Supercritical CO2 Extracts of Onosma Decorticans Riedl: Phytochemical Profiling and Antioxidant, Antibacterial, and Anticancer Activities Metin Yıldırım, Gun Binzet, Rıza Binzet, Erdal Yabalak Chemistryselect, 2026 This study investigated the chemical composition, antioxidant activity, and in vitro cytotoxicity inducing potential of supercritical CO 2 extracts obtained at different pressures from the aerial parts of Onosma decorticans (Boraginaceae). The extract produced at 100 bar (O 100 ) was characterized by LC–MS/MS, identifying 19 phytochemicals, with fumaric acid, cyranoside, cosmosiin, and quinic acid detected as the predominant constituents. Antioxidant activity was evaluated using the DPPH radical scavenging assay, with ascorbic acid (AA) as positive controls. At 400 µg/mL, O 100 and O 150 scavenged 65% ± 3.1% and 43% ± 5.2% of DPPH radicals, respectively, indicating moderate antioxidant capacity. Dose–response analysis revealed statistically significant radical scavenging activity compared to the control at 50 µg/mL for O 100 and 150 µg/mL for O 150 ( p < 0.05).
Onosma rutila (Boraginaceae) Plant Extract: Chemical Composition, Biological Analysis, and Film Forming Potential With Polymers Riza Binzet, Gun Binzet, Ersan Turunc, Pınar Küce Cevik, Didem Demir, et al. Chemistry and Biodiversity, 2025 This study aimed to integrate the ethanolic extract obtained from the aerial parts of endemic Onosma rutila as a new bioactive ingredient into polymeric films and to produce biofunctional composite thin films for use in biomedical applications. Initially, the definition of the plant extract was carried out in terms of chemical composition and biological activities. The main component of the extract was revealed as 9,12‐octadecadienoic acid (15.90%). Antimicrobial activity was evaluated against a total of five microorganisms by the well diffusion method and microdilution technique. MIC99 results showed the lowest inhibition against Candida albicans, suggesting a stronger antifungal effect than antibacterial activity. Also, the 2,2‐diphenyl‐1‐picrylhydrazyl scavenging activity of O. rutila, ascorbic acid, and butylated hydroxytoluene at 500 µg/mL showed values of 87.63, 90.13, and 46.82%, respectively. In the next phase, the extract, which was revealed to be an effective biological agent, was incorporated into the polymer solutions prepared based on chitosan and polyvinyl alcohol at different ratios to produce a series of thin films. For application purposes, the thin films' chemical compositions, water retention capacities, and morphological properties were determined and their potential for use as wound dressing material was evaluated.
Onosma sanninensis (Boraginaceae), a new species from the Mount Sannine Central Lebanon RAMY MAALOUF, RIZA BINZET Phytotaxa, 2025 In this study, a new species of Onosma (Boraginaceae: Lithospermeae), subsect. Asterotricha, from Mount Sannine, Lebanon, is described and illustrated. This new species was conclusively identified through a comprehensive analysis of morphological features and geographical distributions compared across herbarium specimens from multiple collections. The new species is closely related to O. caerulescens and O. inexspectata, but it is different with 1–2 terminal cymes, smaller bracts, longer pedicels in fruit, larger calyx in flower and fruit, different corolla color, smaller anthers, and different pollen shape. Additionally, geographical distributions and map, an image of the holotype specimen, diagnostic characters, detailed photographs, habitat descriptions, and an identification key for the new species, O. caerulescens, and O. inexspectata are provided, along with a vernacular name and IUCN conservation status.
