Rajat Garg

@mangalayatan.in

Assistant Professor, Department of Pharmacy
Mangalayatn University

Rajat Garg


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https://researchid.co/rajatgarg

EDUCATION

B.Pharm, M.Pharm, Ph.D (Pharmaceutics)

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmaceutical Science, General Pharmacology, Toxicology and Pharmaceutics
10

Scopus Publications

46

Scholar Citations

5

Scholar h-index

1

Scholar i10-index

Scopus Publications

  • Design And Evaluation Of Omeprazole Loaded Floating Mucoadhesive Microspheres For Sustained Antiulcer Therapy
    Vivekanand Ankush Kashid, Deepika Aggarwal, Gaurav singh Sikarwar, Rajat Garg, Narendar Bhojak, et al.
    International Journal of Drug Delivery Technology, 2026
    Peptic ulcer disease (PUD) is a critical health issue in the world, and acid suppression using proton pump inhibitors such as omeprazole is an essential part of treatment. The standard administration of omeprazole is, however, undermined by its acid sensitivity, reduced gastric retention and pronounced pharmacokinetic discrepancy thus limiting its local therapeutic activity in healing ulcers and eradication of H. pylori. In a bid to address these limitations, this study endeavored to design and describe a new multifunctional gastroretentive system. The floating mucoadhesive microspheres with omeprazole loaded in spheres were effectively prepared and produced through a hybrid method that involves ionotropic gelation and solvent evaporation of emulsion. The polymeric mixture which was used is a blend of sodium alginate, chitosan, hydroxypropyl methylcellulose (HPMC K4M) and ethyl cellulose. The FTIR and DSC preformulation studies confirmed that drug-excipient incompatibility did not exist. The polymer-to-drug ratio and calcium chloride concentration used were seen to be the factors that had critical impact on the properties of the system, using a factorial design. The optimized formulation (Batch B5, 2:1 ratio, 10% CaCl2) had a high drug entrapment efficiency (89.5 +- 1.4%), good buoyancy with short floating lag time (48.9 +- 4.1 seconds) and total floating time (>12 hours) and high in vitro mucoadhesion (84.6 +2.8%). The SEM revealed the existence of spherical particles having porous surface which is necessary in creating buoyancy. The drug release of the in vitro experiment in 0.1N HCl was maintained in 12 hours and the kinetics were best explained by the KorsmeyerPeppas model (R2=0.994) which is an anomalous transport characterized by polymer relaxation and diffusion. The microspheres had good flow characteristics, and they were stable within accelerated conditions in three months. Finally, this research was able to develop a stable, multi-particulate system that synergistically integrates floating and mucoadhesive. This is an exciting long-term method of gastric retention and localized long-term omeprazole delivery that has the potential to increase the effectiveness of therapies, decrease the dose of the drug, and increase patient compliance in PUD management.
  • Development and evaluation of hyaluronic acid conjugated tacrolimus-loaded nanostructured lipid carriers using moringa oleifera seed oil as liquid lipid
    Rajat Garg, Anuj Garg
    Journal of Drug Delivery Science and Technology, 2024
  • The Research Trends and Scientometric Assessment of Rheumatoid Arthritis in India During 2016-2021
    Anuj Garg, Rajat Garg
    Current Rheumatology Reviews, 2023
    Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affects the synovial joints, causing swelling and joint damage. RA has become a major public health concern, harming more than 1500 people per lakh of the world's population. This inflammatory disorder is more common in females in comparison to males (3:1). In the present work, a scientometric analysis of published articles on RA during the last five years [1st January 2016 to 2021] on 19/08/2021 in the Scopus database is performed and investigates the contribution of India. In this study, the top most productive countries and the contribution of India in this field were analyzed. The different journals, funding agencies, and productive authors from India who contributed to this field are also recognized. The average citation impact is 10 citations per paper. A total of 61% share was found for the International collaboration in India’s publication on rheumatoid arthritis. In India's output on rheumatoid arthritis, medicine produced the largest percentage of paper (60 percent). The top 15 journals publishing the maximum number of Indian papers contribute 1% share of global rheumatoid arthritis research (The highest number of papers (95 papers) published by the Indian Journal of Rheumatology). During the period 2016-2021, the top 10 highly cited papers got a total of 7045 citations, averaging 705 citations per publication. India was found to have a 5% (1974 publications) share of global output (42312 publications). In conclusion, there is a small number of researches on rheumatoid arthritis in a country, which holds the 2nd position in population across the world. There is a need for more research on rheumatoid arthritis in India.
  • A Comprehensive Review on Recent Advances and Considerations for the Selection of Cell-based In-vitro Techniques for the Assessment of Permeability of Drug Molecules
    Anuj Garg, Rajat Garg
    Current Drug Delivery, 2023
    Objective: The main focus of this article is to analyze numerous in-vitro methods and their modifications currently used to assess the absorption or permeability of drug molecules from different formulations. Methods: In the literature, no single method can be applied as a gold standard for measuring the exact permeability of each drug molecule. Various in-vitro methods, including tissue and cell-based models, are reported to assess the absorption of drugs. Caco-2 cell is a widely used model for absorption studies but sometimes provides inaccurate results. Alternative methods like Madin-Darby canine kidney, IEC- 18, TC-7, 2/4/A1, and IPEC-J2 cell lines are also used. In this study, the merits and demerits of each method have been described, along with the factors affecting the results of absorption studies. The selection of an appropriate method is critical in accurately assessing the permeability and absorption of drugs by mechanisms like vesicular and active transport. This review article aims to provide in-depth knowledge regarding the different in-vitro methods, strategies, and selection of appropriate in-vitro models to predict intestinal absorption. Conclusion: A flow chart diagram for decision-making in selecting an appropriate in-vitro permeability model for formulation has been proposed for estimating permeability.
  • Tacrolimus loaded nanostructured lipid carriers using Moringa oleifera seed oil: design, optimization and in-vitro evaluations
    Rajat Garg, Anuj Garg
    Journal of Microencapsulation, 2023
    The proposed research aims to develop Tacrolimus-loaded nanostructured lipid carriers (TAC-loaded NLCs) to overcome poor aqueous solubility and dissolution rate to enhance its oral absorption. A central composite design was used to optimise the amount of Poloxamer 188 and D-α-Tocopherol-polyethylene-glycol-succinate (TPGS). The optimised TAC-loaded NLCs contain stearic acid (250 mg), Moringa oleifera (MO) seed oil (50 mg), TAC (Tacrolimus: 10 mg), TPGS (60 mg), and Poloxamer 188 (1% w/v) with a mean diameter of 393.3 ± 29.68 nm, a zeta potential of −18.3 ± 6.19 mV, high entrapment efficiency (92.12 ± 1.14% w/w), and desirability (0.989). TAC-loaded NLCs showed ∼12 times higher drug dissolution efficiency, while in-vitro anti-inflammatory studies showed ∼1.8 times lower IC50 (half-maximal inhibitory concentration) than TAC suspension. The lyophilised TAC-loaded NLCs were found to be stable after 3 months. Thus, the present study concludes the successful encapsulation of TAC in NLCs made of stearic acid and MO seed oil.
  • Current advances in colloidal based delivery systems for Tacrolimus
    Anuj Garg, Rajat Garg
    Journal of Drug Delivery Science and Technology, 2022
  • Formulation and Evaluation of Throat Paint of Erythromycin Estolate
    Rahul Kumar Singh, Rohit Wadhwa, Rajat Garg
    Research Journal of Pharmacy and Technology, 2021
    The research work was aimed at developing and optimizing erythromycin estolate throat paint solution for improved bioavailability in the oral delivery of based throat paint is prepared by unique method. Potassium iodide, glycerol has been selected based on mouth paint, mucoadhesive strength, and the drug the medication with the goal of treating wooping cough. Erythromycin estolateis released in vitro. A 32factorial prototype was used to preparation the throat paint at concentration of potassium iodide and glycerol was used as an independent variable released in vitro and permeated by percentage.For throat paint, the percentage of mucoadhesion, product consistency,releaseof drugs in vitro, and percentage of rest from permeation were calculated. With mucoadhesive strength, percentage permeation and in-vitro drug releaseperformance, formula f9 has been optimized. Studies of FTIR and have characterised throat paint. Study of stability revealed stable formulation was found.
  • A review on applications of vitamin b12 as therapeutic carrier in drug delivery
    Rajat Garg, Anuj Garg
    Critical Reviews in Therapeutic Drug Carrier Systems, 2021
  • Formulation of smart hydrogel beads for pharmaceutical importance
    Sunam Saha, Kartik Kaushik, Rajat Garg
    Research Journal of Pharmacy and Technology, 2020
  • Formulation and Evaluation of Erythromycin Estolate Loaded Drug Balls
    RK. Singh, R Garg
    Research Journal of Pharmacy and Technology, 2020

RECENT SCHOLAR PUBLICATIONS

  • Development and evaluation of hyaluronic acid conjugated tacrolimus-loaded nanostructured lipid carriers using moringa oleifera seed oil as liquid lipid
    R Garg, A Garg
    Journal of Drug Delivery Science and Technology 95, 105591 , 2024
    2024
    Citations: 6
  • Tacrolimus loaded nanostructured lipid carriers using Moringa oleifera seed oil: design, optimization and in-vitro evaluations
    R Garg, A Garg
    Journal of microencapsulation 40 (7), 502-516 , 2023
    2023
    Citations: 7
  • A Comprehensive Review on Recent Advances and Considerations for the Selection of Cell-based In-vitro Techniques for the Assessment of Permeability of Drug …
    R Garg, A Garg
    Current Drug Delivery 20 (5), 526-544 , 2023
    2023
    Citations: 6
  • The Research Trends and Scientometric Assessment of Rheumatoid Arthritis in India During 2016-2021
    R Garg, A Garg
    Current Rheumatology Reviews 19 (1), 26-35 , 2023
    2023
    Citations: 10
  • Current advances in colloidal based delivery systems for Tacrolimus
    A Garg, R Garg
    Journal of drug delivery science and technology 68, 103108 , 2022
    2022
    Citations: 7
  • Formulation and evaluation of throat paint of erythromycin estolate
    RK Singh, R Wadhwa, R Garg
    Research Journal of Pharmacy and Technology 14 (11), 5808-5812 , 2021
    2021
    Citations: 1
  • A Review on Applications of Vitamin B 12 as Therapeutic Carrier in Drug Delivery
    R Garg, A Garg
    Critical Reviews™ in Therapeutic Drug Carrier Systems 38 (1) , 2021
    2021
    Citations: 2
  • Formulation of Smart Hydrogel beads for Pharmaceutical Importance
    S Saha, K Kaushik, R Garg
    Research Journal of Pharmacy and Technology 13 (2), 901-904 , 2020
    2020
    Citations: 4
  • Formulation and Evaluation of Erythromycin Estolate Loaded Drug Balls
    RK Singh, R Garg
    Research Journal of Pharmacy and Technology 13 (1), 282-286 , 2020
    2020
    Citations: 3

MOST CITED SCHOLAR PUBLICATIONS

  • The Research Trends and Scientometric Assessment of Rheumatoid Arthritis in India During 2016-2021
    R Garg, A Garg
    Current Rheumatology Reviews 19 (1), 26-35 , 2023
    2023
    Citations: 10
  • Tacrolimus loaded nanostructured lipid carriers using Moringa oleifera seed oil: design, optimization and in-vitro evaluations
    R Garg, A Garg
    Journal of microencapsulation 40 (7), 502-516 , 2023
    2023
    Citations: 7
  • Current advances in colloidal based delivery systems for Tacrolimus
    A Garg, R Garg
    Journal of drug delivery science and technology 68, 103108 , 2022
    2022
    Citations: 7
  • Development and evaluation of hyaluronic acid conjugated tacrolimus-loaded nanostructured lipid carriers using moringa oleifera seed oil as liquid lipid
    R Garg, A Garg
    Journal of Drug Delivery Science and Technology 95, 105591 , 2024
    2024
    Citations: 6
  • A Comprehensive Review on Recent Advances and Considerations for the Selection of Cell-based In-vitro Techniques for the Assessment of Permeability of Drug …
    R Garg, A Garg
    Current Drug Delivery 20 (5), 526-544 , 2023
    2023
    Citations: 6
  • Formulation of Smart Hydrogel beads for Pharmaceutical Importance
    S Saha, K Kaushik, R Garg
    Research Journal of Pharmacy and Technology 13 (2), 901-904 , 2020
    2020
    Citations: 4
  • Formulation and Evaluation of Erythromycin Estolate Loaded Drug Balls
    RK Singh, R Garg
    Research Journal of Pharmacy and Technology 13 (1), 282-286 , 2020
    2020
    Citations: 3
  • A Review on Applications of Vitamin B 12 as Therapeutic Carrier in Drug Delivery
    R Garg, A Garg
    Critical Reviews™ in Therapeutic Drug Carrier Systems 38 (1) , 2021
    2021
    Citations: 2
  • Formulation and evaluation of throat paint of erythromycin estolate
    RK Singh, R Wadhwa, R Garg
    Research Journal of Pharmacy and Technology 14 (11), 5808-5812 , 2021
    2021
    Citations: 1