BRAHMAIAH BONTHAGARALA
@brahmaiah.b@svcp.edu.in
Assistant Professor, Department of Pharmaceutics, Shri Vishnu College of Pharmacy, Bhimavaram
Shri Vishnu College of Pharmacy
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmaceutical Science, Pharmaceutical Science
Scopus Publications
Scopus Publications
Brahmaiah Bonthagarala, Varun Dasari, Vijay Kotra, Suryakanta Swain, and Sarwar Beg
Elsevier BV
Brahmaiah Bonthagarala, Varun Dasari, and Vijay Kotra
Future Science Ltd
Aim: The present study revolved around determining the effect of increase in the solubility of these drugs at the absorption site using ritonavir as a drug model. Materials & methods: Ritonavir per-oral tablets were prepared using versatile and nonionic surfactants having high solubilization rate, which were further marked with high rate of dissolution. The high rate of dissolution formula applied to the solid state characterization by means of transition electron microscopy, differential scanning calorimetry, scanning electron microscopy, X-ray diffraction and infrared spectroscopy. Results & conclusion: The drug bioavailability was seen to increase expressively by administration of liquisolid tablets as compared with conventional tablets.
Brahmaiah Bonthagarala, Prasanth Pasumarthi, Katta Vamsi Kiran, Sathram Nataraja, and Sudarshan Donthiboina
Moksha Publishing House
O ral Disintegrating T ablets (ODT s ) may also be used to deliver drugs to the oral cavity, for local action or, in some cases, absorption across the oral mucosa, thereby avoiding first - pass hepatic metabolism and po tentially increasing the rate and extent of uptake, and reducing undesirable metabolites. The o bjectives of the research work wa s to formulate oral disintegrating tablets of Atenolol maleate by using different super disintegrates (Natural, Synthetic) in di fferent ratio by direct compression technique and tablets were evaluated for pre compression and post compression parameters such as angle of repose, bulk density, tapped density, compressibility index, drug content and in - vitro drug release study, hardnes s, friability, wett ing time and in vitro dispersion time. Among the all formulations , the promising formula (CCS3, IH2) have showed fast disintegration and displayed in vitro d ispersion time of 11 s and 10.5 s. The dissolution rates of the optimized formul ations (CCS3, IH2) were found to be good. Among the promising ODT formulation CCS3, IH2 the formula IH2 was found to be superior when compared to formulation CCS3 since formulation IH2 us ed natural disintegrant (i.e . 6 %w/w Isphagula husk) at a lower conce ntration than the formulation CCS3 (8 % w/w Cross Carmellose Sodium) hence it wa s found to be more cost effective. The FTIR studies also showed that there was no interaction between drug and polymer. Formulation CCS3, IH2 were subjected to stability studie s as per ICH guidelines at temperatures and humidity of 25 ± 5oC/60 ± 5 % RH; and 40 ± 5oC/75 ± 5 % RH. Tablets didn’t reveal any appreciable changes with respect t o hardness, disintegration time , drug content and dissolution profile.