AI and Machine Learning Enabled Early Detection of Alzheimer's Disease Using Neuroimaging Data Sabbu Rahul, Vijay Gajananrao Thakare, Rakhmonov Bakhrombek Bakhtiyor o'g'li, Anup Patil, Mayur Porwal, et al. International Journal of Drug Delivery Technology, 2026 Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia worldwide, affecting an estimated 55 million individuals globally. Early and accurate detection is critical for timely therapeutic intervention and to decelerate disease progression. Conventional diagnostic methods, including clinical assessments and standard radiological evaluations, often fail to detect subtle neurological changes in the pre-clinical and prodromal stages. The advent of artificial intelligence (AI) and machine learning (ML) paradigms, particularly deep learning architectures, has opened unprecedented avenues for the automated analysis of neuroimaging data, enabling early-stage detection with high precision. This research investigates the application of diverse AI and ML algorithms — encompassing convolutional neural networks (CNNs), recurrent neural networks (RNNs), transformer-based architectures, generative adversarial networks (GANs), and ensemble methods — to structural magnetic resonance imaging (sMRI), functional MRI (fMRI), diffusion tensor imaging (DTI), and positron emission tomography (PET) data for the early detection of AD. Eight optimised model formulations (F1–F8) were developed and evaluated using multimodal neuroimaging datasets from the Alzheimer's Disease Neuroimaging Initiative (ADNI), Open Access Series of Imaging Studies (OASIS-3), and the Australian Imaging, Biomarker and Lifestyle (AIBL) study. Model performance was assessed using accuracy, sensitivity, specificity, area under the receiver operating characteristic curve (AUC-ROC), and F1-score. Among all formulations, F8 (GAN + U-Net hybrid trained on combined DTI and fMRI data) achieved the highest diagnostic accuracy of 97.1%, with AUC-ROC of 0.98 and F1-score of 0.97. The transformer-based Vision Transformer (ViT) model (F7) demonstrated accuracy of 96.8% and AUC of 0.97. Statistically significant differences were observed between deep learning models and conventional classifiers (p < 0.001). These findings validate the superior capability of deep learning-based neuroimaging analysis for early AD detection, paving the way for its clinical translation and integration into diagnostic pipelines. This study underscores the transformative potential of AI-driven neuroimaging biomarkers and provides a comprehensive framework for future research in computational neurology.
RECENT SCHOLAR PUBLICATIONS
Psychobiotics as adjuncts in depression management: Mechanistic insights and clinical perspectives S Rahul, R Rahul, V Gudupalli Asian journal of psychiatry 117, 104840 , 2026 2026
Study on Clinical Profile and Antimicrobial Prescribing Patterns in Patients with Cellulitis: A Retrospective Study D Rahul Sabbu, Arghya Ghorai, Ketana S Gada, Rashmi Adri, Binu K M, Arun K N Inventi Rapid:Pharmacy Practice 2025 (2), 1-5 , 2025 2025
Case Report on Moxifloxacin Induced Swelling of Eyelid and Redness of Eye. DH Sabbu Rahul, Suman Kumar S, Anupama R Taklikar Inventi Rapid: Pharmacy Practice 2024 (3), 1-2 , 2024 2024
A Study on Prescription Pattern of Drugs in Orthopedics Inpatient Department in a Tertiary Care Teaching Hospital S Rahul International Journal For Multidisciplinary Research (IJFMR) 6 (3), 1-6 , 2024 2024
A Study on Prescription Pattern of Drugs in Orthopedics Inpatient Department in a Tertiary Care Teaching Hospital S Rahul International Journal For Multidisciplinary Research (IJFMR) 6 (3), 1-6 , 2024 2024
A Study of Drug Use Evaluation of Anti-Anemic Drugs in Pregnancy Patients at a Tertiary Care Teaching Hospital S Rahul INTERNATIONAL JOURNAL FOR MULTIDISCIPLINARY RESEARCH 6 (3), 7-12 , 2024 2024
Drug Utilisation Evaluation in the Surgery Outpatient Department of a Tertiary Care Teaching Hospital S Rahul International Journal of Pharmacy and Pharmaceutical Research (Human) 30 (5 … , 2024 2024
Drug Utilization Pattern in Neonatal Intensive Care Unit in a Tertiary Care Teaching Hospital – A Retrospective Study S Rahul International Journal of Pharmacy and Pharmaceutical Research (Human) 30 (6 … , 2024 2024
Drug Utilization Pattern in Neonatal Intensive Care Unit in a Tertiary Care Teaching Hospital – A Retrospective Study S Rahul International Journal of Pharmacy and Pharmaceutical Research (Human) 30 (6 … , 2024 2024
Disease Pattern and Drug Utilization Evaluation of Abnormal Uterine Bleeding in a Tertiary Care Teaching Hospital S Rahul International Journal of Pharmacy and Pharmaceutical Research (Human) 30 (6 … , 2024 2024
Study of Drug Utilization Trends in Lower Respiratory Tract Infections in a Tertiary Care Teaching Hospital S Rahul Inventi Rapid: Pharmacy Practice 2024 (2), 1-5 , 2024 2024
Clinico-Demographic Characteristics and Management of COPD at a Tertiary Care Teaching Hospital in Raichur S Rahul Inventi Rapid: Pharmacy Practice 2024 (3), 1–3 , 2024 2024
Assessment of awareness, perception, and opinions towards artificial intelligence among health care professionals and medical students at tertiary care teaching hospital: a … S Rahul, MD Nawaz, SM Mudgal, H Doddayya Int J Multidiscip Res 6 (1), 1-9 , 2024 2024 Citations: 5
Knowledge, Attitude and Perceptions Towards Vitamin D Among General Public S Rahul International Journal For Multidisciplinary Research (IJFMR) 5 (3), 1-9 , 2023 2023
Study of Drug Use Pattern of Anti Tb Drugs in a Tertiary Care Teaching Hospital of Karnataka, India-Aretrospective Study S Rahu, K Sarmashvali, SM Mudgal, H Doddayya International Journal of Community Pharmacy, 51-55 , 2023 2023
Assessment of Prescribing Pattern of Anti-diabetic Drugs in a Tertiary Care Teaching Hospital S Rahul, A Abdullsalam, H Doddayya International Journal for Multidisciplinary Research 5 (6), 1-5 , 2023 2023
Study of Antihypertensive Drug Therapy in Pregnancy Induced Hypertension S Rahul Inventi Impact: Pharmacy Practice 1 (2), 20-24 , 2022 2022
Study on Prescribing Pattern of Cardiovascular Drugs in Raichur, North Karnataka S Rahul Inventi Rapid: Pharmacy Practice 2022 (2), 1-4 , 2022 2022
Study on Drug Utilization and Pharmacoeconomics Analysis of COVID-19 in a Tertiary Care Teaching Hospital S Rahul Inventi Rapid: Pharmacy Practice 2022 (2), 10-14 , 2022 2022
Study on the Prescription Pattern of Antifungal Medications Used in Dermatology OPD at a Tertiary Care Teaching Hospital S Rahul Inventi Rapid: Pharmacy Practice 2022 (2), 15-19 , 2022 2022
MOST CITED SCHOLAR PUBLICATIONS
Assessment of drug prescribing practices using who prescribing indicators in a private tertiary care teaching hospital M Binu, R Sabbu, K Surendra, D Hiremath IRJIPS 1, 26-31 , 2013 2013 Citations: 15
Study of drug prescribing pattern in pediatric outpatient department at a tertiary care teaching hospital HD Sabbu Rahul, Devathi Sravya J Drug Deliv Ther 11 (5), 23-6 , 2021 2021 Citations: 11
A study on assessment of patients health related quality of life during tuberculosis treatment in a tertiary care teaching hospital SS Patil, A Rawal, R Anuraj, S Rahul, H Doddayya Indian journal of pharmacy practice 9 (1), 19 , 2016 2016 Citations: 11
Assessment of awareness, perception, and opinions towards artificial intelligence among health care professionals and medical students at tertiary care teaching hospital: a … S Rahul, MD Nawaz, SM Mudgal, H Doddayya Int J Multidiscip Res 6 (1), 1-9 , 2024 2024 Citations: 5
Study on drug prescribing pattern in dermatology outpatient Department in a Tertiary Care Teaching Hospital K Herakal, R Sabbu, G Pavani, D Hiremath, AG Mahendraker Manipal Journal of Pharmaceutical Sciences 6 (1), 2 , 2020 2020 Citations: 4
Ceftriaxone Induced Fixed Drug Eruption. AP Thomas, H Suma, R Sabbu, KM Binu, H Doddayya Manipal Journal of Pharmaceutical Sciences 7 (1) , 2021 2021 Citations: 2
Psychobiotics as adjuncts in depression management: Mechanistic insights and clinical perspectives S Rahul, R Rahul, V Gudupalli Asian journal of psychiatry 117, 104840 , 2026 2026
Study on Clinical Profile and Antimicrobial Prescribing Patterns in Patients with Cellulitis: A Retrospective Study D Rahul Sabbu, Arghya Ghorai, Ketana S Gada, Rashmi Adri, Binu K M, Arun K N Inventi Rapid:Pharmacy Practice 2025 (2), 1-5 , 2025 2025
Case Report on Moxifloxacin Induced Swelling of Eyelid and Redness of Eye. DH Sabbu Rahul, Suman Kumar S, Anupama R Taklikar Inventi Rapid: Pharmacy Practice 2024 (3), 1-2 , 2024 2024
A Study on Prescription Pattern of Drugs in Orthopedics Inpatient Department in a Tertiary Care Teaching Hospital S Rahul International Journal For Multidisciplinary Research (IJFMR) 6 (3), 1-6 , 2024 2024
A Study on Prescription Pattern of Drugs in Orthopedics Inpatient Department in a Tertiary Care Teaching Hospital S Rahul International Journal For Multidisciplinary Research (IJFMR) 6 (3), 1-6 , 2024 2024
A Study of Drug Use Evaluation of Anti-Anemic Drugs in Pregnancy Patients at a Tertiary Care Teaching Hospital S Rahul INTERNATIONAL JOURNAL FOR MULTIDISCIPLINARY RESEARCH 6 (3), 7-12 , 2024 2024
Drug Utilisation Evaluation in the Surgery Outpatient Department of a Tertiary Care Teaching Hospital S Rahul International Journal of Pharmacy and Pharmaceutical Research (Human) 30 (5 … , 2024 2024
Drug Utilization Pattern in Neonatal Intensive Care Unit in a Tertiary Care Teaching Hospital – A Retrospective Study S Rahul International Journal of Pharmacy and Pharmaceutical Research (Human) 30 (6 … , 2024 2024
Drug Utilization Pattern in Neonatal Intensive Care Unit in a Tertiary Care Teaching Hospital – A Retrospective Study S Rahul International Journal of Pharmacy and Pharmaceutical Research (Human) 30 (6 … , 2024 2024
Disease Pattern and Drug Utilization Evaluation of Abnormal Uterine Bleeding in a Tertiary Care Teaching Hospital S Rahul International Journal of Pharmacy and Pharmaceutical Research (Human) 30 (6 … , 2024 2024
Study of Drug Utilization Trends in Lower Respiratory Tract Infections in a Tertiary Care Teaching Hospital S Rahul Inventi Rapid: Pharmacy Practice 2024 (2), 1-5 , 2024 2024
Clinico-Demographic Characteristics and Management of COPD at a Tertiary Care Teaching Hospital in Raichur S Rahul Inventi Rapid: Pharmacy Practice 2024 (3), 1–3 , 2024 2024
Knowledge, Attitude and Perceptions Towards Vitamin D Among General Public S Rahul International Journal For Multidisciplinary Research (IJFMR) 5 (3), 1-9 , 2023 2023
Study of Drug Use Pattern of Anti Tb Drugs in a Tertiary Care Teaching Hospital of Karnataka, India-Aretrospective Study S Rahu, K Sarmashvali, SM Mudgal, H Doddayya International Journal of Community Pharmacy, 51-55 , 2023 2023