Patricia Nivoloni Tannure

EDUCATION

PhD in Dentistry - Pediatric Dentistry

RESEARCH INTERESTS

dental caries, satisfaction, cleft lip and palate, genetics

Scopus Publications

Periodontal Disease May Be Diagnosed Using the Matrix Metalloproteinase (aMMP)-8 Point-of-Care Test
Patricia Nivoloni Tannure and Daniel Demétrio Faustino-Silva
Elsevier BV



TOTAL ANTIOXIDANT CAPACITY MAY NOT BE AN ACCURATE WAY TO PREDICT DENTAL CARIES
PATRICIA NIVOLONI TANNURE and DANIEL DEMÉTRIO FAUSTINO-SILVA
Elsevier BV



Is YouTube^TM a reliable source of information regarding ultra-thin ceramic laminates?
Marceli de França, Caroline Uemoto, Dennis de Carvalho Ferreira, Maíra do Prado, and Patricia Nivoloni Tannure
Universidade Estadual de Campinas
An aesthetic smile is usually associated with healthy appearance and success in many areas of life. Currently, individuals access the internet and social media in search of health information. The aim of this study was to analyse the quality and reliability of information in videos available on the YouTubeTM platform about ultra-thin ceramic laminates. Methods: YouTubeTM was searched using the therms “dental ceramic laminates” and “dental contact lens” for videos uploaded on ultra-thin ceramic laminates. The first 100 videos in Portuguese were selected and rated for quality and reliability. The content and source of videos were also noted. The quality of the videos was determined by evaluating the presence or absence of reliable information and distributed into seven domains. To compare the distributions of quantitative variables between the classifications of source, content, and quality, the Kruskal-Wallis and Dunn’s post-hoc tests were performed. Results: Seventy-two videos were included for qualitative analysis. Regarding quality rating, most videos were rated with poor quality. The reliability of the evaluated videos was low. Conclusion: YouTubeTM showed a large number of videos with many views on the topic, but it does not contribute with good quality and reliable information to the population.


Color change, tooth sensitivity, aesthetic self-perceptions and quality of life after at-home dental bleaching




Oral changes associated with the presence of atopy in children: a cross-sectional study
Bruna Mara RUAS, Marianne de Oliveira NASCIMENTO, Marceli DE FRANÇA, Camila Stofella SODRÉ, Patricia Nivoloni TANNURE, and Dennis de Carvalho FERREIRA
FapUNIFESP (SciELO)
Resumo Introdução É por meio da interação entre ambiente, indivíduo, sua predisposição à atopia e exposição a alérgenos que surgem as doenças alérgicas. Em crianças atópicas, foi observada uma alta prevalência de padrão respirador bucal, assim como resposta positiva a testes alérgicos. Essas alterações respiratórias possuem uma associação com deformidades orofaciais, especialmente as maloclusões. Objetivo Identificar a frequência de crianças e adolescentes portadores de alergias e buscar uma provável associação entre atopia e maloclusão, traumatismos dentoalveolares e hábitos bucais viciosos. Material e método Foram avaliados prontuários de crianças e adolescentes atendidos em duas instituições particulares de ensino da cidade do Rio de Janeiro no período compreendido entre agosto de 2017 e julho de 2018. Foram coletados dados do prontuário relacionados ao histórico médico, odontológico e de alergias. Os dados foram analisados descritivamente e por meio do teste qui-quadrado (p<0,05). Resultado Um total de 136 prontuários foi considerado elegível para avaliação. Durante a anamnese, 49 responsáveis (36%) relataram histórico de alergias em suas crianças e adolescentes. A prevalência de hábitos bucais viciosos foi verificada em 87 pacientes (64%), sendo presente em 65,3% de crianças e adolescentes que apresentavam atopia (p<0,05). Conclusão A prevalência de alergias relatada nesta população foi de 34,6%, e foi observada ainda uma alta prevalência de hábitos bucais viciosos e traumatismos dentoalveolares nesses pacientes. Foram constatadas associações significativas entre presença de atopias e histórico de traumatismos dentários, maloclusão e hábitos viciosos, demonstrando haver correlação entre atopia e alguns aspectos de saúde oral.


Evaluation of genetic polymorphisms in MMP2, MMP9 and MMP20 in Brazilian children with dental fluorosis
Priscilla Coutinho Romualdo, Carolina Maschietto Pucinelli, Patricia Nivoloni Tannure, Paulo Nelson-Filho, Raquel Assed Bezerra Segato, João Armando Brancher, Nilza Letícia Magalhães, Marcelo de Castro Costa, Lívia Azeredo A. Antunes, Leonardo Santos Antunes,et al.
Elsevier BV



Diagnosis attitudes and restorative practices of non-carious cervical lesions by a group of Brazilian dentists from the state of Rio de Janeiro
Rodrigo Antonio Modena, Patrícia Nivoloni Tannure, Vinícius Athayde Pessoa, Larissa Maria Cavalcante, and Luis Felipe Jochims Schneider
Springer Science and Business Media LLC



Assessing the association between hypoxia during craniofacial development and oral clefts
Erika Calvano Küchler, Lea Assed da Silva, Paulo Nelson-Filho, Ticiana M. Sabóia, Angela M. Rentschler, José Mauro Granjeiro, Driely Oliveira, Patricia N. Tannure, Raquel Assed da Silva, Leonardo Santos Antunes,et al.
FapUNIFESP (SciELO)
Abstract Objectives To evaluate the association between hypoxia during embryo development and oral clefts in an animal model, and to evaluate the association between polymorphisms in the HIF-1A gene with oral clefts in human families. Material and Methods The study with the animal model used zebrafish embryos at 8 hours post-fertilization submitted to 30% and 50% hypoxia for 24 hours. At 5 days post-fertilization, the larvae were fixed. The cartilage structures were stained to evaluate craniofacial phenotypes. The family-based association study included 148 Brazilian nuclear families with oral clefts. The association between the genetic polymorphisms rs2301113 and rs2057482 in HIF-1A with oral clefts was tested. We used real time PCR genotyping approach. ANOVA with Tukey's post-test was used to compare means. The transmission/disequilibrium test was used to analyze the distortion of the inheritance of alleles from parents to their affected offspring. Results For the hypoxic animal model, the anterior portion of the ethmoid plate presented a gap in the anterior edge, forming a cleft. The hypoxia level was associated with the severity of the phenotype (p<0.0001). For the families, there was no under-transmitted allele among the affected progeny (p>0.05). Conclusion Hypoxia is involved in the oral cleft etiology, however, polymorphisms in HIF-1A are not associated with oral clefts in humans.


Success of preventive approach to mandibular osteoradionecrosis in an adolescent: case report.
T. Franco, M.D.C. Cezini, L. Metropolo, D.C. Ferreira, and P.N. Tannure
Wiley
Osteoradionecrosis (ORN) is defined as the presence of ulceration or necrosis of the mucosa with exposure of necrotic bone that does not heal within a 2-month period after radiotherapy in patients with head and neck tumours. The mandible presents a higher risk of developing ORN than the maxilla and extraction of teeth is also considered a risk factor for the development of ORN. The aim of this article was to present a clinical case where a protocol was used to prevent the development of ORN after the extraction of lower molars in an adolescent who had undergone surgical removal and radiotherapy for a mucoepidermoid carcinoma in the left parotid gland. The results showed that the protocol used was efficient in the prevention of osteoradionecrosis in this adolescent. One year after the extractions, no clinical or radiographic signs of any pathological alteration were observed in the region; the patient remains under periodical clinical and radiographic follow-up.


Alveolar bone raft: Clinical profile and risk factors for complications in oral cleft patients
Macedo Pessoa Erica Alexandra, Braune Andre, Ladeira Casado Priscila, and Nivoloni Tannure Patricia
SAGE Publications
Objective The aim of this study was to investigate clinical aspects and predisposing factors for alveolar bone graft complications in persons born with oral clefts. Design A total of 105 patients, aged 7 to 57 years old, who received alveolar bone graft at the Cranio-maxillofacial Surgery Center in the National Institute of Traumatology and Orthopedics (INTO), Rio de Janeiro (RJ) from 2009 to 2014 were selected. Data were collected concerning the type of oral cleft, family history of cleft, medical and dental exam, donor area, type of graft material, repaired surgical treatment done, and postoperative follow-up examinations. Results Postoperative complications developed in 31 patients (32.9%). The mean age at grafting was 16.79 years for the group without complications (n = 63) and 20.13 years for the group with postoperative complications (n = 31). There was a positive association between age and type of graft and cases with alveolar bone graft complications. Patients aged 12 years or more had a four times more chance of developing alveolar bone graft complications. Particulate bone graft from iliac crest demonstrated better results compared with block graft or mixed graft. Conclusion Patients with cleft lip and palate who were 12 years or older had a greater chance of developing complications after grafting the alveolar bone. Furthermore, particulate alveolar graft from iliac crest had significantly better outcomes.


Risk factors for implant failure: a retrospective study in an educational institution using GEE analyses
Marcelo BORBA, Daniel DELUIZ, Eduardo José Veras LOURENÇO, Luciano OLIVEIRA, and Patrícia Nivoloni TANNURE
FapUNIFESP (SciELO)
This study aimed to evaluate dental implant outcomes and to identify risk factors associated with implant failure over 12 years via dental records of patients attending an educational institution. Dental records of 202 patients receiving 774 dental implants from 2002 to 2014 were analyzed by adopting a more reliable statistical method to evaluate risk factors with patients as the unit [generalized estimating equation (GEE)]. Information regarding patient age at implantation, sex, use of tobacco, and history of systemic diseases was collected. Information about implant location in the arch region and implant length, diameter, and placement in a grafted area was evaluated after 2 years under load. Systemic and local risk factors for early and late implant failure were studied. A total of 18 patients experienced 25 implant failures, resulting in an overall survival rate of 96.8% (2.84% and 0.38% early and late implant failures, respectively). The patient-based survival rate was 91.8%. GEE univariate and multivariate analyses revealed that a significant risk factor for implant failure was the maxillary implant (p = 0.006 and p = 0.014, respectively). Bone grafting appeared to be a risk factor for implant failure (p = 0.054). According to GEE analyses, maxillary implants had significantly worse outcomes in this population and were considered to be a risk factor for implant failure. Our results suggested that implants placed in a bone augmentation area had a tendency to fail.


Measurement of distance between the mental foramina using cone-beam computed tomography: A pilot study with a possible method for planning mandibular implants
LMB Marieiro, D Deluiz, DC Ferreira, and PN Tannure
APESB (Associacao de Apoio a Pesquisa em Saude Bucal)
Objective: To identify the average number of dental implants that can be placed in the lower anterior region to support a fixed mandibular prosthesis based on the distance between the mental foramina, using a cone beam computed tomography (CBCT) scan through a new method of measurement. Material and Methods: Eighty-two CT scans from a total sample of 1,465 exams were selected. The method to measure the space between the foramina was developed using the BlueSky Plan3 software in Dicom format and the axial reconstruction views were chosen for measurements. Descriptive analysis of data was conducted categorical variables were compared using the χ2 test (p <0.05). Results: The mean age of individuals who underwent the scans was 63.51 ± 9.49 years old with a minimum and maximum age of 40 and 86 years old, respectively. The mean linear measurement between the foramina was 40.52 ± 3.92mm. In males the mean distance was 41.93 ± 3.98 mm, and for females it was 39.99 ± 3.80mm, with a significant difference between the means (p = 0.043). There was no positive association between the presence of the anterior loop and gender (p = 0.719). The results showed that the vast majority of subjects (n = 80) could be rehabilitated using a protocol with 4 implants of 3.3mm diameters. Conclusion: Seventy-seven patients would be able to receive protocols of 4 implants with diameters of 3.75 or 4.0mm, and only 4 subjects would be able to be rehabilitated with 6 implants with diameters of 3.75 mm according to the protocol originally described by Branemark.


Patients with Manifest Caries Lesions Have Higher Levels of Salivary Matrix Metalloproteinase-8 Than Patients with no Caries Lesions
Patricia Nivoloni Tannure and Erika Calvano Küchler
Elsevier BV



Oral Rehabilitation and Management for Secondary Sjögren's Syndrome in a Child
Tatiana Kelly da Silva Fidalgo, Carla Nogueira, Marcia Rejane Thomas Canabarro Andrade, Andrea Graciene Lopez Ramos Valente, and Patricia Nivoloni Tannure
Hindawi Limited
The aim of this paper is to describe a rare case report of a pediatric patient with secondary Sjögren’s syndrome (SSS). A 12-year-old female child was referred to the Pediatric Dentistry Clinic with the chief complaint of tooth pain, dry mouth, and tooth sensibility. The patient was submitted to orthodontic treatment prior to syndrome diagnosis. The clinical treatment consisted of the interruption of orthodontic treatment and restoring the oral condition with dental treatment and the use of artificial saliva in an innovative apparatus. Dental therapy involved the control of dental caries, periodontal disease, and opportunistic fungal infections and the use of fluoride-rich solutions. The present clinical case describes clinical and laboratory aspects of SSS in pediatric patients. The management of the oral findings promoted an improvement in the oral health status and quality of life of the child.


Genetic variants in folate and cobalamin metabolism-related genes in nonsyndromic cleft lip and/or Palate
Márcia Waltrick-Zambuzzi, Patricia Nivoloni Tannure, Thays Cristine dos Santos Vieira, Leonardo Santos Antunes, Fábio Lourenço Romano, Willian Fernando Zambuzzi, José Mauro Granjeiro, and Erika Calvano Küchler
FapUNIFESP (SciELO)
The aim of this study was to evaluate the association of the polymorphisms in TCN2 (rs1801198) gene and in MTRR (rs1801394) gene with nonsyndromic cleft lip and/or palate (NSCL/P) in a Brazilian population. Genomic DNA was extracted from buccal cells. The polymorphisms in TCN2 (rs1801198) and MTRR (rs1801394) genes were genotyped by carrying out real-time PCR and Taqman assay. Chi-square test was used to determine the association between genotype and allele frequencies with NSCL/P and NSCL/P subgroups (cleft lip only, cleft lip and palate, and cleft palate only). Eight hundred and sixty seven unrelated individuals (401 cases with NSCL/P and 466 individuals without cleft) were evaluated. Genotype distributions of TCN2 and MTRR polymorphisms were in Hardy-Weinberg equilibrium. The TCN2 polymorphic genotype GG was identified in 16.7% of the NSCL/P group and in 14.1% of the non-cleft group (p&gt;0.05). Similarly, the frequency of MTRR genotype (GG) was similar in NSCL/P group (15.5%) and control group (17.8%) (p&gt;0.05). Multivariate analysis showed an association between MTRR and the subgroup that the mother smoked during pregnancy (p=0.039). Our findings did not demonstrate an association between TCN2 polymorphisms and NSCL/P, however suggests an association between MTRR and NSCL/P etiology


Oral bacteria adherence to suture threads: an in vitro study
Oswaldo de Castro Costa Neto, Leandro Araujo Lobo, Natalia Lopes Pontes Iorio, Maria de Fátima Carvalho Vasconcelos, Lucianne Cople Maia, Patrícia Nivoloni Tannure, and Andréa Gonçalves Antonio
Springer Science and Business Media LLC



BMP2 is associated with caries experience in primary teeth
Helena Freire Romanos, Leonardo Santos Antunes, Ludiana Barbosa Lopes, Ticiana de Medeiros Sabóia, Patricia Nivoloni Tannure, Andrea Lips, Livia Azeredo A. Antunes, Fernanda Volpe de Abreu, Kathleen Deeley, Gutemberg Alves,et al.
S. Karger AG
Bone morphogenetic proteins (BMPs) play an important role during the initial process of enamel development and therefore may play a role in caries susceptibility. The purpose of this study was to evaluate the association between the polymorphisms in the &lt;i&gt;BMP2, BMP4&lt;/i&gt; and &lt;i&gt;BMP7&lt;/i&gt; genes and their association with caries experience and primary enamel microhardness characteristics. DNA from buccal cells as well as clinical and demographic information from 1,731 subjects from three different data sets from Brazil were included. Polymorphisms in &lt;i&gt;BMP2, BMP4&lt;/i&gt; and &lt;i&gt;BMP7&lt;/i&gt; were analyzed by real-time polymerase chain reaction from genomic DNA. Association between caries experience, genotype, and allele distribution in both cohorts was evaluated using &amp;#x03C7;&lt;sup&gt;2&lt;/sup&gt; and logistic regression analyses. In the family-based set, the association between caries experience and alleles was tested using the transmission disequilibrium test. In the Rio de Janeiro cohort, microhardness data on 108 exfoliated primary teeth before and after demineralization and remineralization challenges was included. Associations between microhardness values and genotype and allele distribution were evaluated using &amp;#x03C7;&lt;sup&gt;2&lt;/sup&gt; and logistic regression analyses. Differences between caries experience and some risk factors were statistically significant. In the cohort from Nova Friburgo, &lt;i&gt;BMP2&lt;/i&gt; was associated with caries experience in primary dentition during logistic regression analysis (p = 0.023; OR = 2.58; 95% CI 1.13-5.86). There was no association between genotype and allele distribution for &lt;i&gt;BMP&lt;/i&gt; polymorphisms and primary enamel microhardness alterations. Our result suggests that &lt;i&gt;BMP2&lt;/i&gt; may be involved in caries experience in primary dentition from a Nova Friburgo cohort.


The functional EGF+61 polymorphism and nonsyndromic oral clefts susceptibility in a Brazilian population
Priscila FALAGAN-LOTSCH, Talíria Silva LOPES, Erika Calvano KÜCHLER, Patrícia Nivoloni TANNURE, Marcelo de Castro COSTA, Lidia Maria da Fonte de AMORIM, and José Mauro GRANJEIRO
FapUNIFESP (SciELO)
Nonsyndromic oral clefts are considered a problem of public health in Brazil, presenting a multifactorial etiology that involves genetic and environmental components, such as maternal alcohol consumption. Several candidate genes have been investigated to identify some association with nonsyndromic clefts risk. The epidermal growth factor (EGF) gene is implicated in the normal craniofacial development and its functional +61 A>G polymorphism has been related to cancer susceptibility. It has been suggested that cancer and oral clefts may share the same molecular pathways. Objective Our goal was to evaluate the association between the EGF+61 A>G polymorphism and nonsyndromic oral clefts susceptibility. Material and Methods The case-control study included 218 cleft cases and 253 controls from Brazil. The control group was comprised of individuals without congenital malformations, dental anomalies and family history of clefts. The cleft phenotypes and subphenotypes were determined based on clinical examination. Genomic DNA was extracted from oral mucosa cells obtained by mouthwash. The EGF+61 A>G polymorphism genotype was determined by polymerase chain reaction-restriction fragment length polymorphism. Results We noticed the association between maternal alcohol consumption during pregnancy and cleft occurrence. The A allele and AA genotype were over-represented in cleft cases compared with control group when we considered the bilateral cleft lip with or without cleft palate (CL±P) cases, cleft cases with tooth agenesis and cleft cases presenting family history of cleft, but the differences were not statistically significant. Contradictorily, the G allele was higher in cleft palate only (CP) cases than in control group, showing a borderline p value. Comparing the different cleft phenotypes, we observed statistical differences between CP and CL±P cases. Our data suggest the EGF+61 A>G polymorphism was not related with nonsyndromic oral clefts susceptibility in a Brazilian population, but supported the different genetic background between CL±P and CP. Moreover, we confirmed the potential effect of maternal alcohol intake on cleft risk in our population.


Prosthetic oral rehabilitation of a child with S-ECC: A case report with histopathologic analysis
PN Tannure, GG Moraes, MCU Borba, A Abrahão, MTRC Andrade, and TKS Fidalgo
MRE Press
The aim of this case report is to describe the treatment planning of a young child with severe early childhood caries (S-ECC) as well as the prosthetic rehabilitation technique. A 3-year-old female child was referred to the pediatric dentistry clinic with the chief complaint of tooth pain, difficulty in eating and recurrent hospitalizations caused by dental infections. The mother reported intermittent episodes of fever and recurrent swelling of child's face. The girl presented angular cheilitis and was referred to a dietitian. The treatment plain consisted on a behavior changes in oral hygiene habits, exodontias of all primary teeth and oral rehabilitation with a prosthesis. The extracted teeth with periapical lesions were submitted to histopathologic analysis (hematoxilin and eosin staining) and revealed an inflammatory infiltrate. The aesthetic requirement of children with S-ECC has been a challenge to pediatric dentists. In the present case, the oral rehabilitation provided for the children better aesthetic, nutrition, phonation, and functional conditions.


Genetic association for caries susceptibility among cleft lip and/or palate individuals
Leonardo Santos Antunes, Patricia Nivoloni Tannure, Lívia Azeredo Alves Antunes, Maria Fernanda Reis, Marcelo Castro Costa, Cresus Vinicius Depes Gouvêa, Beni Olej, and Jose Mauro Granjeiro
Jaypee Brothers Medical Publishing
ABSTRACTAimTo evaluate the association of the polymorphisms in the TGFB3 gene (rs2268626), and the BMP4 gene (rs17563) with dental caries in two different groups (noncleft group and oral cleft group) from a cleft center located at Rio de Janeiro, Brazil.Materials and methodsA total of 486 unrelated children and adolescents with or without caries were evaluated using a cohort design. Data on oral health habits was obtained through a questionnaire and caries data was collected by clinical examination. Genotyping of the selected polymorphisms for TGFB3 and BMP4 were carried out by real-time PCR using the TaqMan assay method from a genomic DNA isolated from buccal epithelial cells of all children and adolescents.ResultsNo association was found between BMP4 polymorphism and caries among individuals from both groups. For TGFB3 polymorphism, significant differences were observed for allele and genotype frequencies between caries free and caries affected individuals in oral cleft group (p = 0.013 and 0.006 for allele and genotype frequencies respectively).ConclusionOur findings provide evidence suggesting that TGFB3 may be involved in caries susceptibility in oral cleft group.Clinical significanceIn the future, the possibility of identifying genes related to caries susceptibility can lead to counseling of the individual that carries gene alterations, with the aim of working on preventive measures for caries as well as bioengineering treatments.How to cite this articleAntunes LS, Tannure PN, Antunes LAA, Reis MF, Costa MC, Gouvêa CVD, Olej B, Granjeiro JM, Küchler EC. Genetic Association for Caries Susceptibility among Cleft Lip and/or Palate Individuals. J Contemp Dent Pract 2014;15(3):288-293.


Is dental caries experience increased in HIV-infected children and adolescents? A meta-analysis
Cristiana Aroeira Guimarães Rosa Oliveira, Patricia Nivoloni Tannure, Ivete Pomarico Ribeiro de Souza, Lucianne Cople Maia, Maristela Barbosa Portela, and Gloria Fernanda B. de A. Castro
Informa UK Limited
Abstract Objective. To undertake a systematic review to assess if HIV-infected children and adolescents have an increased dental caries experience. Methods. A search of MEDLINE, BIREME, EMBASE, GOOGLE SCHOLAR, SIGLE (Grey Literature) and reference lists of included studies was carried out. To be eligible the studies had to present HIV-infected and non-infected children/adolescents between 0–18 years old. To assess the methodological quality, the studies were categorized in scores from ‘A’ to ‘C’. To perform a meta-analysis a random effect model was used with 95% confidence intervals and two distinct sub-group analyses were carried out in terms of caries progression: data for cavitated and non-cavitated lesions (sub-group 1) and data only for cavitated lesions (sub-group 2). Results. Five studies fulfilled the selection criteria. Four studies (two ranked A and two B in the quality assessment) revealed higher caries scores in primary teeth in the HIV-infected patients with mean dmft/dmfs scores of 3.8–4.1/7.8–11.0 compared to the control group 1.5–2.4/3.4–5.1. No differences in caries index were found for permanent dentition. The meta-analysis excluded caries data of permanent teeth and showed a significant association between caries experience in primary dentition and HIV infection considering cavitated and non-cavitated lesions (OR = 2.33, 95% CI = 1.48–3.68) or only cavitated lesions (OR = 2.98, 95% CI = 1.59–5.59). Conclusion. Evidence exists that suggests HIV-infected children/adolescents have an increased caries experience in primary dentition.


DLX1 and MMP3 contribute to oral clefts with and without positive family history of cancer
Ticiana M. Sabóia, Maria Fernanda Reis, Ângela M.C. Martins, Helena F. Romanos, Patricia N. Tannure, José Mauro Granjeiro, Alexandre R. Vieira, Leonardo S. Antunes, Erika C. Küchler, and Marcelo C. Costa
Elsevier BV



Studies of genes involved in craniofacial development and tumorigenesis: FGF3 contributes to isolated oral clefts and may interact with PAX9
Erika C. Küchler, Ticiana M. Sabóia, Thays C. Vieira, Andrea Lips, Patricia N. Tannure, Kathleen Deeley, Maria F. Reis, Bao Ho, Ana C. Rey, Marcelo C. Costa,et al.
Informa UK Limited
Abstract Objective. Previous studies suggest individuals born with oral clefts and their families have a higher susceptibility for cancer, which raises the hypothesis that these two conditions share common molecular pathways. This study evaluated the association between oral clefts and polymorphisms in genes that play a role in craniofacial and tumor development. Materials and methods. Four hundred and ninety-seven subjects born with oral clefts and 823 unaffected subjects were recruited. Twenty-nine markers in 13 genes were genotyped by the Taqman method. Chi-square was used to compare allele and genotype frequencies. Bonferroni correction for multiple testing was used and the established alpha was 0.0003. This study also used logistic regression to test if genetic variants were associated with oral clefts using positive family history of cancer and age as covariates. Results. There was no association between family history of cancer and oral clefts (p = 0.51). None of the 1320 study participants had a diagnosis of cancer at the time of participation in the study. The marker rs4980700 in FGF3 was associated with oral clefts (p = 0.0002). Logistic regression analysis also provided evidence for gene–gene interaction between FGF3 (rs4980700) and PAX9 (rs2073242), increasing the risk for isolated oral clefts (p = 0.0003). Conclusion. FGF3 is associated with oral clefts and may interact with PAX9.


Role of estrogen related receptor beta (ESRRB) in DFN35B hearing impairment and dental decay
Megan L Weber, Hong-Yuan Hsin, Ersan Kalay, Dana Š Brožková, Takehiko Shimizu, Merve Bayram, Kathleen Deeley, Erika C Küchler, Jessalyn Forella, Timothy D Ruff,et al.
Springer Science and Business Media LLC



Knowledge and practices of parents and guardians regarding the oral health of children from a shelter and a university in Rio de Janeiro, Brazil
FALDL Trindade, AR Valente, MRTC Andrade, PN Tannure, AG Antonio, and TKS Fidalgo
APESB (Associacao de Apoio a Pesquisa em Saude Bucal)
Objetivo: Avaliar e comparar o conhecimento de pais e responsaveis de criancas em idade escolar sobre cuidados de higiene bucal e dieta entre uma populacao de criancas de um abrigo e o de uma instituicao de ensino superior. Metodologia: Foi realizado um estudo descritivo transversal, cuja amostra foi composta de 82 responsaveis por criancas em idade escolar do Abrigo Teresa de Jesus (ATJ; n = 47) e da Universidade Veiga de Almeida (UVA; n = 35). O instrumento de coleta de dados foi um questionario com 18 perguntas fechadas sobre higiene e dieta. Apos a aplicacao do questionario, os dados foram tabulados, armazenados em um banco de dados e analisados utilizando o programa SPSS 20.0 (SPSS Inc, Il, EUA). Foi realizada analise descritiva dos dados e avaliacao da normalidade por meio to teste de Shapiro-Wilk (p < 0,05). As variaveis categoricas foram comparadas utilizando o teste χ2 com intervalo de confianca de 95%. Resultados: A media de idade das criancas do ATJ foi de 4,9 (± 2,5) e as da UVA, de 7,1 (± 2,7) (p < 0,01). Nao houve diferenca entre os grupos quanto a idade dos responsaveis (p = 0,71) e grau de instrucao (p = 0,93), no entanto, os responsaveis da UVA apresentaram renda superior aos do ATJ (p = 0,02).Os responsaveis do ATJ possuiam mais informacoes sobre os cuidados com os dentes comparados com os da UVA (p < 0,01). Grande parte do grupo do ATJ (98,7%) alegou que visitar ao dentista tambem e um importante fator para a prevencao de doencas bucais comparado com o grupo da UVA (25,7) (p < 0,01), o que se traduziu em maior numero real de visitas ao dentista (p = 0,03). Foi observado maior conhecimento sobre “dentes tortos” (p < 0,01) e aftas (p = 0,04) pelos responsaveis das criancas do ATJ. Eles tambem associam mais as bacterias (p < 0,01) e nao ir ao dentista como fatores causais da carie (p = 0,03). Conclusao: Apesar de piores condicoes socio-economicas, os responsaveis pelas criancas do ATJ apresentaram mais conhecimentos sobre higiene bucal e dieta que os entrevistados da UVA. E provavel que as atividades educacionais do abrigo tenham influenciado esse resultado.

RECENT SCHOLAR PUBLICATIONS

Periodontal disease may be diagnosed using the matrix metallloproteinase (aMMP)-8 point-of-care test.
PN Tannure, DD Faustino-Silva
Journal of Evidence-Based Dental Practice, 102051 2024



TOTAL ANTIOXIDANT CAPACITY MAY NOT BE AN ACCURATE WAY TO PREDICT DENTAL CARIES
PN Tannure, DD Faustino-Silva
The journal of evidence-based dental practice 24 (2), 101982 2024



TOTAL ANTIOXIDANT CAPACITY MAY NOT BE AN ACCURATE WAY TO PREDICT DENTAL CARIES
PN TANNURE, DD FAUSTINO-SILVA
Journal of Evidence-Based Dental Practice 24 (2), 101982 2024



Satisfaction Survey of Patients Using the Brazilian Version of Dental Patient Feedback on Consultation Questionnaire.
LR Lima de Oliveira Melo, D Faissol Pacheco, E Michel Crosato, ...
Journal of Health Sciences (2447-8938) 25 (2) 2023



A Entrevista Motivacional pode ser utilizada na preveno da crie em pr-escolares? Uma reviso integrativa
FN de Souza, TO Pimentel, A Canabarro, DD Faustino-Silva, PN Tannure
Revista de Odontopediatra Latinoamericana 13 2023



ANLISE DE VDEOS EM UM STIO DE COMPARTILHAMENTO VIRTUAL SOBRE O USO DA PRPOLIS NA DOENA PERIODONTAL
AS Simes, N Mecler, D Ferreira, PN Tannure, L Armada, A Canabarro
Revista Rede de Cuidados em Sade 17 (2) 2023



Is YouTube^TM a reliable source of information regarding ultra-thin ceramic laminates?
M Frana, C Uemoto, DC Ferreira, M Prado, PN Tannure
Brazilian Journal of Oral Sciences 22, e230864 2023



La Entrevista Motivacional puede ser utilizada en la prevencin de las caries en preescolares? Una revisin integradora
FN de Souza, TO Pimentel, A Canabarro, DD Faustino-Silva, PN Tannure
Revista de Odontopediatra Latinoamericana, 2 2023



Dor em dentes decduos: busca de informaes em uma plataforma virtual
PN Tannure
Revista Rede de Cuidados em Sade 16 (2) 2022



Biomarcadores Pro y Antiinflamatorios como Posibles Marcadores de Pronstico en el Carcinoma Oral de Clulas Escamosas
KDM Ferreira, R Tramontani Ramos, C Stofela Sodr, P Nivoloni Tannure, ...
International journal of odontostomatology 16 (2), 258-266 2022



Pro-and anti-inflammatory biomarkers as potential prognosis markers in oral squamous cell carcinoma
KDM Ferreira, R Tramontani Ramos, C Stofela Sodr, P Nivoloni Tannure, ...
Int. J. Odontostomatol 16, 258-266 2022



Aplausos s diretrizes para a prtica clnica odontolgica na ateno primria sade
PN Tannure, DD Faustino-Silva
Revista Cientfica do CRO-RJ (Rio de Janeiro Dental Journal) 7 (1), 1-3 2022



Alteraes na clnica odontolgica decorrentes da Pandemia: a mnima interveno como a primeira opo em Odontopediatria
PN Tannure, DSAV Barbieri, APRCB Andrade, T Gimenez, R Siegl, ...
Revista Cientfica do CRO-RJ (Rio de Janeiro Dental Journal) 7 (1), 9-12 2022



Color change, tooth sensitivity, aesthetic self-perceptions and quality of life after at-home dental bleaching
L Cavalcante, C Bomgiovanni, K Antunes, M Cardoso, E Loureiro, ...
Brazilian Dental Science 25 (1) 2022



Risk factors for survival after head and neck cancer: a cohort study in the south of Espirito Santo state
KDM Ferreira, AB Archanjo, MM de Oliveira, AM Alvares-da-Silva, ...
Revista Cientfica do CRO-RJ (Rio de Janeiro Dental Journal) 6 (3), 72-78 2021



Uso da coroa de ao em molares decduos atravs das tcnicas convencional e Hall Technique: uma srie de casos
MC Melo, MM Azevedo, JCP Imparato, IC Costa, LP Morais, PN Tannure
Brazilian Oral Research 35, 174 2021



Molar-incisor malformation: a narrative review
TGR Passos, PN Tannure, JCP Imparato, AVB Pintor
Revista Cientfica do CRO-RJ (Rio de Janeiro Dental Journal) 5 (3), 2-12 2020



Oral changes associated with the presence of atopy in children: a cross-sectional study
BM RUAS, MO NASCIMENTO, M DE FRANA, CS SODR, ...
Revista de Odontologia da UNESP 49, e20200067 2020



Alteraes bucais associadas presena de atopia em crianas: um estudo transversal
BM RUAS, MO NASCIMENTO, M DE FRANA, CS SODR, ...
Revista de Odontologia da UNESP 49, e20200067 2020



Controle do bruxismo do sono na infncia: reviso de literatura
TR dos Santos, AVB Pintor, JCP Imparato, PN Tannure
Revista Rede de Cuidados em Sade 14 (1) 2020

MOST CITED SCHOLAR PUBLICATIONS

Buccal cells DNA extraction to obtain high quality human genomic DNA suitable for polymorphism genotyping by PCR-RFLP and Real-Time PCR
EC Kchler, PN Tannure, P Falagan-Lotsch, TS Lopes, JM Granjeiro, ...
Journal of Applied Oral Science 20, 467-471 2012
Citations: 170



Enamel formation genes influence enamel microhardness before and after cariogenic challenge
T Shimizu, B Ho, K Deeley, J Briseno-Ruiz, IM Faraco Jr, BI Schupack, ...
Public Library of Science 7 (9), e45022 2012
Citations: 146



Prevalence of dental anomalies in nonsyndromic individuals with cleft lip and palate: a systematic review and meta-analysis
PN Tannure, CAGR Oliveira, LC Maia, AR Vieira, JM Granjeiro, ...
The Cleft palate-craniofacial journal 49 (2), 194-200 2012
Citations: 144



Genetic variation in MMP20 contributes to higher caries experience
PN Tannure, EC Kchler, A Lips, M de Castro Costa, RR Luiz, ...
Journal of dentistry 40 (5), 381-386 2012
Citations: 112



MMP13 polymorphism decreases risk for dental caries
PN Tannure, EC Kchler, P Falagan-Lotsch, LMF Amorim, R Raggio Luiz, ...
Caries Research 46 (4), 401-407 2012
Citations: 104



Studies with Wnt genes and nonsyndromic cleft lip and palate
R Menezes, A Letra, AH Kim, EC Kchler, A Day, PN Tannure, ...
Birth Defects Research Part A: Clinical and Molecular Teratology 88 (11 2010
Citations: 99



The influence of smear layer removal on primary tooth pulpectomy outcome: A 24‐month, double‐blind, randomized, and controlled clinical trial evaluation
R Barcelos, PN Tannure, R Gleiser, RR Luiz, LG Primo
International Journal of Paediatric Dentistry 22 (5), 369-381 2012
Citations: 84



Tooth agenesis association with self-reported family history of cancer
EC Kchler, A Lips, PN Tannure, B Ho, MC Costa, JM Granjeiro, ...
Journal of dental research 92 (2), 149-155 2013
Citations: 70



Risk factors for implant failure: a retrospective study in an educational institution using GEE analyses
M Borba, D Deluiz, EJV Loureno, L Oliveira, PN Tannure
Brazilian oral research 31, e69 2017
Citations: 57



Role of estrogen related receptor beta (ESRRB) in DFN35B hearing impairment and dental decay
ML Weber, HY Hsin, E Kalay, DŠ Brožkov, T Shimizu, M Bayram, ...
BMC medical genetics 15, 1-10 2014
Citations: 52



Fine-mapping of 5q12. 1–13.3 unveils new genetic contributors to caries
T Shimizu, K Deeley, J Briseo-Ruiz, IM Faraco Jr, FA Poletta, ...
Caries research 47 (4), 273-283 2013
Citations: 51



Dental needs and management of children with special health care needs according to type of disability
PS Salles, PN Tannure, CAG Rosa Oliveira, IPR de Souza, MB Portela, ...
Journal of Dentistry for Children 79 (3), 165-169 2012
Citations: 51



Long-term outcomes of primary tooth pulpectomy with and without smear layer removal: a randomized split-mouth clinical trial
PN Tannure, CP Azevedo, R Barcelos, R Gleiser, LG Primo
Pediatric Dentistry 33 (4), 316-320 2011
Citations: 48



Caries experience in individuals with cleft lip and palate
PN Tannure, MDC Costa, EC Kchler, HF Romanos, JM Granjeiro, ...
Pediatric dentistry 34 (2), 127-131 2012
Citations: 45



Histopathologic and SEM analysis of primary teeth with pulpectomy failure
PN Tannure, R Barcelos, MB Portela, R Gleiser, LG Primo
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and 2009
Citations: 42



Atendimento odontolgico em uma criana com transtorno do espectro autista: relato de caso
TN Souza, JV Sonegheti, PN Tannure, LHR Andrade
Rev. odontol. Univ. Cid. So Paulo (Online), 191-197 2017
Citations: 39



Genetic mapping of high caries experience on human chromosome 13
EC Kchler, K Deeley, B Ho, S Linkowski, C Meyer, J Noel, MZ Kouzbari, ...
BMC medical genetics 14, 1-10 2013
Citations: 38



Role of TRAV locus in low caries experience
J Briseo-Ruiz, T Shimizu, K Deeley, PM Dizak, TD Ruff, IM Faraco, ...
Human genetics 132, 1015-1025 2013
Citations: 37



Sexual dimorphism involved in the mesiodistal and buccolingual dimensions of permanent teeth
TM Sabia, PN Tannure, RR Luiz, M de Castro Costa, JM Granjeiro, ...
Dentistry 3000 1 (1), 2-6 2013
Citations: 35



BMP4 Polymorphism is Associated with Nonsyndromic Oral Cleft in a Brazilian Population
LS Antunes, EC Kchler, PN Tannure, MC Costa, CVD Gouva, B Olej, ...
The Cleft Palate-Craniofacial Journal 50 (6), 633-638 2013
Citations: 35