Iryna Yermakovych
@snu.edu.ua
Animal Health and Ecology
Volodymyr Dahl East Ukrainian University
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Y. Vystavna, S.I. Schmidt, D. Diadin, P.M. Rossi, Y. Vergeles, M. Erostate, I. Yermakovych, V. Yakovlev, K. Knöller, and I. Vadillo
Elsevier BV
Nataliia Samoilenko, Iryna Yermakovych, Volodymyr Bairachnyi, and Antonina Baranova
Private Company Technology Center
Active development of the pharmaceutical market shows a tendency to increase of pharmaceutical glass waste. The negative impact of waste on the environment shows itself in contamination of its elements by pharmaceutical substances contained in the waste, as well as the effects of medical glass and pathogens of infectious diseases. It was established that increasing of the ecologically safe handling of pharmaceutical glass waste and improvement of the disposal of glass can be provided by the method of electrochemical destruction of pharmaceutical substances. The optimal regimes and conditions to carry out the anodic oxidation process and the kinetic parameters of complete destruction of pharmaceutical substances (diclofenac, beta-estradiol, furosemide, atenolol, cefuroxime) were experimentally determined. The effectiveness of electrochemical destruction of five priority pharmaceutical substances, as well as their mixtures in a solution with sodium chloride using ORTA anode, was experimentally proved. It was established that complete destruction of pharmaceutical substances occurs during the process of electrochemical oxidation. It was noted that the introduction of this method makes it possible to destroy harmful pharmaceutical substances and to disinfect the solutions of pharmaceutical preparations infected with Escherichia coli bacteria in a single process. An additional positive effect of the introduction of the method is the improvement of the quality of pharmaceutical waste as a secondary material resource and promotion of the improvement in the technological processes of pharmaceutical waste disposal
Наталья Николаевна Самойленко and Ирина Анатольевна Ермакович
Private Company Technology Center
Studies, conducted at leading laboratories in Europe and the United States, have revealed that of microconcentrations of pharmaceutical preparations and their derivatives have a significant negative impact on the quality of surface and drinking water, natural food chains of biota, reproductive disorders, developmental abnormalities. Purification from pharmaceutical preparations (PP) at the existing treatment plants, carried out mainly by the biological method, is low for some of the most stable molecules. The content of such hardly-biodegradable substances can be reduced by applying additional aftertreatment methods, including using advanced processes, among which the electrochemical destruction. In Ukraine, the infected sewage of medical establishments before being discharged into the sewer system pass disinfection by chlorination. Given this fact, the authors have investigated the effect of the electrochemical destruction in the presence of chloride ions on the infected wastewater, contaminated with hardly-biodegradable PP (Diclofenac, Ibuprofen, β-estradiol). Criterion for evaluating the wastewater decontamination was the state of the enzymatic machinery of bacteria, namely their dehydrogenase activity, which is analyzed during the control of treated wastewater at municipal treatment plants. It was found that the infected solutions, containing Diclofenac, Ibuprofen and β-estradiol, before the electrochemical destruction cause only inhibitory effect on E. coli, which is somewhat higher than in the case of the presence of one PP (Diclofenac) in it. After the electrochemical destruction in the presence of chloride ions, solutions, containing three components when in contact with a suspension of E. coli have a pronounced bactericidal effect on it. It lies in inhibiting the enzymatic activity of bacteria, fixed by the instrumental method and determined by the absence of pharmazan in the studied solution. The results show the possibility of using the destruction of hardly-degradable medical products, as well as water decontamination from pathogenic microflora in a single electrochemical treatment process of infected wastewater of medical establishments, pharmaceutical preparations, containing pharmaceutical preparations.