Advances in Radiotherapy of Gastrointestinal Cancers Tahreen Taj, Fathima Beegum, M. P. Mohammed Ameen, Biplab Debnath, Sumel Ashique, Debajit Dewan, Raneet Das, Chowdhury Mobaswar Hossain, Shaghayegh Rezvani Nezhad, Neeraj Mishra From Radiobiology to Radiation Oncology, 2025
Vitamin E and Folic Acid as Nutritional Modulators of Neurodevelopment: A Functional Food Perspective Samrat Bose, Himangshu Sekhar Maji, Sougata Das, Biplab Debnath, Mohini Mondal, Debasmita Paul, Debajit Dewan, Raneet Das, Sumel Ashique, Wesam Taher Almagharbeh, Rashmi Pathak, Himanshu Sharma Current Nutrition and Food Science, 2025 Neurodevelopment is a highly regulated and complex process that involves cellular proliferation, differentiation, and synaptic maturation. Nutritional factors, such as vitamin E and folic acid, play pivotal roles in this process. Vitamin E, primarily in the form of α-tocopherol, functions as a potent antioxidant, maintaining neuronal membrane integrity and supporting key neurodevelopmental processes through its interaction with α-TTP. Likewise, maternal folate intake has been extensively linked to positive neurodevelopmental outcomes, including reduced risk of neural tube defects and enhanced cognitive performance in offspring. Folic acid also modulates epigenetic processes, such as DNA methylation of genes essential for neuronal development, including IGF2 and BDNF. Studies in both murine and zebrafish models confirm the crucial role of these nutrients in brain development and function.
A Review of the Phytochemical and Pharmacological Characteristics of Hernandia nymphaeifolia Sumana Das, Afsana Khan, Amlan Bishal, Bratati Badyopadhya, Mohini Mondal, Aveek Datta, Shilpy Jha, Raneet Das, Biplab Debnath Journal of Natural Remedies, 2024 Since ancient times, medicinal plants have been the primary source of most medications. In actuality, a large number of the medications that are now on the market may be obtained either directly in extract form or in modified synthetic form. As phytoconstituents, which are employed by plants to carry out biological processes and defend us from predators like viruses, fungi, and other microbes, they are naturally able to produce goods that are helpful for humans. Hernandia nymphaeifolia is a traditional medicinal plant that is used in several traditional remedies to treat several ailments. The extracts from various portions of the plant have excellent therapeutic effectiveness. Numerous pharmacological investigations have demonstrated this plant’s capacity to display anti-cytotoxic, anti-inflammatory, anti-platelet aggregation, vasodilator, antioxidant, anti-microbial, and Ca2+ signalling properties. The current study covers a thorough examination of the plant’s systematic botanical position, phytochemical analysis, investigations into the plant’s pharmacological activity, and therapeutic uses.
Black Fungus: An Alarming Infection During Novel Coronavirus: A Review Raneet Das, Jayita Roy, Sumel Ashique Anti Infective Agents, 2022 Mucormycosis is the most emerging angioinvasive fungal infection of filamentous fungi of the Zygomycetes class, which, when neglected, causes severe disseminated infection along with significant chances of morbidity and mortality. The diagnosis and treatment remain challenging for the doctors. It has been observed that people who have been suffering from different diseases, such as hematological malignancies and uncontrolled diabetes, or who have gone through different surgeries, such as hematopoietic stem cell transplant, and solid transplantation, are the most affected ones. On the other hand, people who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) typically show the symptoms of mucormycosis after 1-2 weeks of successful recovery. Standard treatment of mucormycosis is traditionally considered an amphotericin B intravenous (IV) drug as initial therapy, although posaconazole and isavuconazole are also used. The core objective of the review is to typically focus on the area of the sudden cause of mucormycosis in the patients who have already recovered from SARS-CoV-2.
Microsphere: A Wander around Drug Delivery Anirban Karmakar, Soumya Dev Maity, Shayeree Barua, Raneet Das Bionatura, 2022 Microspheres have free-flowing powder characteristics consisting of synthetic polymers and proteins with a particle size of 1-1000 μm. Microsphere improves bioavailability, stability and targets the drug to a selected site at a predetermined rate. Sorts of microspheres are bioadhesive, floating, radioactive, polymeric, and biodegradable microspheres. Therefore, the array of practices for the groundwork of microspheres offers a chance to regulate drug administration properties and develop the therapeutic efficacy of a given drug. The microsphere is spherical microparticles & is employed where predictable & consistent particle area is vital. The microspheres have the drug located centrally within the particle encased within the unique polymeric membrane. The present review highlights various sorts of microspheres, different methods of preparation, their applications, and various parameters to gauge their efficiency. Microspheres have received much attention not just for prolonged release but also for targeted medicine. A systematic review of one of the most promising drug delivery systems should be easier to read than the medical research articles, as they target a wider audience. The systematic reviews of the microparticles conclude that spherical microspheres & are accustomed to delivering the drug at the target site with specificity if modified and take care of the specified concentration at the location of interest without the untoward effects presented during a consistent therapy to help research and retrieval of health.
