Dr Prashant A Karni

@kledeemeduniversity.edu.in

Associate Professor, Department of Prosthodontics and Crown Bridge
KAHER's KLE VK IDS

Dr Prashant A Karni


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Scopus Publications

Scopus Publications

  • Comparative Analysis of Post-Endodontic Restoration Designs on Fracture Resistance in Endodontically Treated Premolars
    European Journal of Prosthodontics and Restorative Dentistry, 2026
  • Surface-functionalized Titanium Implant with Gold Nanoparticles on Osteogenic and Antimicrobial Behavior: A Novel Preliminary Research on mg 63 Cell Line
    Santosh Nelogi, Kiran Kaur, Prashant Karni, Amit Porwal
    Biomedical and Pharmacology Journal, 2025
    Background: The enhancement of implant surfaces to promote better osseointegration and reduce infection risks is critical in biomedical applications. Gold nanoparticles (GNP) have shown promise in improving the biological performance of implant materials. This study explores the effects of GNP-coated titanium surfaces on the proliferation, differentiation, and mineralization of MG63 osteoblast-like cells. Methods: Titanium discs were coated with gold nanoparticles synthesized using a green, environmentally friendly method. The coated surfaces were characterized using SEM, EDAX, and SPR techniques to confirm the presence and stability of the GNP. MG63 cells were cultured on these GNP-coated titanium discs, and their growth, proliferation, and differentiation were assessed using fluorescence microscopy, Von Kossa staining, vinculin focal adhesion proteins, and alkaline phosphatase (ALP) activity measurements. The antimicrobial efficacy of the GNP-coated surfaces was also evaluated against Staphylococcus aureus and Escherichia coli. Results: Titanium surfaces coated with (GNP) at 5 ppm significantly enhanced the growth and differentiation of MG63 cells, with no evidence of acute cytotoxicity. The GNP-coated surfaces facilitated improved cell attachment, proliferation, and mineralization, indicating strong osteogenic potential. Additionally, the GNP-coated surfaces exhibited notable antimicrobial efficacy, MICrecorded at 0.3135 mg/cm³ for Staphylococcus aureus and 0.2915 mg/cm³ for Escherichia coli. Conclusion: Gold nanoparticle coatings at a concentration of 5 ppm significantly improve the osteogenic potential of titanium surfaces while also providing antimicrobial protection. These findings suggest that GNP-coated titanium implants could offer a dual benefit of enhanced osseointegration and infection prevention, making them a promising option for future clinical applications. Further in vivo studies are necessary to validate these results and understand the broader implications of GNP in biomedical implants.
  • Assessment of Peri-Implant Tissue Health and Marginal Bone Loss in Immediate Versus Delayed Implant Placement
    Prashant A. Karni, Himaja Kasarla, Annesha Koinyaki Konwar, Irfa Junaid, Manawar Ahmad Mansoor, Sumedh Lone, Pooja Kadam
    Journal of Pharmacy and Bioallied Sciences, 2024
    Objectives: The ambition of this research is to gauge marginal bone loss (MBL) and peri-implant tissue health by comparing immediate and delayed implant implantation in a tertiary care setting. Methods: Subjects who had immediate and delayed implants were assessed. Clinical indicators such as bleeding on probing (BOP), peri-implant probing depth, and MBL were assessed at baseline and six months postimplantation. A result was considered statistically significant if it was P < 0.05. Findings: At first, there was no discernible variance between the demographic traits of the two groups. Regarding MBL and peri-implant probing depth, there were statistically significant (P < 0.05) deviations between groups at the six-month mark following implant installation. There were no appreciable variations in bleeding between the two groups, according to probing. Conclusion: In summary, compared to delayed implant placement, rapid implant placement was associated with MBL and increased peri-implant probing depth throughout a six-month follow-up period. These results emphasize the need for careful patient selection and treatment planning in implant dentistry.
  • Efficacy of Various Herbal Preparations Against Oral Candida: A Lab‑Based Study
    Prashant A. Karni, Aparna Muraleedharan, Srikala Bhandary, Sheetal Mujoo, Anuj Paul Maini, Mudita Chaturvedi
    Journal of Pharmacy and Bioallied Sciences, 2024
    Aim: This research was done to analyze the effectiveness related to herbal chemicals in tackling candidiasis. Materials and Methods: Grounded and ethanol-extracted residues of plants like Avicennia marina, Fagonia indica, Portulaca oleracea, Lawsania inermis, Ziziphus spina, Asphodelus tenuifolius, and Salvadora persica were used in the study. The extract was used against candida species, after which the antibacterial as well as cytotoxicity toward the former were evaluated. Results: L. inermis and P. oleracea with minimal inhibitory concentration of approx. 10 cenmL had an increased activity against candida species. The preparations of these plants acted against Candida albicans during its stages related to pathogenesis during biofilm production. Superadded infections like in case of bacterial infections along with candida can be difficult to cure. On human RBCs, these plant preparations had no toxicity at their minimum inhibitory concentration level. Conclusion: We concluded that, as far as being anti-candida and acting against MDR bacterial infections, preparations of plants were effective as an alternative to allopathic drugs.
  • Unique, cost-effective and retentive removable prosthesis to rehabilitate long span Kennedy'S class I edentulism with custom attachment system: A case report
    Raghunath Patil, Anandkumar G Patil, Abhijit P Patil, Anuradha V Pawar, Prashant Karni, Sayali Mardolkar
    Journal of Contemporary Dental Practice, 2020
    AIM This case report describes about a distinctive custom-made attachment on the abutment teeth to improve the retention and stability of the removable partial denture (RPD). It also throws light on the cost-effective method for altering the abutment teeth with the aid of the crowns and custom-made attachments. BACKGROUND Achieving retention in Kennedy's class I bilateral edentulism usually affects the abutment teeth's periodontal health and eventually the retention is compromised. Distal extension edentulism also affects patient's masticatory efficiency. The rehabilitation of a patient with the long span Kennedy's class I condition complicates the problem because of the unavailability of enough abutments to support the prosthesis. Conventional removable prosthesis with clasps and cantilever fixed partial prosthesis are not advisable in this situation for the same reason. CASE DESCRIPTION A case with Kennedy's class I modification 1 partially edentulous arch with 1st and 2nd molars missing along with central incisors was rehabilitated with an inexpensive custom attachment using die pin and sleeve for giving a fixed prosthesis on abutment teeth and removable prosthesis with missing teeth. CONCLUSION This technique has advantages of retention better than conventional RPDs, protection of abutment health by restoring it with crown, easy to place and remove and very cost-effective. CLINICAL SIGNIFICANCE The entire technique demands less skill compared to semi precision and precision attachments.