Dr. Prashant Murumkar is currently working as Assistant Professor at Faculty of Pharmacy and Dy. Director, Office of Alumni Affair at The Maharaja Sayajirao University of Baroda.
Dr. Prashant is a recipient of highly prestigious “International ICMR-Young Indian Bio-medical Scientist Award” for the year 2016-17. As a part of this award Dr Prashant worked as a visiting scientist at Karolinska Institute, Division of Translational Alzheimer Neurobiology, Stockholm, Sweden.
In addition to receiving a National Doctoral Fellowship during his doctoral work, he was awarded multiple Young Scientist Travel Grants from a number of different government agencies, including Department of Science & Technology (DST), Council of Scientific and Industrial Research (CSIR), and the Indian Council of Medical Research (ICMR), facilitating the presentation of his research work at the International Conferences held in USA in the year 2008, 2009 and 2013.
Research Progress on Pyrazine-based Medicinally Active Compounds: A Review Karan Joshi, Omkumar Prajapati, Sadaf mirza, Ponam Jamwal, Miloni Brambhat, et al. Mini Reviews in Medicinal Chemistry, 2026 Medicinal chemists are highly interested in pyrazine-based compounds due to their diverse biological roles and potential therapeutic applications for various disorders. This research examines the expansion of pyrazine-derived compounds between the years 2014 and 2025. This review emphasizes their established efficacy against Cancer, Tuberculosis, Alzheimer's disease, microbial infections, inflammation, and viral pathogens. Pyrazines have shown significant prospects for drug discovery caused by their ability to target several biological processes. This paves the way for novel therapies. We have discussed significant discoveries of pyrazines, their complex mechanisms, and the necessary future actions to enhance the utility of pyrazine-based compounds as pharmaceuticals.
Synthesis, Characterization, and Computational Insights of Flavone Derivatives as Promising Antimicrobial Agents Sharad Gavale, Devshri Zade, Khushbu Patil, Rasana Yadav, Prashant R. Murumkar, et al. Chemistry and Biodiversity, 2025 A series of flavone derivatives (6a–6k), with varying ─O functionalities, was synthesized and characterized using spectroscopic techniques. In vitro antimicrobial assay against a range of bacterial and fungal strains, including Gram‐positive (Staphylococcus aureus and Streptococcus pyogenes) and Gram‐negative bacteria (Escherichia coli and Pseudomonas aeruginosa), as well as fungal species (Candida albicans and Aspergillus niger), has demonstrated superior antibacterial activity against Gram‐negative bacteria by most derivatives. Interestingly, compounds 6b, 6c, and 6j exhibited the highest potency, with MIC values of 20 µg/mL against E. coli, 50 µg/mL against S. aureus, and 80 µg/mL against E. coli and A. niger, which is better than their respective standard drugs. The structural details and mechanistic insights of flavone derivatives 6a–6k were assessed by computational studies, including DFT, molecular docking, and ADMET analysis. HOMO–LUMO analysis indicated compound 6b exhibited enhanced chemical reactivity, correlating with its superior antibacterial activity against E. coli. Molecular docking revealed strong binding affinities, especially for 6b and 6j, suggesting their potential as therapeutic agents. These compounds adhered to Lipinski's rule and displayed favorable ADMET properties. Molecular dynamics simulations of 6b showed stable binding within the 4PRV protein (E. coli) active site. This study highlights the potential of flavone derivatives as promising antimicrobial agents, offering a new avenue for combating antibiotic resistance.
The Mycobacterium tuberculosis Cell Wall: An Alluring Drug Target for Developing Newer Anti-TB Drugs—A Perspective Monica Chauhan, Rahul Barot, Rasana Yadav, Karan Joshi, Sadaf Mirza, et al. Chemical Biology and Drug Design, 2024 The Mycobacterium cell wall is a capsule‐like structure comprising of various layers of biomolecules such as mycolic acid, peptidoglycans, and arabinogalactans, which provide the Mycobacteria a sort of cellular shield. Drugs like isoniazid, ethambutol, cycloserine, delamanid, and pretomanid inhibit cell wall synthesis by inhibiting one or the other enzymes involved in cell wall synthesis. Many enzymes present across these layers serve as potential targets for the design and development of newer anti‐TB drugs. Some of these targets are currently being exploited as the most druggable targets like DprE1, InhA, and MmpL3. Many of the anti‐TB agents present in clinical trials inhibit cell wall synthesis. The present article covers a systematic perspective of developing cell wall inhibitors targeting various enzymes involved in cell wall biosynthesis as potential drug candidates for treating Mtb infection.
Design, synthesis, biological evaluation and molecular dynamics of some novel 3-phenylpyrazolo[1,5-a]pyrimidine-2,7(1H,4H)-dione based compounds as anti-tubercular agents Monica Chauhan, Chintu Prajapati, Sadaf Mirza, Rahul Barot, Rasana Yadav, et al. Journal of Biomolecular Structure and Dynamics, 2024 Decaprenylphosphoryl-β-d-ribose-2'-epimerase (DprE1) is a druggable target which is being exploited for the development of new anti-TB agents. In the present work, we report developing a pharmacophore model and performing virtual screening of Asinex database using the developed pharmacophore model to get eight hits as potential DprE1 inhibitors. The hits were used as leads to design new 3-phenylpyrazolo[1,5-a]pyrimidine-2,7(1H,4H)-dione based potential anti-TB agents. On the basis of the identified lead molecules, a total of 18 compounds were synthesized and evaluated for their anti-TB activity by using MABA. ADMET predictions for all the compounds revealed that these compounds have drug-like and lead-like properties. One of the final compounds was found to exhibit potent anti-TB activity against Mycobacterium bovis.Communicated by Ramaswamy H. Sarma.
Novel quinolinepiperazinyl-aryltetrazoles targeting the blood stage of Plasmodium falciparum Mahesh A. Barmade, Prakhar Agrawal, Sweta R. Rajput, Prashant R. Murumkar, Bhavika Rana, et al. Rsc Medicinal Chemistry, 2023 This study offers compounds (66 and 75) as a new class of antimalarials, which are active against ACT-resistant strains of the Plasmodium and target several proteins of malaria parasite including the PfGAP50 protein.
Chromene and its derivatives in the treatment of SARS-COV-2 virus infection Role of Chromenes in Drug Discovery and Development, 2023
Structure-based virtual screening in drug discovery Mange Ram Yadav, Prashant R. Murumkar, Rasana Yadav, Karan Joshi Cheminformatics QSAR and Machine Learning Applications for Novel Drug Development, 2023
Vicinal Diaryl Triazoles and Tetrazoles Prashant R. Murumkar, Rupesh V. Chikhale Vicinal Diaryl Substituted Heterocycles A Gold Mine for the Discovery of Novel Therapeutic Agents, 2018
Exploring the antimicrobial landscape of carbazole derivatives through integration of computational and experimental approaches S Soni, K Patil, S Vishwakarma, R Yadav, PR Murumkar, R Kadu Discover Chemistry 3 (1), 149 , 2026 2026
Research Progress on Pyrazine-based Medicinally Active Compounds: A Review PM Karan Joshi, Omkumar Prajapati, Sadaf Mirza, Ponam Jamwal, Miloni ... Mini Rev Med Chem , 2026 2026
Synthesis, Characterization, and Computational Insights of Flavone Derivatives as Promising Antimicrobial Agents S Gavale, D Zade, K Patil, R Yadav, PR Murumkar, R Kadu Chemistry & Biodiversity 22 (12), e02136 , 2025 2025
Exploring Oxazolidinone scaffolds for future antibiotics: synthesis and computational insights with DFT, docking, ADME and MD simulation S Soni, K Patil, S Gavale, S Pathan, R Yadav, PR Murumkar, R Kadu Journal of computer-aided molecular design 39 (1), 58 , 2025 2025 Citations: 2
One-pot synthesis and biological evaluation of some new HERα interacting indolyl-dibenzo [b, e][1, 4] diazepinone scaffolds AA Barot, HD Atara, VM Parmar, TP Patel, NA Raulji, UP Gohel, ... Journal of Molecular Structure, 144001 , 2025 2025 Citations: 1
Synergistic exploration of thiazole derivatives: Synthesis, antimicrobial activity and computational insights S Gavale, S Vishwakarma, S Soni, S Pathan, R Yadav, PR Murumkar, ... Journal of Molecular Structure 1333, 141772 , 2025 2025 Citations: 10
Exploration of Computational Approaches in Toxicity Prediction PR Murumkar, R Yadav, R Barot, R Shah, V Srivastava, MR Yadav Artificial Intelligence for Chemical Sciences, 179-207 , 2025 2025 Citations: 1
Design, synthesis, biological evaluation and molecular dynamics of some novel 3-phenylpyrazolo[1,5- a ]pyrimidine-2,7(1 H ,4 H )-dione based compounds as anti … M Chauhan, C Prajapati, S Mirza, R Barot, R Yadav, M Barmade, ... Journal of Biomolecular Structure and Dynamics 42 (17), 9031-9049 , 2024 2024 Citations: 3
The Mycobacterium tuberculosis Cell Wall: An Alluring Drug Target for Developing Newer Anti‐TB Drugs—A Perspective M Chauhan, R Barot, R Yadav, K Joshi, S Mirza, R Chikhale, ... Chemical Biology & Drug Design 104 (3), e14612 , 2024 2024 Citations: 18
Novel quinolinepiperazinyl-aryltetrazoles targeting the blood stage of Plasmodium falciparum MA Barmade, P Agrawal, SR Rajput, PR Murumkar, B Rana, D Sahal, ... RSC Medicinal Chemistry 15 (2), 572-594 , 2024 2024 Citations: 6
Approved Cholinesterase Inhibitor-Based Derivatives: Synthesis and Their Biological Evaluation MR Yadav, PR Murumkar, K Joshi, R Barot, R Yadav Natural Product-based Synthetic Drug Molecules in Alzheimer's Disease … , 2023 2023 Citations: 2
An efficient one-pot synthesis and docking studies of bioactive new antiproliferative dispiro [oxindole/acenaphthylenone‒benzofuranone] pyrrolidine scaffolds TR Sutariya, GC Brahmbhatt, HD Atara, NJ Parmar, RajniKant, VK Gupta, ... Molecular Diversity, 1-16 , 2023 2023 Citations: 2
Chromene and its Derivatives in the Treatment of SARS-COV-2 Virus Infection DB Ruikar, K Joshi, R Yadav, GJ Deshmukh, S Manekar, PR Murumkar The Role of Chromenes in Drug Discovery and Development, 164-189 , 2023 2023
Role of computational modeling in drug discovery for Alzheimer’s disease MR Yadav, PR Murumkar, R Barot, R Yadav, K Joshi, M Chauhan Current trends in Computational modeling for Drug Discovery, 57-107 , 2023 2023 Citations: 6
Tuberculosis: integrated studies for a complex disease 2050 N Rezaei, NS Hosseini, A Saghazadeh, A Fateh, A Duse, A Ahmad, ... Tuberculosis: Integrated Studies for a Complex Disease, 1063-1098 , 2023 2023 Citations: 15
Exploring Decaprenylphosphoryl-β- d -Ribose 2′-Epimerase 1 (DprE1): A Target for Anti-tubercular Drugs MR Yadav, PR Murumkar, RB Ghuge, RR Barot, M Chauhan Tuberculosis: Integrated Studies for a Complex Disease, 499-539 , 2023 2023 Citations: 5
Selection of suitable protein structure from protein data bank: an important step in structure-based drug design studies PR Murumkar, MK Sharma, P Gupta, NM Patel, MR Yadav Mini Reviews in Medicinal Chemistry 23 (3), 246-264 , 2023 2023 Citations: 18
Structure-based virtual screening in drug discovery MR Yadav, PR Murumkar, R Yadav, K Joshi Cheminformatics, QSAR and Machine Learning Applications for Novel Drug … , 2023 2023 Citations: 12
Design, synthesis and biological evaluation of Piperazinylanthranilamides as potential factor Xa inhibitors AN Khadse, HH Savsani, RV Chikhale, RB Ghuge, DR Prajapati, ... Journal of Molecular Structure 1270, 133974 , 2022 2022 Citations: 2
Design and synthesis of novel N -[3-(benzimidazol-2-ylamino)phenyl]amine and N -[3-(benzoxazol-2-ylamino)phenyl]amine derivatives as potential anticancer agents HY Kumar, PR Murumkar, BP Srinivasan, V Pawar, MR Yadav Molecular Diversity 26 (4), 2269-2293 , 2022 2022 Citations: 1
MOST CITED SCHOLAR PUBLICATIONS
Overview of the development of DprE1 inhibitors for combating the menace of tuberculosis RV Chikhale, MA Barmade, PR Murumkar, MR Yadav Journal of medicinal chemistry 61 (19), 8563-8593 , 2018 2018 Citations: 163
Current perspective of TACE inhibitors: a review S DasGupta, PR Murumkar, R Giridhar, MR Yadav Bioorganic & medicinal chemistry 17 (2), 444-459 , 2009 2009 Citations: 149
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists—A perspective P Naik, P Murumkar, R Giridhar, MR Yadav Bioorganic & medicinal chemistry 18 (24), 8418-8456 , 2010 2010 Citations: 143
Unequivocal role of pyrazine ring in medicinally important compounds: A review P B. Miniyar, P R. Murumkar, P S. Patil, M A. Barmade, K G. Bothara Mini reviews in medicinal chemistry 13 (11), 1607-1625 , 2013 2013 Citations: 135
Prodrug designing of NSAIDs PK Halen, PR Murumkar, R Giridhar, MR Yadav Mini reviews in medicinal chemistry 9 (1), 124-139 , 2009 2009 Citations: 133
Medicinal chemistry perspective of fused isoxazole derivatives M A Barmade, P R Murumkar, M Kumar Sharma, M Ram Yadav Current Topics in Medicinal Chemistry 16 (26), 2863-2883 , 2016 2016 Citations: 128
Benzylpiperidine-linked diarylthiazoles as potential anti-Alzheimer’s agents: synthesis and biological evaluation M Shidore, J Machhi, K Shingala, P Murumkar, MK Sharma, N Agrawal, ... Journal of medicinal chemistry 59 (12), 5823-5846 , 2016 2016 Citations: 123
Prospective therapeutic agents for obesity: molecular modification approaches of centrally and peripherally acting selective cannabinoid 1 receptor antagonists MK Sharma, PR Murumkar, AM Kanhed, R Giridhar, MR Yadav European journal of medicinal chemistry 79, 298-339 , 2014 2014 Citations: 79
Developing steroidal aromatase inhibitors-an effective armament to win the battle against breast cancer MR Yadav, MA Barmade, RS Tamboli, PR Murumkar European journal of medicinal chemistry 105, 1-38 , 2015 2015 Citations: 78
Current and emerging direct oral anticoagulants: state-of-the-art G Lippi, R Gosselin, EJ Favaloro Seminars in thrombosis and hemostasis 45 (05), 490-501 , 2019 2019 Citations: 76
DMSO: a mixed-competitive inhibitor of human acetylcholinesterase A Kumar, T Darreh-Shori ACS chemical neuroscience 8 (12), 2618-2625 , 2017 2017 Citations: 73
Novel TACE inhibitors in drug discovery: a review of patented compounds PR Murumkar, S DasGupta, SR Chandani, R Giridhar, MR Yadav Expert opinion on therapeutic patents 20 (1), 31-57 , 2010 2010 Citations: 67
Contemporary developments in the discovery of selective factor Xa inhibitors: A review NR Patel, DV Patel, PR Murumkar, MR Yadav European journal of medicinal chemistry 121, 671-698 , 2016 2016 Citations: 60
Dihydropyrimidinone-isatin hybrids as novel non-nucleoside HIV-1 reverse transcriptase inhibitors TL Devale, J Parikh, P Miniyar, P Sharma, B Shrivastava, P Murumkar Bioorganic chemistry 70, 256-266 , 2017 2017 Citations: 57
Development of predictive pharmacophore model for in silico screening, and 3D QSAR CoMFA and CoMSIA studies for lead optimization, for designing of potent tumor necrosis factor … PR Murumkar, VP Zambre, MR Yadav Journal of computer-aided molecular design 24 (2), 143-156 , 2010 2010 Citations: 51
Studies on novel 2-imidazolidinones and tetrahydropyrimidin-2 (1H)-ones as potential TACE inhibitors: design, synthesis, molecular modeling, and preliminary biological evaluation S DasGupta, PR Murumkar, R Giridhar, MR Yadav Bioorganic & medicinal chemistry 17 (10), 3604-3617 , 2009 2009 Citations: 48
Novel multitarget directed triazinoindole derivatives as anti-Alzheimer agents DV Patel, NR Patel, AM Kanhed, SP Patel, A Sinha, DD Kansara, ... ACS chemical neuroscience 10 (8), 3635-3661 , 2019 2019 Citations: 44
Development of Predictive 3D‐QSAR CoMFA and CoMSIA Models for β‐aminohydroxamic Acid‐Derived Tumor Necrosis Factor‐α Converting Enzyme Inhibitors PR Murumkar, SD Gupta, VP Zambre, R Giridhar, MR Yadav Chemical Biology & Drug Design 73 (1), 97-107 , 2009 2009 Citations: 40
Structural investigations of acridine derivatives by CoMFA and CoMSIA reveal novel insight into their structures toward DNA G-quadruplex mediated telomerase inhibition and … VP Zambre, PR Murumkar, R Giridhar, MR Yadav Journal of chemical information and modeling 49 (5), 1298-1311 , 2009 2009 Citations: 39
Recent developments and strategies for the discovery of TACE inhibitors PR Murumkar, RB Ghuge, M Chauhan, RR Barot, S Sorathiya, ... Expert Opinion on Drug Discovery 15 (7), 779-801 , 2020 2020 Citations: 37