Rajat Goyal
@mmumullana.org
Assistant Professor
Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, India-133207
Assistant Professor at Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, India-133207.
EDUCATION
Pursuing Ph.D. (Pharmacy) from Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, India-133207.
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmaceutical Science, General Pharmacology, Toxicology and Pharmaceutics
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Faridi Shabnam, Isha Rani, Dhiman Vivek, Rajat Goyal, and Rupesh Kumar Gautam
Bentham Science Publishers Ltd.
Abstract: Generally, Ayurvedic or herbal products are considered safe to use. According to a report, more than 50% of the global population depends upon herbal products. To meet the global demand for ayurvedic products, more and more herbal plants are analyzed for their active constituents and health benefits. Moringa oleifera is one such plant that is analyzed for its therapeutic benefits. Various parts of this plant, such as the leaves, roots, seed, bark, fruit, flowers, and immature pods, act as cardiac and circulatory stimulants with antipyretic, antitumor, anti-inflammatory, antiepileptic, diuretic, antiulcer, antispasmodic, antihypertensive, cholesterol-lowering, antidiabetic, antioxidant, antibacterial, hepatoprotective, and antifungal activities. This review is about the chemical composition of this tree’s market preparation and its different applications
R. Narang, A.M. Khan, R. Goyal, and S. Gangopadhyay
European Association of Geoscientists & Engineers
Manu Sharma and Rajat Goyal
CRC Press
Hitesh Chopra, Rajat Goyal, Atif Amin Baig, Sonia Arora, Kamal Dua, and Rupesh K. Gautam
Springer Nature Singapore
Devesh U. Kapoor, Rajat Goyal, Rajiv R. Kukkar, and Rupesh K. Gautam
Wiley
Rajat Goyal, Shruti Aggarwal, Vipin Saini, Rupesh K. Gautam, and Shakeel Ahmed
Elsevier
Kushal Kumar Bansal, Rajat Goyal, Archana Sharma, Prabodh Chander Sharma, and Ramesh K. Goyal
Springer Nature Singapore
Chunpeng Wan, Rupesh K. Gautam, Pooja Mittal, Rajat Goyal, and Ramit Kapoor
Bentham Science Publishers Ltd.
Abstract: Phytochemicals or natural products have been studied extensively for their potential in the treatment of neurodegenerative diseases (NDs) like Parkinson’s disease, Alzheimer’s disease, etc. The neuronal structure loss and progressive dysfunction are the main characteristics of these diseases. In spite of impressive and thorough knowledge of neurodegenerative molecular pathways, little advancement has been found in the treatment of the same. Moreover, it was proved that natural products can be used efficiently in the treatment of NDs while certain issues regarding the patient's safety and clinical data are still existing. As ND is a bunch of diseases and it will start the myriad of pathological processes, active targeting of the molecular pathway behind ND will be the most efficient strategy to treat all ND-related diseases. The targeting pathway must prevent cell death and should restore the damaged neurons. In the treatment of ND and related diseases, natural products are playing the role of neuroprotective agents. This review will target the therapeutic potential of various phytochemicals which shows neuroprotective action.
Pooja Mittal, Rajat Goyal, Ramit Kapoor, and Rupesh Kumar Gautam
Elsevier
Rupesh K. Gautam, Smriti Parashar, Rajat Goyal, Sanjay Sharma, Sumeet Gupta, and Pooja Mittal
Bentham Science Publishers Ltd.
Abstract: Nature always has enough spirit and resilience to transform our limited vision. Herbal medicines include products prepared from natural herbs which are employed to treat several diseases. In India, about 80% of drugs are of herbal origin. Nowadays, people are much more aware of the various side effects of synthetic drugs, which have molded their interest in herbal products and herbal remedies. In history, various infectious diseases or pandemic conditions have been treated or controlled with herbal medicines. Many herbal plants like Emblica officinalis (Euphorbiaceae), Withania somnifera (Solanaceae), Swertia chirata (Gentianaceae), Asparagus racemosus (Liliaceae), and Vinca rosea/Catharanthus roseus (Apocynaceae) have been reported to be of high medicinal values and preferred in the development of many newer drugs. The active component from plant extract is isolated, standardized, and undergoes safety trials for validation. Novel drug development from herbs is the amalgamation of practices of native systems of medicine and quite a lot of therapeutic experience of earlier generations. It is also believed that most herbal contents are safe, cheap, and easily available. Herbal drugs are useful in various diseased and pathogenic conditions like tuberculosis, cancer, diabetes, AIDS, jaundice, skin diseases, etc. Many countries with ancient cultures like India, Egypt, and America still use various herbal-based medications. Research for future herbal product development is increasing worldwide. Therefore, taking into consideration future perceptions of herbal remedies, this review deals with the present status and future exploration in the development of herbal drugs as modern beneficial agents for treating various infectious diseases and related pharmacological problems.
Rishika Narang, Vaibhav Joshi, and Rajat Goyal
SPE
AbstractThis study discusses sensor-based, real-time detection and monitoring of emissions generated at a wellsite during a hydraulic fracturing treatment. The sensors recorded live data, which was visualized on dashboards and generated alarms whenever the threshold levels were reached beyond the normal emission rate to tell when the workers were being exposed to unsafe levels of greenhouse gas (GHG) and other noxious elements. Algorithms were also developed to check for fuel adulteration and equipment health, identifying low-performing assets that might have undergone wear and tear.The sensing device detected emissions using multiple electrochemical sensors that can identify particulate matter (PM2.5, PM10, PM1), carbon monoxide (CO), carbon dioxide (CO₂), sulphur dioxide (SO₂), nitrogen dioxide (NO₂), ozone (O₃), hydrogen sulfide (H₂S), and methane (CH4), along with temperature, humidity levels, and GPS coordinates. These readings were then transferred via an Application Programming Interface (API) to a cloud server, where they were stored in a database along with a timestamp. Advanced data visualization and analytics dashboards were created so that users could monitor direct emissions in real-time.The sensing device was deployed at various locations: near the pump exhaust (keeping wind flow in mind) to capture outdoor job-related emissions as well as in a closed space to study exhaust efficiency. The sensor successfully captured and transmitted live data of all the gases emitted, without manual calculation. Increased levels of NO₂ were observed after sunset (because NO₂ converts into other derivatives and ozone in sunlight). Algorithms were leveraged to interpolate readings that might be missed by the sensor, due to a power cut or human mishandling, for continuous visualization of emissions taking place. Because the sensor device is customizable to measure emissions data for each type of gas, it will be extremely useful for leak detection for both supplied and produced oil and gas and for checking corrosion in pipelines or wellsite facilities.Such sensor devices are intrinsically safe, portable, easy to install, scalable, nationally certified, and have GPS tracking enabled. To contribute to environmental sustainability and for the world to see a net-zero emissions future, the oil and gas industry has transformed itself using advanced digital technologies. This pilot study, aimed at directly measuring and visualizing emissions in an industrial setting, is one of the major steps toward more pervasive emission monitoring and helping the industry achieve its net-zero goals.
Rajeev K. Singla, Xiaoyan Wang, Rohit Gundamaraju, Shikha Joon, Christos Tsagkaris, Sahar Behzad, Johra Khan, Rupesh Gautam, Rajat Goyal, Jaruporn Rakmai,et al.
Informa UK Limited
Breast cancer (BC) is the most prevalent neoplasm among women. Genetic and environmental factors lead to BC development and on this basis, several preventive - screening and therapeutic interventions have been developed. Hormones, both in the form of endogenous hormonal signaling or hormonal contraceptives, play an important role in BC pathogenesis and progression. On top of these, breast microbiota includes both species with an immunomodulatory activity enhancing the host's response against cancer cells and species producing proinflammatory cytokines associated with BC development. Identification of novel multitargeted therapeutic agents with poly-pharmacological potential is a dire need to combat advanced and metastatic BC. A growing body of research has emphasized the potential of natural compounds derived from medicinal plants and microbial species as complementary BC treatment regimens, including dietary supplements and probiotics. In particular, extracts from plants such as Artemisia monosperma Delile, Origanum dayi Post, Urtica membranacea Poir. ex Savigny, Krameria lappacea (Dombey) Burdet & B.B. Simpson and metabolites extracted from microbes such as Deinococcus radiodurans and Streptomycetes strains as well as probiotics like Bacillus coagulans and Lactobacillus brevis MK05 have exhibited antitumor effects in the form of antiproliferative and cytotoxic activity, increase in tumors' chemosensitivity, antioxidant activity and modulation of BC - associated molecular pathways. Further, bioactive compounds like 3,3'-diindolylmethane, epigallocatechin gallate, genistein, rutin, resveratrol, lycopene, sulforaphane, silibinin, rosmarinic acid, and shikonin are of special interest for the researchers and clinicians because these natural agents have multimodal action and act via multiple ways in managing the BC and most of these agents are regularly available in our food and fruit diets. Evidence from clinical trials suggests that such products had major potential in enhancing the effectiveness of conventional antitumor agents and decreasing their side effects. We here provide a comprehensive review of the therapeutic effects and mechanistic underpinnings of medicinal plants and microbial metabolites in BC management. The future perspectives on the translation of these findings to the personalized treatment of BC are provided and discussed.
Rajat Goyal, Deepak Chandran, Kajal Garg, Pran Mohankumar, Sumeet Gupta, Rupesh K. Gautam, Hitesh Chopra, and Kuldeep Dhama
Journal of Experimental Biology and Agricultural Sciences
Sexuality has become a medical issue in the context of aging due to a variety of aspects, such as growing life expectancy, an optimistic societal paradigm that indorses sexuality as significant for the superiority of life with age, and the medicalization of sexuality with the emergence of remedial medicines to extravagance sexual dysfunction. At any age, a reduction in the desire for sexual activity or inadequate performance of sexual intercourse is considered atypical and requires a medicinal treatment response. However, despite concerns that this is leading to an unhealthy obsession with sexuality from a medical perspective, this line of thinking is likely to continue. In this context, people can identify and take advantage of sexual problems. Sexual desire and performance are affected by normal physiological changes associated with aging in both genders. Medical experts must understand these changes to optimize sexual functioning in older patients. Sexual health can only be improved by addressing both sexual rights and enjoyment, even in the current politically charged context. Through legislation, programming, and lobbying, we may all work to enhance health, happiness, and quality of life by fostering more positive associations between sexual health, sexual rights, and sexual pleasure. This calls for not just a thorough understanding of the real-world consequences of these ideas' interconnectivity, but also conceptual, individual, and systemic approaches that properly acknowledge and alleviate the problems imposed on people's lives due to insufficient consideration of these links. This review describes the factors associated with aging and sexuality, the normalization and medicalization of sexual health, and unusual situations associated with aging, including institutionalized care and the prospects of elder abuse.
Rajeev K. Singla, Pooja Sharma, Dinesh Kumar, Rupesh K. Gautam, Rajat Goyal, Christos Tsagkaris, Ankit Kumar Dubey, Himangini Bansal, Rohit Sharma, and Bairong Shen
Frontiers Media SA
Ovarian cancer, and particularly its most frequent type, epithelial ovarian carcinoma, constitutes one of the most dangerous malignant tumors among females. Substantial evidence has described the potential of phytochemicals against ovarian cancer. The effect of natural compounds on endoplasmic reticulum (ER) stress is of great relevance in this regard. In ovarian cancer, the accumulation of misfolded proteins in the ER lumen results in decompensated ER stress. This leads to deregulation in the physiological processes for the posttranslational modification of proteins, jeopardizes cellular homeostasis, and increases apoptotic signaling. Several metabolites and metabolite extracts of phytochemical origin have been studied in the context of ER stress in ovarian cancer. Resveratrol, quercetin, curcumin, fucosterol, cleistopholine, fucoidan, and epicatechin gallate, among others, have shown inhibitory potential against ER stress. The chemical structure of each compound plays an important role concerning its pharmacodynamics, pharmacokinetics, and overall effectiveness. Studying and cross-comparing the chemical features that render different phytochemicals effective in eliciting particular anti-ER stress actions can help improve drug design or develop multipotent combination regimens. Many studies have also investigated the properties of formulations such as nanoparticles, niosomes, liposomes, and intravenous hydrogel based on curcumin and quercetin along with some other phytomolecules in ovarian cancer. Overall, the potential of phytochemicals in targeting genetic mechanisms of ovarian cancer warrants further translational and clinical investigation.
Rajat Goyal, Hitesh Chopra, Inderbir singh, Kamal Dua, and Rupesh K. Gautam
Frontiers Media SA
siRNA interference, commonly referred to as gene silence, is a biological mechanism that inhibits gene expression in disorders such as cancer. It may enhance the precision, efficacy, and stability of medicines, especially genetic therapies to some extent. However, obstacles such as the delivery of oligonucleotide drugs to inaccessible areas of the body and the prevalence of severe side effects must be overcome. To maximize their potential, it is thus essential to optimize their distribution to target locations and limit their toxicity to healthy cells. The action of siRNA may be harnessed to delete a similar segment of mRNA that encodes a protein that causes sickness. The absence of an efficient delivery mechanism that shields siRNA from nuclease degradation, delivers it to cancer cells and releases it into the cytoplasm of specific cancer cells without causing side effects is currently the greatest obstacle to the practical implementation of siRNA therapy. This article focuses on combinations of siRNA with chemotherapeutic drug delivery systems for the treatment of cancer and gives an overview of several nanocarrier formulations in both research and clinical applications.
Hitesh Chopra, Shabana Bibi, Rajat Goyal, Rupesh K. Gautam, Rashmi Trivedi, Tarun Kumar Upadhyay, Mohd Hasan Mujahid, Mohammad Ajmal Shah, Muhammad Haris, Kartik Bhairu Khot,et al.
Frontiers Media SA
There are more than two hundred fifty different types of cancers, that are diagnosed around the world. Prostate cancer is one of the suspicious type of cancer spreading very fast around the world, it is reported that in 2018, 29430 patients died of prostate cancer in the United State of America (USA), and hence it is expected that one out of nine men diagnosed with this severe disease during their lives. Medical science has identified cancer at several stages and indicated genes mutations involved in the cancer cell progressions. Genetic implications have been studied extensively in cancer cell growth. So most efficacious drug for prostate cancer is highly required just like other severe diseases for men. So nutraceutical companies are playing major role to manage cancer disease by the recommendation of best natural products around the world, most of these natural products are isolated from plant and mushrooms because they contain several chemoprotective agents, which could reduce the chances of development of cancer and protect the cells for further progression. Some nutraceutical supplements might activate the cytotoxic chemotherapeutic effects by the mechanism of cell cycle arrest, cell differentiation procedures and changes in the redox states, but in other, it also elevate the levels of effectiveness of chemotherapeutic mechanism and in results, cancer cell becomes less reactive to chemotherapy. In this review, we have highlighted the prostate cancer and importance of nutraceuticals for the control and management of prostate cancer, and the significance of nutraceuticals to cancer patients during chemotherapy.
Deepika Choudhary, Isha Rani, Jyoti Monga, Rajat Goyal, Asif Husain, Prabha Garg, and Sukhbir Lal Khokra
Bentham Science Publishers Ltd.
Background: Malaria parasite strains are resistant to the therapeutic effect of prophylactics medicines presently available. This resistance now poses a significant challenge to researchers to beat malaria parasitic infections. Strategies such as investigating newer hybrid chemical entities and specified drug targets may help us spot new efficient derivatives that bind to the parasites in a more specific manner and inhibit their growth. Objective: To scientifically perform the experimental, pharmacological, and computational studies of pyrazole-based furanone hybrids as novel antimalarial agents. Methods: A series of new furanone-based pyrazole derivatives were synthesized and investigated as potential antimalarial agents by performing in vitro antimalarial activity. To get further optimization, these synthesized derivatives were virtually screened based on ADME-T filters, and molecular docking studies were also accomplished on the crystal structures of Plasmodium falciparum lactate dehydrogenase (PfLDH). Furthermore, the in-silico prediction was supported by performing an LDH assay. Results: The docking data suggested that the designed hybrid of furanone-pyrazole may act as PfLDH inhibitors. It was found that the results of experimental in vitro antimalarial activity and in silico analysis correlate well to each other to a good extent. The compounds (7d), (7g), and (8e) were found to be the most potent derivatives with IC50 values of 1.968, 1.983, and 2.069 μg/ml, respectively. Conclusion: From the results, it may be concluded that compounds that are active in low doses might be adopted as a lead compound for the development of more active antimalarial agents. The synthesized compounds (7d), (7g), and (8e) exhibited good antimalarial activity with PfLDH inhibition. The best compounds can be explored further in the future for designing the potent inhibitors of PfLDH as new potent antimalarial agents.
S. AGGARWAL, M. DEVGUN, R. NARANG, S. LAL, A.C. RANA, and R. GOYAL
Asian Journal of Chemistry
Thiazolopyrimidine is a nitrogen and sulphur containing heterocyclic aromatic molecule. The bicyclic compound is made by fusing two aromatic rings, thiazole and pyrimidine and replacing one carbon atom with nitrogen and sulphur. The current present work covers a wide range of methods for synthesizing thiazolopyrimidine and its derivatives using a variety of catalysts, solvent medium and microwave irradiation with a goal of achieving a high yield and rapid separation of the product. This article describes the evolution of thiazolopyrimidine as antimicrobial, antiviral, anti-Parkinson, anticancer, anti-inflammatory as well as its structure-activity relationship and potential mode of action for future research. It also includes a list of current patents filed/granted linked to various pharmacological activities in the previous few years.
Rajeev K. Singla, Sahar Behzad, Johra Khan, Christos Tsagkaris, Rupesh K. Gautam, Rajat Goyal, Hitesh Chopra, and Bairong Shen
Frontiers Media SA
Endometrial cancer (EC) is the sixth most prevalent type of cancer among women. Kinases, enzymes mediating the transfer of adenosine triphosphate (ATP) in several signaling pathways, play a significant role in carcinogenesis and cancer cells’ survival and proliferation. Cyclin-dependent kinases (CDKs) are involved in EC pathogenesis; therefore, CDK inhibitors (CDKin) have a noteworthy therapeutic potential in this type of cancer, particularly in EC type 1. Natural compounds have been used for decades in the treatment of cancer serving as a source of anticancer bioactive molecules. Many phenolic and non-phenolic natural compounds covering flavonoids, stilbenoids, coumarins, biphenyl compounds, alkaloids, glycosides, terpenes, and terpenoids have shown moderate to high effectiveness against CDKin-mediated carcinogenic signaling pathways (PI3K, ERK1/2, Akt, ATM, mTOR, TP53). Pharmaceutical regimens based on two natural compounds, trabectedin and ixabepilone, have been investigated in humans showing short and midterm efficacy as second-line treatments in phase II clinical trials. The purpose of this review is twofold: the authors first provide an overview of the involvement of kinases and kinase inhibitors in the pathogenesis and treatment of EC and then discuss the existing evidence about natural products’ derived kinase inhibitors in the management of the disease and outline relevant future research.
Vishal Ranjan, Sanjeev Vermani, Aman Goyal, Shashank Pathak, Rajat Goyal, Diego Camilo Casallas Gelvez, Atul Singh, Shreya Pandey, Glyn Roberts, and Ruchir Mehta
IPTC
Abstract The Raageshwari Deep Gas (RDG) Field in the western part of India is a tight gas reservoir (~0.1mD) with gross pay of ~700 metres at the depths of 2700-3400m TVDSS in which significant gas in place is in the low permeability volcanic reservoir. The challenge to connect the highly laminated reservoir in the most techno-commercial way was achieved by utilizing Limited Entry Fracturing Technique. The effectiveness of the limited entry technique was verified using Step rate/Step down tests, post minifrac/ mainfrac temperature surveys and pressure matching. To get to the closest approximation and calibrate the stresses, DFIT was pumped in non-pay section. Despite robust diagnostics and analysis, sub surface assessments have their own share of uncertainties. The most convincing diagnostic to confirm the efficacy of the limited entry fracturing treatment is to actually "see" the perforations erode after fracturing. Downhole Camera was deployed in one of the fractured wells for final assurance and help identify opportunities for any further optimization in hydraulic fracturing operations. Downhole camera, able to acquire high resolution color video footage across both side and down view directions, was deployed in the well. Images were acquired of individual perforations and their entry holes were visually assessed and measured to determine erosion due to proppant abrasion during the treatment. Variation in the amount of erosion was used to infer the volume of proppant placed at individual perforations qualitatively. Analysis of these measurements at cluster and stage level allowed the uniformity of the proppant placement – a key objective of hydraulic fracture treatment – to be evaluated. The camera footage also confirmed that the base line unstimulated perforation sizes matched with the SPAN analysis of the perforation. Clear confirmation of successful proppant placement in all clusters of the well was obtained. Reservoir zones that had received variable amounts of proppant were identified by analysis of patterns and trends in cluster level erosion. Cluster level erosion was also linked to the SDT analysis in order to check the range of perforation friction which then helped in confidently adding another cluster or holes in the stages to further improve the fracturing efficiency and the diversion with additional cluster was confirmed with temperature surveys. Downhole camera deployment has completed the engineering approach/workflow in the project execution and affirmed the assumptions to a great extent. The affirmations support in improving the efficacy of limited entry fracturing technique leading to improved kH coverage and enhanced per well recovery. The paper will bring forward the details of candidate selection, downhole camera footage, engineering analysis of the captured images, operational constraints such as well bore visibility, camera trouble shooting especially at high temperature (~150 deg C) and the problem-solving approach deployed for the successful execution.