Pietro D'Addabbo

Scopus Publications

Three-Dimensional Modeling of Camelus dromedarius T Cell Receptor Gamma (TRG)_Delta (TRD)/CD1D Complex Reveals Different Binding Interactions Depending on the TRD CDR3 Length
Salvatrice Ciccarese, Marie-Paule Lefranc, Giulia C. M. Perrone, Pietro D’Addabbo, Ciro Leonardo Pierri
Antibodies, 2025
Background: In the adaptive immune response of the dromedary (Camelus dromedarius, Camdro), the T cell receptor (TR) repertoire of the gamma–delta (γδ) T cells is unusually diversified both by somatic hypermutation in rearranged TR gamma (TRG) and delta (TRD) genes and by the diversity in sequence and length of the third complementarity-determining region (CDR3) of the TRD chain. Methods: The purpose was to investigate, in the absence of 3D structures, the role of Camdro γδ T cells, focusing on the binding interactions at the interface between the V-gamma and V-delta domains, and in complex with the CD1D, a major histocompatibily class I (MH1)-like glycoprotein presenting lipid antigen in association with B2M. A combination of hypermutated TRG dromedary cDNA clones was paired with TRD clones bearing very long, long, or short CDR3s, all isolated from the spleen of a single animal. Results: The 3D models of the Camdro TRG_TRD/CD1D_B2M complexes were inferred using the Homo sapiens 3D structure and the ImMunoGeneTics (IMGT) numbering for V, C, and G domains, and investigated for binding interactions at the interface of the paired V-gamma_V-delta and at the interface with CD1D. Our results suggest that transcripts with long CDR3s may derive from a population of CD1D-restricted γδ T cells. Both the CD1D G-alpha1-like and G-alpha-2 like domain helices were contacted by both the V-gamma and V-delta CDR-IMGT loops. Conclusions: Our findings further emphasize the similarity between the γδ T cells population we analyzed in Camelus dromedarius and the CD1D-restricted γδ NKT cells in Homo sapiens.
REDIportal: Toward an integrated view of the A-To-I editing
Pietro D’Addabbo, Roni Cohen-Fultheim, Itamar Twersky, Adriano Fonzino, Domenico Alessandro Silvestris, et al.
Nucleic Acids Research, 2025
A-to-I RNA editing is the most common non-transient epitranscriptome modification. It plays several roles in human physiology and has been linked to several disorders. Large-scale deep transcriptome sequencing has fostered the characterization of A-to-I editing at the single nucleotide level and the development of dedicated computational resources. REDIportal is a unique and specialized database collecting ∼16 million of putative A-to-I editing sites designed to face the current challenges of epitranscriptomics. Its running version has been enriched with sites from the TCGA project (using data from 31 studies). REDIportal provides an accurate, sustainable and accessible tool enriched with interconnections with widespread ELIXIR core resources such as Ensembl, RNAcentral, UniProt and PRIDE. Additionally, REDIportal now includes information regarding RNA editing in putative double-stranded RNAs, relevant for the immune-related roles of editing, as well as an extended catalog of recoding events. Finally, we report a reliability score per site calculated using a deep learning model trained using a huge collection of positive and negative instances. REDIportal is available at http://srv00.recas.ba.infn.it/atlas/.
De Novo Assembly of the Polyhydroxybutyrate (PHB) Producer Azohydromonas lata Strain H1 Genome and Genomic Analysis of PHB Production Machinery
Daniele Traversa, Carlo Pazzani, Pietro D’Addabbo, Lucia Trisolini, Matteo Chiara, et al.
Microorganisms, 2025
Polyhydroxybutyrate (PHB) is a biodegradable natural polymer produced by different prokaryotes as a valuable carbon and energy storage compound. Its biosynthesis pathway requires the sole expression of the phaCAB operon, although auxiliary genes play a role in controlling polymer accumulation, degradation, granule formation and stabilization. Due to its biodegradability, PHB is currently regarded as a promising alternative to synthetic plastics for industrial/biotechnological applications. Azohydromonas lata strain H1 has been reported to accumulate PHB by using simple, inexpensive carbon sources. Here, we present the first de novo genome assembly of the A. lata strain H1. The genome assembly is over 7.7 Mb in size, including a circular megaplasmid of approximately 456 Kbp. In addition to the phaCAB operon, single genes ascribable to PhaC and PhaA functions and auxiliary genes were also detected. A comparative genomic analysis of the available genomes of the genus Azohydromonas revealed the presence of phaCAB and auxiliary genes in all Azohydromonas species investigated, suggesting that the PHB production is a common feature of the genus. Based on sequence identity, we also suggest A. australica as the closest species to which the phaCAB operon of the strain H1, reported in 1998, is similar.
Deep Intronic ETFDH Variants Represent a Recurrent Pathogenic Event in Multiple Acyl-CoA Dehydrogenase Deficiency
Stefania Martino, Pietro D’Addabbo, Antonella Turchiano, Francesca Clementina Radio, Alessandro Bruselles, et al.
International Journal of Molecular Sciences, 2024
Multiple acyl-CoA dehydrogenase deficiency (MADD) is a rare inborn error of metabolism affecting fatty acid and amino acid oxidation with an incidence of 1 in 200,000 live births. MADD has three clinical phenotypes: severe neonatal-onset with or without congenital anomalies, and a milder late-onset form. Clinical diagnosis is supported by urinary organic acid and blood acylcarnitine analysis using tandem mass spectrometry in newborn screening programs. MADD is an autosomal recessive trait caused by biallelic mutations in the ETFA, ETFB, and ETFDH genes encoding the alpha and beta subunits of the electron transfer flavoprotein (ETF) and ETF-coenzyme Q oxidoreductase enzymes. Despite significant advancements in sequencing techniques, many patients remain undiagnosed, impacting their access to clinical care and genetic counseling. In this report, we achieved a definitive molecular diagnosis in a newborn by combining whole-genome sequencing (WGS) with RNA sequencing (RNA-seq). Whole-exome sequencing and next-generation gene panels fail to detect variants, possibly affecting splicing, in deep intronic regions. Here, we report a unique deep intronic mutation in intron 1 of the ETFDH gene, c.35-959A>G, in a patient with early-onset lethal MADD, resulting in pseudo-exon inclusion. The identified variant is the third mutation reported in this region, highlighting ETFDH intron 1 vulnerability. It cannot be excluded that these intronic sequence features may be more common in other genes than is currently believed. This study highlights the importance of incorporating RNA analysis into genome-wide testing to reveal the functional consequences of intronic mutations.
New insight of human-IgH 3′regulatory regions in immunoglobulins switch
Rossella Cianci, Giorgio Mancino, Elena Galli, Eliseo Serone, Renato Massoud, et al.
Gene, 2023
Bioinformatic survey of CRISPR loci across 15 Serratia species
Maria Scrascia, Roberta Roberto, Pietro D'Addabbo, Yosra Ahmed, Francesco Porcelli, et al.
Microbiologyopen, 2023
The Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR‐associated proteins (CRISPR–Cas) system of prokaryotes is an adaptative immune defense mechanism to protect themselves from invading genetic elements (e.g., phages and plasmids). Studies that describe the genetic organization of these prokaryotic systems have mainly reported on the Enterobacteriaceae family (now reorganized within the order of Enterobacterales). For some genera, data on CRISPR–Cas systems remain poor, as in the case of Serratia (now part of the Yersiniaceae family) where data are limited to a few genomes of the species marcescens. This study describes the detection, in silico, of CRISPR loci in 146 Serratia complete genomes and 336 high‐quality assemblies available for the species ficaria, fonticola, grimesii, inhibens, liquefaciens, marcescens, nematodiphila, odorifera, oryzae, plymuthica, proteomaculans, quinivorans, rubidaea, symbiotica, and ureilytica. Apart from subtypes I‐E and I‐F1 which had previously been identified in marcescens, we report that of I‐C and the I‐E unique locus 1, I‐E*, and I‐F1 unique locus 1. Analysis of the genomic contexts for CRISPR loci revealed mdtN‐phnP as the region mostly shared (grimesii, inhibens, marcescens, nematodiphila, plymuthica, rubidaea, and Serratia sp.). Three new contexts detected in genomes of rubidaea and fonticola (puu genes‐mnmA) and rubidaea (osmE‐soxG and ampC‐yebZ) were also found. The plasmid and/or phage origin of spacers was also established.
Evolutive emergence and divergence of an Ig regulatory node: An environmental sensor getting cues from the aryl hydrocarbon receptor?
Pietro D'Addabbo, Domenico Frezza, Courtney E.W. Sulentic
Frontiers in Immunology, 2023
One gene, the immunoglobulin heavy chain (IgH) gene, is responsible for the expression of all the different antibody isotypes. Transcriptional regulation of the IgH gene is complex and involves several regulatory elements including a large element at the 3’ end of the IgH gene locus (3’RR). Animal models have demonstrated an essential role of the 3’RR in the ability of B cells to express high affinity antibodies and to express different antibody classes. Additionally, environmental chemicals such as aryl hydrocarbon receptor (AhR) ligands modulate mouse 3’RR activity that mirrors the effects of these chemicals on antibody production and immunocompetence in mouse models. Although first discovered as a mediator of the toxicity induced by the high affinity ligand 2,3,7,8-tetracholordibenzo-p-dioxin (dioxin), understanding of the AhR has expanded to a physiological role in preserving homeostasis and maintaining immunocompetence. We posit that the AhR also plays a role in human antibody production and that the 3’RR is not only an IgH regulatory node but also an environmental sensor receiving signals through intrinsic and extrinsic pathways, including the AhR. This review will 1) highlight the emerging role of the AhR as a key transducer between environmental signals and altered immune function; 2) examine the current state of knowledge regarding IgH gene regulation and the role of the AhR in modulation of Ig production; 3) describe the evolution of the IgH gene that resulted in species and population differences; and 4) explore the evidence supporting the environmental sensing capacity of the 3’RR and the AhR as a transducer of these cues. This review will also underscore the need for studies focused on human models due to the premise that understanding genetic differences in the human population and the signaling pathways that converge at the 3’RR will provide valuable insight into individual sensitivities to environmental factors and antibody-mediated disease conditions, including emerging infections such as SARS-CoV-2.
Genome characterization and CRISPR-Cas9 editing of a human neocentromere
Antonio Palazzo, Ilaria Piccolo, Crescenzio Francesco Minervini, Stefania Purgato, Oronzo Capozzi, et al.
Chromosoma, 2022
The maintenance of genome integrity is ensured by proper chromosome inheritance during mitotic and meiotic cell divisions. The chromosomal counterpart responsible for chromosome segregation to daughter cells is the centromere, at which the spindle apparatus attaches through the kinetochore. Although all mammalian centromeres are primarily composed of megabase-long repetitive sequences, satellite-free human neocentromeres have been described. Neocentromeres and evolutionary new centromeres have revolutionized traditional knowledge about centromeres. Over the past 20 years, insights have been gained into their organization, but in spite of these advancements, the mechanisms underlying their formation and evolution are still unclear. Today, through modern and increasingly accessible genome editing and long-read sequencing techniques, research in this area is undergoing a sudden acceleration. In this article, we describe the primary sequence of a previously described human chromosome 3 neocentromere and observe its possible evolution and repair results after a chromosome breakage induced through CRISPR-Cas9 technologies. Our data represent an exciting advancement in the field of centromere/neocentromere evolution and chromosome stability.
The Organization of the Pig T-Cell Receptor γ (TRG) Locus Provides Insights into the Evolutionary Patterns of the TRG Genes across Cetartiodactyla
Giovanna Linguiti, Francesco Giannico, Pietro D’Addabbo, Angela Pala, Anna Caputi Jambrenghi, et al.
Genes, 2022
The domestic pig (Sus scrofa) is a species representative of the Suina, one of the four suborders within Cetartiodactyla. In this paper, we reported our analysis of the pig TRG locus in comparison with the loci of species representative of the Ruminantia, Tylopoda, and Cetacea suborders. The pig TRG genomic structure reiterates the peculiarity of the organization of Cetartiodactyla loci in TRGC “cassettes”, each containing the basic V-J-J-C unit. Eighteen genes arranged in four TRGC cassettes, form the pig TRG locus. All the functional TRG genes were expressed, and the TRGV genes preferentially rearrange with the TRGJ genes within their own cassette, which correlates the diversity of the γ-chain repertoire with the number of cassettes. Among them, the TRGC5, located at the 5′ end of the locus, is the only cassette that retains a marked homology with the corresponding TRGC cassettes of all the analyzed species. The preservation of the TRGC5 cassette for such a long evolutionary time presumes a highly specialized function of its genes, which could be essential for the survival of species. Therefore, the maintenance of this cassette in pigs confirms that it is the most evolutionarily ancient within Cetartiodactyla, and it has undergone a process of duplication to give rise to the other TRGC cassettes in the different artiodactyl species in a lineage-specific manner.
A high-resolution map of small-scale inversions in the gibbon genome
Ludovica Mercuri, Donato Palmisano, Alberto L'Abbate, Pietro D'Addabbo, Francesco Montinaro, et al.
Genome Research, 2022
Gibbons are the most speciose family of living apes, characterized by a diverse chromosome number and rapid rate of large-scale rearrangements. Here we performed single-cell template strand sequencing (Strand-seq), molecular cytogenetics, and deep in silico analysis of a southern white-cheeked gibbon genome, providing the first comprehensive map of 238 previously hidden small-scale inversions. We determined that more than half are gibbon specific, at least fivefold higher than shown for other primate lineage-specific inversions, with a significantly high number of small heterozygous inversions, suggesting that accelerated evolution of inversions may have played a role in the high sympatric diversity of gibbons. Although the precise mechanisms underlying these inversions are not yet understood, it is clear that segmental duplication–mediated NAHR only accounts for a small fraction of events. Several genomic features, including gene density and repeat (e.g., LINE-1) content, might render these regions more break-prone and susceptible to inversion formation. In the attempt to characterize interspecific variation between southern and northern white-cheeked gibbons, we identify several large assembly errors in the current GGSC Nleu3.0/nomLeu3 reference genome comprising more than 49 megabases of DNA. Finally, we provide a list of 182 candidate genes potentially involved in gibbon diversification and speciation.
Analysis of four new enterococcus faecalis phages and modeling of a hyaluronidase catalytic domain from saphexavirus
Gustavo Di Lallo, Mattia Falconi, Federico Iacovelli, Domenico Frezza, Pietro D'Addabbo
Phage Therapy Applications and Research, 2021
A genomic survey of Tc1-mariner transposons in nematodes suggests extensive horizontal transposon transfer events
Antonio Palazzo, Elsa Escuder, Pietro D'Addabbo, Domenica Lovero, René Massimiliano Marsano
Molecular Phylogenetics and Evolution, 2021
The genomic organisation of the tra/trd locus validates the peculiar characteristics of dromedary δ-chain expression
Serafina Massari, Giovanna Linguiti, Francesco Giannico, Pietro D’Addabbo, Salvatrice Ciccarese, et al.
Genes, 2021
The establishment of a fungal consortium in a new winery
Hany Abdo, Claudia Rita Catacchio, Mario Ventura, Pietro D’Addabbo, Hervé Alexandre, et al.
Scientific Reports, 2020
Antimicrobial resistance gene shuffling and a three-element mobilisation system in the monophasic Salmonella typhimurium strain ST1030
M. Oliva, C. Calia, M. Ferrara, P. D'Addabbo, M. Scrascia, et al.
Plasmid, 2020
Concerted variation of the 3′ regulatory region of Ig heavy chain and Gm haplotypes across human continental populations
Domenico Frezza, Cristina Martinez‐Labarga, Vincenzo Giambra, Eliseo Serone, Giuseppina Scano, et al.
American Journal of Physical Anthropology, 2020
Colonization of wild saccharomyces cerevisiae strains in a new winery
Hany Abdo, Claudia R. Catacchio, Mario Ventura, Pietro D’Addabbo, Francesco Maria Calabrese, et al.
Beverages, 2020
Characterization of CRISPR-cas systems in serratia marcescens isolated from Rhynchophorus ferrugineus (Olivier, 1790) (coleoptera: Curculionidae)
Maria Scrascia, Pietro D’Addabbo, Roberta Roberto, Francesco Porcelli, Marta Oliva, et al.
Microorganisms, 2019
Concurrent chromothripsis events in a case of TP53 depleted acute myeloid leukemia with myelodysplasia-related changes
D. Tolomeo, A. L'Abbate, A. Lonoce, P. D'Addabbo, M.F. Miccoli, et al.
Cancer Genetics, 2019
Genomic inversions and GOLGA core duplicons underlie disease instability at the 15q25 locus
Flavia A. M. Maggiolini, Stuart Cantsilieris, Pietro D’Addabbo, Michele Manganelli, Bradley P. Coe, et al.
Plos Genetics, 2019
MYC-containing amplicons in acute myeloid leukemia: genomic structures, evolution, and transcriptional consequences
Alberto L′Abbate, Doron Tolomeo, Ingrid Cifola, Marco Severgnini, Antonella Turchiano, et al.
Leukemia, 2018
Correction to: MYC-containing amplicons in acute myeloid leukemia: genomic structures, evolution, and transcriptional consequences (Leukemia, (2018), 32, 10, (2152-2166), 10.1038/s41375-018-0033-0)
Alberto L’Abbate, Doron Tolomeo, Ingrid Cifola, Marco Severgnini, Antonella Turchiano, et al.
Leukemia, 2018
Association between Psoriasis and haplotypes of the IgH 3’ Regulatory Region 1
Pietro D'Addabbo, Eliseo Serone, Maria Esposito, Gabriele Vaccari, Cesare Gargioli, et al.
Gene, 2018
Inversion variants in human and primate genomes
Claudia Rita Catacchio, Flavia Angela Maria Maggiolini, Pietro D'Addabbo, Miriana Bitonto, Oronzo Capozzi, et al.
Genome Research, 2018
Association between IgH enhancer hs1.2 and type 1 diabetes
Rossella Cianci, Pietro D’Addabbo, Giovanni Gambassi, Serena Lolli, Eliseo Serone, et al.
Acta Diabetologica, 2018
Myoblast myogenic differentiation but not fusion process is inhibited via MyoD tetraplex interaction
Stefano Testa, Pietro D’Addabbo, Ersilia Fornetti, Roberta Belli, Claudia Fuoco, et al.
Oxidative Medicine and Cellular Longevity, 2018
Epigenetic origin of evolutionary novel centromeres
Doron Tolomeo, Oronzo Capozzi, Roscoe R. Stanyon, Nicoletta Archidiacono, Pietro D’Addabbo, et al.
Scientific Reports, 2017
A novel group of IncQ1 plasmids conferring multidrug resistance
M. Oliva, R. Monno, P. D'Addabbo, G. Pesole, A.M. Dionisi, et al.
Plasmid, 2017
Evidence for a quadruplex structure in the polymorphic hs1.2 enhancer of the immunoglobulin heavy chain 3’ regulatory regions and its conservation in mammals
Marco Sette, Pietro D'Addabbo, Geoffrey Kelly, Alessandro Cicconi, Emanuela Micheli, et al.
Biopolymers, 2016
Inter-varietal structural variation in grapevine genomes
Maria Francesca Cardone, Pietro D'Addabbo, Can Alkan, Carlo Bergamini, Claudia Rita Catacchio, et al.
Plant Journal, 2016
Identification of pigmented Serratia marcescens symbiotically associated with Rhynchophorus ferrugineus Olivier (Coleoptera: Curculionidae)
Maria Scrascia, Carlo Pazzani, Franco Valentini, Marta Oliva, Valentina Russo, et al.
Microbiologyopen, 2016
Identification of Bari transposons in 23 sequenced Drosophila genomes reveals novel structural variants, MITEs and horizontal transfer
Antonio Palazzo, Domenica Lovero, Pietro D’Addabbo, Ruggiero Caizzi, René Massimiliano Marsano
Plos One, 2016
Ring chromosomes, breakpoint clusters, and neocentromeres in sarcomas
Gemma Macchia, Karolin H. Nord, Monica Zoli, Stefania Purgato, Pietro D'Addabbo, et al.
Genes Chromosomes and Cancer, 2015
Involvement of DNA methylation in the control of cell growth during heat stress in tobacco BY-2 cells
Isabella Centomani, Alessandra Sgobba, Pietro D’Addabbo, Nunzio Dipierro, Annalisa Paradiso, et al.
Protoplasma, 2015
The change in Ig regulation from children to adults disconnects the correlation with the 3'RR hs1.2 polymorphism
Eliseo Serone, Cristina Daleno, Nicola Principi, Laura Porretti, Valentina Iacoacci, et al.
BMC Immunology, 2014
Isolation and partial characterization of bacteriophages infecting Pseudomonas syringae pv. actinidiae, causal agent of kiwifruit bacterial canker
Gustavo Di Lallo, Matteo Evangelisti, Francesco Mancuso, Patrizia Ferrante, Simone Marcelletti, et al.
Journal of Basic Microbiology, 2014
Genomic organization and evolution of double minutes/homogeneously staining regions with MYC amplification in human cancer
Alberto L'Abbate, Gemma Macchia, Pietro D'Addabbo, Angelo Lonoce, Doron Tolomeo, et al.
Nucleic Acids Research, 2014
Polymorphisms of the IgH enhancer HS1.2 and risk of systemic lupus erythematosus
Domenico Frezza, Barbara Tolusso, Vincenzo Giambra, Elisa Gremese, Maurizio Marchini, et al.
Annals of the Rheumatic Diseases, 2012
Mosquitoes ltr retrotransposons: A deeper view into the genomic sequence of culex quinquefasciatus
Renè Massimiliano Marsano, Daniela Leronni, Pietro D'Addabbo, Luigi Viggiano, Eustachio Tarasco, et al.
Plos One, 2012
Balkan endemic nephropathy risk associates to the hs1.2 Ig enhancer polymorphism
D. Frezza, E. Serone, S. Lolli, R. Cianci, P. D'Addabbo, et al.
European Journal of Inflammation, 2012
Refinement of Bos taurus sequence assembly based on BAC-FISH experiments
Giulia Partipilo, Pietro D'Addabbo, Giovanni M Lacalandra, George E Liu, Mariano Rocchi
BMC Genomics, 2011
Analysis of high-identity segmental duplications in the grapevine genome
Giuliana Giannuzzi, Pietro D'Addabbo, Marica Gasparro, Maurizio Martinelli, Francesco N Carelli, et al.
BMC Genomics, 2011
Position and sequence conservation in Amniota of polymorphic enhancer HS1.2 within the palindrome of IgH 3'Regulatory Region
Pietro D'Addabbo, Moira Scascitelli, Vincenzo Giambra, Mariano Rocchi, Domenico Frezza
BMC Evolutionary Biology, 2011
Gene amplification as doubleminutes or homogeneously staining regions in solid tumors: Origin and structure
Clelia Tiziana Storlazzi, Angelo Lonoce, Maria C. Guastadisegni, Domenico Trombetta, Pietro D'Addabbo, et al.
Genome Research, 2010
Genomic segmental duplications on the basis of the t(9;22) rearrangement in chronic myeloid leukemia
F Albano, L Anelli, A Zagaria, N Coccaro, P D'Addabbo, et al.
Oncogene, 2010
Characterization of a hotspot region on chromosome 12 for amplification in ring chromosomes in atypical lipomatous tumors
Domenico Trombetta, Fredrik Mertens, Angelo Lonoce, Pietro D'Addabbo, Karin Rennstam, et al.
Genes Chromosomes and Cancer, 2009
Evolutionary descent of a human chromosome 6 neocentromere: A jump back to 17 million years ago
Oronzo Capozzi, Stefania Purgato, Pietro D'Addabbo, Nicoletta Archidiacono, Paola Battaglia, et al.
Genome Research, 2009
A satellite-like sequence, representing a "clone gap" in the human genome, was likely involved in the seeding of a novel centromere in macaque
Lucia Carbone, Pietro D’addabbo, Maria Francesca Cardone, Maria Grazia Teti, Doriana Misceo, et al.
Chromosoma, 2009
Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: On behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP)
Ilaria Iacobucci, Clelia Tiziana Storlazzi, Daniela Cilloni, Annalisa Lonetti, Emanuela Ottaviani, et al.
Blood, 2009
Evolutionary-new centromeres preferentially emerge within gene deserts
Mariana Lomiento, Zhaoshi Jiang, Pietro D'Addabbo, Evan E Eichler, Mariano Rocchi
Genome Biology, 2008
Bone marrow ectopic expression of a non-coding RNA in childhood T-cell acute lymphoblastic leukemia with a novel t(2;11)(q11.2;p15.1) translocation
Maria Corsignano Guastadisegni, Angelo Lonoce, Luciana Impera, Francesco Albano, Pietro D'Addabbo, et al.
Molecular Cancer, 2008
Hominoid chromosomal rearrangements on 17q map to complex regions of segmental duplication
Maria Francesca Cardone, Zhaoshi Jiang, Pietro D'Addabbo, Nicoletta Archidiacono, Mariano Rocchi, et al.
Genome Biology, 2008
Evolutionary history of chromosome 11 featuring four distinct centromere repositioning events in Catarrhini
Maria Francesca Cardone, Mariana Lomiento, Maria Grazia Teti, Doriana Misceo, Roberta Roberto, et al.
Genomics, 2007
Evolutionary formation of new centromeres in macaque
Mario Ventura, Francesca Antonacci, Maria Francesca Cardone, Roscoe Stanyon, Pietro D'Addabbo, et al.
Science, 2007
Independent centromere formation in a capricious, gene-free domain of chromosome 13q21 in Old World monkeys and pigs
Maria Francesca Cardone, Alicia Alonso, Michele Pazienza, Mario Ventura, Gabriella Montemurro, et al.
Genome Biology, 2006
Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3)
Silvia Canaider, Federica Facchin, Cristiana Griffoni, Raffaella Casadei, Lorenza Vitale, et al.
Gene, 2006
MYC-containing double minutes in hematologic malignancies: Evidence in favor of the episome model and exclusion of MYC as the target gene
Clelia Tiziana Storlazzi, Thoas Fioretos, Cecilia Surace, Angelo Lonoce, Angela Mastrorilli, et al.
Human Molecular Genetics, 2006
t(3;12)(q26;q14) in polycythemia vera is associated with upregulation of the HMGA2 gene [9]
C T Storlazzi, F Albano, C Locunsolo, A Lonoce, S Funes, et al.
Leukemia, 2006
Molecular cytogenetic characterization of an ins(4;X) occurring as the sole abnormality in an aggressive, poorly differentiated soft tissue sarcoma
Cecilia Surace, Clelia Tiziana Storlazzi, Jacob Engellau, Henryk A. Domanski, Pelle Gustafson, et al.
Virchows Archiv, 2005
Uncertainty principle of genetic information in a living cell
Pierluigi Strippoli, Silvia Canaider, Francesco Noferini, Pietro D'Addabbo, Lorenza Vitale, et al.
Theoretical Biology and Medical Modelling, 2005
Evolutionary history of chromosome 20
D. Misceo
Molecular Biology and Evolution, 2005
GeneRecords: A relational database for GenBank flat file parsing and data manipulation in personal computers
P. D'Addabbo, L. Lenzi, F. Facchin, R. Casadei, S. Canaider, et al.
Bioinformatics, 2004
Gene expression profile analysis in human T lymphocytes from patients with Down syndrome
S. Giannone, P. Strippoli, L. Vitale, R. Casadei, S. Canaider, et al.
Annals of Human Genetics, 2004
Recurrent sites for new centromere seeding
Mario Ventura, Stefania Weigl, Lucia Carbone, Maria Francesca Cardone, Doriana Misceo, et al.
Genome Research, 2004
Sequence analysis of ADARB1 gene in patients with familial bipolar disorder
Mario Amore, Pierluigi Strippoli, Caterina Laterza, Pietro Tagariello, Lorenza Vitale, et al.
Journal of Affective Disorders, 2004
mRNA 5′ region sequence incompleteness: A potential source of systematic errors in translation initiation codon assignment in human mRNAs
Raffaella Casadei, Pierluigi Strippoli, Pietro D'Addabbo, Silvia Canaider, Luca Lenzi, et al.
Gene, 2003
The human TruB family of pseudouridine synthase genes, including the Dyskeratosis Congenita 1 gene and the novel member TRUB1.
Cinzia Zucchini, Pierluigi Strippoli, Alessia Biolchi, Rossella Solmi, Luca Lenzi, et al.
International Journal of Molecular Medicine, 2003
Segmental paralogy in the human genome: A large-scale triplication on 1p, 6p, and 21q
Pierluigi Strippoli, Pietro D'Addabbo, Luca Lenzi, Sandra Giannone, Silvia Canaider, et al.
Mammalian Genome, 2002
Cysteine and tyrosine-rich 1 (CYYR1), a novel unpredicted gene on human chromosome 21 (21q21.2), encodes a cysteine and tyrosine-rich protein and defines a new family of highly conserved vertebrate-specific genes
Lorenza Vitale, Raffaella Casadei, Silvia Canaider, Luca Lenzi, Pierluigi Strippoli, et al.
Gene, 2002

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