Dr Gopinath Papichettypalle
@jbrpc.edu.in
Associate Professor
Joginpally BR Pharmacy College
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmaceutical Science, Drug Discovery, General Pharmacology, Toxicology and Pharmaceutics, Toxicology
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
B. Shanthakumar, P. Gopinath, Bharath Kumar Chagaleti, Venkatesan Saravanan, Senthil Kumar Palaniappan, Saeedah Musaed Almutairi, Dina S. Hussein, Yasmine Hamdy Eisa, M.K. Kathiravan, and Jesu Arockiaraj
Elsevier BV
Afroz Patan, Vijey Aanandhi M., and Gopinath P.
Royal Society of Chemistry (RSC)
Compounds bearing thiazole and chalcone groups have been reported to be excellent leads for antibacterial, antitubercular and anticancer activities.
Deivasigamani Priya, Papichettypalle Gopinath, Loganathan Sumathi Dhivya, Anandan Vijaybabu, Manoharan Haritha, Senthilkumar Palaniappan, and Muthu K. Kathiravan
Wiley
AbstractPyrazole moiety is considered as the most important therapeutic agent for the treatment of inflammation and inflammation associated cancers. Celecoxib, Ramifenazone, Rimonabant and Lonazolac are some of the commercially available pyrazole moieties which are potent COX‐2 inhibitors and also acts in inhibiting various cancers. Recently there are numerous reviews on the biological significance of pyrazole derivatives. However, this review discusses pyrazole derivatives possessing anti‐inflammatory and anticancer activity (COX inhibition) and also illustrates the recent updates on pyrazole research emphasizing on the medicinal chemistry aspects such as the key structural fragments required for the biological activity. There are series of pyrazoles like di‐substituted, tri‐substituted, tetra‐substituted pyrazoles, pyrazole hydrazones, pyrazoles bearing various other heterocycles, bicyclic fused pyrazoles, tricyclic fused pyrazoles, and miscellaneous class of pyrazoles. All these pyrazoles are being researched as COX inhibitors, anti‐inflammatory and against related disorders like cancer.
P. Gopinath and M.K. Kathiravan
Elsevier BV
P. Gopinath and M. K. Kathiravan
Rasayan Journal of Chemistry
Selective targeting of the tumor-associated hCA XII isozyme is a promising strategy to obtain effective and safer agents in cancer therapy. A series of mercapto-quinazolinone benzene sulfonamide derivatives were subjected to molecular field analysis to derive 3D-QSAR models. Structural properties such as physicochemical, topological, electro-topological, and quantum-chemical descriptors were calculated using the Molecular Design Suite of V-life MDS 4.6 Software. The contour map generated from the SA-kNN model explains the significance of electrostatic and steric descriptors for hCA XII binding interaction. Molecular docking studies favored structural insights in association with QSAR. Most interacting residues Asn67, Gln92, Thr199 and His119 stabilized the compounds in the active pocket. The results suggest structural insights as well as highlight the key binding features of mercaptoquinazolinone benzene sulfonamide derivatives against hCA XII which can be utilized for the design and development of potent leads.
Gopinath P. and Kathiravan M. K.
Royal Society of Chemistry (RSC)
Compound 27 as best theoritical lead interacting with the residues of hCA IX enzyme.
P. Gopinath and M.K. Kathiravan
Wiley
AbstractCancer is the second leading cause of death worldwide, and breast cancer accounts for 2.09 million cases in the year 2018. Hypoxia‐related human carbonic anhydrase IX enzyme was found to play a key role in metastasis also. In this view, quantitative structure activity relationship (QSAR) studies were carried out by QSARINS on triazole benzene sulfonamide derivatives for carbonic anhydrase IX inhibitory activity targeting breast cancer. A new scope to explore 3D‐MoRSE descriptors in carbonic anhydrase inhibition has been initiated by this study. The best model 3 generated includes five variables MoRSEV22, MoRSEC17, MoRSEV1, MoRSEC4, and MoRSEE2 with statistical values R2 = 0.7852, CCCtr = 0.8797, Q2LOO = 0.7237, Q2LMO = 0.7071, CCCcv = 0.8472, R2ext = 0.7894, and CCCext = 0.8784. The developed QSAR model suggests that the atomic volume, atomic charges, and Sanderson's electronegativity play key roles and were extremely helpful in designing and optimizing the lead. Molecular docking studies were performed using Autodock v 4.2.6 and the residues of active site region involving both hydrophilic and hydrophobic parts interacted with best predicted active compounds 1d, 3e, 6f and 9f. The study leads to the development of new inhibitors targeting breast cancer.