Md Faiyazuddin
@alkarimuniversity.edu.in
Professor, School of Pharmacy
Al - Karim University
Dr. Md. Faiyazuddin is a University Professor (Pharmaceutics) and Formerly Dean, Research & Development of Al – Karim University, INDIA. His role is to oversee all research activities (PhD, PG) in the university and to promote high-quality research addressing social issues in coordination with various national and international stakeholders.
He earned an ‘Executive Degree in Strategic Leadership Management’ from the Jacobs-Abbey Global Institute for Leadership Studies, Woodbridge, USA and in recognition of his work, he was nominated as a Fellow member of the prestigious George Washington University USA (2019-2023), British Society of Nanomedicine UK (Lifetime), International Society of Aerosol in Medicine USA (2018-2021), Institute of Nanotechnology UK (2014-2023).
Prof. Faiyazuddin attracted a research grant and has made path-breaking contributions, particularly in Cancer and Respiratory Nanotechnology. Artificial Intelligence in Drug Delivery, Cancer Nanomedicine and Respiratory Nano
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmacology, Toxicology and Pharmaceutics, Pharmaceutical Science, Drug Discovery
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Mohammad Shabib Akhtar, Karthikeyan Chandrasekaran, Sharmila Saminathan, Siva Ranjani Rajalingam, Nehal Mohsin, Khalid Altigani Awad Alkarem Ahmed, Yasir Alhazmi, Ismail A. Walbi, Basel A. Abdel-Wahab, Amol D. Gholap,et al.
Springer Science and Business Media LLC
AbstractNanoengineered chitosan functionalized titanium dioxide biohybrids (CTiO2@NPs) were prepared with Amomum subulatum Roxb extract via one-pot green method and assessed by UV–Vis spectroscopy, XRD, SEM and EDAX analyses. As revealed by XRD pattern, the nanohybrids exhibits a rutile TiO2 crystallites around 45 nm in size. The emergence of the Ti–O–Ti bond is identified by observing a peak between 400 and 800 cm−1. A wide bandgap (4.8 eV) has been observed in CTiO2@NPs, due to the quantum confinement effects and the oxygen vacancies reveal the intriguing potential of developed nanohybrids for various applications. Surface flaws were identified by observing an emission band at 382, 437, 482, 517, and 556 nm. They also exhibit better antibacterial performances using well diffusion method against Staphylococcus aureus, Bacillus substilis, Klebsiella pneumonia, and Escherichia coli. CTiO2@NPs were discovered to have free radical scavenging activity on DPPH analysis and exhibit IC50 value as 95.80 μg/mL and standard (Vitamin C) IC50 is 87.62 μg/mL. CTiO2@NPs exhibited better anticancer properties against the osteosarcoma (MG-63) cell line. All these findings suggest that there is a forum for further useful therapeutic applications. Therefore, we claim that nano-engineered carbohydrated TiO2 phytohybrid is a promising solution for bacterial infections and bone cancer.
Amol D. Gholap, Sagar R. Pardeshi, Navnath T. Hatvate, Nilesh Dhorkule, Sadikali F. Sayyad, Md Faiyazuddin, and Mohammad Khalid
Elsevier BV
Amol D. Gholap, Juhi Gupta, Pallavi Kamandar, Deblina D. Bhowmik, Satish Rojekar, Md. Faiyazuddin, Navnath T. Hatvate, Sourav Mohanto, Mohammed Gulzar Ahmed, Vetriselvan Subramaniyan,et al.
American Chemical Society (ACS)
Nanotechnology has emerged as a transformative pathway in vaccine research and delivery. Nanovaccines, encompassing lipid and nonlipid formulations, exhibit considerable advantages over traditional vaccine techniques, including enhanced antigen stability, heightened immunogenicity, targeted distribution, and the potential for codelivery with adjuvants or immune modulators. This review provides a comprehensive overview of the latest advancements and applications of lipid and non-lipid-based nanovaccines in current vaccination strategies for immunization. The review commences by outlining the fundamental concepts underlying lipid and nonlipid nanovaccine design before delving into the diverse components and production processes employed in their development. Subsequently, a comparative analysis of various nanocarriers is presented, elucidating their distinct physicochemical characteristics and impact on the immune response, along with preclinical and clinical studies. The discussion also highlights how nanotechnology enables the possibility of personalized and combined vaccination techniques, facilitating the creation of tailored nanovaccines to meet the individual patient needs. The ethical aspects concerning the use of nanovaccines, as well as potential safety concerns and public perception, are also addressed. The study underscores the gaps and challenges that must be overcome before adopting nanovaccines in clinical practice. This comprehensive analysis offers vital new insights into lipid and nonlipid nanovaccine status. It emphasizes the significance of continuous research, collaboration among interdisciplinary experts, and regulatory measures to fully unlock the potential of nanotechnology in enhancing immunization and ensuring a healthier, more resilient society.
Sourav Mohanto, Md Faiyazuddin, Amol Dilip Gholap, Darshan JC, Adrija Bhunia, Kannan Subbaram, Mohammed Gulzar Ahmed, Sagnik Nag, Mohammad Shabib Akhtar, D. Katterine Bonilla-Aldana,et al.
Elsevier BV
Sumel Ashique, Md Faiyazuddin, Obaid Afzal, S. Gowri, Afzal Hussain, Neeraj Mishra, Ashish Garg, Shayan Maqsood, Mohammad Shabib Akhtar, and Abdulmalik S.A. Altamimi
Elsevier BV
S. Kannan, U. Zeba, A. Fatema, F. Razana, A. Huda, L. Punya, I. L. Eya, M. Shayan, M. S. Akhtar, M. Faiyazuddin and A. Miranda
on the Earth is not ruled out 4 . It is crucial to identify host specificity of zombie viruses. These viruses may have a broad range of host heterogeneity. Scientific data are not currently available on the pathogenicity and virulence of these viruses. Viruses of modern era, like zoonotic viruses, arboviruses, rodent borne viruses etc., have the capacity to transfer from one host to another resulting in outbreaks and epidemics. The possibility of similar epide-miological patterns cannot be excluded for zombie viruses. Zombie viruses might be having the potential to cause different types of infections, particularly fatal diseases. Since our medical personnel and researchers are not prepared for the diseases caused by zombie viruses, and out-break of this nature may land up in a catastrophe. This article brings the current update on zombie viruses.
Md. Faiyazuddin, A. Sophia, Sumel Ashique, Amol D. Gholap, S. Gowri, Sourav Mohanto, C. Karthikeyan, Sagnik Nag, Arif Hussain, Mohammad Shabib Akhtar,et al.
Frontiers Media SA
The outbreak of a fatal black fungus infection after the resurgence of the cadaverous COVID-19 has exhorted scientists worldwide to develop a nutshell by repurposing or designing new formulations to address the crisis. Patients expressing COVID-19 are more susceptible to Mucormycosis (MCR) and thus fall easy prey to decease accounting for this global threat. Their mortality rates range around 32-70% depending on the organs affected and grow even higher despite the treatment. The many contemporary recommendations strongly advise using liposomal amphotericin B and surgery as first-line therapy whenever practicable. MCR is a dangerous infection that requires an antifungal drug administration on appropriate prescription, typically one of the following: Amphotericin B, Posaconazole, or Isavuconazole since the fungi that cause MCR are resistant to other medications like fluconazole, voriconazole, and echinocandins. Amphotericin B and Posaconazole are administered through veins (intravenously), and isavuconazole by mouth (orally). From last several years so many compounds are developed against invasive fungal disease but only few of them are able to induce effective treatment against the micorals. Adjuvant medicines, more particularly, are difficult to assess without prospective randomized controlled investigations, which are challenging to conduct given the lower incidence and higher mortality from Mucormycosis. The present analysis provides insight into pathogenesis, epidemiology, clinical manifestations, underlying fungal virulence, and growth mechanisms. In addition, current therapy for MCR in Post Covid-19 individuals includes conventional and novel nano-based advanced management systems for procuring against deadly fungal infection. The study urges involving nanomedicine to prevent fungal growth at the commencement of infection, delay the progression, and mitigate fatality risk.
S. Sharmila, S. Gowri, C. Karthikeyan, and Md. Faiyazuddin
Elsevier
Shantani Kannan, Kannan Subbaram, and Md. Faiyazuddin
Elsevier
Jigna B. Prajapati, Himanshu Paliwal, Surovi Saikia, Bhupendra G. Prajapati, Dhvanil N. Prajapati, Anil K. Philip, and Md. Faiyazuddin
Elsevier
Anil K. Philip and Md. Faiyazuddin
Elsevier
V. Haritha, S. Gowri, B. Janarthanan, Md. Faiyazuddin, C. Karthikeyan, and S. Sharmila
Elsevier BV
Nazia Afroze, Sreepoorna Pramodh, Abdulmajeed G. Almutary, Tahir A. Rizvi, Naushad Rais, Ritu Raina, Md. Faiyazuddin, Abdullah M. Alnuqaydan, and Arif Hussain
MDPI AG
Kaempferol, a flavonoid, contains a plethora of therapeutic properties and has demonstrated its efficacy against cancer. This study aims to unravel the molecular targets that are being modulated by kaempferol on HeLa cells. Various assays were performed, namely: MTT assay, flow cytometry to analyze DNA content and quantitate apoptosis. Quantitative PCR and protein profiling were performed to evaluate the modulated manifestation of different genes involved in apoptosis, cell growth and inflammation. Kaempferol exhibited reduction in cell viability of HeLa cells (IC50 = 50 µM 48 h), whereas it did not show any significant effect on viability of the AC-16 cell line. Kaempferol-impacted apoptosis was definitive, as it induced DNA fragmentation, caused disruption of membrane potential, accumulation of cells in the G2-M phase and augmented early apoptosis. Consistently, kaempferol induced apoptosis in HeLa cells by modulating the expression of various genes at both transcript and protein levels. It upregulated the expression of pro-apoptotic genes, including APAF1, BAX, BAD, Caspases 3, and 9, etc., at the transcript level and Bad, Bax, p27, p53, p21, Caspases 3 and 8 etc. at the protein level, while it downregulated the expression of pro-survival gene BCL-2, BIRC8, MCL-1, XIAP, and NAIP at the transcript level and Bcl-2, XIAP, Livin, clap-2 at the protein level. Kaempferol attenuated oxidative stress by upregulating GSH activity and anti-inflammatory response by suppressing NF-kB pathways. Moreover, kaempferol averted rampant cell division and induced apoptosis by modulating AKT/MTOR and MAP kinase pathways. Hence, kaempferol can be considered as a natural therapeutic agent with a differential profile.
A. Sophia, Md. Faiyazuddin, Prawez Alam, Md. Talib Hussain, and Faiyaz Shakeel
Elsevier BV
Anil K. Philip, Betty Annie Samuel, Kamran Ashraf, and Md. Faiyazuddin
Springer Singapore
Prawez Alam, Faiyaz Shakeel, Mohammed H. Alqarni, Ahmed I. Foudah, Md. Faiyazuddin, and Sultan Alshehri
MDPI AG
The greenness evaluation of literature analytical methods for pterostilbene (PT) analysis was not performed. Accordingly, the rapid, sensitive, and green/sustainable reversed-phase high-performance thin-layer chromatography (RP-HPTLC) method was developed and compared to the normal-phase (NP)-HPTLC (NP-HPTLC) for the estimation of PT with a classical univariate calibration. The RP quantification of PT was performed using green solvent systems; however, the NP analysis of PT was performed using routine solvent systems. The PT was detected at 302 nm for both of the methods. The greenness scores for the current analytical assays were evaluated by the analytical GREEnness (AGREE) metric approach. The classical univariate calibration for RP and NP methods indicated the linearity range as 10–1600 and 30–400 ng band−1, respectively. The RP method was more reliable for PT analysis compared to the NP method. The PT contents in commercial capsule dosage form were found to be 100.84% using the RP method; however, the PT contents in commercial capsule dosage form were determined as 92.59% using the NP method. The AGREE scores for RP and NP methods were 0.78 and 0.46, respectively. The sustainable RP-HPTLC assay was able to detect PT in the presence of its degradation products, and hence it can be considered as a selective and stability-indicating method. Accordingly, the RP-HPTLC method with univariate calibration has been considered as a superior method over the NP-HPTLC method for PT analysis.
Mohamed Jawed Ahsan, Deepak Saini, Piush Sharma, Surender Singh Jadav, Mohammad Afroz Bakht, Salahuddin, Ramesh Alluri, and Md Faiyazuddin
Bentham Science Publishers Ltd.
Cancer is one of the leading causes of death. The aim of the present study was to synthesize and investigate the anticancer and antioxidant activities of some 3,5-bis(substituted benzylidene)- 1-ethylpiperidin-4-one analogues (4a-g). The 3,5-bis(substituted benzylidene)-1-ethylpiperidin-4-one analogues (4a-g) were prepared from the precursor, piperidin-4-one hydrochloride (1). The initial step involved the synthesis of intermediates, 3,5-bis(substituted benzylidene)piperidin-4-one analogues (3a-g) followed by their ethylation with C2H5I in acetone and K2CO3 to obtain the title compounds (4a-g). The Fourier transform infrared (FTIR), nuclear magnetic resonance (1H & 13C NMR), mass spectrometry and microanalysis were used to characterize the title compounds (4a-g). All the compounds were further evaluated for their anticancer activity by SRB assay and NCI US protocol, while the antioxidant activity was evaluated by DPPH free radical assay. All the title compounds (4a-g) were subjected to molecular docking studies against EGRF tyrosine kinase, a potential target for anticancer agents, to study the possible mode of interaction of our compounds with the molecular target. : The compound 4g showed significant anticancer activity with GI50 of 28.2 μM against MCF-7 (Breast cancer cell line). The antioxidant activity of compound 4g (IC50 = 14.98±0.91 μM) was found to be comparable to the standard drug ascorbic acid. The binding modes of compounds 4a-g against the molecular target EGFR tyrosine kinase were also studied. The structure-activity relationship (SAR) was also studied. : The compound 4g showed significant anticancer activity with GI50 of 28.2 μM against MCF-7 (Breast cancer cell line). The antioxidant activity of the compound, 4g was found to be comparable to the standard drug ascorbic acid, while its anticancer activity was found to be less than that of the standard drug adriamycin.
Nikhat Perween, Sultan Alshehri, T. S. Easwari, Vivek Verma, Md. Faiyazuddin, Abdullah Alanazi, and Faiyaz Shakeel
MDPI AG
Molecules with poor aqueous solubility are difficult to formulate using conventional approaches and are associated with many formulation delivery issues. To overcome these obstacles, nanosuspension technology can be one of the promising approaches. Hence, in this study, the feasibility of mefenamic acid (MA) oral nanosuspension was investigated for pediatric delivery by studying the role of excipients and optimizing the techniques. Nanosuspensions of MA were prepared by adopting an antisolvent precipitation method, followed by ultrasonication with varying concentrations of polymers, surfactants, and microfluidics. The prepared nanosuspensions were evaluated for particle size, morphology, and rheological measures. Hydroxypropyl methylcellulose (HPMC) with varying concentrations and different stabilizers including Tween® 80 and sodium dodecyl sulfate (SLS) were used to restrain the particle size growth of the developed nanosuspension. The optimized nanosuspension formula was stable for more than 3 weeks and showed a reduced particle size of 510 nm with a polydispersity index of 0.329. It was observed that the type and ratio of polymer stabilizers were responsive on the particle contour and dimension and stability. We have developed a biologically compatible oral nanoformulation for a first-in-class drug beautifully designed for pediatric delivery that will be progressed toward further in vivo enabling studies. Finally, the nanosuspension could be considered a promising carrier for pediatric delivery of MA through the oral route with enhanced biological impact.
Vandana S. Singh, Shashikant C. Dhawale, Faiyaz Shakeel, Md. Faiyazuddin, and Sultan Alshehri
MDPI AG
Calotropis procera (commonly known as Swallow wort) is described in the Ayurvedic literature for the treatment of inflammation and arthritic disorders. Therefore, in the present work, the antiarthritic activity of potential fractions of Swallow wort leaf was evaluated and compared with standards (indomethacin and ibuprofen). This study was designed in Wistar rats for the investigation of antiarthritic activity and acute toxicity of Swallow wort. Arthritis was induced in Wistar rats by injecting 0.1 mL of Freund’s complete adjuvant (FCA) on the 1st and 7th days subcutaneously into the subplantar region of the left hind paw. Evaluation of our experimental findings suggested that antiarthritic activity of methanol fraction of Swallow wort (MFCP) was greater than ethyl acetate fraction of Swallow wort (EAFCP), equal to standard ibuprofen, and slightly lower than standard indomethacin. MFCP significantly reduced paw edema on the 17th, 21st, 24th, and 28th days. It also showed significant effect (p < 0.01) on arthritic score, paw withdrawal latency, and body weight. The inhibition of serum lysosomal enzymes and proinflammatory cytokines along with improvement of radiographic features of hind legs was also recorded with MFCP. Finally, it was concluded that MFCP can be a feasible therapeutic candidate for the treatment of inflammatory arthritis.
Abdul Qadir, Faiyaz Shakeel, Athar Ali, and Md. Faiyazuddin
Springer Science and Business Media LLC
Abdul Qadir, M.D. Faiyazuddin, M.D. Talib Hussain, Thamir M. Alshammari, and Faiyaz Shakeel
Elsevier BV
Usama Ahmad, Md Faiyazuddin, Md Talib Hussain, Sarfaraz Ahmad, Thamir M Alshammari, and Faiyaz Shakeel
Springer Science and Business Media LLC