SAAHIL ARORA
@gdgu.org
Professor & Dean, School of Medical & allied Sciences
School of Medical & Allied Sciences, G D Goenka University
EDUCATION
B. Pharmacy (Mysore University)
M. Pharmacy (Pharmaceutics) (BITS, Pilani)
PhD (Punjab Technical University, Kapurthala Punjab
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmaceutical Science, General Pharmacology, Toxicology and Pharmaceutics, Oncology, Drug Discovery
FUTURE PROJECTS
Novel Targeted delivery for Breast Cancer
Applications Invited
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Keshav Jindal, Saahil Arora, and Manish Goswami
AIP Publishing
Rajwant Kaur, Saahil Arora, and Manish Goswami
AIP Publishing
Dilpreet Singh, Sahil Arora, and Vimal Arora
Mary Ann Liebert Inc
Effective drug delivery to target sites is critical for achieving desired therapeutic outcomes. However, the poor permeability of certain drugs poses significant challenges in achieving adequate drug concentrations at the desired locations. Biomimetic hydrogels have emerged as a promising approach to enhance the penetration of poorly permeable drugs. These hydrogels, designed to mimic natural biological systems, offer unique properties and functionalities that enable improved drug permeation. In this review, we provide a comprehensive appraisal of the role of biomimetic hydrogels in enhancing drug penetration. We discuss the design principles, properties, and mechanisms by which these hydrogels facilitate drug permeation. Specifically, we explore the applications and benefits of biomimetic hydrogels in controlled drug release, mimicking extracellular matrix microenvironments, promoting cell-mimetic interactions, and enabling targeted drug delivery. Through an examination of key studies and advancements, we highlight the potential of biomimetic hydrogels in enhancing drug penetration and their implications for therapeutic interventions. This review contributes to a deeper understanding of biomimetic hydrogels as a promising strategy for overcoming drug penetration challenges and advancing drug delivery systems, ultimately leading to improved therapeutic efficacy.
Akshay Dahiya, Rajiv Sharm, Saahil Arora, Kundan Singh Bora, and Ram babu Sharma
AIP Publishing
Keshav Jindal, Saahil Arora, and Manish Goswami
AIP Publishing
RAJWANT KAUR, SAAHIL ARORA, and MANISH GOSWAMI
Innovare Academic Sciences Pvt Ltd
Objective: The lack of drugs to effectively cross the stratum corneum (SC), has recently been a significant barrier to transdermal administration. In order to increase the effectiveness of transdermal distribution, this issue has been solved through the development of micron-scale needles. The objective is to develop, formulate and evaluate biocompatible polymeric solid microneedles with a TDDS-loaded Astaxanthin patch involving the poke and patch method. Methods: The solid microneedle arrays were fabricated using an SLA printer with high-resolution potential and was examined using scanning electron microscopy (25 microns at the z-axis and 140 microns at the x-axis, respectively). Fabricated Astaxanthin transdermal film was evaluated by many characterization parameters. The developed microneedle was examined for skin insertion and a drug permeation study was carried out across the porcine skin. Results: Solid MN arrays of 1.85 µm tip-to-tip distance, 600 µm height, 300 µm width, and 30 µm tip diameter, were created using biocompatible Class I Dental SG resin. Microneedle crossed stratum corneum layer and penetrated porcine skin with 381.356 mm in depth, with no structural change. Transdermal patches loaded with astaxanthin drug was developed and using various polymer concentration consistent, good, and transparent films were created of thickness between 0.85±0.07 mm to 0.87±0.01 mm range, with average weights ranging from 168.02±1.05 to 172.22±1.25 10/cm2), Folding Endurance with 10-12 folds was reported for formulated transdermal films; also tensile strength was 0.414±0.002 kg/mm2 and drug content was 94.41±0.42% of the best formulation reported. According to studies on drug permeation, Astaxanthin transdermal patches did not significantly permeate porcine skin without being pierced by microneedles the medication exhibited good penetration characteristics. Conclusion: Upon evaluation, formulated transdermal film was reported to be best for solid microneedle-TDDS of astaxanthin for improved patient compliance, bioavailability, and biomedical applications.
Sahil Arora and Charul Rathore
Future Science Ltd
Aim: In the recent advanced study, the popularity of herbal nano-formulation has gained around the whole world. As we know the reason behind it is that herbal products have comparatively lesser side effects than other synthetic products. Significance: These natural plant extracts have wide medicinal importance as they increase the overall bioavailability of products toward tissues. Key findings: This review provides the use of different herbal nano-formulations, their safety considerations, and the challenges being faced. It also highlights the various Clinical Trials and Patents that are published for skin disorders. Conclusion: The present review describes how the rise of herbal products has made wider interest in transdermal formulations and improve the overall productivity by preventing various skin disorders.
Neha Sharma and Saahil Arora
AIP Publishing
Yunes M. M. A. Alsayadi and Saahil Arora
AIP Publishing
Monika Sharma, Diksha Gulati, Anjoo Kamboj, and Saahil Arora
Oriental Scientific Publishing Company
A simultaneous study is very important analytical parameter which helps to assess compatibility of mixture of drugs. UV spectrophotometer is one of the simplest and efficient methods to assess simultaneous parameters. Due to its economical approach, we have used UV spectrophotometer. Curcumin and Gentamicin sulphate have zero crossing points of 420 nm and 244 nm, respectively, in first-order derivative spectroscopy. The solvent for the spectrophotometric process was 0.1 N NaOH. Curcumin and Gentamicin sulphate linearity was established over range of concentrations of 2–12 g/ml, with correlation coefficients of 0.995 and 0.993. The mean percent recoveries Curcumin and Gentamicin sulphate were found to be in the range of 98.88 percent and 98.54 percent, respectively. The approach has been found to be repeatable in both inter day and intraday testing. The approach was proven to be both precise and reliable. According to the recovery investigation, the approach was effectively applied to pharmaceutical formulation with no interference from excipients. The results of the analysis were statistically evaluated, as well as by recovery trials. The LOD and LOQ for Gentamicin sulphate in phosphate buffer were found to be 0.024µg/ml and 0.045µg/ml, respectively and values for Curcumin were 0.024µg/ml and 0.037 µg/ml, respectively which indicates adequate sensitivity of method
Yunes M. M. A. Alsayadi and Saahil Arora
SCI AND TECH UNIVERSAL INC
Total vaporization solid-phase microextraction (TV-SPME) is a type of extraction technique in which a specific solvent dissolves the analyte. Then a tiny amount of solvent is taken to the vial of SPME. Then, the solvent vaporizes in the SPME vial, and sampling is carried out on the headspace of the SPME fiber. As a result, the partitioning phase of the analyte between the headspace and liquid sample is omitted. The equilibrium phase remains the analyte partitioning between the headspace and SPME. TV-SPME was introduced in 2014 by Goodpaster to increase the recovery compared to the liquid injection method. This review discusses different aspects of TV-SPME, including its impact on sampling techniques, theoretical part, sampling procedure, and method optimization. Special attention was paid to its applications. A comprehensive literature study was conducted in the relevant databases to summarize the research work that has been done on this technique. In TV-SPME, the liquid samples completely vaporized and had a less matrix effect and better adsorption. This method needs no sample preparation, consumes less supply, and can be done automatically. Also, TV-SPME enables a cost-effective and efficient extraction for different matrixes. This review summarizes aspects related to TV-SPME.
Harneet Marwah, Shruti Khare, Pinki Rawat, Sima Singh, Prashant Kesharwani, Mohammad Sarwar Alam, Hinna Hamid, and Saahil Arora
Elsevier
Harneet Marwah, Sima Singh, Prashant Kesharwani, and Saahil Arora
Elsevier
Rajwant Kaur, Saahil Arora, and Manish Goswami
Elsevier BV
Rajwant Kaur, Saahil Arora, and Manish Goswami
Elsevier BV
Monika Sharma, Garima Malik, Diksha Gulati, Peeyush Kaushik, and Saahil Arora
Elsevier BV
Surya Nath Pandey, Naresh Kumar Rangra, Sima Singh, Saahil Arora, and Varun Gupta
American Chemical Society (ACS)
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease that causes dementia by impairing mental capacity growth and disrupting neurocognitive activity. Despite recent advancements in AD therapy, therapeutic effectiveness has been small, noncurative, and susceptible to drug resistance. The reality that AD's origin remains unknown and that the blood-brain barrier limits treatment effectiveness are two significant impediments to science. Plants are repositories for novel chemical entities, which provide an exciting avenue for Alzheimer's disease studies. Although several herbal remedies are unquestionably efficient, only a small number have been clinically tested for their active chemical constituents and biological activities. Using published data in the literature, we summarized commonly used medicinal plants and herbs and their phyto components for the care and diagnosis of Alzheimer's disease as an alternative therapy. In this, we summarize the main compounds found in 30 different herbal medicines that target neurodegenerative diseases. Using the experimental study of physicochemical properties, we put forward a hypothesis about potential medicinal plants and the management of Alzheimer's disease. The summary analysis demonstrates that conventional herbal medicines produce compounds with physicochemical properties with a high degree of similarities with existing approved medicines.
Sima Singh, Arshid Numan, Balaji Maddiboyina, Saahil Arora, Yassine Riadi, Shadab Md, Nabil A. Alhakamy, and Prashant Kesharwani
Elsevier BV
R.B. Sharma, V. Arora, S. Arora, A. Kapila, and R. Sharma
Elsevier BV
Monika Sharma, Neha Dhiman, Prabhjot Singh, Rajiv Sharma, R.B. Sharma, Vimal Arora, and Saahil Arora
Elsevier BV
Paramjot, Nikhat Mansoor Khan, Himani Kapahi, Sahil Kumar, T. R. Bhardwaj, Saahil Arora, and Neeraj Mishra
Informa UK Limited
Abstract Polymers have been utilized to deliver the drug to targeted site in controlled manner, achieving the high-therapeutic efficacy. Polymeric drug conjugates having variable ligands as attachments have been proved to be biodegradable, stimuli sensitive and targeted systems. Numerous polymeric drug conjugates having linkers degraded by acidity or intracellular enzymes or sensitive to over expressed groups of diseased organ/tissue have been synthesized during last decade to develop targeted delivery systems. Most of these organs have number of receptors attached with different cells such as Kupffer cells of liver have mannose-binding receptors while hepatocytes have asialoglycoprotein receptors on their surface which mainly bind with the galactose derivatives. Such ligands can be used for achieving high targeting and intracellular delivery of the drug. This review presents detailed aspects of receptors found in different cells of specific organ and ligands with binding efficiency to these specific receptors. This review highlights the need of further studies on organ-specific polymer–drug conjugates by providing detailed account of polymeric conjugates synthesized till date having organ-specific targeting.
Preeti Gupta, Tarun Garg, M. Tanmay, and Saahil Arora
Begell House
Permeability glycoprotein (P-gp), a multispecific drug transporter belonging to the multidrug resistance (MDR) gene subfamily, is mainly responsible for efflux of diffused intracellular drugs, resulting in poor drug bioavailability. P-gp is overexpressed in the blood-brain barrier, gastrointestinal tract (GIT), kidney, liver, pancreas, and cancerous cells, leading to multidrug resistance and failure of therapy. Because P-gp is transported into cells by way of receptor-mediated endocytosis (in contrast to diffusion for free drug), polymeric efflux pump modulators can have a major role in efficient drug delivery. Various polymer drug conjugates that have been proven to provide potential treatments in MDR cases are reviewed here, with an emphasis on the role of the P-gp efflux pump, bioavailability, and the mechanism of inhibition of the P-gp transporter by various polymers and delivery systems. This review also highlights the potential of specific polymer drug conjugates to act as P-gp efflux pump inhibitors to provide enhanced bioavailability and therapeutic efficacy.
Neha Dhawan, Krishan Kumar, A.N. Kalia, and Saahil Arora
Bentham Science Publishers Ltd.
Oral mucositis is one of the major side effects of cancer chemotherapy (30-76%) and radiotherapy (over 50%). Current palliative treatments of oral mucositis include specialized agents like pelifermin, platelet derived factors etc. or oral hygienic agents which suffered from various drawbacks like systemic side effect, least effect owing to fast wash out of buccal mucosa, patient unfriendly delivery systems, and mere symptomatic relief. In this research work, N-succinyl chitosan gel delivery system of microemulsified eugenol, honey and sodium hyaluronate was prepared to explore their multiple and synergistic effects on various pathological factors of oral mucositis. N-succinyl chitosan was synthesized in our laboratory and loaded with microemulsified eugenol (10% v/v), honey (10% v/v) and sodium hyaluronate (0.2% w/v) to prepare orogel with optimum pH, spreadability, mucoadhesion strength, and viscosity. In vitro eugenol release from N-succinyl chitosan gel after 8 hours in PBS (pH-6.4) was found to be 87.45±0.14%, which was better in comparison to that released from chitosan gel. Ex vivo penetration studies using rat buccal mucosal tissue also suggested better J-efflux of eugenol through N-succinyl chitosan in comparison to chitosan gel with enhancement ratio (ER) of 1.71. The antimicrobial effect of N-succinyl chitosan based orogel against S. aureus and C. albicans efficacy was found to be statistically high in comparison to chitosan based orogel as well as marketed formulation of chlorhexidine (p<0.05). The N-succinyl chitosan orogel in 5-fluoro uracil induced oral mucositis animal (Wistar rats) model showed enhanced survival ratio, weight gain and high tissue regeneration activity than chitosan gel formulation within 15 days. The formulation was successful in elevating the survival and reducing the inflammation in the oral mucosa of animals compared to disease control (p<0.05) and hence suggesting the potential of N-succinyl chitosan orogel in the treatment of oral mucositis.
Sumit Kumar, Deepak Bhargava, Arti Thakkar, and Saahil Arora
Begell House
Poor aqueous solubility impedes a drug's bioavailability and challenges its pharmaceutical development. Pharmaceutical development of drugs with poor water solubility requires the establishment of a suitable formulation layout among various techniques. Various approaches have been investigated extensively to improve the aqueous solubility and poor dissolution rate of BCS class II and IV drugs. In this literature review, novel formulation options, particularly for class II drugs designed for applications such as micronization, self-emulsification, cyclodextrin complexation, co-crystallisation, super critical fluid technology, solubilisation by change in pH, salt formation, co-solvents, melt granulation, and solid dispersion, liposomal/niosomal formulations, are discussed in detail to introduce biopharmaceutical challenges and recent approaches to facilitate more efficient drug formulation and development.
Saahil Arora, HarleenSingh Lamba, and Ravindra Tiwari
BRNSS Publication Hub