Ph.D. in Pharmaceutical Sciences
Bachelors in Law
Masters in Management
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmaceutical Science, Business and International Management, Drug Discovery, General Pharmacology, Toxicology and Pharmaceutics
7
Scopus Publications
443
Scholar Citations
7
Scholar h-index
7
Scholar i10-index
Scopus Publications
Controlled Release of a Vasodilator Drug through Membrane-controlled Transdermal Systems: Development, Characterization, and Ex-vivo Evaluation Sudha B. Patil, Rashmi Boppana, Ravindra G. Kulkarni, Anjanpura V. Raghu, Raghavendra V. Kulkarni Current Materials Science, 2026 Background: An attempt was made to develop and evaluate the membrane- controlled transdermal systems for the controlled release of nicorandil. The carbopol gel was selected as a drug reservoir, crosslinked blend membranes of XG and SA were selected as rate-controlled membranes (RCM), and a film of poly(vinyl alcohol) (PVA) was selected as the backing membrane. Aim: The aim of the current work was to formulate the membrane-controlled transdermal drug delivery systems for the effective delivery of a vasodilator, nicorandil, for the management of hypertension and angina pectoris, and in-vitro and ex-vivo evaluation of these developed formulations. Methods: Reservoir gel was evaluated for drug content, pH, viscosity, and RCMs by weight uniformity, thickness uniformity, differential scanning calorimetric (DSC) analysis, x-ray diffraction (XRD) analysis, scanning electron microscopy (SEM), water vapor transmission, skin irritation, and histopathology. Results: Depending on crosslink density, variation in the water vapor permeation of RCMs was noticed. The RCMs showed no signs of skin irritation. In-vitro drug permeation through rat skin was extended for a period of 24 hours. With an increase in acetaldehyde concentration in the RCM, there was a decrease in drug permeation. Among the two terpenes used as penetration enhancers, the cineole at a concentration of 20% exhibited a maximum permeation rate. The release mechanism from all systems followed non-Fickian transport. Histopathology results indicated minor changes in skin structure after skin permeation studies, which were reversible. Conclusion: The developed transdermal systems were found to have versatile dosage forms for the controlled release of nicorandil, a vasodilator.
Interpenetrating network hydrogel beads of carboxymethylcellulose and egg albumin for controlled release of lipid lowering drug Rashmi Boppana, Raghavendra V. Kulkarni, Srinivas S. Mutalik, C. Mallikarjun Setty, Biswanath Sa Journal of Microencapsulation, 2010 Novel interpenetrating network hydrogel beads of sodium carboxymethylcellulose and egg albumin loaded with a lipid lowering drug, simvastatin, were prepared by ionotropic gelation and covalent cross-linking method. The IPN beads were characterized by differential scanning colorimetric analysis, X-ray diffractometry to understand the crystalline nature of the drug after entrapment into IPN matrix. Fourier transform infrared spectroscopy was used to find the chemical stability of drug in the polymer matrix and scanning electron microscopy was performed to study the surface morphology. The ionically cross-linked beads were capable of releasing drug up to 7 h, whereas the drug release was extended up to 12 h in case of dual cross-linked beads. The beads which were prepared with higher concentration of glutaraldehyde released the drug more slowly. The release data were fitted to an empirical equation to determine the transport mechanism, which indicated the non-Fickian trend for drug transport.
Carboxymethylcellulose - aluminum hydrogel microbeads for prolonged release of simvastatin Acta Pharmaceutica Sciencia, 2010
RECENT SCHOLAR PUBLICATIONS
Controlled Release of a Vasodilator Drug through Membrane-controlled Transdermal Systems: Development, Characterization, and Ex-vivo Evaluation Sudha B. Patil, Rashmi Boppana, Ravindra G. Kulkarni, Anjanpura V. Raghu ... Current Materials Science , 2024 2024
Novel pH-sensitive interpenetrated network polyspheres of polyacrylamide-g-locust bean gum and sodium alginate for intestinal targeting of ketoprofen: In vitro and in vivo … R Boppana, SY Raut, GK Mohan, B Sa, S Mutalik, KR Reddy, KK Das, ... Colloids and Surfaces B: Biointerfaces 180, 362-370 , 2019 2019 Citations: 33
In vitro and in vivo assessment of novel pH-sensitive interpenetrating polymer networks of a graft copolymer for gastro-protective delivery of ketoprofen R Boppana, RV Kulkarni, GK Mohan, S Mutalik, TM Aminabhavi RSC advances 6 (69), 64344-64356 , 2016 2016 Citations: 28
Novel pH-sensitive IPNs of polyacrylamide-g-gum ghatti and sodium alginate for gastro-protective drug delivery R Boppana, GK Mohan, U Nayak, S Mutalik, B Sa, RV Kulkarni International Journal of Biological Macromolecules 75, 133-143 , 2015 2015 Citations: 54
Development and Evaluation of Microbeads Using Modified Polysaccharides for Controlled Release of Ketoprofen 64th Indian Pharmaceutical Congress, Chennai, India , 2012 2012
pH-responsive interpenetrating network hydrogel beads of poly (acrylamide)-g-carrageenan and sodium alginate for intestinal targeted drug delivery: Synthesis, in vitro and in … RV Kulkarni, R Boppana, GK Mohan, S Mutalik, NV Kalyane Journal of Colloid and Interface Science 367 (1), 509-517 , 2012 2012 Citations: 212
Interpenetrating network hydrogel beads of carboxymethylcellulose and egg albumin for controlled release of lipid lowering drug R Boppana, RV Kulkarni, SS Mutalik, CM Setty, B Sa Journal of microencapsulation 27 (4), 337-344 , 2010 2010 Citations: 45
Carboxymethylcellulose–aluminium hydrogel microbeads for prolonged release of simvastatin R Boppana, RV Kulkarni, CM Setty, NV Kalyane Acta Pharmaceutica Sciencia 52 (2), 137-43 , 2010 2010 Citations: 42
Preparation and Evaluation of Hydrogel Beads of Simvastatin 60th Indian Pharmaceutical Congress, Delhi, India , 2008 2008
Development and Evaluation of Controlled release Beads of Lipid Lowering Drug using Natural Polymers National Women's Science Congress organized by Swadeshi Vijnana Andolana … , 2008 2008
Development and evaluation of xyloglucan matrix tablets containing naproxen RV Kulkarni, A Shah, R Boppana Asian Journal of Pharmaceutics (AJP) 2 (2) , 2008 2008 Citations: 29
Preparation and Evaluation of Controlled Release Multiunit Dosage Forms of Simvastatin 59th Indian Pharmaceutical Congress; Varanasi, India , 2007 2007
MOST CITED SCHOLAR PUBLICATIONS
pH-responsive interpenetrating network hydrogel beads of poly (acrylamide)-g-carrageenan and sodium alginate for intestinal targeted drug delivery: Synthesis, in vitro and in … RV Kulkarni, R Boppana, GK Mohan, S Mutalik, NV Kalyane Journal of Colloid and Interface Science 367 (1), 509-517 , 2012 2012 Citations: 212
Novel pH-sensitive IPNs of polyacrylamide-g-gum ghatti and sodium alginate for gastro-protective drug delivery R Boppana, GK Mohan, U Nayak, S Mutalik, B Sa, RV Kulkarni International Journal of Biological Macromolecules 75, 133-143 , 2015 2015 Citations: 54
Interpenetrating network hydrogel beads of carboxymethylcellulose and egg albumin for controlled release of lipid lowering drug R Boppana, RV Kulkarni, SS Mutalik, CM Setty, B Sa Journal of microencapsulation 27 (4), 337-344 , 2010 2010 Citations: 45
Carboxymethylcellulose–aluminium hydrogel microbeads for prolonged release of simvastatin R Boppana, RV Kulkarni, CM Setty, NV Kalyane Acta Pharmaceutica Sciencia 52 (2), 137-43 , 2010 2010 Citations: 42
Novel pH-sensitive interpenetrated network polyspheres of polyacrylamide-g-locust bean gum and sodium alginate for intestinal targeting of ketoprofen: In vitro and in vivo … R Boppana, SY Raut, GK Mohan, B Sa, S Mutalik, KR Reddy, KK Das, ... Colloids and Surfaces B: Biointerfaces 180, 362-370 , 2019 2019 Citations: 33
Development and evaluation of xyloglucan matrix tablets containing naproxen RV Kulkarni, A Shah, R Boppana Asian Journal of Pharmaceutics (AJP) 2 (2) , 2008 2008 Citations: 29
In vitro and in vivo assessment of novel pH-sensitive interpenetrating polymer networks of a graft copolymer for gastro-protective delivery of ketoprofen R Boppana, RV Kulkarni, GK Mohan, S Mutalik, TM Aminabhavi RSC advances 6 (69), 64344-64356 , 2016 2016 Citations: 28
Controlled Release of a Vasodilator Drug through Membrane-controlled Transdermal Systems: Development, Characterization, and Ex-vivo Evaluation Sudha B. Patil, Rashmi Boppana, Ravindra G. Kulkarni, Anjanpura V. Raghu ... Current Materials Science , 2024 2024
Development and Evaluation of Microbeads Using Modified Polysaccharides for Controlled Release of Ketoprofen 64th Indian Pharmaceutical Congress, Chennai, India , 2012 2012
Preparation and Evaluation of Hydrogel Beads of Simvastatin 60th Indian Pharmaceutical Congress, Delhi, India , 2008 2008
Development and Evaluation of Controlled release Beads of Lipid Lowering Drug using Natural Polymers National Women's Science Congress organized by Swadeshi Vijnana Andolana … , 2008 2008
Preparation and Evaluation of Controlled Release Multiunit Dosage Forms of Simvastatin 59th Indian Pharmaceutical Congress; Varanasi, India , 2007 2007
RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)
Patent - IN 282337 (India) : PHARMACEUTICAL COMPOSITION COMPRISING TAMARIND SEED POLYOSE FOR MODIFIED RELEASE OF DRUG
