DR. PRAMOD KUMAR
@cuhimachal.ac.in
Assistant Professor
Central University of Himachal Pradesh
Dr. Pramod Kumar Gangwar joined as an assistant professor in the department of chemistry and chemical sciences at the Central University of Himachal Pradesh(India) in 2020. He received both his B.sc degree(2006) and M.sc degree(2009) in physical chemistry from M.J.P.R. University, Bareilly(U.P.), India. He received his P.hd degree in 2014 from the University of Delhi, India. His research interests focus on the use of various nanoparticles for application in targeted drug delivery, non-viral gene delivery, photodynamic therapy(PDT), and multimodal diagnostic imaging. He has published more than 20 articles in leading scientific journals. He has served as an assistant professor in the department of chemistry at Rajmas College University of Delhi for seven years(2014-2020). His research expertise includes the use of inorganic and gold nanoparticles for applications in targeted drug delivery, non-viral gene delivery, photodynamic therapy(PDT), photothermal therapy(PTT), in vitro diagnostics
EDUCATION
I, Dr. Pramod Kumar Gangwar (Birth July 1985). I obtained B.Sc (2006) & M.Sc (2009) in Physical Chemistry degree from M. J. P. R. University, Bareilly (U.P) India and received my Ph.D degrees (2009-2014) from University of Delhi, India. After that, I had been Former Assistant Department of chemistry, Ramjas College, University of Delhi (2014-2020).
RESEARCH INTERESTS
Nanomedicine, Specialized in the use of inorganic-based and gold nanoparticles for applications in targeted drug delivery, non-viral gene delivery, photodynamic therapy (PDT), photothermal therapy (PTT), in vitro diagnostics and multimodal diagnostic imaging.
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Vijay Kumar, Devender Singh, Pramod Kumar, Garima Chaudhary, Amit P. Singh, and Rajeev Gupta
Elsevier BV
Sujeet Kumar Chaurasia, Abhishek Kumar Gupta, Sarvesh Kumar Gupta, Shivani Gupta, Pramod Kumar, and Manish Pratap Singh
Springer Singapore
Sujeet Kumar Chaurasia, Manish Pratap Singh, Manoj K. Singh, Pramod Kumar, and A. L. Saroj
Springer Science and Business Media LLC
Divya Prabha, Devender Singh, Pramod Kumar, and Rajeev Gupta
American Chemical Society (ACS)
This work describes the synthesis and characterization of three mononuclear nickel complexes supported with amide-based pincer ligands. All three complexes presented an H-bonding-based cavity due to the migration of amidic protons to the appended heterocyclic rings that formed H-bonds with the metal-ligated solvent molecule(s). These complexes functioned as the nanomolar chemosensors for the detection of picric acid and pyrosulfate ion as inferred by the detailed absorption and emission spectral studies while further supported with FTIR, NMR, and mass spectra of the isolated products. We also illustrate a few practical detection methods for the sensing of picric acid in the solution state as the naked-eye colorimetric methods and in the solid state by employing polystyrene films.
Pramod Kumar, Sanya Pachisia, and Rajeev Gupta
Royal Society of Chemistry (RSC)
This review illustrates a variety of luminescent chemosensors for the selective detection of assorted phosphates via the “Turn-On” emission mechanism with focus on their design aspects, chemical structures and sensing mechanism.
Sushil Kumar, Siddhant Singh, Arun Kumar, and Pramod Kumar
Royal Society of Chemistry (RSC)
Selective recognition of biorelevant Cu2+ and Fe2+/Fe3+ ions using fluorescent Ru(ii)-polypyridyl based sensors via both “turn-on” and “turn-off” emissive response is the main focus of present article.
Heerak Chugh, Pramod Kumar, Neeraj Kumar, Rajesh K. Gaur, Gagan Dhawan, and Ramesh Chandra
Royal Society of Chemistry (RSC)
Noscapine binds human hemoglobin spontaneously forming a stable complex that affects noscapine's ADMET profile, bioavailability and toxicity.
Sudheer, Vijay Kumar, Pramod Kumar, and Rajeev Gupta
Royal Society of Chemistry (RSC)
Hybrid chemosensors, based on a pyridine-2,6-dicarboxamide fragment while containing a 4-nitrobenzoxadiazole group, are used for the sensing of Al3+ and Fe3+ ions where detection was significantly controlled by the selection of a solvent.
Pramod Kumar, Vijay Kumar, and Rajeev Gupta
Royal Society of Chemistry (RSC)
This perspective presents fluorescent chemosensors based on dipicolinamide and isophthalamide groups that participate in the molecular recognition, sensing and detection of assorted analytes either via a “turn-on” or “turn-off” mechanism.
Himanshu Singh, Rajat Tiwari, Poonam Sharma, Pramod Kumar, and Nidhi Jain
Royal Society of Chemistry (RSC)
1,3-Bis(1-alkyl-1H-indol-3-yl)benzene derivatives have been synthesized through a Zn(OTf)2 catalyzed reaction between cyclohexanones and indoles.
Pramod Kumar and Sushil Kumar
Elsevier BV
Shyam Lal, Kunal Prakash, Sunita Hooda, Vikrant Kumar, and Pramod Kumar
Elsevier BV
Gulshan Kumar, Sanya Pachisia, Pramod Kumar, Vijay Kumar, and Rajeev Gupta
Wiley
We present two ZnII - and CdII -based coordination polymers (CPs), L-Zn and L-Cd, offering H-bonding-based cavities of varying dimensions. Both CPs were used for the highly selective detection of S2 O7 2- and Fe3+ ions where H-bonding based cavities played an important role. Fluorescence quenching, competitive binding studies and binding parameters substantiated significant recognition of S2 O7 2- and Fe3+ ions by both CPs.
Sushil Kumar, Aayushi Arora, Jolly Kaushal, Preeti Oswal, Arun Kumar, and Pramod Kumar
Elsevier BV
Vijay Kumar, Pramod Kumar, Sushil Kumar, Divya Singhal, and Rajeev Gupta
American Chemical Society (ACS)
Rationally designed multiple hydroxyl-group-based chemosensors L1-L4 containing arene-based fluorophores are presented for the selective detection of Al3+ and Ga3+ ions. Changes in the absorption and emission spectra of L1-L4 in ethanol were easily observable upon the addition of Al3+ and Ga3+ ions. Competitive binding studies, detection limits, and binding constants illustrate significant sensing abilities of these chemosensors with L4, showing the best results. The interaction of Al3+/Ga3+ ions with chemosensor L4 was investigated by fluorescence lifetime measurements, whereas Job's plot, high-resolution mass spectrometry, and 1H NMR spectral titrations substantiated the stoichiometry between L4 and Al3+/Ga3+ ions. The solution-generated [L-M3+] species further detected pyrophosphate ion (PPi) by exhibiting emission enhancement and a visible color change. The binding of Al3+/Ga3+ ions with chemosensor L4 was further supported by density functional theory studies. Reversibility for the detection of Al3+/Ga3+ ions was achieved by utilizing a suitable proton source. The multiionic response, reversibility, and optical visualization of the present chemosensors make them ideal for practical applications for real samples, which have been illustrated by paper-strip as well as polystyrene film-based detection.
Pramod Kumar, Mohit Mann, and Naresh Chandra Gupta
Springer Science and Business Media LLC
Aayushi Arora, Jolly Kaushal, Arun Kumar, Pramod Kumar, and Sushil Kumar
Wiley
Heerak Chugh, Pramod Kumar, Vartika Tomar, Navrinder Kaur, Damini Sood, and Ramesh Chandra
Elsevier BV
Ashish Dixit, Pramod Kumar, and Surendra Singh
Wiley
Chiral salalen ligands derived from (S)-proline and derivatives of salicyaldehydes were synthesized, and their in-situ generated Cu (II) complexes were evaluated in the asymmetric Henry reaction. Salalen ligand of different substituents on the phenyl moiety showed remarkable effect on the enantioselectivity of nitro-aldol product of 4-nitrobenzaldehyde and nitromethane. Cu (II) complex generated in situ with (S)-2-(tert-butyl)-6-((2-(((2-hydroxy-3-methylbenzylidene)amino)methyl)pyrrolidin-1-yl)methyl) phenol (10 mol%) and Cu (OAc)2 .H2 O (10 mol%), found to be better catalyst for nitro-aldol reaction between 4-nitrobenzaldehyde and nitromethane, gave corresponding product in 85% yield and 88% enantiomeric excess (ee) in isopropanol at 35°C after 40 hours. The catalyst also used for the Henry reaction with different substituted benzaldehydes and corresponding products were obtained in 22% to 99% yields with 66% to 92% ee. Henry reaction of 4-nitrobenzaldehyde and prochiral nitroethane gave anti-selective product (dr = 79/21; anti/syn) in a 91% yield with 80% ee.
Shyam Lal, Satish Kumar, Sunita Hooda, and Pramod Kumar
Elsevier BV
Ashish Dixit, Pramod Kumar, Geeta Devi Yadav, and Surendra Singh
Elsevier BV
Pramod Kumar, Sandeep Kaur, Rajeev Gupta, and Kristin Bowman-James
Elsevier
Pramod Kumar, Shrish Agnihotri, and Indrajit Roy
Informa UK Limited
Iron oxide nanoparticles have unique magnetic properties and therefore readily respond to applied magnetic fields. Moreover, their surfaces can be used to attach active molecules via various covalent or noncovalent interactions. Thus, they can be used as drug carriers for magnetically controlled delivery to specific biological sites of interest. In the present study, we have synthesized aqueous dispersed samples of citric acid-capped iron oxide nanoparticles, and the anticancer drug doxorubicin was then linked with these superparamagnetic iron oxide nanoparticles via a simple noncovalent interaction. Our results show that the conjugated drug releases from the nanoparticles in a sustained manner. The cellular uptake of these nanoparticles was found to be substantial, although it can be further enhanced using magnetic guidance. These nanoparticles (drug free) were found to be nontoxic to cells; however, upon drug conjugation, drug-induced toxicity was observed, owing to the slow release of drug from the nanoparticles.
Sushil Kumar, Ram Kishan, Pramod Kumar, Sanya Pachisia, and Rajeev Gupta
American Chemical Society (ACS)
This work presents the synthesis and characterization of two palladium-based fluorescent macrocycles offering hydrogen-bonding cavities of contrasting dimensions. Both palladium macrocycles function as chemosensors for the detection of nitroaromatics, whereas the larger macrocycle not only illustrates nanomolar detection of picric acid but also transports its significant amount from an aqueous to an organic phase.
RECENT SCHOLAR PUBLICATIONS
MOST CITED SCHOLAR PUBLICATIONS
GRANT DETAILS
Title of Projects “Microemulsion Mediated Multifunction Iron-Oxide/Ormosil Nanoparticles for Bioimaging and Drug Delivery” Funding Agency, Science and Engineering Research Board (DST), Duration 2 Years (11.11.2020 to 10.11.2022) Total grant 21.15520 Lakhs, Role as PI.
STARTUP
Title of Projects “Microemulsion Mediated Multifunction Iron-Oxide/Ormosil Nanoparticles for Bioimaging and Drug Delivery” Funding Agency, Science and Engineering Research Board (DST), Duration 2 Years (11.11.2020 to 10.11.2022) Total grant 21.15520 Lakhs, Role as PI.