Pilot study of screening method for pancreatic cancer using lipidomic profiling of plasma or serum Ondřej Peterka, Robert Jirásko, Zuzana Dolečková, Mária Dosoudilová, Josef Bártl, Jakub Idkowiak, Ondřej Slavíček, Karolína Pešková, Milan Vošmik, Beatrice Mohelníková-Duchoňová, Irena Kozubíková, Martin Loveček, Ondřej Urban, Jan Trna, Petr Karásek, Bohuslav Melichar, Michal Holčapek Communications Medicine, 2026 Pancreatic cancer is one of the most aggressive malignancies with a 5-year relative survival rate of only 13%. Its poor prognosis is largely attributed to the lack of reliable tools for early detection. Current diagnostic standards rely on imaging methods that are invasive, costly, and often inadequate to detect early-stage disease. A noninvasive blood-based test with high sensitivity and specificity could substantially improve patient outcomes. Lipid concentrations in plasma and serum samples were determined by ultrahigh-performance supercritical fluid chromatography–mass spectrometry, and multivariate statistical modeling was used to analyze lipid profiles and differentiate between groups. Here, we present results from a pilot study evaluating lipidomic profiling of prospectively collected plasma and serum samples from patients with pancreatic ductal adenocarcinoma (PDAC, n = 177), healthy controls (n = 218), and high-risk individuals for pancreatic cancer (n = 93). The lipidomic test distinguishes PDAC patients from healthy controls with an accuracy exceeding 95%, including robust detection of early-stage cases and even individuals with low CA 19-9 secretion. The sensitivity is approximately 30% higher than that of CA 19-9. In high-risk individuals, the method achieves a specificity of over 96% (95% CI, 89–99%), comparable to established imaging-based approaches. This pilot study demonstrates the promising potential of lipidomic profiling as a noninvasive, blood-based screening tool for pancreatic cancer. The method outperforms current biomarkers, maintains high diagnostic accuracy in early-stage disease, and performs reliably in high-risk populations. These findings support the initiation of a clinical trial aimed at validating the lipidomic test for the early detection of PDAC. Pancreatic cancer is often diagnosed too late because early symptoms are vague and difficult to recognize. Current blood markers do not reliably detect early-stage disease, and imaging methods can be uncomfortable or invasive. Earlier detection is critical to improve patient outcomes. This study shows that a simple blood test measuring lipid molecules, combined with the statistical analysis, can identify pancreatic cancer, including early stages, with high accuracy and may serve as a future screening tool for individuals at high risk. Peterka et al. develop a noninvasive blood-based lipidomic test that distinguishes pancreatic cancer patients from healthy controls. The test achieves >95% accuracy, detects early-stage disease, shows >96% specificity in high-risk individuals compared with imaging, and supports initiation of a multicenter clinical trial.
Resolving lipid isomers up to the double bond position level using reversed-phase chromatography, EAD fragmentation, and high-resolution mass spectrometry: Application to pancreatic cancer Marlene Pühringer, Leonida M. Lamp, Denisa Kolářová, Milan Vošmik, Lisa Panzenboeck, Gunda Köllensperger, Michal Holčapek, Jürgen Hartler, Evelyn Rampler Analytica Chimica Acta, 2026 Electron-activated dissociation (EAD) is a radical-based fragmentation technique that provides detailed structural information on lipids in a single spectrum, including double-bond positions, sn -1/ sn -2 assignment, and molecular species. Its broader application, however, remains limited by the low intensity of diagnostic fragments. An alternative computational approach, called LC=CL, which is an extension of the software Lipid Data Analyzer (LDA), leverages retention time (RT) information obtained by reversed-phase liquid chromatography (RPLC) to identify ω-positions in intact lipid species. Here, we present an integrated RPLC-EAD-TOF-MS/MS workflow that combines LC=CL’s RT-based with EAD’s fragmentation-based annotation for deep structural characterization using a ZenoTOF 7600. This strategy was validated using both unlabeled and uniformly 13 C-labeled yeast extracts. By combining the benefits of retention-time identification and radical-induced fragmentation, our method enables the reliable identification of double-bond locations and sn -positional isomers across 15 lipid classes. In the analysis of plasma samples from pancreatic ductal adenocarcinoma (PDAC) patients and healthy controls, we demonstrate the power of our strategy for unambiguously resolving lipid isomers, revealing structure-specific patterns of dysregulated lipids. A total of 353 lipids were identified across 15 classes composed of glycerolipids, glycerophospholipids, and sphingolipids. Our findings not only confirmed known biomarkers, but also revealed additional chain isomers (e.g., SM 18:1;O2/20:0 and SM 16:1;O2/22:0), where only one of them was differentially regulated. Moreover, we discovered novel double-bond location-specific regulations, such as differential regulation of PC 16:0/18:3(n-6) in PDAC patients, whereas the isomer PC 16:0/18:3(n-3) did not exhibit any significant changes. Such an observation would have remained concealed using conventional methods. Accordingly, the presented RPLC-EAD-TOF-MS/MS platform facilitates detailed structural lipidomics in biologically and clinically relevant samples. • Comprehensive structural lipidomics workflow combining reversed-phase chromatography, electron-activated dissociation, and high-resolution time-of-flight mass spectrometry (ZenoTOF 7600) • Automated annotation of EAD spectra using the open-source software Lipid Data Analyzer (version 2.11.2) that enabled identification of double bond locations and sn -positional isomers in plasma, covering phospholipids, ceramides, diacylglycerols, and triacylglycerols • Extension of LC=CL retention time library for RPLC-MS/MS analysis of double bond positional isomers in lipids accessible for CID and EAD-based MS profiling • Characterization of 353 lipids across 14 classes in pancreatic ductal adenocarcinoma and healthy controls using complementary retention-time separation and radical-based fragmentation for improved isomer resolution • Confirmation of known regulated pancreatic cancer lipids, and discovery of additional isomer-specific regulations showing the power of the presented RPLC-EAD-TOF-MS/MS assay • Small structural changes on the double bond level matter, as exemplified by the significant down-regulation of PC 16:0/18:3(n-6) in pancreatic ductal adenocarcinoma samples, whereas no such event could be observed for the respective n-3 isomer
Transvaginal tru-cut biopsy versus ascitic fluid cytology in gynaecologic tumours: A comparative diagnostic study Munachiso Iheme Ndukwe, Petra Bretova, Ivan Praznovec, Denisa Pohanková, Dominik Karasek, Martin Stepan, Dominik Habes, Jan Laco, Eva Hovorkova, Akaninyene Eseme Ubom, Milan Vosmik, Igor Sirak Plos One, 2026 Objective To compare the diagnostic performance- including adequacy, accuracy, safety, sensitivity, specificity, and predicitve values- of transvaginal tru-cut biopsy and ascitic fluid cytology in women with gynaecologic tumours. Methods A retrospective review was conducted of women with gynaecologic tumours who underwent ultrasound-guided transvaginal tru-cut biopsy and ascitic fluid cytology at the Department of Obstetrics and Gynaecology, University Hospital Hradec Kralove, between January 2018 and December 2021. Results A total of 104 women with gynaecologic tumours underwent transvaginal tru-cut biopsy, of whom 47 also had ascitic fluid cytology. The diagnostic accuracy [93.3% (95% CI: 84.1%−97.4%) vs. 83.9% (95% CI: 67.4%−92.9%)], sensitivity [93.3% (95% CI: 82.1%−97.7%) vs. 79.2% (95% CI: 59.5%−90.8%)], and negative predictive value [82.4% (95% CI: 59.0%−93.8%) vs. 58.3% (95% CI: 32.0%−80.7%)] were higher for transvaginal tru-cut biopsy compared to ascitic fluid cytology. Adequacy [93.3% (95% CI: 86.8%−96.7%) vs. 93.6% (95% CI: 82.8%−97.8%)], specificity [93.3% (95% CI: 70.2%−98.8%) vs. 100.0% (95% CI: 64.6%−100.0%)], and positive predictive value [97.7% (95% CI: 88.2%−99.6%) vs. 100.0% (95% CI: 83.2%−100.0%)] were similar for the two methods. Only one tru-cut biopsy was complicated by bleeding, giving an overall complication rate of 1% (95% CI: 0.2%−5.3%). There was no complication with ascitic fluid cytology. Concordance of tru-cut histopathological diagnoses with ascitic fluid cytological diagnoses was 78% (95% CI: 63.6%−87.5%). Conclusion Ultrasound-guided tru-cut biopsy provides more diagnostic information than ascitic fluid cytology and is the preferred method when feasible. However, ascitic fluid cytology remains a safe and practical option when biopsy is unavailable.
Urodynamic and Quality-of-Life Outcomes After Endometrial Cancer Treatment: A Prospective Cohort Study Jiri Spacek, Dominik Habes, Munachiso Iheme Ndukwe, Ondrej Dvorak, Pavel Navratil, Petra Bretova, Denisa Pohankova, Igor Sirak, Milan Vosmik, Jaroslav Pacovsky, Akaninynene Eseme Ubom, Martin Stepan International Urogynecology Journal, 2026 Introduction and Hypothesis Endometrial cancer therapy may affect lower urinary tract function and quality of life (QoL). We prospectively evaluated short-term urodynamic and QoL outcomes after surgical treatment with or without adjuvant radiotherapy. Methods Women with biopsy-confirmed endometrial cancer underwent standardized urodynamic testing before surgery and 6 months after treatment completion. Parameters included detrusor pressure, bladder capacity, compliance, and post-void residual (PVR) urine volume. QoL was assessed using EORTC QLQ-C30 and QLQ-EN24 questionnaires. Pre- and post-treatment data were compared using nonparametric tests (α = 0.05). Surgery was performed either robotically or via the open abdominal approach. Results Of the 101 participants, 55 received adjuvant radiotherapy and 46 were treated with surgery alone. No clinically significant urodynamic deterioration was observed post-surgery. Median PVR urine volume decreased from 50 to 40 mL ( p = 0.002) and detrusor pressure from 30 to 28 cmH 2 O ( p = 0.08) following surgery; other parameters remained stable. No acute radiation cystitis occurred. QoL scores were high at baseline and follow-up, with no domain showing a ≥ 10-point change. Sexual and urinary symptom scores remained unchanged. Conclusions Within 6 months after endometrial cancer treatment, urodynamic parameters and QoL remained stable. These results suggest short-term functional safety of contemporary surgical and radiotherapy protocols, warranting longer-term follow-up.
High Treg and PMN-MDSC densities are a hallmark of tertiary lymphoid structures in fatal cases of cervical cancer Linn A Syding, Klára Plačková, Lucie Pavelková, Cecilia Aquino-Perez, Saskia J Santegoets, Jan Laco, Marek Grega, Pavel Dundr, Kristýna Němejcová, Miroslav Hodek, Jan Bouček, Michal Zábrodský, Hana Vošmiková, Michael J Halaška, Lukáš Rob, Petr Čelakovský, Viktor Chrobok, Munachiso Ndukwe Iheme, Ivan Práznovec, Milan Vošmik, Stanislav Katina, David Cibula, Aleš Ryška, Sjoerd H van der Burg, Radek Špíšek, Anna Fialová Journal for Immunotherapy of Cancer, 2025 Background High densities of tertiary lymphoid structures (TLSs) are associated with improved clinical outcomes in various malignancies, including human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC). However, the role of TLSs in shaping antitumor immunity in HPV-induced cervical cancer (CESC) remains unclear. Therefore, we analyzed the density, composition, and prognostic impact of TLSs in patients with CESC as well as patients with HNSCC. Methods Multiplex immunofluorescence, immunohistochemistry, and spatial transcriptomics were used to analyze TLS density and composition in HNSCC and CESC tissue sections with respect to patient prognosis. The spatial approach was supplemented by flow cytometry-based analysis of the polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC) phenotype in freshly resected primary tumor tissues. Results Although both indications were associated with HPV infection, we confirmed a positive correlation between TLS density and improved overall survival only in patients with HNSCC. The TLS composition differed markedly between HNSCC and CESC samples, with a shift toward high regulatory T cell (Treg) and PMN-MDSC abundance in CESC samples. The highest Treg and PMN-MDSC levels were observed in patients with CESC who died of the disease. CESC-infiltrating PMN-MDSCs showed high arginase 1 expression, which correlated with diminished T-cell receptor (TCR)ζ chain expression in CESC-infiltrating T cells. Additionally, the high number of PMN-MDSCs in TLSs was associated with the absence of HPV-specific T cells in CESC. Conclusions Unlike in HNSCC, the composition of TLSs, rather than their quantity, was associated with the overall survival of patients with CESC. High numbers of Tregs and PMN-MDSCs infiltrating immature TLSs prevail in patients with CESC who succumbed to the disease and seem to affect tumor-specific immune responses.
Safety, Adequacy, and Accuracy of Transvaginal Ultrasound-Guided Tru-Cut Biopsy of Gynaecologic Tumours: A Retrospective Single-Centre Study Munachiso Iheme Ndukwe, Dominik Karasek, Denisa Pohanková, Ivan Praznovec, Petra Bretova, Martin Stepan, Dominik Habes, Jan Laco, Akaninyene Eseme Ubom, Milan Vosmik, Igor Sirak Diagnostics, 2025 Objective: To evaluate the safety, adequacy, and accuracy of tru-cut biopsy of gynaecologic tumours in a population of Czech women. Methods: A four-year retrospective study of ultrasound-guided tru-cut biopsy of gynaecologic tumours was conducted in the Department of Obstetrics and Gynaecology, Charles University, Hradec Kralove, Czech Republic. Results: One hundred and four women with gynaecologic tumours underwent transvaginal tru-cut biopsy within the study period. The most common indication for tru-cut biopsy in more than one-half of the women was a suspicion of malignancy/inability to exclude malignancy (59, 56.7%). Most of the tumours were malignant on histopathological examination (71, 68.3%), with advanced ovarian cancer being the most common type of malignancy (43/71, 60.6%). The overall adequacy and accuracy rates of tru-cut biopsy were 93.3% and 93.3%, respectively. Most of the inadequate samples were obtained from overweight and obese women (5/7, 71.4%), with only one biopsy sample taken in the majority of the inadequate biopsies (5/7, 71.4%). Accuracy was higher for malignant than benign tumours (97.7% vs. 82.4%). For malignant tumours, accuracy was highest for advanced ovarian cancers (33/40, 82.5%). Only one case was complicated by bleeding, giving an overall complication rate of 1%. The complicated biopsy was taken by a gynae-oncology trainee. Conclusions: Tru-cut biopsy is a cost-effective and safe preoperative diagnostic modality for patients with gynaecologic tumours, offering high adequacy and accuracy. It is particularly useful in patients with advanced ovarian cancer, most of whom present late with inoperable tumours that contraindicate primary surgery.
Quality evaluation of synthetic CT using a gamma analysis for prostate cancer MR-only radiotherapy Viktor Babka, Lubos Rehounek, Iva Jakubcová, Igor Sirak, Petr Paluska, Linda Kašaová, Milan Vosmik, Jakub Grepl Reports of Practical Oncology and Radiotherapy, 2025 Background: This study evaluates the quality of synthetic computed tomography (sCT) images for MR-only radiotherapy in prostate cancer using gamma analysis. A software tool, MRGamma, was developed to address challenges like the absence of electron density maps and registration uncertainties between magnetic resonance imaging (MRI) and planning CT (pCT). Materials and methods: Aplication developed in MATLAB assesses Hounsfield units (HU) discrepancies between CT and sCT images via 2D and 3D gamma analysis (GA). GA computes a gamma index (γ) for each voxel based on HU differences and distance to agreement (DTA). The study analyzed prostate cancer patients using the MRCAT algorithm to generate sCT images. Preprocessing included registration, resampling, and cropping to standardize image dimensions. GA was performed with thresholds of 100 HU and 70 HU for HU differences and 3 mm for DTA to evaluate image quality. Results: Aplication demonstrated high agreement between sCT and CT images. For 3D GA (100 HU, 3 mm), 95.5 ± 1.8% of voxels passed the threshold, with slightly lower rates for 70 HU. Discrepancies were most pronounced at tissue interfaces and air cavities, where HU variations were more significant. Mean γ values for 3D GA were 0.19 ± 0.04 (milder parameters) and 0.23 ± 0.05 (stricter parameters), showing consistent trends in 2D GA. Maximum γ values confirmed good overall agreement. Conclusions: Aplication effectively evaluates sCT quality, supporting the feasibility of MR-only radiotherapy. By providing detailed HU comparisons, the tool enhances MR-based treatment planning, reducing costs and ionizing radiation exposure. Its implementation may improve workflow efficiency and patient safety in clinical practice.
Long-term aspirin use influences the probability of distant metastases and operability in patients with pancreatic ductal adenocarcinoma: a single-center retrospective study Aml Mustafa Banni, Milan Vosmik, Stanislav John, Filip Čečka, Libor Hruška, Miroslav Hodek, Ondřej Sobotka, Igor Sirak Reports of Practical Oncology and Radiotherapy, 2025 Background: Aspirin, a non-steroidal anti-inflammatory drug and platelet inhibitor, has been shown to reduce cancer incidence, lower metastatic rates and improve survival in certain cancer types. However, data on the effect of aspirin on prognosis in pancreatic ductal adenocarcinoma (PDAC) are limited. Therefore, we conducted a retrospective, single-center study to evaluate the impact of aspirin use on disease characteristics and survival in PDAC patients. Materials and methods: The study analyzed data from all consecutively treated PDAC patients over a 6-year period. Operability, Tumor-Node-Metastasis (TNM) stage, and survival endpoints were compared between patients who had used aspirin for 2 or more years prior to their diagnosis (ASA ≥ 2) and those who did not (ASA 0). Results: A total of 182 patients were included. In the ASA ≥ 2 group, significantly fewer patients had metastatic disease at diagnosis, and a significantly larger proportion presented in the operable stages, compared to the ASA 0 group. No significant differences were observed between the two groups in the T or N stages, overall survival, disease-free survival, or time to progression-free survival. Conclusions: Although long-term aspirin use did not influence survival endpoints, it was associated with a significantly lower probability of demonstrable distant metastases at diagnosis and a higher rate of resectable disease. This finding warrants further research to explore new therapeutic approaches for the treatment of PDAC.
Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomised, double-blind, phase 3 trial Jean-Pascal Machiels, Yungan Tao, Lisa Licitra, Barbara Burtness, Makoto Tahara, Danny Rischin, Gustavo Alves, Iane Pinto Figueiredo Lima, Brett G M Hughes, Yoann Pointreau, Sercan Aksoy, Simon Laban, Richard Greil, Martin Burian, Marcin Hetnał, Jean-Pierre Delord, Ricard Mesía, Miren Taberna, John N Waldron, Christian Simon, Vincent Grégoire, Kevin J Harrington, Ramona F Swaby, Yayan Zhang, Burak Gumuscu, Behzad Bidadi, Lillian L Siu, Danny Rischin, Brett GM Hughes, Bo Gao, Margaret McGrath, Richard Greil, Dietmar Thurnher, Thorsten Fuereder, Martin Burian, Sylvie Rottey, Jean-Pascal Machiels, Paul M Clement, Stéphanie Henry, Stéphanie Deheneffe, Gustavo Vasconcelos Alves, Iane Pinto Figueiredo Lima, Josiane Mourão Dias, Pedro Rafael Martins De Marchi, Milena Perez Mak, Andrea Juliana Pereira de Santana Gomes, Dalvaro Oliveira de Castro Junior, Tatiane Cardoso Motta, Monica Luciana Agostinho Padoan, Ana Paula Victorina, Sergio Jobim de Azevedo, Lillian L Siu, Stephanie Brule, John Hilton, Chang Shu Wang, Nathaniel Bouganim, Marc Webster, John Walker, Neil Chua, Angela Regina Zambrano, Alicia Quiroga Echeverri, Oscar Mauricio Niño Gomez, Carlos Alberto Ortiz, Luis Rojas, Andrés Cardona Zorilla, Olga Marcela Urrego Meléndez, Petra Beran Holečková, Bohuslav Melichar, Jakub Cvek, Jana Prausová, Milan Vošmik, Jean-Pierre Delord, Xavier Zasadny, Lionnel Geoffrois, Yungan Tao, Yoann Pointreau, Rainer Fietkau, Marlen Haderlein, Andreas H Mueller, Ursula Schroeder, Barbara Wollenberg, Simon Laban, Philipp Ivanyi, Viktor Gruenwald, Philippe Schafhausen, Orit Gutfeld, Iris Gluck, Aron Popovtzer, Amichay Meirovitz, Salem Billan, Baruch Brenner, Aron Popovtzer, Dror Limon, Lisa Licitra, Francesco Perri, Francesco Caponigro, Martina Violati, Daris Ferrari, Franco Nole, Federica Bertolini, Lorenzo Livi, Maria Grazia Ghi, Ilaria Imarisio, Makoto Tahara, Akihiro Homma, Tsutomu Ueda, Yukinori Asada, Tomoko Yamazaki, Koji Matsumoto, Takashi Fujii, Sadakatsu Ikeda, Shunji Takahashi, Takashi Kinoshita, Keita Sasaki, Akihito Tsuji, Myung-Ju Ahn, Byoung Chul Cho, Keun-Wook Lee, Ki Hyeong Lee, Moon Ki Choi, Hwan Jung Yun, Mathijs P Hendriks, Sjoukje F Oosting, Jan Buter, Esther Van Meerten, Jonathan Graham, Andrzej Kawecki, Izabella Debicka, Adam Maciejczyk, Maciej Pysz, Dorota Filarska, Marcin Hetnał, Piotr Koralewski, Andrzej Wygoda, Krzysztof Składowski, Małgorzata Talerczyk, Alfonso Berrocal Jaime, Pedro Pérez Segura, Irene Braña García, Neus Basté Rotllan, Ricard Mesía Nin, Miren Taberna Sanz, Lara Iglesias Docampo, Ainara Soria Rivas, Antonio Rueda Domínguez, José Manuel Trigo Pérez, Ruey-Long Hong, Shau-Hsuan Li, Hung-Ming Wang, Chia-Jui Yen, Muh-Hwa Yang, Yi-Fang Chang, Yi-Chun Liu, Jin-Ching Lin, Meltem Ekenel, Hakan Harputluoğlu, Sercan Aksoy, Özgür Özyilkan, Ahmet Bılıcı, Mehmet Alı Nahıt Şendur, Cagatay Arslan, Kevin Harrington, Shanmugasundaram Ramkumar, Dorothy Gujral, Simon Stewart, Melanie Powell, Amen Sibtain, Tom Roques, Kent Yip, Arafat Mirza, Muthiah Sivaramalingam, Neil D Belman, Sanjiv Agarwala, Ian Anderson, Arpan Patel, Ronald Maggiore, Megan Baumgart, Barbara Burtness, Mary Jo Fidler, Varinder Kaur, Elizabeth Gaughan, Francis Worden, Cristina P Rodriguez, Ammar Sukari, Deborah Wong, Sue Yom, William V Walsh, Joseph A Fiorillo, Jeffrey T Yorio, Grzegorz S Obara Lancet Oncology, 2024
Non-Genomic Hallmarks of Aging—The Review Drahomira Holmannova, Pavel Borsky, Helena Parova, Tereza Stverakova, Milan Vosmik, Libor Hruska, Zdenek Fiala, Lenka Borska International Journal of Molecular Sciences, 2023
Breast reconstruction and radiotherapy Igor Sirák, Aleš Fibír, Igor Slaninka, Adam Paulík, Iveta Kolářová, Petr Motyčka, Jakub Grepl, Petr Paluska, Milan Vošmik Onkologie Czech Republic, 2023
Konsensuální doporučení České kooperativní skupiny pro nádory hlavy a krku (2019): definice resekčních okrajů, reportování krčních disekcí a vyšetřování HPV/p16 Ceskoslovenska Patologie, 2021
O nádorech hlavy a krku v době covidu Onkologie Czech Republic, 2021
Total laryngectomy or larynx-preservation strategy? Current treatment approaches Onkologie Czech Republic, 2021
Consensus recommendations from the Czech Head and Neck Cancer Cooperative Group (2019): definition of surgical margins status, neck dissection reporting, and HPV/p16 status assessment Onkologie Czech Republic, 2021
Impact of Hormone Receptor Status on the Behaviour of HER2+ Breast Cancer IVETA KOLAROVA, LADISLAV DUSEK, ALES RYSKA, KAREK ODRAZKA, MARTIN DOLEZEL, JAROSLAV VANASEK, BOHUSLAV MELICHAR, JIRI PETERA, TOMAS BUCHLER, MILAN VOSMIK, KATARINA PETRAKOVA, PETRA TERAROVA, ZDENA VILASOVA, JIRI JARKOVSKY In Vivo, 2020
Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study Barbara Burtness, Kevin J Harrington, Richard Greil, Denis Soulières, Makoto Tahara, Gilberto de Castro, Amanda Psyrri, Neus Basté, Prakash Neupane, Åse Bratland, Thorsten Fuereder, Brett G M Hughes, Ricard Mesía, Nuttapong Ngamphaiboon, Tamara Rordorf, Wan Zamaniah Wan Ishak, Ruey-Long Hong, René González Mendoza, Ananya Roy, Yayan Zhang, Burak Gumuscu, Jonathan D Cheng, Fan Jin, Danny Rischin, Guillermo Lerzo, Marcelo Tatangelo, Mirta Varela, Juan Jose Zarba, Michael Boyer, Hui Gan, Bo Gao, Brett Hughes, Girish Mallesara, Danny Rischin, Anne Taylor, Martin Burian, Thorsten Fuereder, Richard Greil, Carlos Henrique Barrios, Dalvaro Oliveira de Castro Junior, Gilberto Castro, Fabio Andre Franke, Gustavo Girotto, Iane Pinto Figueiredo Lima, Ulisses Ribaldo Nicolau, Gustavo Dix Junqueira Pinto, Lucas Santos, Ana-Paula Victorino, Neil Chua, Felix Couture, Richard Gregg, Aaron Hansen, John Hilton, Joy McCarthy, Denis Soulieres, Rodrigo Ascui, Pablo Gonzalez, Luis Villanueva, Marco Torregroza, Angela Zambrano, Petra Holeckova, Zdenek Kral, Bohuslav Melichar, Jana Prausova, Milan Vosmik, Maria Andersen, Niels Gyldenkerne, Hannes Jurgens, Kadri Putnik, Petri Reinikainen, Viktor Gruenwald, Simon Laban, Gerasimos Aravantinos, Ioannis Boukovinas, Vassilis Georgoulias, Amanda Psyrri, Dora Kwong, Yousuf Al-Farhat, Tibor Csoszi, Jozsef Erfan, Geza Horvai, Laszlo Landherr, Eva Remenar, Agnes Ruzsa, Judit Szota, Salem Billan, Iris Gluck, Orit Gutfeld, Aron Popovtzer, Marco Benasso, Simona Bui, Vittorio Ferrari, Lisa Licitra, Franco Nole, Takashi Fujii, Yasushi Fujimoto, Nobuhiro Hanai, Hiroki Hara, Koji Matsumoto, Kenji Mitsugi, Nobuya Monden, Masahiro Nakayama, Kenji Okami, Nobuhiko Oridate, Kiyoto Shiga, Yasushi Shimizu, Masashi Sugasawa, Makoto Tahara, Masanobu Takahashi, Shunji Takahashi, Kaoru Tanaka, Tsutomu Ueda, Hironori Yamaguchi, Tomoko Yamazaki, Ryuji Yasumatsu, Tomoya Yokota, Tomokazu Yoshizaki, Iveta Kudaba, Zinaida Stara, Wan Zamaniah Wan Ishak, Soon Keat Cheah, Jose Aguilar Ponce, Rene Gonzalez Mendoza, Carlos Hernandez Hernandez, Francisco Medina Soto, Jan Buter, Ann Hoeben, S. Oosting, Karijn Suijkerbuijk, Aase Bratland, Marianne Brydoey, Renzo Alvarez, Luis Mas, Priscilla Caguioa, John Querol, Eugenio Emmanuel Regala, Maria Belen Tamayo, Ellie May Villegas, Andrzej Kawecki, Andrey Karpenko, Arkadiy Klochikhin, Alexey Smolin, Oleg Zarubenkov, Boon Cher Goh, Graham Cohen, Johanna du Toit, Christa Jordaan, Gregory Landers, Paul Ruff, Waldemar Szpak, Neonyana Tabane, Irene Brana, Lara Iglesias Docampo, Javier Lavernia, Ricard Mesia, Edvard Abel, Valentina Muratidu, Niels Nielsen, Valerie Cristina, Tamara Rordorf, Sacha Rothschild, Ruey-Long Hong, Hung-Ming Wang, Muh-Hwa Yang, Su-Peng Yeh, Chia-Jui Yen, Nuttapong Ngamphaiboon, Nopadol Soparattanapaisarn, Virote Sriuranpong, Sercan Aksoy, Irfan Cicin, Meltem Ekenel, Hakan Harputluoglu, Ozgur Ozyilkan, Kevin Harrington, Sanjiv Agarwala, Haythem Ali, Robert Alter, Daniel Anderson, Justine Bruce, Barbara Burtness, Nicholas Campbell, Miguel Conde, John Deeken, William Edenfield, Lawrence Feldman, Elizabeth Gaughan, Basem Goueli, Balazs Halmos, Upendra Hegde, Brian Hunis, Robert Jotte, Anand Karnad, Saad Khan, Noel Laudi, Douglas Laux, Danko Martincic, Steven McCune, Dean McGaughey, Krzysztof Misiukiewicz, Deborah Mulford, Eric Nadler, Prakash Neupane, Johannes Nunnink, James Ohr, Meaghan O'Malley, Brian Patson, Doru Paul, Elizabeta Popa, Steven Powell, Rebecca Redman, Vincent Rella, Chaio Rocha Lima, Abirami Sivapiragasam, Yungpo Su, Ammar Sukari, Stuart Wong, Emrullah Yilmaz, Jeffrey Yorio Lancet, 2019
HPV Status and Mutation Analysis Using Multiparallel Sequencing in Distal Oesophageal and Gastro-oesophageal Junction Adenocarcinomas Folia Biologica Czech Republic, 2018
Quality of life in patients with head and neck cancer in the course of three years of observation in a Nutritional Outpatient Department Objective Otorinolaryngologie A Foniatrie, 2016
Rectal cancer. More or less radiation? Rozhledy V Chirurgii Mesicnik Ceskoslovenske Chirurgicke Spolecnosti, 2015
Current status in the treatment of rectal cancer in the Czech Republic regarding the rate of complete pathological response after neoadjuvant therapy--PATOD C20 study 2011-2012 Rozhledy V Chirurgii Mesicnik Ceskoslovenske Chirurgicke Spolecnosti, 2015
Prevalence of perfusion defects detected by stress 99mtechnetium sestamibi myocardial perfusion single-photon emission computed tomography in asymptomatic patients with breast cancer Anticancer Research, 2014
Using a single-capillary bidirectional sequencing for genotyping the TGFβ1 gene Chemicke Listy, 2013
Radiotherapy in vulvar cancer treatment Ceska Gynekologie, 2013
The radicality of surgical resection in rectal cancer. Analysis of factors associated with incomplete mesorectal excision Rozhledy V Chirurgii Mesicnik Ceskoslovenske Chirurgicke Spolecnosti, 2013
Five-year results of IMRT for prostate cancer - Tumor control Karel Odrážka, Martin Doležel, Jaroslav Vaňásek, Miloslava Vaculíková, Milan Zouhar, Jana Šefrová, Petr Paluska, Milan Vošmik, Tereza Kohlová, Iveta Kolářová, Miloš Broďák, Pavel Navrátil, Petr Prošvic, Petr Hoffmann, Abdulbaset Hafuda Klinicka Onkologie, 2013
Modern technologies in head and neck cancer radiotherapy Onkologie, 2012
Magnetic resonance imaging in postprostatectomy radiotherapy planning Jana Sefrova, Karel Odrazka, Petr Paluska, Zdenek Belobradek, Milos Brodak, Martin Dolezel, Petr Prosvic, Zuzana Macingova, Milan Vosmik, Petr Hoffmann, Miroslav Louda, Anna Nejedla International Journal of Radiation Oncology Biology Physics, 2012
Clinical results of intensity-modulated radiation therapy (IMRT) for tumors of the head and neck region Neoplasma, 2005
Intensity-modulated radiotherapy in the treatment of thyroid cancer Acta Medica Hradec Kralove Supplementum Universitas Carolina Facultas Medica Hradec Kralove, 2004
