Yuliya Safonova

@szgmu.ru

Department of Geriatrics
North-Western State Medical University named after I.I. Mechnikov



                 

https://researchid.co/safonova

RESEARCH, TEACHING, or OTHER INTERESTS

Geriatrics and Gerontology, Rheumatology

13

Scopus Publications

994

Scholar Citations

12

Scholar h-index

17

Scholar i10-index

Scopus Publications

  • Quality of life in sarcopenia measured with the SarQoL questionnaire: A meta-analysis of individual patient data
    Charlotte Beaudart, Noémie Tilquin, Pawel Abramowicz, Fátima Baptista, Dao Juan Peng, Fabiana de Souza Orlandi, Michael Drey, Marta Dzhus, Raquel Fábrega-Cuadros, Julio Fernandez-Garrido,et al.
    Elsevier BV

  • Quality of life and fatigue in elderly patients with sarcopenia
    Yu. A. Safonova, E. G. Zotkin, and N. V. Toroptsova
    IMA Press, LLC
    Objective: to assess the quality of life (QoL) using general and special questionnaires and to identify the relationship between fatigue and sarcopenia (SP) in elderly and senile people.Patients and methods. The cohort study included 230 patients, including 177 women (77%) and 53 men (23%) over 65 years old (median age 75 [68; 79] years). The presence of SP was determined according to the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP2, 2018). QoL was studied using the general questionnaires EQ-5D, SF-36 and a special questionnaire SarQoL, the level of fatigue – using the FACIT-F questionnaire. To assess the possibility of using the FACIT-F scale for SP screening, its sensitivity, specificity, diagnostic accuracy, positive and negative predictive value were determined, a receiver operating characteristic (ROC) curve (ROC analysis) was constructed, and the area under the ROC curve (AUC) was calculated.Results and discussion. The assessment of QoL using the EQ-5D and SF-36 questionnaires did not reveal significant differences between the groups of patients with and without SP (p>0.05). When analyzing the state of health in the study cohort using the special SarQoL questionnaire, the overall indicator was 63.12±18.83 points, while in patients with SP it was significantly lower than in patients without SP (50.65±14.23 and 75,10±14.46 points, respectively; p<0.001). The mean score for all domains was also lower in the presence of SP than in its absence (p<0.001).The level of fatigue on the FACIT-F scale ranged from 10 to 52 points and averaged 32.5 [29.1; 35.3] points, while in patients with SP the overall score was lower than in elderly people without SP (25.1 [22.13; 29.23] and 39.8 [36.4; 42.4] points respectively; p<0.001). In patients with severe fatigue, SP was diagnosed 4.6 times (95% confidence interval, CI 2.80–7.57) more often than in those without it (p<0.001). Fatigue was associated with senile age, underweight, falls in the previous year, weak muscle strength, low SPPB test scores and an appendicular muscle mass index, CRP >10 mg/L (p<0.05).The possibility of using the FACIT-F questionnaire for screening patients with SP was evaluated. Its sensitivity reached 76%, specificity – 73%, positive predictive value – 53%, and negative predictive value – 88%, diagnostic accuracy – 74%. The area under the ROC-curve (AUC) was 0.726 (95% CI 0.627–0.826; p<0.0001).Conclusion. It has been shown that the general questionnaires EQ-5D and SF-36 do not reflect the true QoL impairment in SP. A significant deterioration in the state of health in elderly people with SP can be identified by a special SarQol questionnaire. The FACIT-F fatigue scale can also be used to screening in SP.

  • COVID-19 and osteoporosis: Problems in patient management and the impact of osteoporosis therapy on the incidence of clinical infection
    O. M. Lesnyak, E. N. Gladkova, K. E. Zotkina, A. L. Grigoryeva, Yu. A. Safonova, O. Yu. Kuznetsova, and M. A. Pokhaznikova
    Mediar Press
    The global diversion of health resources during the COVID-19 pandemic from the provision of routine medical care, and the more frequent and severe course of this infection in older patients justify the need to study the impact of the pandemic on the management of patients with osteoporosis.Aim – to assess the impact of the COVID-19 pandemic on the management of patients with osteoporosis, as well as the impact of anti-osteoporotic drugs on the incidence of COVID-19.Material and methods. A cross-sectional study was conducted, including a telephone survey and analysis of outpatient records of 304 patients with osteoporosis, who were recommended therapy with anti-osteoporotic medications. The average age was 70.8±8.8 years. The vast majority of patients took bisphosphonates in oral or parenteral forms.Results. Problems with the timely conduct of laboratory tests were noted by 91 (30.4%) subjects, DXA testing – 98 (32.8%). 65 (22.1%) were unable to receive the drug in a timely manner. Problems were more common when taking parenteral drugs (p=0.002). The cumulative incidence of COVID-19 was 12.2%, which is twice as high as in the population. There was a tendency to a lower incidence of confirmed SARS-CoV-2 infection when treated with denosumab or zoledronic acid. COVID-19 cases were not associated with either a vitamin D dose or a 25(OH)D level.Conclusions. During the COVID-19 pandemic, there is a significant decline in the quality of medical care for patients with osteoporosis, which cannot but lead to a new epidemic in the future – an epidemic of low-energy fractures. Our data confirmed the predisposition of older age groups to a higher incidence of COVID-19. However, there is no clear association of osteoporosis therapy with the risk of developing clinical manifestations of COVID-19.

  • Diagnostic Criteria and Prevalence of Sarcopenia in the Elderly
    J. A. Safonova and G. M. Glazunova
    Pleiades Publishing Ltd


  • Diagnosis for risk for falls and their prevention: Draft clinical guidelines by the association of rheumatologists of Russia and the Russian Osteoporosis Association
    Yu. A. Safonova, E. G. Zotkin, and N. V. Toroptsova
    Mediar Press
    These clinical guidelines have been developed under the auspices of the All-Russian public organization «The Association of Rheumatologists of Russia» and the public organization «Russian Osteoporosis Association» and are dedicated to the diagnosis of the risk of falls and their prevention in elderly people who have a high frequency of falls and their serious consequences as injuries varying in severity, as fractures, developed pain, a loss of ability to perform everyday activities and to take care of themselves. The paper presents risk factors for falls and risk assessment methods and formulates main provisions for preventing falls in older people, by taking into account their place of stay: at home, hospital or social services facilities.

  • Diagnostic criteria and the prevalence of sarcopenia in the elderly


  • Sarcopenia in older patients with osteoarthritis of large joints
    Yu. A. Safonova and E. G. Zotkin
    Mediar Press
    Pathological changes of large joints (knee, hip) in osteoarthritis (OA) are accompanied by the development of muscle weakness, decreased proprioception and imbalance.Objective: assessment of skeletal muscles state in women over 65 years old with OA of large joints and determination of the main factors affecting the risk of sarcopenia.Subjects and methods. In 159 women with OA (mean age 74±6 years), muscle mass was assessed with the appendicular lean mass index (ALM) using dual-energy X-ray absorptiometry (DXA). Muscle strength was measured by hand dynamometer, muscle function was determined by the results of a brief set of physical activity tests (short physical performance battery – SPP). The quality of life was analyzed by the EQ-5D questionnaire, pain assessment was carried out using a visual analog scale (VAS).Results and discussion. Patients with sarcopenia were significantly more likely to have lower rates of ALM index (p<0.001), body mass index (p<0.001) and muscle strength (p<0.01). The incidence of sarcopenia increased with age (p<0.01). Muscle function measures are reduced in women with OA, regardless of the presence of sarcopenia. Falls in the previous 12 months before inclusion in the study in patients with sarcopenia were observed significantly more often than without sarcopenia: in 90 and 24.8% of cases (95% CI 78.2–96.7 and 17.0–34.0, respectively p<0.001). Clinically expressed pain in large joints in patients with and without sarcopenia was found with the same frequency. The average value of the EQ-5D index in women with sarcopenia was significantly less than without sarcopenia (0.48±0.22 and 0.74±0.27 respectively), mainly due to a decrease of the usual daily activities (p<0.01). However, in women over 85 years of age, the quality of life was comparable regardless of the presence or absence of sarcopenia.

  • RUSSIAN TRANSLATION and VALIDATION of SarQoL® - QUALITY of LIFE QUESTIONNAIRE for PATIENTS with SARCOPENIA
    Yu. A. Safonova, O. M. Lesnyak, I. A. Baranova, A. K. Suleimanova, and E. G. Zotkin
    Mediar Press
    The aim is to carry out language adaptation and validation on the Russian sample of a special SarQoL questionnaire, designed to assess the quality of life of elderly people with sarcopenia. Material and methods. 100 patients over 65 years, mean age 74.0±6.5 years, observed on an outpatient basis were included. 50 from them had sarcopenia and 50 participants were without it. The diagnosis of sarcopenia was based on criteria developed by the European working group on sarcopenia (EWGSOP, 2010). The validation procedure was carried out in accordance with the Protocol. Results and discussion. There was a significant decrease in the overall quality of life according to SarQoL questionnaire in patients with sarcopenia compared with the control group without sarcopenia (50.65±14.23 and 75.10±14.46, respectively; p<0.001). High internal consistency of the SarQoL (Cronbach's á coefficient 0.924) was revealed. A significant positive correlation of domains with the overall SarQoL index in the range from r=0.37, p=0.0083 to r=0.92, p<0.001 was established. Moderate correlations of SarQoL with some domains SF-36 and the EQ-5D questionnaires were revealed. High internal consistency (ICC) of 0.935 (95% CI 0.91-0.96) was found. Conclusion. The Russian version of the SarQoL questionnaire is valid, consistent and reliable and can be used to assess the quality of life in older patients with sarcopenia.

  • Analysis of security by vitamin D of the elderly people


  • Prediction of the risk of falls and fractures using stabilometric studies in the elderly


  • Assessment methods risk of falls in people over age 65


  • The syndrome of falls in the elderly


RECENT SCHOLAR PUBLICATIONS

  • Междисциплинарный консенсус по оказанию помощи пожилым пациентам с переломами проксимального отдела бедренной кости на основе ортогериатрического подхода
    ОМ Лесняк, АЮ Кочиш, ИГ Беленький, МВ Белов, КЮ Белова, ...
    Медицинский Альянс 13 (1) 2025

  • Факторы риска дефицита витамина D и его взаимосвязь с саркопенией у людей в возрасте 65 лет и старше
    ЮА Сафонова
    Остеопороз и остеопатии 27 (2), 15-23 2024

  • Взаимосвязь коморбидности и функционального состояния мышц у пациентов с саркопенией
    ЮА Сафонова
    Российский журнал гериатрической медицины, 185-192 2024

  • Эффективность нативных форм витамина D3 в лечении саркопении у людей пожилого и старческого возраста
    ЮА Сафонова
    Российский журнал гериатрической медицины, 193-201 2024

  • ГЕРИАТРИЧЕСКИЕ СИНДРОМЫ: ВАЖНОСТЬ ПРОБЛЕМЫ, СПОРНЫЕ ВОПРОСЫ ТЕРМИНОЛОГИИ
    ЕС Лаптева, АЛ Арьев, ЮА Сафонова, ДС Дьячкова-Герцева
    ADVANCES 37 (1-2), 60-66 2024

  • Серологические маркеры саркопении у людей в возрасте 65 лет и старше
    ЮА Сафонова
    Клиницист 17 (4), 19-26 2023

  • НОВЫЙ СКРИНИНГОВЫЙ МЕТОД ДИАГНОСТИКИ САРКОПЕНИИ У ЛЮДЕЙ 65 ЛЕТ И СТАРШЕ
    ЮА Сафонова, ОА Клиценко
    ADVANCES 36 (5), 647-653 2023

  • ПАДЕНИЯ КАК ИСХОД СТАРЧЕСКОЙ АСТЕНИИ: ЧАСТОТА И ФАКТОРЫ РИСКА
    ДС Дьячкова-Герцева, АС Винтовкин, ЮА Сафонова
    МЕЧНИКОВСКИЕ ЧТЕНИЯ-2023, 394-395 2023

  • Гериатрия. Национальное руководство
    РИ Абсалямов, ЕА Андреева, АН Баринова, Ю Беленков, ...
    Общество с ограниченной ответственностью Издательская группа ГЭОТАР-Медиа 2023

  • Интеллектуальное развитие детей, 6–7 лет. Конспекты практических занятий
    Л Сорокина
    Litres 2022

  • ВОСПИТАНИЕ ЭКОЛОГИЧЕСКОЙ КУЛЬТУРЫ У ДЕТЕЙ МЛАДШЕГО ШКОЛЬНОГО ВОЗРАСТА ВО ВНЕУРОЧНОЕ ВРЕМЯ
    ЮА Сафонова
    Вестник Международной академии наук. Русская секция, 113-114 2022

  • Частота и факторы риска саркопении у пожилых людей с остеоартритом крупных суставов
    ЮА Сафонова, ЕГ Зоткин
    Остеопороз и остеопатии 25 (3), 110-111 2022

  • САРКОПЕНИЯ КАК ПРЕДИКТОР ПАДЕНИЙ И ПЕРЕЛОМОВ У ЛЮДЕЙ СТАРШЕГО ВОЗРАСТА
    ЮА Сафонова
     2022

  • ВОЗМОЖНОСТИ РЕАБИЛИТАЦИИ ПАЦИЕНТОВ С ЗАБОЛЕВАНИЯМИ КОСТНО-МЫШЕЧНОЙ СИСТЕМЫ С ПОМОЩЬЮ СТАБИЛОМЕТРИИ
    ЮА Сафонова
    Медицинская реабилитация: научные исследования и клиническая практика, 325-326 2022

  • Роль и место калькулятора FRAX в принятии решения об инициации лечения остеопороза: анализ регистра центра остеопороза
    ЕН Гладкова, ОМ Лесняк, АГ Закроева, ИЗ Гайдукова, АЛ Григорьева, ...
    Остеопороз и остеопатии 25 (2), 4-13 2022

  • Частота и факторы риска саркопении у людей старших возрастных групп
    ЮА Сафонова, НВ Торопцова
    Клиницист 16 (2), 40-47 2022

  • ПРОГНОСТИЧЕСКАЯ ЦЕННОСТЬ ДИАГНОСТИКИ САРКОПЕНИИ У ПАЦИЕНТОВ С ОСТЕОПОРОЗОМ
    ЮА Сафонова
    ДНИ РЕВМАТОЛОГИИ В САНКТ-ПЕТЕРБУРГЕ-2021, 167-168 2021

  • Качество жизни и синдром усталости у пожилых пациентов с саркопенией
    ЮА Сафонова, ЕГ Зоткин, НВ Торопцова
    Современная ревматология 15 (6), 41-47 2021

  • ВОЗМОЖНОСТИ ТЕРАПИИ БОЛЕВОГО СИНДРОМА У ПАЦИЕНТОВ С КОМПРЕССИОННЫХ ПЕРЕЛОМОВ ТЕЛ ПОЗВОНКОВ МЕТОДОМ КИНЕЗИОТЕЙПИРОВАНИЯ
    ВГ Финоженок, ЮА Сафонова, ОВ Инамова
    БОТКИНСКИЕ ЧТЕНИЯ, 294-295 2021

  • Дефицит и недостаточность витамина D, факторы риска и его коррекция у людей пожилого возраста
    ЮА Сафонова, НВ Торопцова
    РМЖ 29 (6), 96-100 2021

MOST CITED SCHOLAR PUBLICATIONS

  • Методика проведения судебной психолого-лингвистической экспертизы материалов по делам, связанным с противодействием экстремизму и терроризму
    ОВ Кукушкина, ЮА Сафонова, ТН Секераж
    ФБУ РФЦСЭ при Минюсте России 2014
    Citations: 204

  • Теоретические и методические основы судебной психолого-лингвистической экспертизы текстов по делам, связанным с противодействием экстремизму
    ОВ Кукушкина, ЮА Сафонова, ТН Секераж
    ЭКОМ Паблишерз 2011
    Citations: 189

  • Профилактика, диагностика и лечение дефицита витамина D и кальция у взрослого населения России и пациентов с остеопорозом (по материалам подготовленных клинических рекомендаций)
    ОМ Лесняк, ОА Никитинская, НВ Торопцова, ЖЕ Белая, КЮ Белова, ...
    Научно-практическая ревматология 53 (4), 403-408 2015
    Citations: 97

  • Офтальмоонкология: новое за последние два десятилетия
    АФ Бровкина, ИЕ Панова, СВ Саакян
    Вестник офтальмологии 130 (6), 13-19 2014
    Citations: 88

  • Учебный орфографический словарь русского языка
    В Лопатин, Ю Сафонова, О Иванова
    Litres 2012
    Citations: 32

  • Профилактика, диагностика и лечение дефицита витамина D и кальция среди взрослого населения и у пациентов с остеопорозом
    ЖЕ Белая, КЮ Белова, ЕВ Бордакова, АЖ Гильманов, ЕЮ Гуркина, ...
    Общество с ограниченной ответственностью Издательская группа ГЭОТАР-Медиа 2016
    Citations: 28

  • Методика проведения комплексной судебной психолого-лингвистической экспертизы по делам, связанным с противодействием экстремизму и терроризму
    ОВ Кукушкина, ЮА Сафонова, ТН Секераж
    М.: ФБУ РФЦСЭ 2014
    Citations: 23

  • Интеллектуальное развитие детей, 6–7 лет. Конспекты практических занятий
    Л Сорокина
    Litres 2022
    Citations: 20

  • Синдром падений в пожилом и старческом возрасте
    ЮА Сафонова, ЕГ Зоткин
    Успехи геронтологии 29 (2), 342-6 2016
    Citations: 16

  • Диагностика риска и профилактика падений: проект клинических рекомендаций Ассоциации ревматологов России и Российской ассоциации по остеопорозу
    ЮА Сафонова, ЕГ Зоткин, НВ Торопцова
    Научно-практическая ревматология 58 (2), 133-139 2020
    Citations: 15

  • Образовательная программа для пациентов с остеопорозом и ее влияние на приверженность к лечению: результаты многоцентрового рандомизированного исследования
    ЛП Евстигнеева, ОМ Лесняк, НМ Кузнецова, ЮА Сафонова, ...
    Остеопороз и остеопатии, 33-37 2012
    Citations: 14

  • Диагностическая значимость функциональных тестов для оценки возраст-ассоциированной саркопении
    ЮА Сафонова, ЕГ Зоткин
    Остеопороз и остеопатии, 109 2016
    Citations: 13

  • АНАЛИЗ ОБЕСПЕЧЕННОСТИ ВИТАМИНОМ D ЛЮДЕЙ ПОЖИЛОГО И СТАРЧЕСКОГО ВОЗРАСТА
    ЮА Сафонова, ЕГ Зоткин, ГМ Глазунова, ЕЛ Струков
    Успехи геронтологии 31 (2), 184-190 2018
    Citations: 12

  • Влияние уровня обеспеченности витамина D на состояние костно-мышечной ткани у людей старше 65 лет
    ЮА Сафонова
    Остеопороз и остеопатии, 47-48 2016
    Citations: 12

  • Памятка по вопросам назначения судебной лингвистической экспертизы
    ЕИ Галяшина, МВ Горбаневский, БН Пантелеев, ЮА Сафонова
    Медея 2004
    Citations: 12

  • Частота и факторы риска саркопении у людей старших возрастных групп
    ЮА Сафонова, НВ Торопцова
    Клиницист 16 (2), 40-47 2022
    Citations: 11

  • Саркопения как фактор риска падений и переломов
    ЮА Сафонова
    Клиницист 13 (3-4), 22-28 2019
    Citations: 11

  • Частота саркопении у пациентов со стабильной хронической обструктивной болезнью легких: сравнение диагностических алгоритмов Европейской рабочей группы по саркопении у пожилых
    АК Сулейманова, ЮА Сафонова, ИА Баранова
    Пульмонология 29 (5), 564-570 2019
    Citations: 9

  • Результаты исследований естественных и точных наук: междисциплинарный подход и cверхаддитивный эффект
    АА Абзалов, МА Асеева, ММ Атабаев, ПС Белов, СВ Беляева, ...
    Общество с ограниченной ответственностью Поволжская научная корпорация 2018
    Citations: 9

  • Факторы риска падений в пожилом возрасте
    ЮА Сафонова, ВВ Цурко
    Клиническая геронтология 23 (5-6), 8-14 2017
    Citations: 9