 2020
Citations: 34



The complexation of steroid hormones into cyclodextrin alters the toxic effects on the biological parameters of zebrafish (Danio rerio)
MCG da Silva, JF da Silva, TP Santos, NPC da Silva, AR Dos Santos, ...
Chemosphere 214, 330-340 2019
Citations: 33



Cationic liposomes containing antioxidants reduces pulmonary injury in experimental model of sepsis: Liposomes antioxidants reduces pulmonary damage
AM Galvo, JS Galvao, MA Pereira, PG Cadena, NSS Magalhes, JB Fink, ...
Respiratory Physiology & Neurobiology 231, 55-62 2016
Citations: 25



Evaluation of the toxic effect of endocrine disruptor Bisphenol A (BPA) in the acute and chronic toxicity tests with Pomacea lineata gastropod
ALC de Andrade, PRL Soares, SCBL da Silva, MCG da Silva, TP Santos, ...
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2017
Citations: 24



Zebrafish (Danio rerio) larvae show behavioral and embryonic development defects when exposed to opioids at embryo stage
MRS Cadena, PG Cadena, MR Watson, S Sarmah, SL Boehm II, JA Marrs
Neurotoxicology and teratology 85, 106964 2021
Citations: 21



Immobilized invertase studies on glass–ceramic support from coal fly ashes
AVP Albertini, JL Silva, VN Freire, RP Santos, JL Martins, BS Cavada, ...
Chemical Engineering Journal 214, 91-96 2013
Citations: 21



Protective effects of quercetin, polydatin, and folic acid and their mixtures in a zebrafish (Danio rerio) fetal alcohol spectrum disorder model
PG Cadena, MRS Cadena, S Sarmah, JA Marrs
Neurotoxicology and teratology 82, 106928 2020
Citations: 19



Simple determination of deoxycholic and ursodeoxycholic acids by phenolphthalein-β-cyclodextrin inclusion complex
PG Cadena, EC Oliveira, AN Arajo, MC Montenegro, MCB Pimentel, ...
Lipids 44, 1063-1070 2009
Citations: 18



Efeitos de hormnios esteroides de contraceptivos orais combinados sobre os parmetros comportamentais de Betta splendens (Regan, 1909)
BD Santos, MCG Silva, TP Santos, S Silva, MRS Cadena, PG Cadena
Arquivo brasileiro de medicina veterinria e zootecnia 68, 387-396 2016
Citations: 16



Performance of invertase immobilized on glass–ceramic supports in batch bioreactor
AVP Albertini, PG Cadena, JL Silva, GA Nascimento, ALS Reis, VN Freire, ...
Chemical Engineering Journal 187, 341-350 2012
Citations: 16



Kinetics and bioreactor studies of immobilized invertase on polyurethane rigid adhesive foam
PG Cadena, FN Wiggers, RA Silva, JL Lima Filho, MCB Pimentel
Bioresource technology 102 (2), 513-518 2011
Citations: 15



Efeitos txicos de compostos de vandio sobre os parmetros biolgicos de embries e adultos de zebrafish (Danio rerio)
TQM Bittencourt, AR Santos, MCG Silva, JF Silva, NPC Silva, WE Silva, ...
Arquivo Brasileiro de Medicina Veterinria e Zootecnia 70, 1877-1886 2018
Citations: 12



Marijuana and opioid use during pregnancy: using zebrafish to gain understanding of congenital anomalies caused by drug exposure during development
S Sarmah, MR Sales Cadena, PG Cadena, JA Marrs
Biomedicines 8 (8), 279 2020
Citations: 10



Physical–chemical parameters and validation of a colorimetric method for deoxycholic and ursodeoxycholic acids: kit reagent and optical sensor
PG Cadena, AN Arajo, MC Montenegro, MCB Pimentel, JL Lima Filho, ...
Chemistry and Physics of Lipids 164 (2), 99-105 2011
Citations: 8



Glutamine-Loaded Liposomes: Preliminary Investigation, Characterization, and Evaluation of Neutrophil Viability
LC Costa, BNRF Souza, FF Almeida, CJ Lagranha, PG Cadena, ...
AAPS PharmSciTech 17, 446-453 2016
Citations: 5



Single and joint toxic effects of thyroid hormone, levothyroxine, and amiodarone on embryo-larval stages of zebrafish (Danio rerio)
TP Santos, PE da Silva Bastos, JF da Silva, SM de Medeiros Vieira, ...
Ecotoxicology 32 (4), 525-535 2023
Citations: 4



Essential oils produce developmental toxicity in zebrafish embryos and cause behavior changes in zebrafish larvae
II da Silva Jr, NPC da Silva, JA Marrs, PG Cadena
Biomedicines 11 (10), 2821 2023
Citations: 3