Samah Sayed Mehanny
@cu.edu.eg
Department of Oral Biology/ Faculty of Dentistry
Cairo and Galala Universities
Professor Samah Sayed Mehanny is a course coordinator of the Oral Biology department in the Dentistry field at Gu, with Ph.D. in Oral Biology from Cairo University. Before joining GU, Professor Samah was the former head of the oral biology department, Faculty of Dentistry, Future University, and a course coordinator (dental anatomy), Faculty of Dentistry, Cairo University. Professor Samah is trying to correlate basic science with clinical studies.
RESEARCH INTERESTS
Stem cells, secretome, Factors affecting orthodontic tooth movement, Rate of bone healing, Artificial intelligence
FUTURE PROJECTS
student self assessment application based on Artificial intelligence for dental students
Applications Invited
collaboration with AI specialists
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Mahmoud Elseidy, Yehya A. Mostafa, Sammah S. Mehanni, and Fouad A. El-Sharaby
Scientific Foundation SPIROSKI
Objectives: To evaluate the effects of one versus four weeks reactivation of the elastomeric chain on the rate of orthodontic tooth movement (OTM) and supporting structures.
 Methods: The 3rd maxillary premolars of 8 male mongrel dogs were extracted. Custom made appliance was constructed so that the 2nd premolars were allowed to slide bodily. An elastomeric chain with calibrated force of 150g was attached to the hooks of soldered tubes on the 2nd premolar’s crowns. The sample was divided into two groups based on the interval of reactivation of the elastomeric chains used for tooth movement where in group I activation was scheduled every one week versus four weeks in group II. Measurements of the amount and rate of OTM were performed every week for 12 weeks using digital caliper. The animals were then sacrificed and specimens were prepared for decalcified histological examination using Hematoxylin and Eosin stains under light microscope.
 Results: No remarkable difference in the rate of OTM between the two groups was reported. The total amount of tooth movement in group I was 1.44mm ± 0.5 compared to 1.46mm ± 0.6 in group II. Histological examination revealed a more favorable tissue reaction associated with 4 weeks reactivation as regards the new formed bone, root resorption and periodontal ligament structure.
 Conclusion: Altering the reactivation interval of the elastomeric chains from four to one week doesn’t have a significant impact on the rate of OTM. However, four weeks reactivation interval showed a more favorable tissue reaction associated with orthodontic tooth movement.
Fatma Saad, Iman Aboushady, and Samah Mehanni
Egypts Presidential Specialized Council for Education and Scientific Research
Background: Extra hepatic adverse effects associated with the therapy of chronic HCV infection with sofosbuvir treatment regimens have recently arisen.Objective: This study aimed to assess the inflammatory effect of sofosbuvir and its influence on cellular proliferation, functionality and differentiation of both submandibular (SMGs) and Von Ebner's salivary glands (EGs).Methodology: 21 adult male albino rats were divided into three equal groups: GroupI (control) received orally distilled water; GroupII received orally sofosbuvir (40 mg/kg/day) dissolved in distilled water for one month and GroupIII received sofosbuvir for 2 months. SMGs and EGs sections were processed for HE shrunken acini, glandular cell vacuolization, nuclear degenerative signs, wide degenerative stromal areas and flattening of excretory ductal lining with stagnant secretion as well as the transformation of few serous glandular cells into mucous-like cells particularly in SMGs of groupIII. Likewise, both glands of groupIІ showed significantly increased immunoreactivity to COX-2 in acini and some ductal cells but with a significant decrease in those of groupIII. Regarding PCNA immunoreactivity and α-amylase immunofluorescence, significantly diminished positivity in the glandular cells of both glands in groupII was detected compared to control group whilst insignificant improvement was elucidated in those of groupIII comparing to groupII except for the significant reactivity to α-amylase in EGs of groupIII.Conclusions: It was concluded that the oxidative stress associated degenerative changes caused by sofosbuvir in salivary glands after one month of administration seemed to be diminished after two months of administration due to the body acquired drug tolerance to restore the disturbed physiological processes. Hence, the use of anti-oxidants as an adjuvant treatment could be beneficial.
Dina Farag and Samah Mehanny
Wroclaw Medical University
BACKGROUND
Bisphosphonates (BPs) are widely used as anti-bone-resorptive agents. Despite the great benefits of BPs, they may cause local and systemic adverse side effects.
OBJECTIVES
The aim of this study was to evaluate the histopathological effect zoledronic acid (ZA), which belongs to BPs, has on the intrinsic tongue muscles in a rat model.
MATERIAL AND METHODS
A total of 30 adult male albino rats were divided into 3 groups (10 rats each): group I served as a control; group II was given an intraperitoneal (i.p.) injection of 0.2 mg/kg of ZA once per week for 3 weeks; and group III received the same dosage of ZA, but for 8 weeks. After the animals were euthanized, the tongue tissue was dissected and examined histologically, histochemically and immunohistochemically.
RESULTS
Histologically, a normal architecture of the muscle fascicles was observed in the control group. Group II showed degenerated muscle fibers with an indistinct sarcolemma. In group III, the muscle fibers were degenerated with severe sarcoplasmic dissolution. The histochemical examination using Masson's trichrome (MT) demonstrated a significant increase in collagen fibers in groups II and III as compared to the control group. The immunohistochemical results revealed a statistically significantly higher expression of nuclear factor kappa B (NF‑κB) in the ZA-treated groups (II and III) as compared to the control group, with the highest mean value recorded in group III.
CONCLUSIONS
Zoledronic acid induced histopathological changes to the intrinsic tongue muscles, and this effect was exaggerated with a longer duration of administration.
A. Rashid, F. A. ElSharaby, E. M. Nassef, S. Mehanni, and Y. A. Mostafa
Wiley
OBJECTIVES
To evaluate the effect of platelet-rich plasma (PRP) on the rate of orthodontic tooth movement.
METHODS
The sample comprised six skeletally mature male mongrel dogs. The maxillary second premolar in each dog was extracted bilaterally. PRP was prepared and injected around the first premolar in one randomly selected maxillary quadrant while the other quadrant served as the control. Coil springs (150 g) were used to distalize the first premolars for 63 days using TAD as anchorage.
RESULTS
Total maxillary tooth movement was significantly faster on the experimental than on the control side.
CONCLUSION
Local injection of PRP in the present animal study resulted in accelerated orthodontic tooth movement with no obvious clinical or microscopic side effects.
Samah S. Mehanni, Noha F. Ibrahim, Alyaa R. Hassan, and Laila A. Rashed
Korean Society for Stem Cell Research
BACKGROUND AND OBJECTIVES
Irradiated wound healing is a highly complex and dynamic process. The latest technology making a huge difference in this process is stem cell therapy. The goal of this study was to evaluate the use of bone marrow-derived mesenchymal stem cells (BM-MSCs) or human amniotic epithelial cells (HAECs) in the healing of irradiated wounds.
METHODS AND RESULTS
Forty five male albino rats were subjected to whole body 6 gray gamma radiations. One day post irradiation, full-thickness incisional wound was created in the tibial skin. The rats were randomly equally divided into three groups. The incisions of the first group (gp I) were injected intra-dermally with saline before stitching and those of both the second (gp II) and the third groups (gp III) were intradermally injected with BM-MSCs and HAECs before stitching respectively. Animals were sacrificed after the third, seventh and fourteenth days postoperative. The healing process was assessed histopathologically. CXCL-5, SDF-1 and Transforming growth factor-beta 1 (TGF-β1) expression were also detected in biopsies from all wounds. Expression of TGF-β1 in gp I was more than the other groups leading to severe inflammation, deficient healed dermis and delayed reepithelialization. SDF-1 expression was high in gp II while CXCL-5 expression was high in gp III causing accelerated wound healing. BM-MSCs showed a great effect on the quality of the dermis, while superiority of the epithelium and its appendages were achieved in HAECs group.
CONCLUSIONS
Using BM-MSCs and HAECs could be used safely in case of irradiated wounds.
Nahed S. Korany, Samah S. Mehanni, Heba M. Hakam, and Eman M.F. El-Maghraby
Elsevier BV
Yehya Ahmed Mostafa, Mona Mohamed Salah Fayed, Samah Mehanni, Nader Nabil ElBokle, and Ahmed Mostafa Heider
Elsevier BV