Ramon Eritja

@csic.es

Research Professor, Surfactants and Nanobiotechnology/ IQAC-CSIC
Spanish National Research Council (CSIC)

Ramon Eritja
Postdoctoral Fellow in Dr. Itakura’s (Beckman Research Institute at City of Hope, CA, USA, 1984-1988) and Dr. Caruthers’s (University of Colorado at Boulder, USA, 1988-1989) laboratories. Postdoctoral fellow, University of Barcelona, 1989-1990. Group Leader at CSIC, Barcelona, 1990-1994. Group Leader and responsible of DNA synthesis facility at EMBL, Heidelberg, Germany, 1994-1999. Research Professor at IBMB-CSIC leading the Nucleic Acid Chemistry Group since 1999. Invited member of the IRB Barcelona (2006-2012). Selected as member of the Networking Center on Bioengennering, Biomaterials and Nanomedicine of Spain (CIBER-BBN) since 2006. Director of institute (IQAC, 2012-2017). Expertise on oligonucleotide and peptide synthesis especially on the methodological aspects of solid-phase synthesis (monomer synthesis, preparation of solid supports, synthesis and purification). Experience in most areas related to the synthesis and properties of oligonucleotide derivatives.

EDUCATION

B. Sc. Chemistry, University of Barcelona, 1977. B. Sc. Pharmacy, University of Barcelona 1982. Ph.D. Chemistry, University of Barcelona, 1983.

RESEARCH, TEACHING, or OTHER INTERESTS

Organic Chemistry, Drug Discovery, Biochemistry, Genetics and Molecular Biology, Structural Biology
441

Scopus Publications

18252

Scholar Citations

68

Scholar h-index

324

Scholar i10-index

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

  • G-quadruplexes as therapeutic platforms for anticancer drug delivery: from intrinsic cytotoxicity to drug delivery and nanotechnology
    A Domínguez, N Navarro, A Aviñó, C Fàbrega, R Eritja
    Expert Opinion on Drug Delivery , 2026
    2026
    Citations: 1
  • Covalent functionalization of polymeric nanoparticles prepared from nano-emulsion templates for gene silencing and antioxidant delivery at neuronal level
    M Bel-Esteve, M Carrasco, N Moral, A Aviñó, C Fàbrega, R Eritja, ...
    International Journal of Pharmaceutics, 126918 , 2026
    2026
  • Engineering G-quadruplex aptamer-5-fluoro-2′-deoxyuridine conjugates: Impact of tail orientation and RNA spacer insertion on structure and antitumor activity
    N Navarro, D Benigno, C Aliberti, A Virgilio, A Galeone, R Eritja, ...
    International journal of biological macromolecules, 151523 , 2026
    2026
    Citations: 1
  • Enhanced muscle uptake of chemically optimized miR-23b antisense oligonucleotides as lead compounds for Myotonic Dystrophy type 1
    I González-Martínez, E Cerro-Herreros, M Carrascosa-Sàez, ...
    The American Journal of Human Genetics 113 (3), 529-547 , 2026
    2026
  • Replication Data for: Conjugation strategy shapes antitumor efficacy and enables dose-sparing in non-antibody protein nanoconjugates
    LC Alba Castellon, U Unzueta Elorza, R Mangues, A Rueda, D Paez, ...
    2026
  • Conjugation strategy shapes antitumor efficacy and enables dose-sparing in non-antibody protein nanoconjugates.
    A Rueda, A Garcia-Leon, LA Arena, JI Mendoza, A Aviñó, C Fabrega, ...
    Materials Today Bio, 102698 , 2025
    2025
  • Enhanced i‐Motif Stability through Consecutive 2′, 2′‐Difluorocytidine Incorporation
    A Domínguez, C Cabrero, I Gómez‐Pinto, C Fàbrega, R Gargallo, R Eritja, ...
    Chemistry–A European Journal 31 (71), e03008 , 2025
    2025
  • 8 Oligonucleotide conjugates
    AF Jorge, S Grijalvo, A Aviñó, C Fàbrega, R Eritja
    Nucleic Acids Chemistry: Modifications and Conjugates for Biomedicine and … , 2025
    2025
  • 5 Nucleic acids triple helices
    A Domínguez, R Eritja
    Nucleic Acids Chemistry: Modifications and Conjugates for Biomedicine and … , 2025
    2025
  • 9 DNA nanotechnology for drug delivery
    N Navarro, C Fàbrega, R Eritja
    Nucleic Acids Chemistry: Modifications and Conjugates for Biomedicine and … , 2025
    2025
  • Nucleic Acids Chemistry: Modifications and Conjugates for Biomedicine and Nanotechnology
    R Eritja
    Walter de Gruyter GmbH & Co KG , 2025
    2025
    Citations: 2
  • The Effect of 2′ F-RNA on I-Motif Structure and Stability
    C Ugedo, A Domínguez, I Gómez-Pinto, R Eritja, C González, A Aviñó
    Molecules 30 (17), 3561 , 2025
    2025
    Citations: 1
  • Resolution of complex mixtures of duplex and antiparallel triplex DNA structures by capillary electrophoresis and multivariate analysis
    K Hatamli, R Eritja, E Giménez, F Benavente, R Gargallo
    Talanta 288, 127616 , 2025
    2025
    Citations: 2
  • Unraveling the Amplification-Free Quantitative Detection of Viral RNA in Nasopharyngeal Swab Samples Using a Compact Electrochemical Rapid Test Device
    M Gutiérrez-Capitán, E Balada, A Avino, L Vilaplana, R Galve, A Lacoma, ...
    Analytical chemistry 97 (22), 11863-11873 , 2025
    2025
    Citations: 3
  • Modified Bis-pyrimidine Clamps for Triplex Formation and Their Use in SARS-CoV-2 Detection
    A Dominguez, R Gargallo, C Cuestas-Ayllón, I Gomez-Pinto, C Fàbrega, ...
    ACS omega 10 (22), 23535-23548 , 2025
    2025
    Citations: 2
  • Targeted Tumor Microenvironment Delivery of Floxuridine Prodrug via Soluble Silica Nanoparticles in Malignant Melanoma as a Model for Aggressive Cancer Treatment
    A Ramos‐Valle, A Domínguez, N Navarro, A Márquez‐López, A Aviñó, ...
    Small 21 (20), 2407752 , 2025
    2025
    Citations: 4
  • On the interaction of anticancer G-quadruplex ligands with GalNAc-functionalized G-quadruplex-forming carriers for selective recognition and treatment of hepatocellular carcinoma
    A Clua, C Fàbrega, D Musumeci, F Doria, V Pirota, F Ghirga, C Platella, ...
    Bioorganic chemistry 157, 108299 , 2025
    2025
    Citations: 3
  • Systematic study of hybrid triplex topology and stability suggests a general triplex-mediated regulatory mechanism
    V Genna, G Portella, A Sala, M Terrazas, I Serrano-Chacón, J González, ...
    Nucleic acids research 53 (5), gkaf170 , 2025
    2025
    Citations: 8
  • Assessment of methodologies based on the formation of antiparallel triplex DNA structures and fluorescent silver nanoclusters for the detection of pyrimidine-rich sequences
    C Poyato, J Pacheco, A Domínguez, R Eritja, A Aviñó, R Gargallo
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 329, 125567 , 2025
    2025
    Citations: 2
  • Polypurine Reverse Hoogsten hairpins as a potential therapeutic tool for COVID-19 infection
    V Noe, S Valiuska, P Nogales-Altozano, J Rojas, A Avino, R Eritja, ...
    HUMAN GENE THERAPY 36 (3-4), E338-E338 , 2025
    2025

MOST CITED SCHOLAR PUBLICATIONS

  • Carbon nanotubes with DNA recognition
    KA Williams, PTM Veenhuizen, BG de la Torre, R Eritja, C Dekker
    Nature 420 (6917), 761-761 , 2002
    2002
    Citations: 708
  • Convergent solid-phase peptide synthesis
    P Lloyd-Williams, M Gairi, G Jou, R Eritja
    1993
    Citations: 309
  • Base pairing and mutagenesis: observation of a protonated base pair between 2-aminopurine and cytosine in an oligonucleotide by proton NMR.
    LC Sowers, GV Fazakerley, R Eritja, BE Kaplan, MF Goodman
    Proceedings of the National Academy of Sciences 83 (15), 5434-5438 , 1986
    1986
    Citations: 303
  • Nucleotide insertion kinetics opposite abasic lesions in DNA.
    SK Randall, R Eritja, BE Kaplan, J Petruska, MF Goodman
    Journal of Biological Chemistry 262 (14), 6864-6870 , 1987
    1987
    Citations: 299
  • Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach
    G Mahmoodi Chalbatani, H Dana, E Gharagouzloo, S Grijalvo, R Eritja, ...
    International journal of nanomedicine, 3111-3128 , 2019
    2019
    Citations: 293
  • Crystal structure of a DNA Holliday junction
    M Ortiz-Lombardía, A González, R Eritja, J Aymamí, F Azorín, M Coll
    nature structural biology 6 (10), 913-917 , 1999
    1999
    Citations: 277
  • Biochemical basis of SOS-induced mutagenesis in Escherichia coli : Reconstitution of in vitro lesion bypass dependent on the UmuD′ 2 C mutagenic complex and …
    M Tang, I Bruck, R Eritja, J Turner, EG Frank, R Woodgate, M O’Donnell, ...
    Proceedings of the National Academy of Sciences 95 (17), 9755-9760 , 1998
    1998
    Citations: 248
  • Biofunctionalization of silica-coated CdTe and gold nanocrystals
    A Schroedter, H Weller, R Eritja, WE Ford, JM Wessels
    Nano Letters 2 (12), 1363-1367 , 2002
    2002
    Citations: 237
  • Fundamental aspects of the nucleic acid i-motif structures
    S Benabou, A Aviñó, R Eritja, C González, R Gargallo
    RSC advances 4 (51), 26956-26980 , 2014
    2014
    Citations: 235
  • A novel p34cdc2-binding and activating protein that is necessary and sufficient to trigger G2/M progression in Xenopus oocytes
    I Ferby, M Blazquez, A Palmer, R Eritja, AR Nebreda
    Genes & development 13 (16), 2177-2189 , 1999
    1999
    Citations: 227
  • Label-free DNA biosensors based on functionalized carbon nanotube field effect transistors
    MT Martínez, YC Tseng, N Ormategui, I Loinaz, R Eritja, J Bokor
    Nano letters 9 (2), 530-536 , 2009
    2009
    Citations: 218
  • Spectroscopic and calorimetric characterizations of DNA duplexes containing 2-aminopurine
    SM Law, R Eritja, MF Goodman, KJ Breslauer
    Biochemistry 35 (38), 12329-12337 , 1996
    1996
    Citations: 218
  • Abasic translesion synthesis by DNA polymerase β violates the “A-rule”: Novel types of nucleotide incorporation by human DNA polymerase β at an abasic lesion in different …
    E Efrati, G Tocco, R Eritja, SH Wilson, MF Goodman
    Journal of Biological Chemistry 272 (4), 2559-2569 , 1997
    1997
    Citations: 216
  • A novel cationic niosome formulation for gene delivery to the retina
    G Puras, M Mashal, J Zárate, M Agirre, E Ojeda, S Grijalvo, R Eritja, ...
    Journal of Controlled Release 174, 27-36 , 2014
    2014
    Citations: 211
  • Transgenic rice plants expressing the antifungal AFP protein from Aspergillus giganteus show enhanced resistance to the rice blast fungus Magnaporthe grisea
    M Coca, C Bortolotti, M Rufat, G Peñas, R Eritja, D Tharreau, AM Del Pozo, ...
    Plant Molecular Biology 54 (2), 245-259 , 2004
    2004
    Citations: 211
  • The structure of plasmid‐encoded transcriptional repressor CopG unliganded and bound to its operator
    FX Gomis‐Rüth, M Sola, P Acebo, A Párraga, A Guasch, R Eritja, ...
    The EMBO journal 17 (24), 7404-7415 , 1998
    1998
    Citations: 208
  • Efficient self-assembly in water of long noncovalent polymers by nucleobase analogues
    BJ Cafferty, I Gállego, MC Chen, KI Farley, R Eritja, NV Hud
    Journal of the American Chemical Society 135 (7), 2447-2450 , 2013
    2013
    Citations: 204
  • Boronic acid-modified alginate enables direct formation of injectable, self-healing and multistimuli-responsive hydrogels
    A Pettignano, S Grijalvo, M Haering, R Eritja, N Tanchoux, F Quignard, ...
    Chemical communications 53 (23), 3350-3353 , 2017
    2017
    Citations: 200
  • Water‐soluble carbosilane dendrimers: synthesis biocompatibility and complexation with oligonucleotides; evaluation for medical applications
    JF Bermejo, P Ortega, L Chonco, R Eritja, R Samaniego, M Müllner, ...
    Chemistry–A European Journal 13 (2), 483-495 , 2007
    2007
    Citations: 190
  • Biodegradable liposome-encapsulated hydrogels for biomedical applications: A marriage of convenience
    S Grijalvo, J Mayr, R Eritja, DD Díaz
    Biomaterials science 4 (4), 555-574 , 2016
    2016
    Citations: 189