Priya Iyer
@wcc.edu.in
Associate Professor Biotechnology
Womens Christian College Chennai
1
Scopus Publications
109
Scholar Citations
1
Scholar h-index
1
Scholar i10-index
Scopus Publications
- Determination of anti-tuberculosis activity of biosynthesized gold nanocompounds against M. tuberculosis H37RV
M.R.Kamala Priya, Magizhaveni Balasubramanian, Christy Rosaline Nirmal, Azger Dusthakeer, and Priya R. Iyer
Elsevier BV - Nanomedicine perspective in HIV therapy: biosynthesized gold nanoparticles exhibiting enhanced anti-HIV property
M. R. Kamala Priya, Manickam Ashokkumar, Lucia K. Precilla, Luke Elizabeth Hanna, and Priya R. Iyer
Springer Science and Business Media LLC
Abstract Background Globally, HIV/AIDS is a major public health issue. Currently, available antiretroviral therapy (ART) has a number of impediments. The need for long-term usage of antiretroviral drugs is associated with the problem of drug resistance, high cost, and other side effects. Hence, there is a constant urge for the development of novel drugs to combat the disease. The synthesis of nanoparticles is of great interest because of their reported application in diverse fields. In contrast to chemical synthesis, green synthesis is inexpensive and enviro-safe. Results Calophyllum inophyllum (CI) is a plant that is known to possess anti-HIV activity. Hence, this plant was exploited for the synthesis of gold nanoparticles (AuNPs) in the present study. Two parts of the plant, namely, the fruit and leaves (CIF and CIL) were used for the synthesis of nanocompounds. The two nanocompounds were tested on HIV-1 isolates at different concentrations and the EC50 values were determined. While CIF-AuNP demonstrated very good anti-HIV activity with an EC50 value of 0.09097 ng/ml, CIL-AuNPs did not show significant anti-HIV activity. Conclusions The present study is a novel attempt to produce nanocompounds that incorporate the medicinal properties of certain plants that are known to have anti-HIV activity within nanoparticles, such that the compound possesses the attributes of a nanomaterial alongside the phytoactivity. Our results provide evidence to suggest that the CIF-AuNP can be further explored for in vivo activity. In vitro cytotoxicity of the AuNPs was checked in VERO cell lines using the MTT assay. Cytotoxicity was observed to be minimal at all the tested concentrations. - Production Of Plastic Degrading Enzymes From Organisms Isolated From Plastic Polluted Areas
- Antiproliferative effects on tumor cells of the synthesized gold nanoparticles against Hep2 liver cancer cell line
Kamala Priya M R and Priya R. Iyer
Springer Science and Business Media LLC
Abstract Background Currently, nanomaterials (NMs) research and development is at a fastest pace due to the enhanced implication in different areas of applications. The synthesis of such NMs through biosynthesis methods is gaining much importance because of low cost involved and environment-friendly approach. In this present study, the nanoparticles (NPs) are synthesized using a medicinal plant, with anticancer properties so as to incorporate the therapeutic activity within the NPs, such that the NPs will have the attributes of NMs alongside the phytoactivity. Results The synthesis of gold nanoparticles (AuNPs) using Graviola, the fruit of Annona muricata (Ramaphal fruit) commonly referred as Mullu seetha fruit (Tamil), was successfully carried out. The initial confirmations of the NPs were using UV-vis spectra, which showed the characteristic peak for the NPs. HRSEM analysis gave an insight on the size and morphology of the NPs. The zeta potential was measured to check the stability of the NPs. The cytotoxicity was carried out in VERO cell line and anticancer study in Hep2 liver cancer cell line. The surface plasmon resonance (SPR) band showed the characteristic peak at 536 nm for the AuNPs. In SEM micrographs, the size was ranging between 20 and 30 nm, on an average of 15 nm with spherical morphology. On the various tested concentrations in VERO cell line, the nanoparticles were non-toxic to the cells. The anticancer study gave an IC50 value at 10.94 μg/ml. Conclusions The NPs showed anticancer activity in treated Hep2 liver cancer cell line and as well as commendable non-toxic effect on normal VERO cell line. The results pose a positive impact to expand further studies in the development of potential drug molecules to tackle the disease of interest. - Apoptotic Activity in Cervical Cancer HeLa Cell Lines Treated with Chitosan Nanoconjugated Drug Doxorubicin – as Nanocarrier for Drug Delivery
M. R. Kamala Priya and Priya R. Iyer
Springer International Publishing
Nanocarriers play an indispensible role in drug delivery mechanisms thereby increasing the efficiency and overall activity of the specified drug in the given dosage. Chitosan is a well known biocompatible molecule that is exploited for various in vivo applications. In this current study, a biocompatible nanocarrier is developed as a conjugate using chitosan nanoparticles for the drug Doxorubicin. A nanoparticle is synthesized using the green extract of a medicinal plant. Upon successful synthesis, a chitosan conjugate is prepared along with the drug and synthesized nanoparticles. The synthesis of gold nanomaterials using Catharanthus roseus (Nithyakalyani) is successfully carried out. The initial confirmation of the nanoconjugate is from UV visible spectrophotometric analysis, which showed the characteristic peak for nanoparticles. SEM & HRSEM analysis revealed the size and shape of the nanocojugate. The Zeta potential is measured to check the stability of the nanoconjugate. The in vitro cytotoxicity is carried out in VERO cell lines and anti cancer study in cervical cancer HeLa cell lines. Further, the gene expression of one of the apoptotic molecule, Caspase was screened. The nanocarrier showed anti cancer activity in treated cervical cancer HeLa cell lines and as well as commendable non toxicity in treated normal vero cell lines. On this positive note, this nanocarrier study could be further expanded. - Isolation and characterization of pigments from microorganisms isolated from marine soil
P. Senthamil Selvi and Priya Iyer
A and V Publications - Isolation, identification and antimicrobial activity of bioactive compound from saraca asoca
- Anticancer studies of the synthesized gold nanoparticles against MCF 7 breast cancer cell lines
M. R. Kamala Priya and Priya R. Iyer
Springer Science and Business Media LLC
It has been previously stated that gold nanoparticles have been successfully synthesized using various green extracts of plants. The synthesized gold nanoparticles were characterized under scanning electron microscopy and EDX to identify the size of the nanoparticles. It was found that the nanoparticles were around 30 nm in size, which is a commendable nano dimension achieved through a plant mediated synthesis. The nanoparticles were further studied for their various applications. In the current study, we have made attempts to exploit the anticancer ability of the gold nano particles. The nanoparticles were studied against MCF 7 breast cancer cell lines. The results obtained from the studies of anticancer activity showed that gold nanoparticles gave an equivalent good results, in par with the standard drugs against cancer. The AuNP’s proved to be efficient even from the minimum concentrations of 2 μg/ml, and as the concentration increased the anticancer efficacy as well increased. - Antibiotic efficacy of cinnamon (cinnamon zeylanicum) against urinary pathogens in type II diabetic men
T. Sivapriya, Sheila John, and Priya R. Iyer
Informa UK Limited
The antibiotic efficacy of cinnamon (Cinnamon zeylanicum) powder on type-2 male diabetic subjects was investigated. A total of 24 type-2 male diabetic subjects were randomly assigned into experimental and control group. The experimental group consumed 1 g cinnamon powder capsule daily for a period of 45 d. Antimicrobial activity of cinnamon powder was evaluated against pathogens causing urinary tract infection before and after supplementation and compared against standard antibiotics. Urine culture examination indicated Escherichia coli as the most predominant pathogen causing urinary tract infection. The minimum inhibitory concentration (MIC) value of cinnamon extract was found to be 0.452 μg whereas the MIC of erythromycin and tetracycline were 10 μg and 30 μg, respectively. The supplementation of cinnamon capsule did not have any effect on gram-negative bacteria. - Comparative study of the production of biosurfactant by Pseudomonas fluorescens 2421 and Pseudomonas aeroginosa isolated from soil
- Isolation, characterization and purification of chitinase from Penicillium, Pseudomonas and Bacillus amyloliquefaciens
- Antimicrobial activity of Aloevera barbedensis, Daucus carota, Emblica officinalis, Honey and Punica granatum and formulation of a health drink and salad
- Deinking of note book papers and effuent degradation using Aspergillus fumigatus
- Antagonistic activity of probiotic organism against Vibrio cholerae and Cryptococcus neoformans
- Production, purification and application of collagenase
RECENT SCHOLAR PUBLICATIONS
- In vitro efficacy of cinnamon derived copper nanoconjugates against drug-resistant and sensitive strains of Mycobacterium tuberculosis
P Rajan, A Devi, A Dusthackeer, PR Iyer
SCIREA Journal of Information Science and Systems Science 8 (4), 139-153 2024 - A Green perspective on the ability of nanomedicine to inhibit tuberculosis and lung cancer
P Rajan, A Devi, A Dusthackeer, P Iyer
International Research Journal on Advanced Science Hub 5 (11), 389-396 2023 - Determination of anti-tuberculosis activity of biosynthesized gold nanocompounds against M. tuberculosis H37RV
MRK Priya, M Balasubramanian, CR Nirmal, A Dusthakeer, PR Iyer
Indian Journal of Tuberculosis 70 (3), 329-338 2023 - Isolation of bacteria producing lipase from copra (Cocos nucifera l.) Cake for degradation of vegetable waste oils
KM Bethapudi, PR Iyer
2023 - Biosynthesis and optimization of highly stable gold nanoparticles, nanoconjugates, nanodrug conjugates and chitosan nanoconjugates using medicinal plants
MRK Priya, PR Iyer
Bulletin of the National Research Centre 46 (1), 134 2022 - Nanomedicine perspective in HIV therapy: biosynthesized gold nanoparticles exhibiting enhanced anti-HIV property
MRK Priya, M Ashokkumar, LK Precilla, LE Hanna, PR Iyer
Beni-Suef University Journal of Basic and Applied Sciences 10, 1-12 2021 - A study on ER stress-induced apoptosis pathway in cervical cancer HeLa cells treated with biosynthesized gold nanoparticles
MR Kamala Priya, PR Iyer
Bulletin of the National Research Centre 45, 1-8 2021 - ACUTE 8 AND CHRONIC TOXICOLOGICAL STUDIES OF THE BIOSYNTHESIZED GOLD NANOPARTICLES ON WISTAR RATS
MRK Priya, PR Iyer
Journal of Advanced Scientific Research 12 (03 Suppl 1), 54-66 2021 - A review on antifungal agents against Candida albicans and Aspergillus niger
R Vishnuvardhini, PR Iyer
International Journal of Biological and Pharmaceutical Sciences Archive 2 2021 - Antiproliferative effects on tumor cells of the synthesized gold nanoparticles against Hep2 liver cancer cell line
K Priya MR, PR Iyer
Egyptian Liver Journal 10, 1-12 2020 - Characterisation of the biosynthesised gold nanomaterials-spectroscopic, dimensional, morphological, stability and structural analysis
MRK Priya, PR Iyer
International Journal of Biomedical Nanoscience and Nanotechnology 4 (3-4 2020 - Molecular and Phenotypic Evaluation of the Mesenchymal-Type Cell Population from Early-Phase Patient-Derived Cultures of Neuroblastoma for Personalized Drug Response Testing
EXY Hee, MK Wong, SH Tan, ZX Chen, Z Choo, CH Kuick, SAC Ling, ...
PEDIATRIC BLOOD & CANCER 66, S55-S55 2019 - Chitosan based films incorporated with turmeric/clove/ginger essential oil for food packaging
M Yashaswini, P Iyer
J. Nanomed. Nanotechnol 10, 537 2019 - Scalable Production of Collagen Isolated from Streptococcus pyogenes
RM Akshaya, PR Iyer
Int. J. Curr. Microbiol. App. Sci 8 (9), 2565-2578 2019 - Apoptotic Activity in Cervical Cancer HeLa Cell Lines Treated with Chitosan Nanoconjugated Drug Doxorubicin–as Nanocarrier for Drug Delivery
MR Kamala Priya, PR Iyer
Proceedings of the International Conference on Nanomedicine (ICON-2019), 42-53 2019 - Isolation and characterization of pigments from marine soil microorganisms
PS Selvi, P Iyer
IJLSSR 4, 2003-2011 2018 - Biosciences and Plant Biology
R Gautami, P Iyer
Int. J. Curr. Res. Biosci. Plant Biol 5 (1), 60-66 2018 - Ex-traction of dopamine, serotonin, and gamma-aminobutyric acid from Lactobacillus spp and yeast
A Pragalya, P Iyer
International Journal of Neuroscience Research 2, 8 2018 - Naringin loaded chitosan nanoparticle for bone regeneration: A preliminary in vitro study
S Malathy, PR Iyer
J. Nanomed. Nanotechnol 9 (4.10), 4172 2018 - Biosynthesis, characterization and application of chitin nanoparticle with Cassia auriculata
B Dhandapani, PR Iyer
American Journal of Biomedical and Life Sciences 6 (5), 96-102 2018
MOST CITED SCHOLAR PUBLICATIONS
- An 80-tile 1.28 TFLOPS network-on-chip in 65nm CMOS
S Vangal, J Howard, G Ruhl, S Dighe, H Wilson, J Tschanz, D Finan, ...
2007 IEEE International Solid-State Circuits Conference. Digest of Technical 2007
Citations: 966 - Anticancer studies of the synthesized gold nanoparticles against MCF 7 breast cancer cell lines
MR Kamala Priya, PR Iyer
Applied nanoscience 5 (4), 443-448 2015
Citations: 60 - Antiproliferative effects on tumor cells of the synthesized gold nanoparticles against Hep2 liver cancer cell line
K Priya MR, PR Iyer
Egyptian Liver Journal 10, 1-12 2020
Citations: 59 - Antimicrobial efficacy of mango peel powder and formulation of recipes using mango peel powder (Mangifera indica L.)
PA Thambi, S John, E Lydia, P Iyer, SJ Monica
Int. J. Home Sci 2 (2), 155-161 2016
Citations: 38 - Antimicrobial activity of aloevera barbedensis, daucus carota, emblica officinalis, honey and punica granatum and formulation of a health drink and salad
J Philip, S John, P Iyer
Malays J Microbiol 8 (3), 141-147p 2012
Citations: 32 - Naringin loaded chitosan nanoparticle for bone regeneration: A preliminary in vitro study
S Malathy, PR Iyer
J. Nanomed. Nanotechnol 9 (4.10), 4172 2018
Citations: 24 - Chitosan based films incorporated with turmeric/clove/ginger essential oil for food packaging
M Yashaswini, P Iyer
J. Nanomed. Nanotechnol 10, 537 2019
Citations: 17 - Isolation and optimization of PHB (poly-β-hydroxybutyrate) based biodegradable plastics from Chlorella vulgaris
R Robert, PR Iyer
Journal of Bioremediation & Biodegradation 9 (2), 2-5 2018
Citations: 17 - Anti-microbial, anti-fungal and anti-carcinogenic properties of coconut milk kefir
TS Lakshmi, A MaryPramela, P Iyer
Int. J. Home Sci 3, 365-369 2017
Citations: 17 - Testing high-speed IO links using on-die circuitry
P Iyer, S Jain, B Casper, J Howard
19th International Conference on VLSI Design held jointly with 5th 2006
Citations: 15 - Antibacterial activity of mangosteen (Garcinia mangostana) pericarp
D Jacob, N Vigasini, PR Iyer
World J. Pharm. Res 5 (9), 1797-1802 2016
Citations: 10 - Nanomedicine perspective in HIV therapy: biosynthesized gold nanoparticles exhibiting enhanced anti-HIV property
MRK Priya, M Ashokkumar, LK Precilla, LE Hanna, PR Iyer
Beni-Suef University Journal of Basic and Applied Sciences 10, 1-12 2021
Citations: 9 - Isolation, identification and antimicrobial activity of bioactive compound from Saraca asoca
M Maman, A Devi, P Iyer, ARJ Singh, P Jeyakumar
Int J Curr Pharm Res 8 (1), 57-61 2016
Citations: 7 - Antimicrobial activity and characterisation of microflora of vinegar preparations developed from peels and fruit of sweet lime
S Priyadarshini, S John, P Iyer
European Journal of Biotechnology and Bioscience 2 (2), 42-45 2014
Citations: 7 - Extracellular rapid biosynthesis of AuNP’s using various green extracts of plants
MR Kamala Priya, PR Iyer
International journal of molecular biology & biochemistry 2, 33-40 2014
Citations: 7 - Biosynthesis and optimization of highly stable gold nanoparticles, nanoconjugates, nanodrug conjugates and chitosan nanoconjugates using medicinal plants
MRK Priya, PR Iyer
Bulletin of the National Research Centre 46 (1), 134 2022
Citations: 6 - Studies on the various parameters underlying the Synthesis of nanoparticles and the in-vitro stability of nanoparticles
MR Kamala Priya, PR Iyer
Front Biotechnol 1, 1-4 2014
Citations: 6 - Tuberculosis in buffaloes.
PRK Iyer
1944
Citations: 6 - Comparitive study on the characterisation of AuNP’s synthesized using various plant extracts
MR Kamala Priya, PR Iyer
International Journal of Phytotherapy 5, 17-21 2015
Citations: 5 - Determination of anti-tuberculosis activity of biosynthesized gold nanocompounds against M. tuberculosis H37RV
MRK Priya, M Balasubramanian, CR Nirmal, A Dusthakeer, PR Iyer
Indian Journal of Tuberculosis 70 (3), 329-338 2023
Citations: 4