Dr Konda Ravi Kumar

@hip.ac.in

Professor & Principal and Pharmaceutical Sciences
Hetero Institute of Pharmaceutical Sciences

Dr Konda Ravi Kumar


                           Download Compact PDF  
https://researchid.co/ravikkonda

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmaceutical Science, Drug Discovery, General Pharmacology, Toxicology and Pharmaceutics, Pharmacology, Toxicology and Pharmaceutics
5

Scopus Publications

433

Scholar Citations

12

Scholar h-index

17

Scholar i10-index

Scopus Publications

  • Development and validation of high performance thin layer chromatographic method for the determination of voglibose in bulk and their formulations
    Mallikharjuna Rao, Ravikumar Konda, N. Mallikarjuna Rao, Y Yamasaki, N Katakami, et al.
    Letters in Applied Nanobioscience, 2020
    To develop a simple, fast, specific, precise and accurate High Performance Thin Layer Chromatographic method (HPTLC) for the determination of Voglibose in bulk and their dosage forms. The chromatographic separation was achieved on precoated silica gel 60F254 aluminum plates using a combination of acetonitrile: methanol: ammonia (15:4:0.1 % V/V/V) as mobile phase and densitometric evaluation of spots was carried out at 284 nm using Camag TLC scanner III with CATS 1.3.4 version software. The experimental parameters like band size of the chamber saturation time, spot application, slit width, solvent front migration, etc. were studied critically and evolved optimized conditions. The drug was well resolved satisfactorily with Rf value 0.66±0.03. The repeatability and accuracy of the optimized method were ascertained by evaluating various validation parameters like linearity (100 to 450 ng/spot), precision (intra-day % RSD 0.21 to 0.74, inter-day % RSD 0.21 to 0.29), accuracy (99.8% to 101.2%, % RSD below 1%), and specificity according to ICH guidelines. The limits of detection and quantification were 40 ng/spot and 100 ng/spot respectively. The developed HPTLC method was faster and cost effective quantitative control for routine analysis of Voglibose in bulk and its formulations.
  • Synthesis, characterization and biological screening of novel substituted chalcones
    Der Pharmacia Lettre, 2014
  • Development and validation of a sensitive LC-MS/MS method for determination of valacyclovir in human plasma: Application to a bioequivalence study
    R. K. Konda, B. R. Chandu, B. R. Challa, K. B. Chandrasekhar
    Acta Chromatographica, 2013
    Summary A simple, sensitive, and highly specific method has been developed for determination of valacyclovir (VL) in human plasma. The analytical procedure involves a solid-phase extraction method using Valacyclovir-D8 (VLD8) as an internal standard. Chromatographic separation was carried out on a reversed phase Zorbax, SB C18, 4.6 × 75 mm, 3.5μm column. Valacyclovir and Valacyclovir-D8 were detected with proton adducts at m/z 325.2 → 152.0 and 333.3 → 152.0 in multiple reaction monitoring (MRM) positive mode. The method was linear over the concentration range of 0.5–700.0 ng mL−1. The limit of detection (LOD) and limit of quantification (LOQ) for valacyclovir were 0.2 pg mL−1 and 0.5 ng mL−1, respectively. The method was shown to be precise with the average within-run and between-run variations of 0.7 to 3.5% and 3.1 to 4.7%, respectively. The average within-run and between-run accuracies of the method throughout its linear range were 96.7 to 97.9 and 94.7 to 97.3%, respectively. The mean recoveries of valacyclovir and Valacyclovir-D8 from human plasma by the developed method were 99.17 ± 10.78% and 110.84 ± 8.74%, respectively. The method was successfully applied in bioequivalence study with 20 healthy male volunteers under fasting condition.
  • Bioanalytical method development and validation of memantine in human plasma by high performance liquid chromatography with tandem mass spectrometry: Application to bioequivalence study
    Ravi Kumar Konda, B. R. Challa, Babu Rao Chandu, Kothapalli B. Chandrasekhar
    Journal of Analytical Methods in Chemistry, 2012
    A simple, sensitive, and rapid HPLC-MS/MS method was developed and validated for quantitative estimation of memantine in human plasma. Chromatography was performed on Zorbax SB-C18(4.6×75 mm, 3.5 μm) column. Memantine (ME) and internal standard Memantine-d6(MED6) were extracted by using liquid-liquid extraction and analyzed by LC-ESI-MS/MS using multiple-reaction monitoring (MRM) mode. The assay exhibited a linear dynamic range of 50.00–50000.00 pg/ml for ME in human plasma. This method demonstrated an intra- and interday precision within the range of 2.1–3.7 and 1.4–7.8%, respectively. Further intra- and interday accuracy was within the range of 95.6–99.8 and 95.7–99.1% correspondingly. The mean recovery of ME and MED6 was86.07±6.87and80.31±5.70%, respectively. The described method was successfully employed in bioequivalence study of ME in Indian male healthy human volunteers under fasting conditions.
  • Bio-analytical method development and validation of Rasagiline by high performance liquid chromatography tandem mass spectrometry detection and its application to pharmacokinetic study
    Ravi Kumar Konda, Babu Rao Chandu, B.R. Challa, Chandrasekhar B. Kothapalli
    Journal of Pharmaceutical Analysis, 2012
    The most suitable bio-analytical method based on liquid–liquid extraction has been developed and validated for quantification of Rasagiline in human plasma. Rasagiline-13C3 mesylate was used as an internal standard for Rasagiline. Zorbax Eclipse Plus C18 (2.1 mm×50 mm, 3.5 μm) column provided chromatographic separation of analyte followed by detection with mass spectrometry. The method involved simple isocratic chromatographic condition and mass spectrometric detection in the positive ionization mode using an API-4000 system. The total run time was 3.0 min. The proposed method has been validated with the linear range of 5–12000 pg/mL for Rasagiline. The intra-run and inter-run precision values were within 1.3%–2.9% and 1.6%–2.2% respectively for Rasagiline. The overall recovery for Rasagiline and Rasagiline-13C3 mesylate analog was 96.9% and 96.7% respectively. This validated method was successfully applied to the bioequivalence and pharmacokinetic study of human volunteers under fasting condition.

RECENT SCHOLAR PUBLICATIONS

  • FORMULATION AND EVALUATION OF GANCICLOVIR PROLIPOSOMAL GEL FOR TRANSDERMAL DRUG DELIVERY SYSTEM
    B Saraswathi, RK Konda
    International Journal of Indigenous Herbs and Drugs, 25-30 , 2026
    2026
  • Challenges and Opportunities in the Early Detection and Prevention of Cancer: A Comprehensive Review
    RK Konda
    Zoology, Ecology and Pharma Advances, 22-26 , 2026
    2026
  • Design-driven discovery of 3,5-disubstituted Hydantoin -based anticonvulsants supported by In-vivo and insilico studies.
    PN D.Alekhya, Konda Ravi Kumar
    Asian Journal of Pharmaceutical and Clinical Research 19 (1), 73-80 , 2026
    2026
  • NOVEL HETEROCYCLIC SCAFFOLDS IN DRUG DISCOVERY: DESIGN STRATEGIES AND THERAPEUTIC APPLICATIONS
    RK KONDA
    BioNexus Bulletin, 3-4 , 2025
    2025
  • Artificial Intelligence and Machine Learning in Pharmaceutical Chemistry: Transforming Drug Design, Optimization, and Development
    RK Konda
    Zoology, Ecology and Pharma Advances, 1-3 , 2025
    2025
    Citations: 1
  • Green and Sustainable approaches in Pharmaceutical Synthesis: Emerging trends and future prospects.
    KR Kumar
    BioSpecia 1 (1), 1-3 , 2025
    2025
    Citations: 1
  • Hydantoin Derivatives Bearing Morpholine Moiety: Design, Synthesis, Characterization, In-Silico ADMET and Molecular Docking Investigations
    PBBR D.Alekhya, Konda Ravi Kumar
    International Journal of Environmental Sciences 11 (7s), 269 -279 , 2025
    2025
  • Advancements in Nanotechnology for Enhancing Post-Harvest Handling and Storage of Horticultural Crops
    N Satheeshkumar, KR Kumar, P Bhuvaneswari, L Kumar, S Alagendran, ...
    JOURNAL OF EXPERIMENTAL AGRICULTURE INTERNATIONAL Учредители: Sciencedomain … , 2025
    2025
    Citations: 1
  • Recent developments in drug repurposing: A medicinal chemistry perspective.
    KR Kumar
    Zoology,Bio and Pharma Research (ZBPR) 1 (1), 8-9 , 2025
    2025
  • Pharmacovigilance: Importance and role of the clinical pharmacist in assessing and managing adverse drug Reactions.
    KRK G.V.Nagaraju
    American Journal of Medical and Natural Sciences 6 (2), 12-14 , 2025
    2025
  • Validated RP-HPLC method for Simultaneous estimation of Cabotegravir and Rilpivirine in tablet dosage form.
    MRR P.V.Balaji, Konda Ravi Kumar
    International Journal of Pharmaceutics and Drug Analysis 13 (3), 23 - 33 , 2025
    2025
  • Method development and validation for the estimation of Doxofylline in bulk and formulation by RP-HPLC
    LK G.Nagavalli, Konda Ravi Kumar, B.Saraswathi, P.Nagaraju
    Indo American Journal of Pharmaceutical Research 15 (4), 1-11 , 2025
    2025
  • Beyond the spectrum: Exploring unconventional applications of fourier transform infrared (FTIR) spectroscopy
    SPNK Mangam Vinny Therissa, Narla Divya, Konda Ravi Kumar
    Asian Journal of Pharmaceutical Analysis 14 (2), 86 - 94 , 2024
    2024
    Citations: 30
  • Revealing the risks: stevens-johnson syndrome induced by diclofenac-from pain relief to dermatological crisis
    TH Konda Ravi Kumar,Gorre Venkata Nagaraju
    International Journal of Zoology, Environment and Life Sciences 1 (1), 4 - 6 , 2024
    2024
  • Assessing the positive and negative syndrome scale and analyzing the prescribing patterns among patients with shizophrenia at the department of Psychiatry constitutes a …
    KRK Gorre Venkata Nagaraju, Dinesh Kumar Upadhyay
    Asian Journal of Pharmaceutics 17 (04), 818-826 , 2023
    2023
  • Efficient determination of Abemaciclib concentrations in human plasma via LC-MS/MS: A Rapid and Reliable Approach
    BM Sharmila Alladi, Konda Ravi Kumar
    Journal of Chemical Health Risks 13 (6), 2746-2754 , 2023
    2023
  • Drug delivery throgu nails
    CHS Kameswara Rao.S, Konda Ravi Kumar, B.V.U.Gayathri, J.S.Veena, S.Jahnavi
    Strad Research 10 (10), 146-153 , 2023
    2023
  • In-vitro evaluation of anti-mitotic activity of different extracts of abutilon indicum Linn. seed
    CAL K Naga Kumari,Konda Ravi Kumar,Sk.Shakeela,B.Harika,J.Madhavi Latha,T ...
    Indo American Journal of Pharmaceutical Sciences 10 (5), 323-327 , 2023
    2023
  • Synergistic effect of caffeine in B16f10 cells in combination with Doxorubicin and Oxaliplatin
    KRK Anil Kumar Yerragopu, V.Chitra
    Toxicology International 30 (2), 225-232 , 2023
    2023
    Citations: 2
  • In-vitro evaluation of extract of Fabiana Imbricata
    S K.Naga Kumari, Konda Ravi Kumar
    International Journal of Scientific Development and Research 8 (4), 789-794 , 2023
    2023

MOST CITED SCHOLAR PUBLICATIONS

  • Bioanalytical method development and validation of memantine in human plasma by high performance liquid chromatography with tandem mass spectrometry: application to …
    RK Konda, BR Challa, BR Chandu, KB Chandrasekhar
    Journal of analytical methods in chemistry 2012 (1), 101249 , 2012
    2012
    Citations: 39
  • Beyond the spectrum: Exploring unconventional applications of fourier transform infrared (FTIR) spectroscopy
    SPNK Mangam Vinny Therissa, Narla Divya, Konda Ravi Kumar
    Asian Journal of Pharmaceutical Analysis 14 (2), 86 - 94 , 2024
    2024
    Citations: 30
  • Green synthesis of Benzimidazole derivatives: An overview of bulk drug synthesis
    KRK K.Naga Prashant*
    International Journal of PharmTech Research 8 (9), 60-68 , 2015
    2015
    Citations: 29
  • Synthesis, characterization and biological evaluation of benzothiazole derivatives as potential antimicrobial and analgesic agents
    KR Kumar, KNS Karthik, PR Begum, C Rao
    Asian J. Res. Pharm. Sci 7 (2), 115-119 , 2017
    2017
    Citations: 27
  • Design and invitro evaluation of gastro retentive oral matrix tablet formulations of Ketorolac Tromethamine
    BB Thimmaraju Manish Kumar, ...
    International Journal of Health Sciences (IJHS) 6 (S2), 1945 - 1952 , 2022
    2022
    Citations: 21
  • RP-HPLC method development and validation for estimation of Voglibose in bulk and tablet dosage forms
    NM Rao, KR Kumar, J Bagyalakshmi, TK Ravi, R Mogili
    Int. J. Res. Pharm. Sci 1 (2), 190-194 , 2010
    2010
    Citations: 18
  • Assessment on Elements Involving the Academic Performance among Pharmacy Students: A Cross-Sectional Observational Study
    KR Kumar, GV Nagaraju, SN Subrahmanyam, K Nagarani, S Shareef, ...
    Int J Cur Res Rev| Vol 13 (23), 141 , 2021
    2021
    Citations: 16
  • Development and validation of RP-HPLC method for the estimation of ascorbic acid in health drinks
    PPKNMR Konda Ravi Kumar *1
    JOCPR 3 (3), 363-374 , 2011
    2011
    Citations: 16
  • Bio-analytical method development and validation of Rasagiline by high performance liquid chromatography tandem mass spectrometry detection and its application to …
    RK Konda, BR Chandu, BR Challa, CB Kothapalli
    Journal of pharmaceutical analysis 2 (5), 342-349 , 2012
    2012
    Citations: 14
  • Method development and validation of almotriptan in human plasma by HPLC tandem mass spectrometry: application to pharmacokinetic study
    K Ravikumar, BR Chandu, BR Challa, KB Chandrasekhar
    Scientia Pharmaceutica 80 (2), 367 , 2012
    2012
    Citations: 13
  • Synthesis and Antimicrobial Activity of some new α N-phthilimido amino acids analogues
    R Srinivasan, KR Kumar, PP Kumar
    International Journal of ChemTech Research 2 (2), 895-898 , 2010
    2010
    Citations: 13
  • Estimation of Nevirapine anhydrous bulk formulation by using IR, Rp-HPLC, GC methods
    CMM Rao, R Konda, RN Rao, S Ramanjeneeyulu, PG Reddy
    Research Journal of Pharmacy and Technology 3 (4), 1088-1092 , 2010
    2010
    Citations: 13
  • Evaluation of Diuretic and Sedative Activity for Ethanolic Leaves Extract of Basella Alba L. Var Rubra
    DKRK J. Divya*, D.Brahma Srinivasa Rao, Y. Anil Kumar
    World journal of current medical and pharmaceutical research 2 (1), 74-84 , 2020
    2020
    Citations: 11
  • Evaluation of Analgesic, Anti-Inflammatory of stem bark ethanolic Extract of Michelia champaca Linn
    KNS Karthik, KR Kumar
    Asian J. Pharmaceut. Res 7, 94 , 2017
    2017
    Citations: 10
  • Synthesis, characterization and biological evaluation of 3, 4-dihydropyrimidin-2 (1H)-thione derivatives
    LV Harika, KR Kumar, AB Shaik
    Archives of Applied Science Research 6 (6), 121-127 , 2014
    2014
    Citations: 10
  • Validation of Spectrophotometric determination of Rabeprazole using Ferric Chloride (FeCl3)
    KRK D. Madhuri*1, K.B. Chandrasekhar1, M. Ramakotaiah1, G. Somasekhar2, K ...
    International Journal of Research in Pharmaceutical Sciences 1 (2), 209-211 , 2010
    2010
    Citations: 10
  • RP-HPLC method development and validation for estimation of capecitabine in capsules
    KR Kumar, C Rao, CHB Rao, KB Chandra
    Int. J. Chem. Tech. Res 2, 307-311 , 2010
    2010
    Citations: 10
  • Simultaneous estimation of ofloxacin and tinidazole in tablet dosage form by RP-HPLC
    MR Kotaiah, SH Rasheed, YN Rao, Y Venkateswarlu, KR Kumar
    Research journal of pharmaceutical, biological and chemical sciences 1 (4) , 2010
    2010
    Citations: 9
  • Micro Emulsions: An Overview and Pharmaceutical Applications.
    VVN Sk Azad, Sk Nagul Meeravali, P Chinna Babu,Konda Ravi Kumar
    World Journal of Current Medical and Pharmaceutical Research 2 (2), 201-205 , 2020
    2020
    Citations: 8
  • Carbon Tetrachloride, Alcohol and Ranitidine Induced Hepatotoxicity and Its Protection by Bark Extracts of Bassia Latifolia in Wister Rats
    MK Thimmaraju, P Mondal, K Venu, B Padmaja, GS Babu, ...
    Journal of Herbs, Spices & Medicinal Plants 21 (6), 1-16 , 2020
    2020
    Citations: 7