Priyadarshini

Verified @gmail.com

Biotechnology
Rama Devi Women's University, Bhubaneswar



        

https://researchid.co/ppadhi9220

EDUCATION

M.Sc (Life Sciences), M.Phil (Life Sciences)

5

Scopus Publications

Scopus Publications

  • Deep learning techniques for hepatocellular carcinoma diagnosis
    Dillip Kumar Bishi, Priyadarshini Padhi, Chhabi Rani Panigrahi, Bibudhendu Pati, and Chandi Charan Rath
    Elsevier

  • Anticancer therapeutic efficacy of biogenic Am-ZnO nanoparticles on 2D and 3D tumor models
    S.C. Chabattula, P.K. Gupta, S.K. Tripathi, R. Gahtori, P. Padhi, S. Mahapatra, B.K. Biswal, S.K. Singh, K. Dua, J. Ruokolainen,et al.
    Elsevier BV

  • Phytoplankton Mediated Nanoparticles for Cancer Therapy
    Priyadarshini Padhi, Manasa Kumar Panda, Yengkhom Disco Singh, Kaushik Kumar Bharadwaj, Kausika Kumar Malik, and Binata Nayak
    Springer Singapore

  • Advances and applications of biofiber polymer composites in regenerative medicine
    Dillip Kumar Bishi, Santosh S. Mathapati, Priyadarshini Padhi, K.S. Venkataprasanna, Hariharan Ezhilarasu, Raghavendra Ramalingam, Mohd Hasbi Ab. Rahim, and Jayarama Reddy Venugopal
    Elsevier

  • Terminalia bellirica extract induces anticancer activity through modulation of apoptosis and autophagy in oral squamous cell carcinoma
    Srimanta Patra, Prashanta Kumar Panda, Prajna Paramita Naik, Debasna Pritimanjari Panigrahi, Prakash Priyadarshi Praharaj, Chandra Sekhar Bhol, Kewal Kumar Mahapatra, Priyadarshini Padhi, Mrutyunjay Jena, Shankargouda Patil,et al.
    Elsevier BV
    Terminalia bellirica (TB) has been used in traditional Indian medical system, Ayurveda. However, the mechanism underlying the efficacy of the TB extract against oral squamous cell carcinoma (OSCC) is yet to be explored. The present study established a connecting link between the TB extract induced apoptosis and autophagy in relation to reactive oxygen species (ROS). Our study revealed that gallic acid in the TB extract possess a strong free radical scavenging capacity contributing towards selective anti-proliferative activity. Furthermore, TB extract markedly enhanced the accumulation of ROS that facilitated mitochondrial apoptosis through DNA damage, indicating ROS as the vital component regulating apoptosis. This effect was effectively reversed by the use of a scavenger, N-acetyl cysteine (NAC). Moreover, it was observed to induce autophagy; however, it attenuated the autophagosome-lysosome fusion in Cal33 cells without altering the lysosomal activity. Pharmacological inhibitors of autophagy, namely, 3-methyladenine and chloroquine, were observed to regulate the stage-specific progression of autophagy post treatment with the TB extract, favouring subsequent activation of apoptosis. These findings revealed presence of gallic acid in TB extract below NOAEL value causes oxidative upset in oral cancer cells and promote programmed cell death which has a potential therapeutic value against oral squamous cell carcinoma.