Poornachandar Gugulothu
@poornachandar@cutn.ac.in
Assistant Professor
Central University of Tamil Nadu
EDUCATION
Ph.D. from Osmania University, Department of Biochemistry, Hyderabad
M.Sc Biotechnology from Jawaharlal Nehru Technological University, Hyderabad
B.Sc Biotechnology from Kavitha memorial degree and PG college, Khammam, under Kakatiya University warangal
RESEARCH INTERESTS
Cancer biology, Phytochemical algal biotechnology, and biohydrogen production.
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Subhisha Raj, Amrutha Sajith, Arathi Sreenikethanam, Swathi Vadlamani, Aiswarya Satheesh, Anurup Ganguly, J. Rajesh Banu, Sunita Varjani, Poornachandar Gugulothu, and Amit K. Bajhaiya
Informa UK Limited
Vijetha Valsa, Geethu Krishnan S, Rashmi Gondi, Preethi Muthu, Kavitha Sankarapandian, Gopalakrishnan Kumar, Poornachandar Gugulothu, and Rajesh Banu Jeyakumar
MDPI AG
The current study intended to improve the disintegration potential of paper mill sludge through alkyl polyglycoside-coupled disperser disintegration. The sludge biomass was fed to the disperser disintegration and a maximum solubilization of 6% was attained at the specific energy input of 4729.24 kJ/kg TS. Solubilization was further enhanced by coupling the optimum disperser condition with varying dosage of alkyl polyglycoside. The maximum solubilization of 11% and suspended solid (SS) reduction of 8.42% were achieved at the disperser rpm, time, and surfactant dosage of 12,000, 30 min, and 12 μL. The alkyl polyglycoside-coupled disperser disintegration showed a higher biogas production of 125.1 mL/gCOD, compared to the disperser-alone disintegration (70.1 mL/gCOD) and control (36.1 mL/gCOD).
Preethi, J. Rajesh Banu, Gopalakrishnakumar, Vinay Kumar Tyagi, Amit Kumar Bajhaiya, Poornachandar Gugulothu, and M. Gunasekaran
Elsevier BV
Arathi Sreenikethanam, Subhisha Raj, Rajesh Banu J, Poornachandar Gugulothu, and Amit K. Bajhaiya
Frontiers Media SA
Microalgae are highly diverse photosynthetic organisms with higher growth rate and simple nutritional requirements. They are evolved with an efficiency to adapt to a wide range of environmental conditions, resulting in a variety of genetic diversity. Algae accounts for nearly half of global photosynthesis, which makes them a crucial player for CO2 sequestration. In addition, they have metabolic capacities to produce novel secondary metabolites of pharmaceutical, nutraceutical and industrial applications. Studies have explored the inherent metabolic capacities of microalgae with altered growth conditions for the production of primary and secondary metabolites. However, the production of the targeted metabolites at higher rates is not guaranteed just with the inherent genetic potentials. The strain improvement using genetic engineering is possible hope to overcome the conventional methods of culture condition improvements for metabolite synthesis. Although the advanced gene editing tools are available, the gene manipulation of microalgae remains relatively unexplored. Among the performed gene manipulations studies, most of them focus on primary metabolites with limited focus on secondary metabolite production. The targeted genes can be overexpressed to enhance the production of the desired metabolite or redesigning them using the synthetic biology. A mutant (KOR1) rich in carotenoid and lipid content was developed in a recent study employing mutational breeding in microalgae (Kato, Commun. Biol, 2021, 4, 450). There are lot of challenges in genetic engineering associated with large algal diversity but the numerous applications of secondary metabolites make this field of research very vital for the biotech industries. This review, summarise all the genetic engineering studies and their significance with respect to secondary metabolite production from microalgae. Further, current genetic engineering strategies, their limitations and future strategies are also discussed.
Arathi Sreenikethanam, Subhisha Raj, J. Rajesh Banu, Poornachandar Gugulothu, Sunita Varjani, and Amit K. Bajhaiya
Springer Science and Business Media LLC
Subhisha Raj, Anusree M. Kuniyil, Arathi Sreenikethanam, Poornachandar Gugulothu, Rajesh Banu Jeyakumar, and Amit K. Bajhaiya
MDPI AG
Mycosporine-like amino acids (MAAs), are secondary metabolites, first reported in 1960 and found to be associated with the light-stimulated sporulation in terrestrial fungi. MAAs are nitrogenous, low molecular weight, water soluble compounds, which are highly stable with cyclohexenone or cycloheximine rings to store the free radicals. Microalgae are considered as a good source of different kinds of MAAs, which in turn, has its own applications in various industries due to its UV absorbing, anti-oxidant and therapeutic properties. Microalgae can be easily cultivated and requires a very short generation time, which makes them environment friendly source of biomolecules such as mycosporine-like amino acids. Modifying the cultural conditions along withmanipulation of genes associated with mycosporine-like amino acids biosynthesis can help to enhance MAAs synthesis and, in turn, can make microalgae suitable bio-refinery for large scale MAAs production. This review focuses on properties and therapeutic applications of mycosporine like amino acids derived from microalgae. Further attention is drawn on various culture and genetic engineering approaches to enhance the MAAs production in microalgae.
Godvin Sharmila V, Dinesh Kumar M, Arulazhagan Pugazhendi, Amit Kumar Bajhaiya, Poornachander Gugulothu, and Rajesh Banu J
Informa UK Limited
ABSTRACT The current fossil fuel reserves are not sufficient to meet the increasing demand and very soon will become exhausted. Pollution, global warming, and inflated oil prices have led the quest for renewable energy sources. Macroalgae (green, brown, and red marine seaweed) is gaining popularity as a viable and promising renewable source for biofuels production. Numerous researches have been conducted to access the potential of macroalgae for generating diverse bioproducts such as biofuels. The existence of components such as carbohydrates and lipids, and the lack or deficiency of lignin, create macroalgae an enviable feedstock for biofuels generation. This review briefly covers the potential macroalgal species promoting the production of biofuels and their cultivation methods. It also illustrates the biofuel generation pathway and its efficiency along with the recent techniques to accelerate the product yield. In addition, the current analysis focuses on a cost-effective sustainable generation of biofuel along with commercialization and scaleup.