Dr. TAMILARASAN RAMALINGAM

@ritchennai.org

Assistant Professor, Department of chemistry
Rajalakshmi Institute of Technology

Dr. TAMILARASAN RAMALINGAM


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https://researchid.co/ramasusitamil

RESEARCH, TEACHING, or OTHER INTERESTS

Organic Chemistry, Catalysis, Chemical Engineering
8

Scopus Publications

90

Scholar Citations

5

Scholar h-index

3

Scholar i10-index

Scopus Publications

  • Enhanced dermal delivery of myrtenol via polymer-lipid nanoparticle hydrogel for psoriasis therapy
    Hongmei Yan, Sriram Kaliamoorthy, Lakshmanan Sivalingam, Poovaragan Samikannu, Ramalingam Tamilarasan, Govindaraj Dharman, Kalaiyarasi Jayaprakasam
    Colloids and Surfaces A Physicochemical and Engineering Aspects, 2026
  • Facile green synthesis of gelatin sodium alginate cerium oxide hydrogel nanocomposite and their photocatalytic and its biological applications
    A. S. Stella Shalini, L. Shahanaz, P. Rajeswaran, R. Tamilarasan, S. Kumaran, P. Siva Karthik
    Chemical Papers, 2024
  • Catalytic response and molecular simulation studies in the development of synthetic routes in trimeric triaryl pyridinium type ionic liquids
    Ramalingam Tamilarasan, Annadurai Subramani, G. Sasikumar, Pandurangan Ganapathi, S. Karthikeyan, Sasikumar Ponnusamy, Salim Albukhaty, Mustafa K. A. Mohammed, Zaidon T. Al-aqbi, Faris A. J. Al-Doghachi, Duha S. Ahmed, Yun Hin Taufiq-Yap
    Scientific Reports, 2023
    Under conventional and silica-supported Muffle furnace methods, water-soluble substituted trimeric triaryl pyridinium cations with various inorganic counter anions are synthesized. The solvent-free synthesis method is superior to the conventional method in terms of non-toxicity, quicker reaction times, ease of workup, and higher yields. Trimeric substituted pyridinium salts acted as excellent catalytic responses for the preparation of Gem-bisamide derivatives compared with available literature. To evaluate the molecular docking, benzyl/4-nitrobenzyl substituted triaryl pyridinium salt compounds with VEGFR-2 kinase were used with H-bonds, π–π stacking, salt bridges, and hydrophobic contacts. The results showed that the VEGFR-2 kinase protein had the most potent inhibitory activity. Intriguingly, the compound [NBTAPy]PF6- had a strongly binds to VEGFR-2 kinase and controlled its activity in cancer treatment and prevention.
  • Catalytic, Theoretical, and Biological Investigations of Ternary Metal (II) Complexes Derived from L-Valine-Based Schiff Bases and Heterocyclic Bases
    Gopalakrishnan Sasikumar, Annadurai Subramani, Ramalingam Tamilarasan, Punniyamurthy Rajesh, Ponnusamy Sasikumar, Salim Albukhaty, Mustafa K. A. Mohammed, Subramani Karthikeyan, Zaidon T. Al-aqbi, Faris A. J. Al-Doghachi, Yun Hin Taufiq-Yap
    Molecules, 2023
    A new series of ternary metal complexes, including Co(II), Ni(II), Cu(II), and Zn(II), were synthesized and characterized by elemental analysis and diverse spectroscopic methods. The complexes were synthesized from respective metal salts with Schiff’s-base-containing amino acids, salicylaldehyde derivatives, and heterocyclic bases. The amino acids containing Schiff bases showed promising pharmacological properties upon complexation. Based on satisfactory elemental analyses and various spectroscopic techniques, these complexes revealed a distorted, square pyramidal geometry around metal ions. The molecular structures of the complexes were optimized by DFT calculations. Quantum calculations were performed with the density functional method for which the LACVP++ basis set was used to find the optimized molecular structure of the complexes. The metal complexes were subjected to an electrochemical investigation to determine the redox behavior and oxidation state of the metal ions. Furthermore, all complexes were utilized for catalytic assets of a multi-component Mannich reaction for the preparation of -amino carbonyl derivatives. The synthesized complexes were tested to determine their antibacterial activity against E. coli, K. pneumoniae, and S. aureus bacteria. To evaluate the cytotoxic effects of the Cu(II) complexes, lung cancer (A549), cervical cancer (HeLa), and breast cancer (MCF-7) cells compared to normal cells, cell lines such as human dermal fibroblasts (HDF) were used. Further, the docking study parameters were supported, for which it was observed that the metal complexes could be effective in anticancer applications.
  • Synthesis, Characterization, Pharmacogenomics, and Molecular Simulation of Pyridinium Type of Ionic Liquids and Their Applications
    Ramalingam Tamilarasan, Kilivelu Ganesan, Annadurai Subramani, Liyakath Benazir Ali, Mohammed Mujahid Alam, Amanullah Mohammed
    ACS Omega, 2023
    Substituted pyridinium bromides are prepared by conventional and solvent-free greener methods. The solvent-free solid-phase (greener) method is superior to the conventional method because of its nontoxic nature, simple reaction setup procedure, and twenty times less time consumption. Column chromatography and toxic organic solvents are avoided. Substituted pyridinium salts 1–2(a–c) show excellent catalytic response in the preparation of β-amino carbonyl derivatives using the conventional approach. Pharmacokinetics is very important in target validation and in shifting a lead compound into a drug. The physicochemical properties discussed here can be used effectively in the drug designing candidate, which is a cumbersome process in clinical research. In addition, molecular simulations are demonstrated, and compounds 1–2(a–c) possess the most potent VEGFR-2 kinase protein inhibitory activities, and most interestingly, compound 2a strongly binds and regulates the VEGFR-2 kinase activity in therapeutic approaches and cancer prevention.
  • Synthesis of new nicotinic acid hydrazide metal complexes: Potential anti-cancer drug, supramolecular architecture, antibacterial studies and catalytic properties.
    A. Ashma, Showket Yahya, A. Subramani, R. Tamilarasan, G. Sasikumar, S.J. Askar Ali, Hamad A. Al-Lohedan, Muthusamy Karnan
    Journal of Molecular Structure, 2022
  • Synthesis of dimeric pyridinium bromide under silica supported approach
    Ramalingam Tamilarasan, Sadaiyan Govindaraj, Kilivelu Ganesan
    Synthetic Communications, 2020
    Synthesis of dimeric substituted ester derivative of pyridinium salt with flexible linker units under conventional/silica supported approach. Solid-phase approach is much superior to the conventional method due to nontoxic, solvent free, easy work up procedure, and lesser reaction period. Synthesized dimeric ester derivative of pyridinium salts is showed excellent catalytic response for the preparation of oxizinone derivatives under conventional/approach. Graphical Abstract
  • A Facile and Solvent-Free Silica-Supported Route for the Preparation of Pyrazolium Salts and Its Catalytic Responses
    Tamilarasan Ramalingam, Ganesan Kilivelu
    Journal of Heterocyclic Chemistry, 2017
    Synthesis of di/trimeric substituted pyrazolium salts was carried out under a conventional/solvent‐free silica‐supported muffle furnace method. The solid phase method observed remarkable response compared with the conventional method for the preparation of pyrazolium salts. Di/trimeric substituted pyrazolium salts acted as a very good catalyst for benzilic acid preparation while compared with existing literatures.

RECENT SCHOLAR PUBLICATIONS

  • Enhanced bone regeneration and cellular protection from oxidative stress using a vitamin C-based scaffold
    P Sharmila, S Ramkumar, S Sivagami, S Suja, T Ramalingam, ...
    Iranian Journal of Basic Medical Sciences 29 (2), 280 , 2026
    2026
  • Enhanced Dermal Delivery of Myrtenol via Polymer-Lipid Nanoparticle Hydrogel for Psoriasis Therapy
    H Yan, S Kaliamoorthy, L Sivalingam, P Samikannu, R Tamilarasan, ...
    Colloids and Surfaces A: Physicochemical and Engineering Aspects, 138853 , 2025
    2025
    Citations: 3
  • Eco-Friendly Synthesis of water-soluble Imidazole Derivatives: Exploring Multiple Pathways and Their Catalytic Properties
    P Murugana, TR Kumarb, R Tamilarasanc, R Raju
    Cuestiones de Fisioterapia 54 (3), 5375-5381 , 2025
    2025
  • Facile green synthesis of gelatin sodium alginate cerium oxide hydrogel nanocomposite and their photocatalytic and its biological applications
    ASS Shalini, L Shahanaz, P Rajeswaran, R Tamilarasan, S Kumaran, ...
    Chemical Papers 78 (5), 3111-3123 , 2024
    2024
    Citations: 25
  • Catalytic, theoretical, and biological investigations of ternary metal (II) complexes derived from L-valine-based schiff bases and heterocyclic bases
    G Sasikumar, A Subramani, R Tamilarasan, P Rajesh, P Sasikumar, ...
    Molecules 28 (7), 2931 , 2023
    2023
    Citations: 5
  • Catalytic response and molecular simulation studies in the development of synthetic routes in trimeric triaryl pyridinium type ionic liquids
    R Tamilarasan, A Subramani, G Sasikumar, P Ganapathi, S Karthikeyan, ...
    Scientific reports 13 (1), 4453 , 2023
    2023
    Citations: 7
  • Synthesis, characterization, pharmacogenomics, and molecular simulation of pyridinium type of ionic liquids and their applications
    R Tamilarasan, K Ganesan, A Subramani, L Benazir Ali, MM Alam, ...
    ACS omega 8 (4), 4146-4155 , 2023
    2023
    Citations: 17
  • Synthesis of new nicotinic acid hydrazide metal complexes: Potential anti-cancer drug, supramolecular architecture, antibacterial studies and catalytic properties.
    A Ashma, S Yahya, A Subramani, R Tamilarasan, G Sasikumar, SJA Ali, ...
    Journal of Molecular Structure 1250, 131860 , 2022
    2022
    Citations: 28
  • Synthesis and characterization of dimeric phenyl pyridinium bromide and its application.
    RT Vijayan M
    International Journal of humanities, Law and Social Sciences Published … , 2022
    2022
  • Green Synthesis And Characterization of Di/ Trimeric Isoquinolinium type of ionic Liquids Under Multiple Apporach and its Applications.
    RT Vanitha C, Kavimani V, Uma P
    Journal of Fundamental & Comparative Research 8, 1-5 , 2022
    2022
  • Synthesis of dimeric pyridinium bromide under silica supported approach
    R Tamilarasan, S Govindaraj, K Ganesan
    Synthetic Communications 50 (8), 1190-1198 , 2020
    2020
    Citations: 4
  • A Facile and Solvent‐Free Silica‐Supported Route for the Preparation of Pyrazolium Salts and Its Catalytic Responses
    T Ramalingam, G Kilivelu
    Journal of Heterocyclic Chemistry 54 (5), 2817-2821 , 2017
    2017
    Citations: 1
  • Synthesis of Triaryl Pyridinium Derivatives under Silica Supported Approach and Their Applications
    R Tamilarasan, R Rajalakshmi, K Ganesan
    Journal of Advanced Catalysis Science and Technology 4, 22-27 , 2017
    2017
  • Synthesis, Characterization of novel Trimeric Ionic liquids and its Applications
    KG Ramalingam Tamilarasan
    International Journal of Innovative Research in Science & Engineering 2 (1 … , 2014
    2014

MOST CITED SCHOLAR PUBLICATIONS

  • Synthesis of new nicotinic acid hydrazide metal complexes: Potential anti-cancer drug, supramolecular architecture, antibacterial studies and catalytic properties.
    A Ashma, S Yahya, A Subramani, R Tamilarasan, G Sasikumar, SJA Ali, ...
    Journal of Molecular Structure 1250, 131860 , 2022
    2022
    Citations: 28
  • Facile green synthesis of gelatin sodium alginate cerium oxide hydrogel nanocomposite and their photocatalytic and its biological applications
    ASS Shalini, L Shahanaz, P Rajeswaran, R Tamilarasan, S Kumaran, ...
    Chemical Papers 78 (5), 3111-3123 , 2024
    2024
    Citations: 25
  • Synthesis, characterization, pharmacogenomics, and molecular simulation of pyridinium type of ionic liquids and their applications
    R Tamilarasan, K Ganesan, A Subramani, L Benazir Ali, MM Alam, ...
    ACS omega 8 (4), 4146-4155 , 2023
    2023
    Citations: 17
  • Catalytic response and molecular simulation studies in the development of synthetic routes in trimeric triaryl pyridinium type ionic liquids
    R Tamilarasan, A Subramani, G Sasikumar, P Ganapathi, S Karthikeyan, ...
    Scientific reports 13 (1), 4453 , 2023
    2023
    Citations: 7
  • Catalytic, theoretical, and biological investigations of ternary metal (II) complexes derived from L-valine-based schiff bases and heterocyclic bases
    G Sasikumar, A Subramani, R Tamilarasan, P Rajesh, P Sasikumar, ...
    Molecules 28 (7), 2931 , 2023
    2023
    Citations: 5
  • Synthesis of dimeric pyridinium bromide under silica supported approach
    R Tamilarasan, S Govindaraj, K Ganesan
    Synthetic Communications 50 (8), 1190-1198 , 2020
    2020
    Citations: 4
  • Enhanced Dermal Delivery of Myrtenol via Polymer-Lipid Nanoparticle Hydrogel for Psoriasis Therapy
    H Yan, S Kaliamoorthy, L Sivalingam, P Samikannu, R Tamilarasan, ...
    Colloids and Surfaces A: Physicochemical and Engineering Aspects, 138853 , 2025
    2025
    Citations: 3
  • A Facile and Solvent‐Free Silica‐Supported Route for the Preparation of Pyrazolium Salts and Its Catalytic Responses
    T Ramalingam, G Kilivelu
    Journal of Heterocyclic Chemistry 54 (5), 2817-2821 , 2017
    2017
    Citations: 1
  • Enhanced bone regeneration and cellular protection from oxidative stress using a vitamin C-based scaffold
    P Sharmila, S Ramkumar, S Sivagami, S Suja, T Ramalingam, ...
    Iranian Journal of Basic Medical Sciences 29 (2), 280 , 2026
    2026
  • Eco-Friendly Synthesis of water-soluble Imidazole Derivatives: Exploring Multiple Pathways and Their Catalytic Properties
    P Murugana, TR Kumarb, R Tamilarasanc, R Raju
    Cuestiones de Fisioterapia 54 (3), 5375-5381 , 2025
    2025
  • Synthesis and characterization of dimeric phenyl pyridinium bromide and its application.
    RT Vijayan M
    International Journal of humanities, Law and Social Sciences Published … , 2022
    2022
  • Green Synthesis And Characterization of Di/ Trimeric Isoquinolinium type of ionic Liquids Under Multiple Apporach and its Applications.
    RT Vanitha C, Kavimani V, Uma P
    Journal of Fundamental & Comparative Research 8, 1-5 , 2022
    2022
  • Synthesis of Triaryl Pyridinium Derivatives under Silica Supported Approach and Their Applications
    R Tamilarasan, R Rajalakshmi, K Ganesan
    Journal of Advanced Catalysis Science and Technology 4, 22-27 , 2017
    2017
  • Synthesis, Characterization of novel Trimeric Ionic liquids and its Applications
    KG Ramalingam Tamilarasan
    International Journal of Innovative Research in Science & Engineering 2 (1 … , 2014
    2014