Ines Pineda-Torra

@cabimer.es/en

Integrative Pathophysiology and Therapies
Fundacion Progreso y Salud-CABIMER



                    

https://researchid.co/ipinedatorra

EDUCATION

PhD in Pharmaceutical Sciences Univ. of Lille/Pasteur Institute of Lille/France 2001
Research Year Erasmus University of Utrecht, The Netherlands 1996
BSc in Chemistry (5 year degree, esp. in Biochemistry) Universidad Complutense de Madrid 1995

RESEARCH, TEACHING, or OTHER INTERESTS

Biochemistry, Genetics and Molecular Biology, Endocrinology, Molecular Medicine, Cell Biology

12920

Scholar Citations

43

Scholar h-index

62

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • Dysregulated Lipid Metabolism Networks Modulate T-cell Function in People with Relapsing Remitting Multiple Sclerosis
    L Martin-Gutierrez, KE Waddington, A Maggio, L Coelewij, A Oppong, ...
    Clinical and Experimental Immunology, uxae032 2024

  • Blood metabolomic and transcriptomic signatures stratify patient subgroups in multiple sclerosis according to disease severity
    AE Oppong, L Coelewij, G Robertson, L Martin-Gutierrez, KE Waddington, ...
    iScience 2024

  • Systemic lupus erythematosus patients have unique changes in serum metabolic profiles across age associated with cardiometabolic risk
    EC Jury, J Peng, A Van Vijfeijken, L Martin Gutierrez, L Woodridge, ...
    Rheumatology, kead646 2023

  • Insulin resistance in macrophages impacts cholesterol biosynthesis and interferon gene expression and reduces foam cell formation capacity
    G Chabrier, I Pineda-Torra, S Hobson, N Yuldasheva, M Kearney, ...
    Endocrine Abstracts 94 2023

  • Differentially expressed genes in insulin resistant macrophages are shared across multiple diabetes associated morbidities
    K Goodhew, K Grammatopoulos, A Jackson, A Makahamadze, ...
    Endocrine Abstracts 86 2022

  • Macrophage-specific SHIP2 knockdown mice display sex-dependent liver steatosis
    G Chabrier, I Pineda-Torra, N Yuldasheva, M Kearney, M Gage
    Endocrine Abstracts 86 2022

  • CD4 (+) T cell gene expression profile of relapsing-remitting multiple sclerosis patients reveals a dysregulated nuclear receptor signalling
    L Martin-Gutierrez, L Coelewij, KE Waddington, N Yang, M Adriani, ...
    MULTIPLE SCLEROSIS JOURNAL 28 (3_ SUPPL), 760-760 2022

  • Using serum metabolomic signatures to classify multiple sclerosis progression using machine learning models
    AE Oppong, L Coelewij, KE Waddington, L Martin-Gutierrez, R Farrell, ...
    MULTIPLE SCLEROSIS JOURNAL 28 (3_ SUPPL), 316-316 2022

  • Investigating sex differences in T regulatory cells from cisgender and transgender healthy individuals and patients with autoimmune inflammatory disease: a cross-sectional study
    GA Robinson, J Peng, H Peckham, G Butler, I Pineda-Torra, C Ciurtin, ...
    The Lancet Rheumatology 4 (10), e710-e724 2022

  • PO. 1.6 Investigating monocyte transcriptomics and targeted proteomics signatures in SLE with atherosclerosis uncovers heterogeneity in inflammatory profiles
    L Woodridge, EC Navarro, P Ashford, G Robinson, K Waddington, ...
    Lupus Science & Medicine 9 (Suppl 2) 2022

  • Sex differences in Tregs may contribute to autoimmune disease susceptibility
    GA Robinson, J Peng, H Peckham, G Butler, I Pineda-Torra, C Ciurtin, ...
    The Lancet Rheumatology 4 (10), e710-e724 2022

  • Monocyte Transcriptomic Analysis Uncovers Heterogeneous Gene Expression Profiles in Systemic Lupus Erythematous (SLE) with and Without Subclinical Atherosclerosis
    L Woodridge, EC Navarro, G Robinson, P Ashford, K Waddington, ...
    ARTHRITIS & RHEUMATOLOGY 74, 2221-2222 2022

  • POS0039 MONOCYTE TRANSCRIPTOMICS AND TARGETED PROTEOMICS DEFINE HETEROGENEOUS SUBGROUPS IN WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) AND SUBCLINICAL ATHEROSCLEROSIS
    L Woodridge, E Chocano, P Ashford, G Robinson, K Waddington, ...
    Annals of the Rheumatic Diseases 81 (Suppl 1), 234-235 2022

  • POS0460 METABOLOMICS ACROSS AGE IDENTIFIES UNIQUE CHANGES IN THE SERUM METABOLIC PROFILE IN PATIENTS WITH SLE
    G Robinson, A Van Vijfeijken, L Martin-Gutierrez, D Isenberg, IP Torra, ...
    Annals of the Rheumatic Diseases 81 (Suppl 1), 483-484 2022

  • Liver macrophages and inflammation in physiology and physiopathology of non‐alcoholic fatty liver disease
    R Thibaut, MC Gage, I Pineda‐Torra, G Chabrier, N Venteclef, F Alzaid
    The FEBS Journal 289 (11), 3024-3057 2022

  • Comorbidity in young patients with juvenile systemic lupus erythematosus: how can we improve management?
    C Ciurtin, GA Robinson, I Pineda-Torra, EC Jury
    Clinical Rheumatology, 1-4 2022

  • Challenges in implementing cardiovascular risk scores for assessment of young people with childhood-onset autoimmune rheumatic conditions
    C Ciurtin, GA Robinson, IC Pineda-Torra, EC Jury
    Frontiers in Medicine, 265 2022

  • Lipid metabolism in autoimmune rheumatic disease: implications for modern and conventional therapies
    G Robinson, I Pineda-Torra, C Ciurtin, EC Jury
    Journal of Clinical Investigation 132 (2), e148552 2022

  • Clinical management, pathogenesis and biomarkers of cardiovascular disease associated with systemic autoimmune disorders
    C Perez-Sanchez, I Pineda-Torra, C Lopez-Pedrera
    Frontiers in Immunology 13 2022

  • Sex Differences in Lipid Metabolism: Implications for Systemic Lupus Erythematosus and Cardiovascular Disease Risk
    GA Robinson, I Pineda-Torra, C Ciurtin, EC Jury
    Frontiers in Medicine, 1492 2022

MOST CITED SCHOLAR PUBLICATIONS

  • Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
    B Staels, W Koenig, A Habib, R Merval, M Lebret, IP Torra, P Delerive, ...
    Nature 393 (6687), 790-793 1998
    Citations: 1506

  • PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
    G Chinetti, S Lestavel, V Bocher, AT Remaley, B Neve, IP Torra, ...
    Nature medicine 7 (1), 53 2001
    Citations: 1483

  • Activation of proliferator-activated receptors α and γ induces apoptosis of human monocyte-derived macrophages
    G Chinetti, S Griglio, M Antonucci, IP Torra, P Delerive, Z Majd, ...
    Journal of Biological Chemistry 273 (40), 25573-25580 1998
    Citations: 1246

  • Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption
    YF Guan, C Hao, DR Cha, R Rao, W Lu, DE Kohan, MA Magnuson, ...
    Nature medicine 11 (8), 861-866 2005
    Citations: 717

  • Pleiotropic actions of peroxisome proliferator–activated receptors in lipid metabolism and atherosclerosis
    O Barbier, IP Torra, Y Duguay, C Blanquart, JC Fruchart, C Glineur, ...
    Arteriosclerosis, thrombosis, and vascular biology 22 (5), 717-726 2002
    Citations: 598

  • Estrogen-related receptor α directs peroxisome proliferator-activated receptor α signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle
    JM Huss, IP Torra, B Staels, V Giguere, DP Kelly
    Molecular and cellular biology 24 (20), 9079-9091 2004
    Citations: 594

  • Bile acids induce the expression of the human peroxisome proliferator-activated receptor α gene via activation of the farnesoid X receptor
    I Pineda Torra, T Claudel, C Duval, V Kosykh, JC Fruchart, B Staels
    Molecular endocrinology 17 (2), 259-272 2003
    Citations: 516

  • Bile acid-activated nuclear receptor FXR suppresses apolipoprotein AI transcription via a negative FXR response element
    T Claudel, E Sturm, H Duez, IP Torra, A Sirvent, V Kosykh, JC Fruchart, ...
    The Journal of clinical investigation 109 (7), 961-971 2002
    Citations: 408

  • Regulation of lipid and lipoprotein metabolism by PPAR activators
    P Gervois, IP Torra, JC Fruchart, B Staels
    Clinical Chemistry and Laboratory Medicine (CCLM) 38 (1), 3-11 2000
    Citations: 363

  • Peroxisome proliterator-activated receptor alpha in metabolic disease, inflammation, atherosclerosis and aging
    IP Torra, P Gervois, B Staels
    Current opinion in lipidology 10 (2), 151-160 1999
    Citations: 335

  • Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice
    IP Torra, G Chinetti, C Duval, JC Fruchart, B Staels
    Current opinion in lipidology 12 (3), 245-254 2001
    Citations: 278

  • Peroxisome proliferator–activated receptor α gene regulates left ventricular growth in response to exercise and hypertension
    Y Jamshidi, HE Montgomery, HW Hense, SG Myerson, IP Torra, B Staels, ...
    Circulation 105 (8), 950-955 2002
    Citations: 260

  • Variation in the PPARα gene is associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects
    DM Flavell, IP Torra, Y Jamshidi, D Evans, JR Diamond, RS Elkeles, ...
    Diabetologia 43, 673-680 2000
    Citations: 237

  • FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity
    O Barbier, IP Torra, A Sirvent, T Claudel, C Blanquart, D Duran-Sandoval, ...
    Gastroenterology 124 (7), 1926-1940 2003
    Citations: 230

  • PPARs: transcription factors controlling lipid and lipoprotein metabolism
    V Bocher, I PINEDA‐TORRA, JC FRUCHART, B Staels
    Annals of the New York Academy of Sciences 967 (1), 7-18 2002
    Citations: 217

  • Characterization of the human PPARα promoter: identification of a functional nuclear receptor response element
    I Pineda Torra, Y Jamshidi, DM Flavell, JC Fruchart, B Staels
    Molecular endocrinology 16 (5), 1013-1028 2002
    Citations: 217

  • Peroxisome proliferator-activated receptor α gene variants influence progression of coronary atherosclerosis and risk of coronary artery disease
    DM Flavell, Y Jamshidi, E Hawe, I Pineda Torra, MR Taskinen, MH Frick, ...
    Circulation 105 (12), 1440-1445 2002
    Citations: 216

  • Circadian and glucocorticoid regulation of Rev-erbα expression in liver
    IP Torra, V Tsibulsky, F Delaunay, R Saladin, V Laudet, JC Fruchart, ...
    Endocrinology 141 (10), 3799-3806 2000
    Citations: 215

  • LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression
    JE Feig, I Pineda-Torra, M Sanson, MN Bradley, Y Vengrenyuk, ...
    The Journal of clinical investigation 120 (12) 2010
    Citations: 202

  • A truncated human peroxisome proliferator-activated receptor α splice variant with dominant negative activity
    P Gervois, IP Torra, G Chinetti, T Grötzinger, G Dubois, JC Fruchart, ...
    Molecular Endocrinology 13 (9), 1535-1549 1999
    Citations: 193

Publications

• Robinson, G.A., Peng, J., Peckham, H., Butler, G., Pineda-Torra,I. #, Jury, E.C. #, Ciurtin, C. # (#senior authors). Investigating sex differences in T regulatory cells from cisgender and transgender healthy individuals and patients with autoimmune inflammatory disease: a cross-sectional study. Lancet Rheumatol (2022) Published online August 31,
• Robinson, G.A., Peng, J., Peckham, H., Radziszewska, A., Butler, G., Pineda-Torra,I. #, Jury, E.C. #, Ciurtin, C. # (#senior authors). (2021). Sex hormones drive changes in lipoprotein metabolism, iScience, 24, 11,103257, PMID: 34761181
• Waddington, K. E., Robinson, G. A., Rubio-Cuesta, B., . . Jury, E. C.#, Pineda-Torra, I. (#senior authors). (2021). LXR directly regulates glycosphingolipid synthesis and affects human CD4+ T cell function. PNAS, 118(21), PMID: 34006637
• Robinson, G. A., Waddington, K. E., Coelewij, L.,. . . Ciurtin, C. #, Pineda-Torra, I. #, Jury, E. C. (#senior authors) (2021). Increased apolipoprotein-B:A1 ratio predicts cardiometabolic risk in patients with juvenile onset SLE. EBioMedicine, 103243. PMID: 33640328
• Coelewij, L., Waddington, K. E., Robinson, G. A., . . . Jury, E. C. #, Pineda-Torra, I. # (#senior authors) (2021). Serum Metabolomic Signatures Can Predict Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus. Arterioscler Thromb Vasc Biol, ATVBAHA120315321. PMID: 33535791
• Voisin, M., Shrestha, E., Rollet, C.,. . . Goldberg, I.