Sandip Sapkal currently working as Professor at Laddhad College of Pharmacy, Buldana. Total 15 years teaching & research experience. Sandip does research in Pharmacy. Their current project is 'Solubility & Bio-availability enhancement of some BCS class II drugs by Solid dispersion technique using Natural polymer'.
EDUCATION
M. Pharm in Pharmaceutics in 2010, PhD in Pharmacy in 2018.
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmaceutical Science, Pharmacy, Pharmacology, Toxicology and Pharmaceutics, Drug Discovery
10
Scopus Publications
Scopus Publications
Stimuli-Responsive Biomaterials for Infammatory Arthritis and Other Bone Disorders Vaishali Pawar, Glynis Almeida, Divya Dubey, Sameer Patel, Sandip Sapkal, Rohit Srivastava Stimuli Responsive Biomaterials for Inflammatory Diseases Advances in Research and Clinical Applications, 2026 Inflammation, a fundamental response of the human body when dysregulated, can result in menacing inflammatory diseases. Stimuli-responsive biomaterials can play a significant role in managing such inflammatory diseases. Their unique ability to react to specific internal/external stimulus and in response to deliver the drug in a sustained fashion, whilst being biocompatible, is what makes the use of these biomaterials a fascinating strategy. Additionally, their synthesis could involve innovative advances in their material design to provide targeted and localized disease therapy which is essential in inflammatory disease management to circumvent off-target effects. Hence, stimuli-responsive biomaterials are a promising alternative to opt for in the long run; however, their limitations are inevitable. This chapter gives a detailed exploration on stimuli-responsive biomaterials for inflammatory diseases, broken down by key aspects of their role in inflammatory disease management, significance, types, mechanism of action, application of stimuli-responsive controlled-release systems in specific inflammatory diseases, advances in material design and synthesis, current status of preclinical and clinical trials, associated challenges, and future prospects, along with references to relevant research.
Biologically Derived Nanohydroxyapatite: A Comparative Analysis with a Commercial Counterpart Arati Patil, Nagesh Aloorkar, Anand Kakde, Mangesh Mapari, Sandip Sapkal, Gauri Laddhad Agricultural Science Digest, 2025 Background: In the present paper, Nano-Hydroxyapatite (n-HAp) is synthesized from Indian Hen (Busra breed) and Hybrid Hen eggshell waste using chemical precipitation methods. The principal objectives of this research are to synthesize natural HAp from eggshell waste and comparing with commercial available Hydroxyapatite (HAp) as reference sample (NnanoXIM-Hap-202). Methods: Analytical methods were used to characterize n-HAp and HAp including Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), Differential Scanning Calorimetry (DSC) and Thermogravimetry-Differential Thermal Analysis (TG-DTA). Calcinations of eggshell waste at 850 to 900oC yielded HAp with a calcium / phosphorus ratio of 1.71 to 1.75. Result: A comparative analysis with a reference sample (commercially available HAp) revealed that the synthesized HAp exhibited similar structural and chemical properties, with slight variations in their morphological and thermal characteristics.
Formulation and characterization of solid dispersions of etoricoxib using natural polymers Sandip Babarao SAPKAL, Vaibhav Suresh ADHAO, Raju Rambhau THENGE, Rahul Ashok DARAKHE, Sushilkumar Ananda SHINDE, Vinayak Natthuji SHRIKHANDE Turkish Journal of Pharmaceutical Sciences, 2020 Objectives: The main objective of the present investigation to develop and evaluate solid dispersions of BCS Class II drugs etoricoxib employing various natural polymers, compatible with conventional manufacturing method to enhance solubility of poorly soluble drugs. Materials and Methods: In this study, etoricoxib solid dispersion were prepared using xanthan gum, gaur gum and acacia and their combinations by solvent evaporation method. Solid dispersions and pure etoricoxib in the form of powder were characterized in comparison with pure drug and corresponding physical mixtures in the same ratios by Fourier transform infrared spectroscopy, differential scanning calorimetry (DSC), powder X-ray diffractogram, and in vitro drug release. Results: Solid dispersion (ET11) prepared with 1: 2: 2: 2 drug carrier ratios were showed highest solubility in different solvents. Hence the solid dispersion (ET11) of 1: 2: 2: 2 ratios were selected for characterization. The DSC study indicated that the crystalline nature of etoricoxib was reduced to amorphous. The diffraction pattern of the solid dispersions in each figure indicates that diffraction peaks at 2ɵ values has less intensity than that of pure drugs. This indicated that the crystalline nature of drug sample was converted to amorphous with ET11. Scanning electron microscope photographs of solid dispersion seem to be more porous in nature. From the in vitro drug release profile, it can be seen that formulation ETM11 shows higher dissolution rate i.e. 98.2±1.3% compared with other formulations. It is predicted that, increasing concentration of carrier, increases the drug dissolution rate. Conclusion: This study has shown that the solid dispersion of etoricoxib using natural carrier can be promising formulation for solubility and dissolution enhancement. Natural polymers used have shown promising results in the modification of drug release from the formulations.
Once a daily tablet formulation and in vitro evaluation of HPMC based intra gastric floating tablet of Levofloxacin P.S Gangane, S. B. Sapkal, A.S. Welankiwar, P.S. Magar, D.V. Bhusari Research Journal of Pharmacy and Technology, 2015 The aim of this study was to develop a new intra-gastric floating tablet for controlled delivery of Levofloxacin for the treatment of peptic ulcer disease caused by Helicobacter pylori (H. pylori). The method of preparation is direct compression method. HPMC, K-grade and effervescent material sodium bicarbonate formed the floating layer. The release layer contained Levofloxacin and various polymers such as HPMC-K15M, HPMC-K100M, PVP-K30 and MCC in combination with the drug. The in vitro drug release was studied in pH 1.2 HCl using USP dissolution Apparatus II at 50 rpm. Zero-order, first-order, Higuchi and Korsmeyer et al. models were used to estimate the kinetics of drug release. Optimized formulation released approximately 98% drug in 12 h in vitro, while the floating lag time was 49 sec and the tablet remained floatable throughout all studies. Optimized formulation (D3) followed the Korsmeyer and Peppas model and showed no significant change in physical appearance, drug content, floatability and invitro dissolution pattern after storage at 45°C/75% RH for three month.
HPMC based extended release matrix tablet of gabapentin by direct compression method Turkish Journal of Pharmaceutical Sciences, 2014
Formulation and evaluation of intraorally fast dissolving tablet of olmesartan medoxomil Der Pharmacia Lettre, 2013
Formulation and evaluation of solid dispersion incorporated mouth dissolving tablet of gliclazide International Journal of Drug Development and Research, 2013
Natural polymers: Best carriers for improving bioavailability of poorly water soluble drugs in solid dispersions Sandip Sapkal Marmara Pharmaceutical Journal, 2013 Natural polymers and its modified forms can be used as best alternative for improving bioavailability of poorly water soluble drugs in solid dispersion. Most of the natural polymers are hydrophilic and having high swelling capacity. Recent trend towards the use of natural polymer demands the replacement of synthetic additives with natural ones. Many plant derived natural polymers are studied for use in solid dispersion systems, out of which natural gums, cyclodextrin and carbohydrate are most extensively studied and used. This review discusses about the majority of these natural polymers, its uses and some recent investigations about modification of natural polymer in solid dispersion systems. KEYWORDS: Modified natural gum, carbohydrate, dissolution enhancement, solid dispersion
An overview on the mechanisms of solubility and dissolution rate enhancement in solid dispersion International Journal of Pharmtech Research, 2013
Formulation development of gastro retentive floating tablet of acyclovir using natural gums Der Pharmacia Lettre, 2011
