PRAVEEN JEYACHANDRAN
@nus.edu.sg
Research Fellow and Department of Orthopaedic Surgery
National University of Singapore
RESEARCH, TEACHING, or OTHER INTERESTS
Mechanical Engineering, Multidisciplinary, Biomedical Engineering
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Naresh Kumar, Si Jian Hui, Shahid Ali, Renick Lee, Praveen Jeyachandran, and Jiong Hao Tan
Elsevier BV
Ganesan Narendran, Avdhoot Walunj, A. Mohan Kumar, Praveen Jeyachandran, Nasser S. Awwad, Hala A. Ibrahium, M. R. Gorji, and D. Arumuga Perumal
MDPI AG
In this paper, we designed and demonstrated a stimuli-responsive hydrogel that mimics the mass diffusion function of the liver. We have controlled the release mechanism using temperature and pH variations. Additive manufacturing technology was used to fabricate the device with nylon (PA-12), using selective laser sintering (SLS). The device has two compartment sections: the lower section handles the thermal management, and feeds temperature-regulated water into the mass transfer section of the upper compartment. The upper chamber has a two-layered serpentine concentric tube; the inner tube carries the temperature-regulated water to the hydrogel using the given pores. Here, the hydrogel is present in order to facilitate the release of the loaded methylene blue (MB) into the fluid. By adjusting the fluid’s pH, flow rate, and temperature, the deswelling properties of the hydrogel were examined. The weight of the hydrogel was maximum at 10 mL/min and decreased by 25.29% to 10.12 g for the flow rate of 50 mL/min. The cumulative MB release at 30 °C increased to 47% for the lower flow rate of 10 mL/min, and the cumulative release at 40 °C climbed to 55%, which is 44.7% more than at 30 °C. The MB release rates considerably increased when the pH dropped from 12 to 8, showing that the lower pH had a major impact on the release of MB from the hydrogel. Only 19% of the MB was released at pH 12 after 50 min, and after that, the release rate remained nearly constant. At higher fluid temperatures, the hydrogels lost approximately 80% of their water in just 20 min, compared to a loss of 50% of their water at room temperature. The outcomes of this study may contribute to further developments in artificial organ design.
Praveen Jeyachandran, Srikanth Bontha, Subhadip Bodhak, Vamsi Krishna Balla, and Mrityunjay Doddamani
Praveen Jeyachandran, Srikanth Bontha, Subhadip Bodhak, Vamsi Krishna Balla, and Mrityunjay Doddamani
Elsevier BV
Praveen Jeyachandran, Srikanth Bontha, Subhadip Bodhak, Vamsi Krishna Balla, Biswanath Kundu, and Mrityunjay Doddamani
Elsevier BV
K. Chockalingam, N. Jawahar, and J. Praveen
Informa UK Limited
Fused Deposited Modeling (FDM) is one of the Rapid Prototyping (RP) processes that use thermoplastics to fabricate parts layer by layer. The parts built using ABS M30 plastics using FDM shows anisotropic property. This direction-dependent failure criterion results in parts with strength lesser than the maximum possible available strength. Also the orientation for building the parts is selected by the proprietary software based on minimum fabrication time and material consumption. When it comes to sand casting patterns, tensile strength and density play a major role in determining its service life and load bearing capacity. So in this paper an attempt has been made to study the dependency of process parameters (orientation, raster angle, raster width and air gap) on tensile strength and density. The design of the experiment is formulated based on Face Centered Central Composite Design (FCCCD). Response plots are plotted to study how the levels of process parameters influence each other in the resulting response. Scanning Electron Microscope (SEM) images are taken to study the fracture surface of the specimen. The multi-objective optimization of tensile strength and density is performed by using Non-Dominated Sorting Genetic Algorithm (NSGA-2).