Sahar B. Aljuboori

@ruc.edu.iq

faculty of phramacetical chemistry / department of phramacy
doctor in rafidain university college

RESEARCH INTERESTS

I completed a Bachelor’s and Master’s degrees in organic chemistry at the University of Tahrin, and a PhD in organic chemistry from the University of Al-Mustansiriya. I then worked at Al-Rafidain University College, Department of Pharmacy. Until now, he has published research in local and Scopus mag

Scopus Publications

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

Synthesis, antimicrobial evaluation and docking study of new schiff bases of benzo[d]oxazol-5-amine derivatives.
Nedaa A. Hameed A. Rahim, Sumayah Saadi Abbas, Sahar B. Aljuboori, and Ammar A Razzak Mahmood
Research Journal of Pharmacy and Technology A and V Publications
Objective: Benzoxazole derivatives have antifungal, anticancer, antibacterial, and anticonvulsant function. Encouraged by this comment, we agreed to synthesize new Benzoxazole compounds connected to the bases of Schiff's. Methods: 2,4-diaminophenol (1) was prepared by the reaction of 2,4-dinitrophenol and sodium dithionate. Compound (1) reacted with either acetic acid to afford compound (2) or with formic acid to afford compound (3). The Schiff bases were preparation from the reaction condensing reaction of compound (2) or (3) and aromatic aldehydes or ketone; [p-nitrobenzaldehyde, p-hydroxybenzaldehyde, p-chlorobenzaldehyde, p-bromoacetophenone and terephthaldehyde]. Results: FTIR and 1H-NMR spectroscopy characterized all of the preparation compounds. The synthesized derivatives against (Gram positive bacteria GPB) (Bacillus subtilis) and two (Gram-negative bacteria GNB) (Klebsiella pneumoniae and Escherichia coli) and (one fungal species Candida albicans), have been evaluated to their antibacterial activity in vitro. all results showed which most of them have good antibacterial activity, while their antifungal activity revealed that compounds displayed slight antifungal activity. The synthesized Benzoxazole derivatives were docked using, glucosamine 6-phosphate synthase as a ligand. Conclusion: The antimicrobial activity indicates that compounds (4), (7) and (8) have more potent antibacterial activity than the compounds (5) and (6). Molecular docking study revealed that compounds (7) and (8), with bulky phenyl groups are essential to block the active centers of (GluN-6-Ps) amino acids synthase in the bacteria.

Synthesis, antimicrobial evolution, defibrillation threshold studies, docking studies, silico admet analysis and per-metabolism study of some new dihydropyrmidine derivatives
Sahar B. Al-Juboori
Dr. Yashwant Research Labs Pvt. Ltd.
Dihydropyrimidinone and dihydropyrimidine derivatives are reported to possess broad biological activities. Many synthetic samples have been studied as antibacterial, antiviral, and anticancer agents. We decided to synthesize novel compounds of new pyrimidine derivatives. The present work involves the synthesis of new dihydropyridine derivatives. The starting vanillin, compound (1) was used as the key intermediate to prepare the 5-acetyl-4-(4-hydroxy-3-methoxyphenyl)-6-methyl pyrimidine-2(1H)-one(2),Ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2-dihydropyrimidine-5-carboxylate (3), 4-(4-hydroxy-3-methoxyphenyl)-5,6,7,8-tetrahydro quinazoline-2(1H)-one (4), respectively, through the reaction with urea and acetylacetone or ethyl acetoacetate or cyclohexanone but 4-(4-hydroxy-3-methoxyphenyl)-5,6,7,8-tetrahydro quinazoline-2(1H)-thione (5) reacted with thiourea and cyclohexanone. FTIR,1H-NMRand13C-NMR spectroscopy characterized all the synthesized compounds. The synthesized derivatives were screened for their in vitro, antibacterial activity against two gram-positive bacteria: Bacillus subtilis, and Staphylococcus aureus and two gram-negative bacteria: Klebsiella pneumonia and Salmonella typhi and the results showed that most of them have good antibacterial activity. While their antifungal activity against three fungi species: (Aspergillus fumigates, Aspergillus niger, and Rhizopus), revealed that compounds (1-5) displayed the most potent antifungal activity. Density functional theory ( DFT) calculations for the synthesized compounds (1-5) were conducted, using a molecular structure with optimized geometry. Highest occupied molecular orbital/lowest unoccupied molecular orbital energies and structures are demonstrated. The antimicrobial activity indicates that compounds 3 and 4 are the most active than the compounds 2 and 5. Molecular docking revealed that compounds (4) and (5), with cyclohexyl groups are important to block the active centers of glucose -6-phosphate synthase in the bacteria and fungi.

Synthesis, characterization and antibacterial evaluation with computational study of new Schiff bases derived from 7-hydroxy-4-methyl coumarin
Dana M. Hussein, Sahar B. Al-juboory, and Ammar A. Razzak Mahmood
Oriental Scientific Publishing Company
New derivatives of 7-hydroxy-4-methylcoumarin were synthesized via oxidation of methyl group at C4 of parent coumarin nucleus using SeO2 as an oxidizing agent. Then the condensation with different aromatic amines and amino acids under conventional method. The structures of the title Schiff bases were elucidated by spectral analysis: FT-IR,13CNMR, and MS.All the compounds were tested in vitro for their preliminary antibacterial activity against two Gram-positive and two Gram –negative bacteria, using serial dilution method, and determining their minimum inhibitory concentrations for the title compounds. Most of the derivatives showed moderate to high antibacterial activity.Compound 7 showed a good antibacterial activity against Grampositive Staphylococcus aureus and Micrococcus luteus also very potent antibacterial activity against Gram-negative E.coli. Density functional theory (DFT)calculations for the synthesized coumarins were performed using a molecular structure with optimized geometry. Molecular orbital calculations supported a full description of the orbitals, including spatial characteristics, nodal patterns, and the contributions of individual atoms.Highest occupied molecular orbital/lowest unoccupied molecular orbital energies and structures are demonstrated. keywords: Antibacterial activity, broth dilution method, density functional theory(DFT), 7-hydroxy-4-methylcoumarin, Schiff base,

Synthesis, characterization and antifungal evaluation of some novel quinoline derivatives derived from ethyl p-aminobenzoate

RECENT SCHOLAR PUBLICATIONS

COVID-19: infection, origin, transmission, diagnosis, tests and treatment options.
SB Aljuboori, HA Sahib, NAHA Rahim, RMH Ali
2021

Synthesis, antimicrobial evaluation and Docking study of new Schiff bases of benzo [d] oxazol-5-amine derivatives
NAHA Rahim, SS Abbas, SB Aljuboori, AAR Mahmood
Research Journal of Pharmacy and Technology 14 (8), 4129-4136 2021

Omeg3 discovery, types, preparation, and application in medicinal life
SB Aljuboori
European Journal of Molecular & Clinical Medicine 7 (09), 2747-2753 2020

Synthesis, Antimicrobial Evolution, Defibrillation Threshold Studies, Docking Studies, Silico Admet Analysis and PER-Metabolism Study of Some New Dihydropyrmidine Derivatives
SB Aljuboori
IJDDT, 10 (Issue 1) 2020

A review: saccharin discovery, synthesis, and applications
AAR Mahmood, SB Al-Juboori
Ibn AL-Haitham Journal For Pure and Applied Sciences 33 (2), 43-61 2020

Saccharin Discovery, Synthesis, and Applications
SBA ammar a. kubba
Ibn Al-Haitham Jour. for Pure & Appl. Sci. 33 (2) 2020

Evaluate factors influencing depression in Baghdad: Using deck-depression inventory
SB Aljuboori, AJA Azeez, AAR Mahmood, R Fathel, H Talab
INNOVATIONS in pharmacy 10 (3), 10.24926/iip. v10i3. 2036 2019

SYNTHESIS, ANTIMICROBIAL EVALUATION, DENSITY FUNCTIONAL THEORY, AND DOCKING STUDIES OF SOME NEW 2-MERCAPTO PYRIMIDINE SCHIFF BASES
AARM SAHAR B. AL-JUBOORI
Asian J Pharm Clin Res, Vol 12 (2019, 2), 496-502 2019

Synthesis, antimicrobial evaluation, DFT and docking studies of some new -2-macrapto pyrimidine Schiff bases.
SBAAAR Mahmood
2018

Factors Influencing Depression in Baghdad: A Study Using Beck- Depression Inventory
BSP 1 Sahar B. Aljuboori, , Ali Azeez Al-Jumaili, , Ammar A. Razzak Mahmood ...
2018

“Synthesis, Antibacterial Activity and DFT Study of New Derivatives Derived from Oxidation of 7-hydroxy-4-methyl coumarin”
AARM Dana M. Hussein
International Journal of Pharmaceutical Sciences Review and Research 2 (46 2017

Synthesis, Characterization and Antibacterial Evaluation With Computational Study of new Schiff Bases Derived from 7-Hydroxy-4-Methyl Coumarin
DM Hussein, SB Al-Juboory, AAR Mahmood
Oriental Journal of Chemistry 33 (2), 768-782 2017

Synthesis, characterization and antifungal evaluation of some novel quinoline derivatives derived from ethyl p-aminobenzoate
SBAAARM Kubba
Synthesis 123 (60.9), 14.1 2017

SYNTHESIS, PHYSICAL PROPERTIES OF NEW 4- METHYL COUMARIN DERIVATIVES
RIHALBSM AL-Sayed
International Journal of Pharmacognosy 3 (4), 175-183 2016

Synthesized novel coumarin derivatives together with quantum chemical studies
Redah I. Al-Bayati , Shakeeb Majeed AL-Sayed
Journal of the Kalash Science 3 (2321-7634), 59-70 2015

REVIEW ARTICLE: COVID – 19: INFECTION, ORIGIN, TRANSMISSION, DIAGNOSIS, TESTS AND TREATMENT OPTIONS

Synthesized novel coumarin derivatives together with quantum chemical studies
SB AL-Juboori, RI Al-Bayati, SM AL-Sayed

MOST CITED SCHOLAR PUBLICATIONS

A review: saccharin discovery, synthesis, and applications
AAR Mahmood, SB Al-Juboori
Ibn AL-Haitham Journal For Pure and Applied Sciences 33 (2), 43-61 2020
Citations: 25

Omeg3 discovery, types, preparation, and application in medicinal life
SB Aljuboori
European Journal of Molecular & Clinical Medicine 7 (09), 2747-2753 2020
Citations: 1