Anthony Procès

@neurosciences.univ-grenoble-alpes.fr

Grenoble Institut Neurosciences
Université Grenoble Alpes

Anthony Procès


                        Download Compact PDF  
https://researchid.co/procesa

RESEARCH, TEACHING, or OTHER INTERESTS

Cellular and Molecular Neuroscience, Biochemistry, Genetics and Molecular Biology, Biophysics, Biomaterials
8

Scopus Publications

393

Scholar Citations

7

Scholar h-index

6

Scholar i10-index

Scopus Publications

  • Nanoscale Activity Mapping of Chloride-Permeable Pentameric Receptors
    Yana Vella, Anthony Procès, Amber Van Bocxlaer, Chloë Trippaers, César O Lara, et al.
    ACS Sensors, 2026
  • Unlocking the therapeutic potential of cellular mechanobiology
    Yohalie Kalukula, Giuseppe Ciccone, Danahe Mohammed, Anthony Procès, Marie Versaevel, et al.
    Science Advances, 2025
    Mechanobiology is a rapidly advancing field at the intersection of biology, physics, and engineering that reveals how mechanical forces shape cellular behavior, tissue architecture, and disease progression. By elucidating how cells sense and transduce mechanical cues, mechanobiology has fundamentally advanced our understanding of processes ranging from migration and differentiation to immune responses and tissue remodeling. These advances have driven the development of innovative biophysical tools and engineered biomaterials that enable precise modulation of the cellular microenvironment. Translating mechanobiological principles into clinical practice is giving rise to mechanomedicine, a previously unrecognized paradigm that integrates mechanical forces as key modulators of health and disease. This review highlights how mechanobiology informs therapeutic strategies across diverse domains, including cancer immunotherapy, cardiovascular and neurodegenerative disorders, and regenerative medicine. By bridging fundamental discoveries with translational applications, this review positions mechanobiology as a cornerstone of next-generation medical innovation, translating mechanistic insights into impactful clinical applications.
  • Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems
    Anthony Procès, Sylvain Gabriele
    Neural Regeneration Research, 2025
  • Stretch-injury promotes microglia activation with enhanced phagocytic and synaptic stripping activities
    Anthony Procès, Yeranddy A. Alpizar, Sophie Halliez, Bert Brône, Frédéric Saudou, et al.
    Biomaterials, 2024
  • Multiscale Mechanobiology in Brain Physiology and Diseases
    Anthony Procès, Marine Luciano, Yohalie Kalukula, Laurence Ris, Sylvain Gabriele
    Frontiers in Cell and Developmental Biology, 2022
    Increasing evidence suggests that mechanics play a critical role in regulating brain function at different scales. Downstream integration of mechanical inputs into biochemical signals and genomic pathways causes observable and measurable effects on brain cell fate and can also lead to important pathological consequences. Despite recent advances, the mechanical forces that influence neuronal processes remain largely unexplored, and how endogenous mechanical forces are detected and transduced by brain cells into biochemical and genetic programs have received less attention. In this review, we described the composition of brain tissues and their pronounced microstructural heterogeneity. We discuss the individual role of neuronal and glial cell mechanics in brain homeostasis and diseases. We highlight how changes in the composition and mechanical properties of the extracellular matrix can modulate brain cell functions and describe key mechanisms of the mechanosensing process. We then consider the contribution of mechanobiology in the emergence of brain diseases by providing a critical review on traumatic brain injury, neurodegenerative diseases, and neuroblastoma. We show that a better understanding of the mechanobiology of brain tissues will require to manipulate the physico-chemical parameters of the cell microenvironment, and to develop three-dimensional models that can recapitulate the complexity and spatial diversity of brain tissues in a reproducible and predictable manner. Collectively, these emerging insights shed new light on the importance of mechanobiology and its implication in brain and nerve diseases.
  • Appreciating the role of cell shape changes in the mechanobiology of epithelial tissues
    Marine Luciano, Marie Versaevel, Eléonore Vercruysse, Anthony Procès, Yohalie Kalukula, et al.
    Biophysics Reviews, 2022
    The wide range of epithelial cell shapes reveals the complexity and diversity of the intracellular mechanisms that serve to construct their morphology and regulate their functions. Using mechanosensitive steps, epithelial cells can sense a variety of different mechanochemical stimuli and adapt their behavior by reshaping their morphology. These changes of cell shape rely on a structural reorganization in space and time that generates modifications of the tensional state and activates biochemical cascades. Recent studies have started to unveil how the cell shape maintenance is involved in mechanical homeostatic tasks to sustain epithelial tissue folding, identity, and self-renewal. Here, we review relevant works that integrated mechanobiology to elucidate some of the core principles of how cell shape may be conveyed into spatial information to guide collective processes such as epithelial morphogenesis. Among many other parameters, we show that the regulation of the cell shape can be understood as the result of the interplay between two counteracting mechanisms: actomyosin contractility and intercellular adhesions, and that both do not act independently but are functionally integrated to operate on molecular, cellular, and tissue scales. We highlight the role of cadherin-based adhesions in force-sensing and mechanotransduction, and we report recent developments that exploit physics of liquid crystals to connect cell shape changes to orientational order in cell aggregates. Finally, we emphasize that the further intermingling of different disciplines to develop new mechanobiology assays will lead the way toward a unified picture of the contribution of cell shape to the pathophysiological behavior of epithelial tissues.
  • Inflammatory Molecules Released by Mechanically Injured Astrocytes Trigger Presynaptic Loss in Cortical Neuronal Networks
    Joséphine Lantoine, Anthony Procès, Agnès Villers, Sophie Halliez, Luc Buée, et al.
    ACS Chemical Neuroscience, 2021
    Deformation, compression, or stretching of brain tissues cause diffuse axonal injury (DAI) and induce structural and functional alterations of astrocytes, the most abundant cell type in the brain. To gain further insight into the role of mechanically activated astrocytes on neuronal networks, this study was designed to investigate whether cytokines released by mechanically activated astrocytes can affect the growth and synaptic connections of cortical neuronal networks. Astrocytes were cultivated on elastic membranes and subjected to repetitive mechanical insults, whereas well-defined protein micropatterns were used to form standardized neuronal networks. GFAP staining showed that astrocytes were mechanically activated after two cycles of stretch and mesoscale discovery assays indicated that injured astrocytes released four major cytokines. To understand the role of these cytokines, neuronal networks were cultured with the supernatant of healthy or mechanically activated astrocytes, and the individual contribution of the proinflammatory cytokine tumor necrosis factor-α (TNF-α) was studied. We found that the supernatant of two-cycle stretched astrocytes decreased presynaptic terminals and indicated that TNF-α must be considered a key player of the synaptic loss. Furthermore, our results indicate that cytokines released by injured astrocytes significantly modulate the balance between TNFR1 and TNFR2 receptors by enhancing R2 receptors. We demonstrated that TNF-α is not involved in this process, suggesting a predominant role of other secreted cytokines. Together, these results contribute to a better understanding of the consequences of repetitive astrocyte deformations and highlight the role of inflammatory signaling pathways in synaptic plasticity and modulation of TNFR1 and TNFR2 receptors.
  • Innovative tools for mechanobiology: Unraveling outside-in and inside-out mechanotransduction
    Danahe Mohammed, Marie Versaevel, Céline Bruyère, Laura Alaimo, Marine Luciano, et al.
    Frontiers in Bioengineering and Biotechnology, 2019
    Cells and tissues can sense and react to the modifications of the physico-chemical properties of the extracellular environment (ECM) through integrin-based adhesion sites and adapt their physiological response in a process called mechanotransduction. Due to their critical localization at the cell-ECM interface, transmembrane integrins are mediators of bidirectional signaling, playing a key role in “outside-in” and “inside-out” signal transduction. After presenting the basic conceptual fundamentals related to cell mechanobiology, we review the current state-of-the-art technologies that facilitate the understanding of mechanotransduction signaling pathways. Finally, we highlight innovative technological developments that can help to advance our understanding of the mechanisms underlying nuclear mechanotransduction.

RECENT SCHOLAR PUBLICATIONS

  • Nanoscale Activity Mapping of Chloride-Permeable Pentameric Receptors
    Y Vella, A Procès, A Van Bocxlaer, C Trippaers, CO Lara, Ö Uslu, ...
    ACS sensors 40 (XXX), XXX-XXX , 2026
    2026
  • Unlocking the therapeutic potential of cellular mechanobiology
    Y Kalukula, G Ciccone, D Mohammed, A Procès, M Versaevel, ...
    Science advances 11 (44), eaea6817 , 2025
    2025
    Citations: 15
  • Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems
    A Procès, S Gabriele
    Neural Regeneration Research 20 (8), 2304-2306 , 2025
    2025
    Citations: 1
  • Stretch-injury promotes microglia activation with enhanced phagocytic and synaptic stripping activities
    A Proces, YA Alpizar, S Halliez, B Brône, F Saudou, L Ris, S Gabriele
    Biomaterials 305, 122426 , 2024
    2024
    Citations: 20
  • Phagocytosis and synaptic pruning are enhanced in mechanically activated glial cells
    A Proces, YA Aguiar, B Brône, F Saudou, S Gabriele, L Ris
    Neuroscience 2022 , 2022
    2022
  • Multiscale mechanobiology in brain physiology and diseases
    A Procès, M Luciano, Y Kalukula, L Ris, S Gabriele
    Frontiers in Cell and Developmental Biology 10, 823857 , 2022
    2022
    Citations: 70
  • Appreciating the role of cell shape changes in the mechanobiology of epithelial tissues
    M Luciano, M Versaevel, E Vercruysse, A Procès, Y Kalukula, A Remson, ...
    Biophysics Reviews 3 (1) , 2022
    2022
    Citations: 46
  • Deciphering the role of mechanical cues on activation of microglial cells
    A Proces, L Ris, S Gabriele
    BSCDB Autumn Meeting: Mechanobiology in Cell Biology and Development , 2021
    2021
  • Inflammatory molecules released by mechanically injured astrocytes trigger presynaptic loss in cortical neuronal networks
    J Lantoine, A Proces, A Villers, S Halliez, L Buée, L Ris, S Gabriele
    ACS Chemical Neuroscience 12 (20), 3885-3897 , 2021
    2021
    Citations: 15
  • Mechano-activation of astrocytes and microglial cells.
    A Proces, L Ris, S Gabriele
    ImmunoBiophysics: From fundamental physics to understanding immune response , 2021
    2021
  • Deciphering the role of activated glial cells on neuronal connectivity using in vitro models of traumatic brain injury
    A Proces, J Lantoine, L Ris, S Gabriele
    GDR CellTiss Days , 2019
    2019
  • Innovative tools for mechanobiology: unraveling outside-in and inside-out mechanotransduction
    D Mohammed, M Versaevel, C Bruyère, L Alaimo, M Luciano, ...
    frontiers in Bioengineering and Biotechnology 7, 162 , 2019
    2019
    Citations: 217
  • The beneficial and harmful effects of glial cells on neuronal connectivity in in vitro models of traumatic brain injury.
    A Proces, J Lantoine, S Gabriele, L Ris
    Front. Neurosci. Conference Abstract: 13th National Congress of the Belgian … , 2019
    2019
  • Innovative tools for mechanobiology: Unraveling outside-in and inside-out mechanotransduction. Front. Bioeng. Biotechnol. 7: 162
    D Mohammed, M Versaevel, C Bruyere, L Alaimo, M Luciano, ...
    2019
    Citations: 9
  • Development of an experimental model of traumatic brain injury using hippocampal slice cultures.
    A Proces, A Villers, S Gabriele, L Ris
    BSCDB and RBSM meeting: Cell and Tissue Mechanics in Physiology and Disease , 2018
    2018

MOST CITED SCHOLAR PUBLICATIONS

  • Innovative tools for mechanobiology: unraveling outside-in and inside-out mechanotransduction
    D Mohammed, M Versaevel, C Bruyère, L Alaimo, M Luciano, ...
    frontiers in Bioengineering and Biotechnology 7, 162 , 2019
    2019
    Citations: 217
  • Multiscale mechanobiology in brain physiology and diseases
    A Procès, M Luciano, Y Kalukula, L Ris, S Gabriele
    Frontiers in Cell and Developmental Biology 10, 823857 , 2022
    2022
    Citations: 70
  • Appreciating the role of cell shape changes in the mechanobiology of epithelial tissues
    M Luciano, M Versaevel, E Vercruysse, A Procès, Y Kalukula, A Remson, ...
    Biophysics Reviews 3 (1) , 2022
    2022
    Citations: 46
  • Stretch-injury promotes microglia activation with enhanced phagocytic and synaptic stripping activities
    A Proces, YA Alpizar, S Halliez, B Brône, F Saudou, L Ris, S Gabriele
    Biomaterials 305, 122426 , 2024
    2024
    Citations: 20
  • Unlocking the therapeutic potential of cellular mechanobiology
    Y Kalukula, G Ciccone, D Mohammed, A Procès, M Versaevel, ...
    Science advances 11 (44), eaea6817 , 2025
    2025
    Citations: 15
  • Inflammatory molecules released by mechanically injured astrocytes trigger presynaptic loss in cortical neuronal networks
    J Lantoine, A Proces, A Villers, S Halliez, L Buée, L Ris, S Gabriele
    ACS Chemical Neuroscience 12 (20), 3885-3897 , 2021
    2021
    Citations: 15
  • Innovative tools for mechanobiology: Unraveling outside-in and inside-out mechanotransduction. Front. Bioeng. Biotechnol. 7: 162
    D Mohammed, M Versaevel, C Bruyere, L Alaimo, M Luciano, ...
    2019
    Citations: 9
  • Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems
    A Procès, S Gabriele
    Neural Regeneration Research 20 (8), 2304-2306 , 2025
    2025
    Citations: 1
  • Nanoscale Activity Mapping of Chloride-Permeable Pentameric Receptors
    Y Vella, A Procès, A Van Bocxlaer, C Trippaers, CO Lara, Ö Uslu, ...
    ACS sensors 40 (XXX), XXX-XXX , 2026
    2026
  • Phagocytosis and synaptic pruning are enhanced in mechanically activated glial cells
    A Proces, YA Aguiar, B Brône, F Saudou, S Gabriele, L Ris
    Neuroscience 2022 , 2022
    2022
  • Deciphering the role of mechanical cues on activation of microglial cells
    A Proces, L Ris, S Gabriele
    BSCDB Autumn Meeting: Mechanobiology in Cell Biology and Development , 2021
    2021
  • Mechano-activation of astrocytes and microglial cells.
    A Proces, L Ris, S Gabriele
    ImmunoBiophysics: From fundamental physics to understanding immune response , 2021
    2021
  • Deciphering the role of activated glial cells on neuronal connectivity using in vitro models of traumatic brain injury
    A Proces, J Lantoine, L Ris, S Gabriele
    GDR CellTiss Days , 2019
    2019
  • The beneficial and harmful effects of glial cells on neuronal connectivity in in vitro models of traumatic brain injury.
    A Proces, J Lantoine, S Gabriele, L Ris
    Front. Neurosci. Conference Abstract: 13th National Congress of the Belgian … , 2019
    2019
  • Development of an experimental model of traumatic brain injury using hippocampal slice cultures.
    A Proces, A Villers, S Gabriele, L Ris
    BSCDB and RBSM meeting: Cell and Tissue Mechanics in Physiology and Disease , 2018
    2018