Dr. Mayank Kulshreshtha has completed his Ph.D from Babu Banarasi Das University, Lucknow, India, M.Pharm., in Pharmacology (Research from National Botanical Research Institute, Lucknow, India), B.Pharm., from Rajiv Academy for Pharmacy, Mathura, D.Pharm., from Luqman Collage of Pharmacy, Karnataka, India. He has guided lots of post graduate students in various pharmacological activities. He is life time member of Indian Society of Pharmacology, Indian red cross society, Association of Community Pharmacist in India etc. Dr. Kulshreshtha has selected as a brand ambassador for Bentham Science and Lambert Publication, Germany. He has a near about 40 national and international publications. He recruited as a judge in various pharma completions. He has participated near 60 pharma national and international conferences and an active member of various Pharmacy journals. He has achieved lots of awards like young scientist award etc.
Antimicrobial Potential of Bempedoic Acid as a Gastroprotective Agent Ketan Sharma, Anuj Kumar Sharma, Yogesh Murti, Sachdev Yadav, Akash Ved, Mayank Kulshreshtha Anti Infective Agents, 2026 Introduction: Bempedoic acid is a well-known lipid-lowering agent which in-hibits the HMG-CoA reductase enzyme. It contains various chemical groups in its struc-ture, which are responsible for antimicrobial potential. The study investigates the antimi-crobial activity of Bempedoic Acid (BA) against pathogenic bacteria, including Bacillus subtilis, Enterococcus faecalis, Salmonella Typhi, and Staphylococcus aureus. Methods: The disc diffusion method was employed for this study. Initially, Mueller Hinton Agar (MHA) was prepared according to the standard formulation provided by Himedia. Specifically, 38 grams of MHA powder was dissolved in 1 liter of distilled water. The medium was then sterilized by autoclaving at 121°C and 15 psi for 15 minutes using an autoclave (Gentek India Pvt. Ltd.). After sterilization, the medium was poured into sterile glass Petri dishes inside a laminar airflow cabinet (Toshiba, India) under aseptic condi-tions, with each plate receiving 30 ml of the medium. The plates were left to solidify in the laminar flow. Once solidified, the bacterial inoculum was evenly spread across the surface of the agar using a sterile cotton swab. Ten minutes after inoculation, discs were placed onto the agar using sterile forceps. Each disc was loaded with 25 μl of sample at three different concentrations: 100 mg/ml, 50 mg/ml, and 25 mg/ml. The samples were allowed to diffuse into the agar, after which the plates were sealed with parafilm and incubated at 37°C for 24 hours. Results: BA lacked significant activity against B. subtilis but exhibited notable inhibition against E. faecalis (zone of inhibition: 11±0.00 mm at 50 mg/kg), S. Typhi (10±0.00 mm at 50 mg/kg and 100 mg/kg), and S. aureus (significant activity at 100 mg/kg). Discussion: Comparative analysis revealed BA exhibited efficacy comparable to that of ciprofloxacin in certain cases. Molecular studies highlighted BA's ability to mitigate bac-terial virulence by disrupting mechanisms, such as pro-inflammatory protein synthesis and mitochondrial genomic integrity, especially in E. faecalis. These findings underscore BA’s selective antimicrobial properties, suggesting its potential for therapeutic application in managing polymicrobial infections, gastrointestinal pathologies, and systemic diseases. Conclusion: The pharmacodynamic profile suggests BA exerts its antimicrobial effects by targeting bacterial virulence mechanisms, including the suppression of pro-inflammatory responses and the disruption of mitochondrial genomic stability. These attributes position BA as a promising candidate for further pharmacological development, especially as a po-tential adjunct to conventional antibiotics for managing drug-resistant and opportunistic infections. Further in vivo validation and clinical studies are warranted to establish its ther-apeutic potential and safety profile.
Antimicrobial Potential and HPLC Analysis of BGR-34: An Antidiabetic Ayurvedic Formulation Anuj Kumar Sharma, Yogesh Murti, Sachdev Yadav, Akash Ved, Ketan Sharma, Mayank Kulshreshtha Anti Infective Agents, 2026 Background: BGR-34, a polyherbal formulation, has garnered attention for its antimicrobial properties, attributed to its diverse composition of primary and secondary me-tabolites. Objective: The objective of the study was to generate good scientific data regarding BGR -34. Methods: This study was carried out to investigate the phytochemical screening, High Per-formance Liquid Chromatography (HPLC) analysis using Quercetin as a standard, and an-timicrobial efficacy of BGR-34 against significant human pathogens, including Klebsiella pneumoniae, Vibrio cholerae, Staphylococcus epidermidis, Listeria monocytogenes, Esch-erichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella Typhi, Strepto-coccus mutans, Streptococcus pyogenes, Enterococcus faecalis, Bacillus subtilis, and Xan-thomonas oryzae. Results: The findings revealed a dose-dependent antimicrobial effect, with optimal activity observed at 100 mg/mL, highlighting its potential as a therapeutic agent. The phytochemical screening confirmed the presence of various primary and secondary metabolites, such as flavonoids, alkaloids, saponins, carbohydrates, alkaloids, tannins, proteins, terpenoids, etc. HPLC analysis demonstrated the presence of quercetin (2.2974 ug/mL), which is responsi-ble for various pharmacological activities. Antimicrobial potential showed activity of BGR-34 against various microbes that are responsible for various diseases. The bioactive com-pounds in BGR-34, such as phenolics, flavonoids, and terpenoids, exhibit mechanisms like biofilm disruption and microbial membrane interference, underscoring its broad-spectrum efficacy. Furthermore, its potential role in addressing infections related to biofilm-forming pathogens and resistant strains establishes its clinical significance. Conclusion: These results support the continued exploration of BGR-34 as a viable option in combating microbial infections, with implications for managing resistant pathogens, and reducing the burden of infectious diseases.
A Contemporary Review of Myocardial Infarction with Emphasis on: Clinical Trials and Therapeutic Approaches Anuj Kumar Sharma, Yogesh Murti, Akash Ved, Karuna Shanker Shukla, Sabeena Anjum, Mayank Kulshreshtha Current Hypertension Reviews, 2026 Myocardial infarction (MI), a major manifestation of coronary artery disease, remains a global health challenge despite significant advances in research and therapy. This review highlights current developments in diagnostic criteria, pathophysiology, treatment strategies, and emerging therapeutic targets. Type 1 MI, driven by atherosclerotic plaque rupture and thrombosis, continues to dominate, but growing recognition of type 2 MI and MINOCA (myocardial infarction with nonobstructive coronary arteries) underscores the need for refined diagnostic and therapeutic approaches. High-sensitivity cardiac troponins and advanced imaging have improved early detection, classification, and risk stratification. The management now emphasizes personalized, evidence-based care, including percutaneous coronary intervention or thrombosis, dual antiplatelet therapy, lipid-lowering agents, and cardioprotective drugs. Despite improved outcomes, challenges, such as late presentation, treatment disparities, recurrent events, and progression to heart failure, persist. A comprehensive literature search was conducted using electronic databases, such as Web of Science, Google Scholar, PubMed, SciFinder, Reaxys, and the Cochrane Library. By identifying persistent gaps, this work aimed to inform clinicians, researchers, and policymakers on innovative strategies for prevention, early detection, and optimal MI management.
Formulation and Comparison of Herbal Gels Containing Essential Oils and their Antimicrobial Evaluation Karan Agrawal, Vibha, Yogesh Murti, Migul Agrawal, Mayank Kulshreshtha Infectious Disorders Drug Targets, 2025 Objective: The current study aimed to formulate and evaluate herbal gels con-taining essential oils for the treatment of infection caused by microbial species, i.e., S. au-reus, E. coli, P. aeruginosa, and B. subtilis. These species are also responsible for acne directly and indirectly. Material and Methods: The gels were prepared using a gelling agent with 1% Carbopol-940, and they were further evaluated for physical appearance, drug content, in-vitro drug release, viscosity, extrudability, pH, and spreadability. Further, anti-microbial screening was done with various microbial species. Results: Studies revealed that the gel was highly effective against the selected species ex-cept for the fungal strain. ZOI was observed ranging from 3.1 ± 0.01 mm to 13.4 ± 0.14 mm. The maximum ZOI was observed at 13.4 ± 0.14 mm against S. aureus. The physical properties of the gel satisfied the standard parameters. Conclusion: The prepared herbal gel was found to have highly promising activity against bacterial species associated with bacterial infection but in a dose-dependent manner. How-ever, more research is required.
Medicinal Plants in the Treatment of Tuberculosis: A Systematic Review Radha Agrawal, Yogesh Murti, Mohit Mangla, Mohit Sandhuja, Anuj Kumar Sharma, Vibha Kumari, Mayank Kulshreshtha Central Nervous System Agents in Medicinal Chemistry, 2025 Introduction: Tuberculosis is the most common disease that affects the lungs, and it is associated with Mycobacterium tuberculosis infection. Many synthetic medications, such as pyrazinamide, isoniazid, and ethambutol, are available to treat TB; however, their adverse effects are severe. Medicinal herbs have lately become popular, safe, and effective alternative treatments for TB. Method: The purpose of this review was to assess the possible use of natural plants in the development of herbal treatments and remedies for TB by studying the medicinal plants and phytochemicals that have been used for the disease. Information was gathered from a variety of sources, including Bentham, Elsevier, Springer, Nature, Google Scholar, PubMed, Sci-Finder, and the Web of Science. For the investigation, common and scientific names of plants, as well as terms like "mycobacterium tuberculosis," "herbal plants," "flavonoids," and "alkaloids" were employed. In the end, 376 plants belonging to 83 families were discovered, and details about each plant family, as well as the section of the plant utilized, chemical components, extract, and strain, were extracted. Result: The findings showed that although flavonoids and alkaloids were the most prevalent naturally occurring substances found in plants, the Fabiaceae family had a greater potential to eradicate TB. Conclusion: The leaf portion was shown to be more active, and the S-37 RV strain of Mycobacterium TB was employed more frequently.The leaf portion was shown to be more active, and the S-37 RV strain of Mycobacterium TB was employed more frequently.
Pharmacological investigation of Achras sapota against scopolamine induce amnesia and cognitive impairment in laboratory animals Khushboo Singh, Yogesh Murti, Anuj Kumar Sharma, Dharamveer, Akash Ved, Sachdev Yadav, Mayank Kulshreshtha Toxicology Reports, 2024 The present study was undertaken to investigate the effect of Achras sapota ( A. sapota ) fruits in scopolamine induced amnesia & cognitive impairment in mice. A. sapota commonly known as Chiku belong to Sapotaceae family. Memory impairment was induced in Swiss albino mice by a single injection of scopolamine (1 mg/kg, i.p). Animals (Swiss albino mice) were divided into five separate groups of six animals each. Positive control group received CMC (carboxy methyl cellulose) as vehicle, negative control group received scopolamine along with vehicle, standard group received Donepezil (5 mg/kg, p.o) with scopolamine. Ethanolic extract of A. sapota (EEAS, 200 mg & 400 mg/kg, p.o) was administered to group Test 1 and Test 2 respectively along with scopolamine. Elevated plus maze (EPM), modified passive avoidance test, Morris water maze (MWM) models and locomotor activity were employed as exteroceptive behaviour models to assess learning and memory activity. Thereafter lipid peroxidation, reduced glutathione and catalase level were estimated in homogenized brain of mice. The extract showed the presence of different chemical constituents like flavonoids, tannins, glycosides and alkaloids. The pre-treatment of mice with EEAS (200 mg/kg & 400 mg/kg) significantly reduced the scopolamine induced increase in EL time in MWM, whereas in EPM administration of extract produces significant decrease in TL. In Modified passive avoidance test significant increase in SDL, was shown by the animals. In locomotor activity, treatment of EEAS did not alter normal locomotor activity whereas lipid peroxidation was significantly decreased, catalase & reduced glutathione levels were significantly increased in animals of test 1 & test 2 when compared to negative control group. Hence it would be worthwhile to explore the potential of this plant in management of cognitive impairment and other memory disorders • The present study was undertaken to investigate the effect of Achras sapota ( A. sapota ) fruits. • Memory impairment was induced in Swiss albino mice by a single injection of scopolamine. • Animals (Swiss albino mice) were divided into five separate groups of six animals each. Positive control group received CMC (carboxy methyl cellulose) as vehicle, negative control group received scopolamine along with vehicle, standard group received Donepezil (5 mg/kg, p.o) with scopolamine. • Ethanolic extract of A. sapota (EEAS, 200 mg & 400 mg/kg, p.o) was administered to group Test 1 and Test 2 respectively along with scopolamine. • Lipid peroxidation, reduced glutathione and catalase level were estimated in homogenized brain of mice.
A comprehensive review on Chinese honeysuckle (Qusqualis indica): A Traditional Chinese plant Anuj Kumar Sharma, Deepti M. Sati, Yogesh Murti, Akash Ved, Sachdev Yadav, Arpita Singh, Anita Singh, Manjul Pratap Singh, Amit Kumar Nigam, Karuna Shanker Shukla, Mayank Kulshreshtha Toxicology Reports, 2024 According to Chinese Medicine system, Chinese honeysuckle have a lot of valuable metabolites which have a various potential like anti-inflammatory action, antidiabetic, analgesics, antipyretic, eliminates pollutants etc. According to Chinese Medicinal System, the plant is mentioned to cure various diseases like peptic ulcer, diabetes, inflammation etc. It is frequently given for patients with colds that include fever, headaches, and sore throats, but it may also be used to help people who are overheated or under stress chill down. Total 72 articles were found out by the help of online database including Google Scholar, Scopus, PubMed, and Web of Science and 63 had selected. Different keywords like Chinese honeysuckle, Qusqualis indica phytochemistry, pharmacology and toxicology were used to searched the content. The purpose of this review is to summarize the previously reported phytochemicals, pharmacological status of the chosen Chinese plant species. Our findings indicate that Chinese honeysuckle contains a diverse array of bioactive compounds, including flavonoids and terpenoids. Moreover, previous studies have demonstrated that extracts and isolated constituents exhibit significant pharmacological activities and other therapeutic properties. Chinese honeysuckle is a rich source of bioactive compounds that can be incorporated into human diets in low doses and hold potential for treating a range of medical conditions, from minor to severe. This review aims to encourage further research on this plant species, particularly focusing on its toxicity and bioactivity. • According to Chinese Medicine system, Chinese honeysuckle have a lot of valuable metabolites which have a various potential like anti-inflammatory action, antidiabetic, analgesics, antipyretic, eliminates pollutants etc. • Total 72 articles were found out by the help of online database including Google Scholar, Scopus, PubMed, and Web of Science and 63 had selected. Different keywords like Chinese honeysuckle, Qusqualis indica phytochemistry, pharmacology and toxicology were used to searched the content. • The purpose of this review is to summarize the previously reported phytochemicals, pharmacological status of the chosen Chinese plant species. • Our findings indicate that Chinese honeysuckle contains a diverse array of bioactive compounds, including flavonoids and terpenoids. Moreover, previous studies have demonstrated that extracts and isolated constituents exhibit significant pharmacological activities and other therapeutic properties.
A mini review on Aconitum ferox: A traditional Chinese plant Anuj Kumar Sharma, Mayank Kulshreshtha Pharmacological Research Modern Chinese Medicine, 2024 Chinese fuzi, or Aconitum ferox (A. ferox), is a member of the Ranunculaceae family. The Chinese medical system states that A. ferox tubers and roots are frequently used to treat a wide range of illnesses, including rheumatic fever, collapse, syncope, sore joints, gastroenteritis, diarrhea, diabetes, oedema, bronchial asthma, tumors, and several endocrine issues. Total 60 articles were found out by the help of online database including Google Scholar, Scopus, PubMed, and Web of Science and 55 had selected. Different keywords like A. ferox phytochemistry, pharmacology and toxicology were used to searched the content. The purpose of this review is to summarize the previously reported phytochemicals, pharmacological status of the chosen Chinese plant species. Our findings show that A. ferox includes a wide range of physiologically active chemicals, such as flavonoids and terpenoids. Furthermore, past research has shown that A. ferox plant extracts and extracted principles have substantial pharmacological action, including anti-tumor, anti-inflammatory, antioxidant, anti-melanogenic, and other properties. According to the research listed below, A. ferox has a high potential for developing medicines and supplements for prophylactic as well as therapy of cancer, ulcer, diabetes, and other diseases. Furthermore, clinical research has demonstrated that A. ferox is a safe and effective plant for human consumption. A. ferox is a great source of bioactive compounds that may be put into human meals in a low dose and show promise in the treatment of minor to life-threatening medical conditions. This review will inspire other scientists to conduct more research on the selected plant species, particularly in the areas of toxicity and bioactivity.
Characterization of different screened proteins from Chinese honeysuckle leaves and evaluate their antimicrobial potential Mayank Kulshreshtha, Anuj Kumar Sharma, Yogesh Murti, Vibha, Neeraj Verma, Anita Singh, Soumyadip Mukherjee, Amit Nigam, Manjul Pratap Singh Pharmacological Research Modern Chinese Medicine, 2024 According to Chinese Medicine system, Chinese honeysuckle have a lot of valuable metabolites which have a various potential like anti-inflammatory action, antidiabetic, analgesics, antipyretic, eliminates pollutants etc. It is frequently given for patients with colds that include fever, headaches, and sore throats, but it may also be used to help people who are overheated or under stress chill down. The present study is designed to screen out through SDSPAGE electrophoresis from the various proteins from Chinese honeysuckle (characterized by IR, NMR and mass spectrometry), evaluated their antimicrobial potential by using various microbial species (Bacillus subtilis MTCC 0441 and Escherichia coli MTCC 1573 with renowned standards). Phytochemical analysis of different extracts showed the presence of different primary and secondary metabolite like alkaloids, glycosides, tannins, proteins, saponin, phenolic compounds etc. Various proteins are screened out with different kds weight like 10, 25, 30, 35, 48, 50, 55 and 70. The analytical analysis revealed the presence of various groups, protons etc in proteins. The range of zone of inhibition was found to be 1.2±0.01 to 14.5±0.21. The maximum activity was found out in 70 kda protein against Bacillus subtilis. The data generated would be useful for the preparation of monograph of the plant. Generated scientific data may open the various doors for new researchers in coming future,
A biological active mushroom agaricus bisporus: An update of its phytopharmacology and medicinal properties with respect to various diseases Research Advances in the Fungal World Culture Isolation Identification Classification Characterization Properties and Kinetics, 2020
Prescription analysis in pediatrics: A clinical survey report International Journal of Pharmaceutical Sciences Review and Research, 2011
Anti ulcer potential of Lawsonia inermis leaf International Journal of Pharmaceutical Sciences Review and Research, 2011
A clinical survey on correlation study between tuberculosis and its predisposing factors in Mathura region International Journal of Pharmaceutical Sciences Review and Research, 2011
Estimation of antioxidant potential of aqueous extract of Ficus bengalensis leaf on gastric ulcer International Journal of Pharmaceutical Sciences Review and Research, 2011
Anti-ulcer potential of Lawsonia inermis l. Leaves against gastric ulcers in rats Journal of Applied Pharmaceutical Science, 2011
Anti-Ulcerogenic potential of Ficus bengalensis leaf, biochemical parameter & histopathological study Journal of Applied Pharmaceutical Science, 2011
Elucidation of analgesic and antipyretic activities of ficus bengalensis linn. Leaves in rats Journal of Applied Pharmaceutical Science, 2011
