Dr. Md Sabir Alam
@sgtuniversity.ac.in
ASSOCIATE PROFESSOR and Pharmaceutics/ Pharmacy
SGT College of Pharmacy, SGT University, Gurgaon, Haryana
Dr. Md Sabir Alam’s main area of research is Pharmaceutical Nanotechnology and its Biomedical application with a specialization in Drug delivery for various targeted diseases, including Psoriasis, Neurological disorders, Cancer targeting, Antimicrobial, and Antimalarial Activity. Currently working as an Associate Professor at the Department of Pharmaceutics, SGT College of Pharmacy, SGT University Gurgaon, Haryana, India. He has ten years of teaching and research experience. He has authored more than 30 research and review articles in international peer-reviewed journals, 1 Book, 35 Book chapters, and 4 Patents. His area of interest includes Synthesis, Characterization Application of Various Nanocarriers for drug delivery/delivery for treating Neurological disease, Cancer, and Malarial disease.
EDUCATION
In my Ph.D. research work, I successfully developed another novel approach for designing of Polymer-based gold Nanoparticles and their impacts on Microbial disease and DNA Damage activity; being used for diagnosis purposes. Developed Gold Nano formulation for their unique geometrical morphology, significantly effective against multi-drug resistance microbial disease because of their unique mechanism of action which imparts antimicrobial effects and apoptosis in cancer cells. I preferred to explore a better understanding of different phenomena, prediction of end performance parameters, and minimize the usage of resources, by integrating different tools of In-silico drug designing for enhancement of end product performance. During the process I am collaborating with various organizations for research like AIIMS for SEM and TEM Characterization, JNU for Microbial activity, GGSIP University for Antimicrobial and DNA Damage Activity.
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmaceutical Science, Multidisciplinary, Materials Science, Neuroscience
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Ahmad Salawi, Jafrin Jobayer Sonju, Sami Nazzal, Ahmed Abu-Fayyad, Turki Al Hagbani, Mohammad M. Kamal, and Md Sabir Alam
African Journals Online (AJOL)
Purpose: To characterize the physicochemical and dissolution properties of Soluplus®/ibupofen solid dispersions prepared by solvent casting technique.
 Methods: Soluplus® was used as a film-forming agent whereas ibuprofen served as a poorly soluble biopharmaceutics classification system (BCS) class II active pharmaceutical ingredient (API). The solution casting of ethanolic Soluplus®/ibuprofen was carried out on a release liner and dried under a vacuum. The crystallinity of crushed films was examined using powder x-ray diffraction (PXRD), while a USP Type II apparatus was used to determine their dissolution behaviour.
 Results: Ibuprofen was uniformly distributed in an amorphous form into the cast films. The PXRD-based confirmation of crystalline peaks' absence revealed a significantly higher dissolution rate in alkaline and acid media when compared to the pure drug.
 Conclusion: Soluplus® (polymeric dispersant)-based solvent casting is a simple and efficient technique to prepare highly water-soluble solid dispersions of ibuprofen. This film cast technique may be suitable for various applications where a film or powder form of a drug with enhanced solubility in different aqueous media is desired.
Namita, Arti, Md Sabir Alam, Md Noushad Javed, Md Naushad Alam, and Jamilur R. Ansari
CRC Press
Manish Kumar, Navneet Mehan, Shailendra Bhatt, Md Sabir Alam, and Rupesh K. Gautam
CRC Press
Md Sabir Alam, Md Noushad Javed, and Jamilur R. Ansari
CRC Press
Md Sabir Alam, Mansi Garg, Vijay Bhalla, Puja Kumari, Renu Kadyan, Md Meraj Anjum, Tejpal Yadav, Madhu Yadav, Mukesh Kumar, Aafrin Waziri,et al.
CRC Press
Biswakanth Kar, Anindya Bose, Sudipta Roy, Pranabesh Chakraborty, Soumalya Chakraborty, Sanjoy Kumar Das, Gautam Pal, Farheen Waziri, and Md Sabir Alam
CRC Press
Laxmi Devi, Tarique Mahmood Ansari, Md Sabir Alam, Ashish Kumar, and Poonam Kushwaha
CRC Press
Emna Melliti, Alma Mejri, Md Sabir Alam, Jamilur R. Ansari, Hamza Elfil, and Abdelmoneim Mars
CRC Press
Renu Kadian, Jayamanti Pandit, Charu Bharti, Rabiya, Aafrin Waziri, Puja Kumari, Arun Garg, Md Noushad Javed, Jamilur R. Ansari, and Md Sabir Alam
CRC Press
Syed Muzammil Munawar, Khaleel Basha Sabjan, Aafrin Waziri, Meena Bhandari, Renu Kadian, and Md Sabir Alam
CRC Press
Charu Bharti, Garima Sahu, Smriti Gohri, Rabiya, Aafrin Waziri, and Md Sabir Alam
CRC Press
Meena Bhandari, Dilraj Preet Kaur, Seema Raj, Tejpal Yadav, Mohammed A. S. Abourehab, and Md Sabir Alam
Springer International Publishing
Shikha Choudhary, Raminderjit Kaur, Aafrin Waziri, Arun Garg, Renu Kadian, and Md Sabir Alam
Open Exploration Publishing
Neuropathic pain (NP) remains maltreated for a wide number of patients by the currently available treatments and little research has been done in finding new drugs for treating NP. Ziconotide (PrialtTM) had been developed as the new drug, which belongs to the class of ω-conotoxin MVIIA. It inhibits N-type calcium channels. Ziconotide is under the last phase of the clinical trial, a new non-narcotic drug for the management of NP. Synthetically it has shown the similarities with ω-conotoxin MVIIA, a constituent of poison found in fish hunting snails (Conus magus). Ziconotide acts by selectively blocking neural N-type voltage-sensitized Ca2+ channels (NVSCCs). Certain herbal drugs also have been studied but no clinical result is there and the study is only limited to preclinical data. This review emphasizes the N-type calcium channel inhibitors, and their mechanisms for blocking calcium channels with their remedial prospects for treating chronic NP.
Meena Bhandari, Seema Raj, Romila Manchanda, and Md. Sabir Alam
Bentham Science Publishers Ltd.
Abstract: Among conventional treatment methodologies, surgery, hyperthermia, radiation, and chemotherapy have become integral components of treatment for most cancers. Radiation therapy in the treatment of many malignancies is always the better choice over surgery and chemotherapy. Ionizing radiation produced as a consequence of using these radiations has always been a concern in these treatment methods. Synthetic radio-protectors with their inherent limitations are being used to date to reduce the mortality of these radiations; still, it compromises the clinical efficacy of these administrations. Hence, investigations for alternative methods, including natural resources such as plant and fruit extracts, are being explored to treat radiation-mediated ailments. The present review article endeavors to provide a comprehensive, updated, and chronological account of these promising plants and fruit extracts and their bioactive principles as radio-protectors. We present the merits and demerits of radiation therapy and cell stress generation of reactive oxygen species (ROS) associated with radiation need and availability of radio-protectors. Finally, we discuss green-based bioactive compounds that have radioprotective properties.
Md. Noushad Javed, Mohammed Aslam, Hala Hasan Deeb, Michel Kaisar Nicola, Mohd. Aamir Mirza, Md. Sabir Alam, Md. Habban Akhtar, and Aafrin Waziri
Bentham Science Publishers Ltd.
: Significant efforts have been made in research to discover newer neurotherapeutics, however, the rate of reported neurological disorders has been increasing at an alarming speed. Neurotherapeutics delivery in the brain is still posing a significant challenge, owing to the blood-brain barrier and blood-cerebrospinal fluid barrier. These physiological barriers restrict the passage of systemically available fractions of neurotherapeutics into the brain, owing to low permeability and drug localization factors. Neurotherapeutics encapsulating lipid carriers favor a significant increase in bioavailability of poorly water-soluble drugs by enhancing solubility in the gastrointestinal tract and favoring stability. Due to their small size and lipid-based composition, these carriers offer enhanced permeability across the semi-permeable blood-brain barrier to effectively transport encapsulated loads, such as synthetic drugs, nutraceuticals, phytoconstituents, herbal extracts, and peptides, thereby reducing incidences of off-target mediated adverse impacts and toxicity. The most significant advantage of such lipid-based delivery systems is non–invasive nature and targeting of neurotherapeutics to the central nervous system. Critical attributes of lipid-based carriers modulate release rates in rate-controlled manners, enable higher penetration through the blood-brain barrier, and bypass the hepatic first-pass metabolism leading to higher CNS bioavailability neurotherapeutics. The current review discusses a brief and introductory account of the limitations of neurotherapeutics, pharmacological barriers, challenges in brain-targeted delivery, and the potential of nanotechnology- processed lipid-based carriers in the clinical management of neuronal disorders.
Abdallah Mohammad Ibrahim, Lalita Chauhan, Aditi Bhardwaj, Anjali Sharma, Faizana Fayaz, Bhumika Kumar, Mohamed Alhashmi, Noora AlHajri, Md Sabir Alam, and Faheem Hyder Pottoo
MDPI AG
Globally, neurodegenerative diseases cause a significant degree of disability and distress. Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role in the development and maintenance of various nerve roles and is associated with the family of neurotrophins, including neuronal growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5). BDNF has affinity with tropomyosin receptor kinase B (TrKB), which is found in the brain in large amounts and is expressed in several cells. Several studies have shown that decrease in BDNF causes an imbalance in neuronal functioning and survival. Moreover, BDNF has several important roles, such as improving synaptic plasticity and contributing to long-lasting memory formation. BDNF has been linked to the pathology of the most common neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. This review aims to describe recent efforts to understand the connection between the level of BDNF and neurodegenerative diseases. Several studies have shown that a high level of BDNF is associated with a lower risk for developing a neurodegenerative disease.
Aafrin Waziri, Charu Bharti, Mohammed Aslam, Parween Jamil, Mohd. Aamir Mirza, Md Noushad Javed, Uzma Pottoo, Amirhossein Ahmadi, and Md Sabir Alam
Bentham Science Publishers Ltd.
Background:Chemo- and radiation therapy-based clinical management of different types of cancers is associated with toxicity and several side effects. Therefore, there is always an unmet need to explore agents that reduce such risk factors. Among these, natural products have attracted much attention because of their potent antioxidant and antitumor effects. In the past, some breakthrough outcomes established that various bacteria in the human intestinal gut are bearing growth-promoting attributes and suppressing the conversion of pro-carcinogens into carcinogens. Hence probiotics integrated approaches are nowadays being explored as rationalized therapeutics in the clinical management of cancer.Methods:Here, published literature was explored to review chemoprotective roles of probiotics against toxic and side effects of chemotherapeutics.Results:Apart from excellent anti-cancer abilities, probiotics alleviate toxicity & side effects of chemotherapeutics, with a high degree of safety and efficiency.Conclusion:Preclinical and clinical evidence suggests that due to the chemoprotective roles of probiotics against side effects and toxicity of chemotherapeutics, their integration in chemotherapy would be a judicious approach.
Sangeet Kumar Mall, Tejpal Yadav, Aafrin Waziri, and Md Sabir Alam
Open Exploration Publishing
Fernandoa adenophylla (FA, Heterophragma adenophyllum) is a plant, cultivated throughout Africa and Southeast Asia. It contains potent phytochemicals such as novel naphthoquinones, their derivatives (peshwaraquinone, dilapachone, adenophyllone, indadone, and lapachol), and triterpenoids [ursolic acid (UA), β-sitosterol (BS), α-amyrin, and oleanolic acid (OA)] that have been assessed and reported to show potential pharmacological activities. The crude extract obtained from the plant has been investigated for certain pharmacological activities such as antibacterial, antifungal, anti-tubercular (TB), antihypertensive, and leishmanicidal activity. A novel drug delivery systems (NDDS) is the latest technique that combines innovative development, formulations, new technology, and methodologies for the safe delivery of pharmaceutical substances in the body. The present study reports the possible treatment opportunities of FA and recent possible novel drug delivery approaches for the natural medicinal phytochemicals.
Ritesh Kumar, Gulshan Dhamija, Jamilur R. Ansari, Md. Noushad Javed, and Md. Sabir Alam
CRC Press
Jayamanti Pandit, Md. Sabir Alam, Jamilur R. Ansari, Monisha Singhal, Nidhi Gupta, Aafrin Waziri, Kajal Sharma, and Fahim Hyder Potto
CRC Press
Md. Sabir Alam, Md. Farhan Naseh, Jamilur R. Ansari, Aafrin Waziri, Md. Noushad Javed, Amirhossein Ahmadi, Muhammad Khalid Saifullah, and Arun Garg
CRC Press
Anita Kamra Verma, Namrata Kumari, Nagarjuna Daram, and Md. Sabir Alam
Bentham Science Publishers Ltd.
Abstract: Neurodegenerative diseases are a heterogeneous group of disorders among aging populations worldwide characterized by the progressive degeneration of the structure and function of brain cells and the nervous system. Alzheimer's disease and Parkinson's disease are common neurodegenerative diseases (NDs). Classic pathological features of AD are the accumulation of the amyloid betaprotein and aggregates of hyperphosphorylated tau protein around the brain cells. Dopaminergic neuronal death in the midbrain and accumulation of β- synuclein in the neurons are the hallmark of Parkinson’s disease. The pathogenesis is multifactorial, and both neurodegenerative disorders have complex etiology. Oxidative stress closely linked with mitochondrial dysfunction, excitotoxicity, nitric oxide toxicity, and neuro-inflammation, is anticipated to trigger neuronal death. Ample evidence has implicated that oxidative stress and inflammation contribute to the pathology of neurodegeneration in AD and PD. Currently, acetylcholinesterase inhibitors are the main treatment option for AD, while LDOPA is the gold standard therapy for PD. Along with the main therapy, many endogenous antioxidants, like vitamin E, selenium, etc., are also given to the patients to combat oxidative stress. Current treatment for these NDs is limited due to the blood–brain barrier (BBB) that hinders drug targeting towards neurons. In this review, we emphasize adjunct treatment with anti-inflammatory agents that act at the site of the disease and can halt the disease progression by attenuating the effect of ROS triggering neuro-inflammatory response. Polyphenols, either as purified compounds or extracts from various natural plant sources, have been well studied and documented for anti-inflammatory effects, but their use for ND is limited due to their physicochemical attributes. Nanoparticle-mediated drug delivery system exhibits immense potential to overcome these hurdles in drug delivery to the CNS, enabling nanoparticle-based therapies to directly target the inflammation and release bioactive compounds with anti-inflammatory properties to the site of action.
Sugandha Singhal, Meenal Gupta, Md. Sabir Alam, Md. Noushad Javed, and Jamilur R. Ansari
CRC Press
Md Noushad Javed, Md Habban Akhter, Mohamad Taleuzzaman, Md Faiyazudin, and Md Sabir Alam
Elsevier
Md Noushad Javed, Faheem Hyder Pottoo, Athar Shamim, Md Saquib Hasnain, and Md Sabir Alam
Springer Singapore
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