RAJADURAI MURUGAN
@msruas.ac.in
Assistant Professor, Department of Food Technology
Ramaiah University of Applied Sciences
Dr. Rajadurai Murugan, has completed M.Sc., M. Phil., Ph.D., Biochemistry, in Annamalai University, Chidambaram, Tamilnadu, India. Presently working as Assistant Professor, Department of Food Technology, Faculty of Life & Allied Health Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka, India. He has published 46 Research papers in peer reviewed national and international journals, 3 book chapters. He is having more than 15 years of teaching experience, guided 3 Ph.D., and 18 M.Phil., research scholars, participated presented and delivered guest lecture in more than 50 national and international conferences. He is a Visiting Faculty in Biocon Academy, Biocon Limited, Bangalore, BOS member in Bangalore Central University. Serving as a reviewer, Editorial board member and lead guest editor in several international journals.
EDUCATION
M.Sc., M.Phil., Ph.D.,
RESEARCH INTERESTS
Free Radical Biology and Phytochemistry.
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Murugan Rajadurai, Natchimuthu Karmegam, Soundarapandian Kannan, Ananthanarayanan Yuvaraj, and Ramasundaram Thangaraj
Elsevier BV
T.A. Anitha and M. Rajadurai
Elsevier BV
M. Rajadurai and P. Stanely Mainzen Prince
Wiley
The present study was undertaken to evaluate the preventive role of naringin on mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol (ISO)‐induced myocardial infarction (MI) in male Wistar rats. Rats subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for 2 days resulted in a significant increase in the levels of mitochondrial lipid peroxides with a significant decrease in the activities/levels of mitochondrial antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione‐S‐transferase and reduced glutathione). ISO‐induction also showed a significant increase in the levels of mitochondrial cholesterol, triglycerides and free fatty acids with a subsequent decrease in the levels of phospholipids. Oral pretreatment with naringin (10, 20 and 40 mg/kg) to ISO‐induced rats daily for a period of 56 days significantly decreased the levels of mitochondrial lipid peroxides with a significant increase in the activities/levels of mitochondrial antioxidants and significantly minimized the alterations in the mitochondrial lipid levels in ISO‐induced rats. Thus, the findings demonstrate that naringin prevents alterations in mitochondrial lipid peroxides, antioxidants and lipids in ISO‐induced MI in rats. Copyright © 2008 John Wiley & Sons, Ltd.
Mannangatti Padmanabhan, Murugan Rajadurai, and Ponnian Stanely Mainzen Prince
Wiley
This study was aimed to evaluate the preventive role of S-allylcysteine (SAC) on creatine kinase-MB, iron, iron binding capacity, uric acid, total protein, membrane-bound enzymes such as sodium potassium-dependent adenosine triphosphatase, calcium-dependent adenosine triphosphatase and magnesium-dependent adenosine triphosphatase, and glycoproteins such as hexose, hexosamine, fucose and sialic acid in isoproterenol-induced myocardial infarction in rats. Male albino Wistar rats were pre-treated with SAC (50, 100 and 150 mg/kg) daily for a period of 45 days. After the treatment period, isoproterenol (150 mg/kg) was subcutaneously injected in rats at an interval of 24 hr for 2 days. Isoproterenol-induced rats showed significantly (P < 0.05) increased activities of serum creatine kinase-MB and calcium-dependent adenosine triphosphatase and magnesium-dependent adenosine triphosphatase in the heart, and the levels of iron and uric acid in serum and significantly (P < 0.05) decreased the levels of plasma iron binding capacity, plasma total protein, plasma albumin/globulin ratio and activity of sodium potassium-dependent adenosine triphosphatase in the heart. Isoproterenol induction also showed a significant increase in the levels of glycoproteins in serum and the heart. Pre-treatment with SAC (100 and 150 mg/kg) daily for a period of 45 days exhibited significant (P < 0.05) effect and altered these biochemical parameters positively. SAC (50, 100 and 150 mg/kg) treatment to normal rats did not exhibit any significant effect in any of the parameters studied. Thus, our study shows that SAC has a protective role in isoproterenol-induced myocardial infarction in rats. The observed effects might be due to the free radical scavenging, antioxidant and membrane stabilizing properties of SAC.
M. Rajadurai and P. Stanely Mainzen Prince
Wiley
Dietary flavonoids intake has been reported inversely related to the incidence of cardiovascular diseases (CVD). The present study is undertaken to evaluate the preventive role of naringin on mitochondrial enzymes in isoproterenol (ISO)‐induced myocardial infarction in male albino Wistar rats. Rats subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for 2 days, resulting in significant (p < 0.05) increase in the levels of mitochondrial lipid peroxides. ISO‐induction also showed significant (p < 0.05) decrease in the activities of mitochondrial tricarboxylic acid cycle enzymes (isocitrate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, and α‐ketoglutarate dehydrogenase) and respiratory chain enzymes (NADH dehydrogenase and cytochrome c oxidase). Oral pretreatment with naringin (10, 20, and 40 mg/kg) to ISO‐induced rats daily for a period of 56 days significantly (p < 0.05) minimized the alterations in all the biochemical parameters and restored the normal mitochondrial function. Transmission electron microscopic (TEM) observations also correlated with these biochemical findings. Thus, our findings demonstrate that naringin prevents the mitochondrial dysfunction during ISO‐induced myocardial infarction in rats. © 2007 Wiley Periodicals, Inc. J Biochem Mol Toxicol 21:354–361, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20203
M. Rajadurai and P. Stanely Mainzen Prince
Elsevier BV
M. Rajadurai and P. Stanely Mainzen Prince
Elsevier BV
M. Rajadurai and P. Stanely Mainzen Prince
Elsevier BV
M. Rajadurai and P. Stanely Mainzen Prince
Wiley
This study was designed to evaluate the preventive effect of naringin in isoproterenol (ISO)‐induced myocardial infarction (MI) in rats. Rats were pretreated with naringin (10, 20, and 40 mg/kg body weight) orally for a period of 56 days. After the treatment period, ISO (85 mg/kg body weight) was administered subcutaneously to rats at an interval of 24 h for 2 days. There was a significant increase in the levels of total, ester, and free cholesterol, triglycerides (TG), and free fatty acids (FFA) in serum and heart and decrease in heart phospholipids (PL) in ISO‐induced rats. Altered levels of lipoproteins and activities of 3‐hydroxy‐3‐methylglutaryl‐Coenzyme reductase A in liver and heart, lecithin cholesterol acyl transferase and lipoprotein lipase in plasma were also observed in ISO‐induced rats. Pretreatment with naringin (10, 20, and 40 mg/kg) for a period of 56 days significantly decreased the levels of total, ester, and free cholesterol, TG, FFA in serum and heart and increased PL in heart. It also minimized the alterations in serum lipoproteins and lipid metabolic enzymes in ISO‐induced rats. Thus, naringin has a lipid‐lowering effect in ISO‐induced MI rats. © 2006 Wiley Periodicals, Inc. J Biochem Mol Toxicol 20:191–197, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20136
P Stanely Mainzen Prince and M Rajadurai
Oxford University Press (OUP)
Abstract We have evaluated the preventive effects of an aqueous Aegle marmelos leaf extract (AMLEt) in isoprenaline (isoproterenol)-induced myocardial infarction in rats. Rats were pretreated with AMLEt (50, 100 or 200 mg kg−1) for 35 days. After the treatment period, isoprenaline (200 mg kg−1) was administered subcutaneously to rats at an interval of 24 h for two days. The activity of creatine kinase (CK) and lactate dehydrogenase (LDH) was significantly increased in serum and significantly decreased in heart of isoprenaline-treated rats. Pretreatment with AMLEt decreased the activity of CK and LDH in serum and increased them in the heart. The activity of sodium-potassium dependent adenosine triphosphatase (Na+K+ATPase) was significantly decreased while the activity of calcium dependent adenosine triphosphatase (Ca2+ATPase) was simultaneously increased in the heart and aorta. AMLEt pretreatment increased the activity of Na+K+ATPase and decreased the activity of Ca2+ATPase in the heart and aorta simultaneously. The levels of cholesterol and triglycerides increased, while the levels of phospholipids decreased in the heart and aorta of isoprenaline-treated rats. In AMLEt-pretreated rats the levels of cholesterol and triglycerides decreased whereas phospholipids increased in heart and aorta. All the deranged biochemical parameters were restored with 200 mg kg−1 AMLEt. Similarly α-tocopherol (60 mg kg−1)-pretreatment to isoprenaline-treated rats exhibited a significant effect on all the parameters studied. The results from this study may have clinical relevance.
N. Kamalakkanan, M. Rajadurai, and P. Stanely Mainzen Prince
Mary Ann Liebert Inc
The present study evaluates the antidiabetic effect of an aqueous extract of Aegle marmelos fruits (AMFEt) in diabetes. Female albino Wistar rats were randomly divided into five groups: normal (untreated), normal + AMFEt, streptozotocin (STZ)-treated, STZ-treated + AMFEt, and STZ-treated + glibenclamide. Rats were rendered diabetic by STZ (45 mg/kg) administered intraperitoneally. AMFEt (250 mg/kg) was given twice daily for 1 month. Blood glucose, plasma insulin, glycosylated hemoglobin, liver glycogen, and change in body weight were determined. Food intake and water intake were monitored daily. An oral glucose tolerance test was also performed to determine the effect of this extract. The results show that glucose level and glycosylated hemoglobin were increased and plasma insulin and liver glycogen were decreased in diabetic rats, and that treatment with AMFEt reversed the effects of diabetes on these biochemical parameters to near-normal levels.