Sapna - Patel
@jssonline.org
Associate Professor, Pathology
JSSAHER
Dr. Sapna Patel M.C is an MD in Pathology with 18 years of service in the department of pathology at JSS medical College and Hospital. She is alumni of PG in Pathology of the same institution. As an academician, pathologist, and teacher by profession she is passionate towards diagnostic pathology and teaching. Skilled in teaching, designing curriculum and teaching schedule for undergraduates (MBBS, BDS), postgraduates (MD) and various paramedical courses (BSc allied health sciences).
She has 36 publications in national and international journals with poster and paper presentations in various national CMEs and conferences. She has guided two UG students for STS projects funded by ICMR, New Delhi and many Post graduate students. Her areas of special interest are Bone marrow aspiration and biopsies, histopathology, forensic pathology, fetal autopsies, and cytology with research work in the same field. She is actively involved as NAAC Coordinator, NABL Coordinator in cytopathology, Member
EDUCATION
MBBS, MD Pathology
RESEARCH, TEACHING, or OTHER INTERESTS
Pathology and Forensic Medicine, Multidisciplinary, Multidisciplinary, Multidisciplinary
13
Scopus Publications
9053
Scholar Citations
36
Scholar h-index
46
Scholar i10-index
Scopus Publications
- The Nasal Microarchitecture: How Does Tracheostomy Affect it?
Kiran Hegde, Shilpa Chandrashekarappa, Sapna Patel, Sandeep Shetty, and B. G. Prakash
Springer Science and Business Media LLC - A Case Report of Pulmonary Alveolar Proteinosis with Associated Opportunistic Infection of Pneumocystis jirovecii and Molluscum Contagiosum
Sapna Patel, Deepika Gurumurthy, Smitha Rani, and Sheela Devi
Medknow
Abstract Pulmonary alveolar proteinosis (PAP) is an idiopathic rare diffuse pulmonary disease, first described in 1958 by Rosen et al. Its estimated prevalence is about 1 in 3.7–6.9 × 106 with a male: female ratio of 1:1–2:1. Majority of the patient’s age ranges between 20 and 50 years. PAP on microscopy is characterized by the presence of massive insoluble, amorphous, phospholipid-rich protein deposits in the bronchial and alveolar cavities. Most patients with acquired PAP present with cough and exertional dyspnea. It has been studied that there is increased risk of superinfection in PAP with opportunistic organisms like pneumocystis and vice versa. Definitive diagnosis of Pneumocystis jirovecii pneumonia rests on the demonstration of the organism within the alveoli by special stains like Grocott Methenamine Silver stain. Molluscum contagiosum (MC) is a common superficial skin infection caused by the poxvirus. MC is characterized by painless papules commonly seen in children and immunocompromised individuals. Here, we present a 34-year-old female who had complaints of severe difficulty in breathing and was brought dead to our hospital. On external examination, she had multiple warts over chest, abdomen, and over genitalia. Internal examination was unremarkable. Specimens of kidney, lung, and skin biopsy of genital warts sent for histopathological examination revealed acute tubular necrosis, P. jirovecii with PAP, and MC respectively. - DEATH DUE TO TRAUMA OR DISEASE?-A CASE REPORT
Smitha Rani, Gowri S Nair, Suraj S Shetty, MC Sapna Patel, and M Arun
Diva Enterprises Private Limited - Spectrum of Neural Tube Defects Among the Fetal Autopsies in a Tertiary Care Hospital in Southern India
- The Spectrum of Congenital Central Nervous System Anomalies Among Stillborn: An Autopsy Based Study
S. P. Vinutha, D. Narayanappa, G. V. Manjunath, M. S. Sujatha, M. C. Sapna Patel, and Deepa Bhat
SAGE Publications
Background: Congenital central nervous system (CNS) anomalies are the structural or functional abnormalities of the brain and spinal cord that occur during the intrauterine developmental process. Purpose: The present study aims to detect the prevalence of congenital CNS anomalies among stillborn fetuses, the association between congenital anomalies and maternal factors, and also the association between autopsy and ultrasound findings. Methods: This study was conducted on 50 stillborn fetuses, obtained from the Department of Obstetrics and Gynecology at JSS Medical College and Hospital, Mysuru. The fetuses were fixed in 10% formalin and autopsies were performed as per the standard fetal autopsy protocol. The congenital CNS anomalies were studied in detail. Results: CNS anomalies were the most common congenital anomalies observed. Out of the total 50 stillborn fetuses studied, CNS anomalies were found in 17 fetuses and their occurrence was more common among male stillborn than females. Meningomyelocele was the most common anomaly, followed by anencephaly. The other anomalies documented were meningocele, encephalocele, meningoencephalocele, agenesis of the corpus callosum, craniorachischisis, bifid cerebellum with hypoplastic vermis, holoprosencephaly, and sirenomelia. Fisher’s exact test showed a significant association between maternal hypothyroidism and congenital CNS anomalies ( P < .05). The autopsy confirmed the ultrasound findings in 40 (80%) fetuses. There were significant additional findings observed in seven (14%) fetal autopsies and ultrasound diagnosis completely changed in three (6%) cases, after the final autopsy procedure. Conclusion: The fetal autopsy is the single most directly evident investigation, which gives information that changes or significantly improves the clinical diagnosis. A multidisciplinary holistic approach toward pregnancy will help to detect any kind of abnormality in the fetus and thus to take a timely decision toward the management. - Gender differences in the lumen of the left anterior descending artery—An autopsy based histomorphometric study
Pravinkumar N. Kamaradgi, H.V. Chandrakanth, Tanuj Kanchan, M. Arun, Sapna Patel, and Alok Atreya
Medknow - Histopathologic findings in autopsies with emphasis on interesting and incidental findings-A pathologist’s perspective
Sapna Patel
JCDR Research and Publications
INTRODUCTION Autopsy aids to the knowledge of pathology by unveiling the rare lesions which are a source of learning from a pathologist's perspective Some of them are only diagnosed at autopsy as they do not cause any functional derangement. This study emphasizes the various incidental lesions which otherwise would have been unnoticed during a person's life. AIM The aim of this study was to determine the spectrum of histopathological findings including neoplastic lesions related or unrelated to the cause of death. It was also aimed to highlight various incidental and interesting lesions in autopsies. MATERIALS AND METHODS A retrospective study of medicolegal autopsies for six years was undertaken in a tertiary care centre to determine the spectrum of histopathological findings including neoplastic lesions related or unrelated to the cause of death and to highlight various incidental and interesting lesions in autopsies. Statistical Analysis: Individual lesions were described in numbers and incidence in percentage. RESULTS The study consisted of a series of 269 autopsy cases and histopathological findings were studied only in 202 cases. The commonest cause of death was pulmonary oedema. The most common incidental histopathological finding noted was atherosclerosis in 55 (27.2%) cases followed by fatty liver in 40 (19.8%) cases. Neoplastic lesions accounted for 2.47% of cases. CONCLUSION This study has contributed a handful of findings to the pool of rare lesions in pathology. Some of these lesions encountered which served as feast to a pathologist are tumour to tumour metastasis, a case with coexistent triple lesions, Dubin Johnson syndrome, von Meyenburg complex, Multilocular Cystic Renal Cell Carcinoma (MCRCC), Autosomal Dominant Polycystic Kidney Disease (ADPKD), liver carcinod and an undiagnosed vaso-occlusive sickle cell crisis. Autopsy studies help in the detection of unexpected findings significant enough to have changed patient management had they been recognized before death. - Pathological findings of liver in autopsy with emphasis on incidentally detected lesions
Sapna Patel, , Rajalaxmi B.R., Manjunath G.V., , and
Red Flower Publication Private, Ltd. - Cytopathological yarn of a suprasellar mass lesion: Diagnostic clues and pitfalls
G. V. Manjunath, C. S. Sheeladevi, Sunila, M. C. Sapna Patel, and B.N. Kumarguru
Scientific Scholar
A 35-year-old female presented with left-sided hemiparesis of 3 months duration, followed by left-sided unilateral headache. On physical examination, power was reduced in left-sided extremities. Magnetic resonance imaging (MRI) revealed a large lobulated heterogeneously enhancing extra-axial lesion in sellar, parasellar, and suprasellar regions with erosion of bony sellar and clivus with extension. Figure Figure1a1a–d shows the cytomorphological features of the squash smear of the lesion. Figure 1 Squash smear cytology of sellar lesion. (a) Cellular smear showing tumor cells in clusters and singles against a metachromatic fibrillary mxyoid background (MGG, ×200). (b) Tumor cells are large round to oval cells having distinct cell borders, ... - Insight to neoplastic thyroid lesions by fine needle aspiration cytology
M Rangaswamy, KL Narendra, S Patel, C Gururajprasad, and GV Manjunath
Medknow
Background: Fine needle aspiration cytology (FNAC) is a valuable adjunct to pre-operative screening in the diagnosis of thyroid nodules, and in most cases, it can distinguish between benign and malignant lesions. Aim: To study the cytology of neoplastic thyroid lesions to minimize surgical intervention and for confirmation of the diagnosis by histopathological study. Materials and Methods: 100 cases of thyroid FNAC smears were analyzed and cyto-histopathological correlation was done in 47 cases. Galen and Gambino's method was used to calculate the sensitivity and positive predictive value. Results: Of the 100 cases, 90 were diagnosed as neoplastic lesions by FNAC and ten cases as non-neoplastic lesions, which turned out to be neoplasms on histopathological study. Among 100 cases, 47 were biopsied and subjected to histopathological study. The sensitivity of FNAC was 75.60%, and positive predictive value was 83.78% for malignant lesions. Conclusions: FNAC is a rapid, efficient, cost-effective, relatively painless procedure with a high diagnostic accuracy. It has high rate of sensitivity and positive predictive value in diagnosing thyroid neoplastic lesions. Hence, it is a valuable tool in the diagnosis and management of patients.
RECENT SCHOLAR PUBLICATIONS
- MA19. 09 AI-Based Early Detection and Subtyping of Non-Small Cell Lung Cancer from Blood Samples Using Orphan Noncoding RNAs
M Karimzadeh, TB Cavazos, J Wang, M Multhaup, Y Fang, J Ku, X Zhao, ...
Journal of Thoracic Oncology 18 (11), S173 2023 - Ipilimumab with or without nivolumab in PD-1 or PD-L1 blockade refractory metastatic melanoma: a randomized phase 2 trial
A VanderWalde, SL Bellasea, KL Kendra, NI Khushalani, KM Campbell, ...
Nature medicine 29 (9), 2278-2285 2023 - Concurrent intrathecal and intravenous nivolumab in leptomeningeal disease: phase 1 trial interim results
IC Glitza Oliva, SD Ferguson, R Bassett Jr, AP Foster, I John, ...
Nature medicine 29 (4), 898-905 2023 - Neoadjuvant–adjuvant or adjuvant-only pembrolizumab in advanced melanoma
SP Patel, M Othus, Y Chen, GP Wright Jr, KJ Yost, JR Hyngstrom, ...
New England Journal of Medicine 388 (9), 813-823 2023 - Advances in the clinical management of uveal melanoma
RD Carvajal, JJ Sacco, MJ Jager, DJ Eschelman, R Olofsson Bagge, ...
Nature reviews Clinical oncology 20 (2), 99-115 2023 - Death due to trauma or disease?-A case report
S Rani, GS Nair, SS Shetty, MC Sapna Patel, M Arun
Journal of Forensic Medicine and Toxicology 40 (1), 121-124 2023 - Neoadjuvant relatlimab and nivolumab in resectable melanoma
RN Amaria, M Postow, EM Burton, MT Tetzlaff, MI Ross, C Torres-Cabala, ...
Nature 611 (7934), 155-160 2022 - Intermittent MEK inhibition for the treatment of metastatic uveal melanoma
S Khan, SP Patel, AN Shoushtari, G Ambrosini, S Cremers, S Lee, ...
Frontiers in Oncology 12, 975643 2022 - Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy
CP Vellano, MG White, MC Andrews, M Chelvanambi, RG Witt, ...
Nature 606 (7915), 797-803 2022 - Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy
ST Kim, Y Chu, M Misoi, ME Suarez-Almazor, JH Tayar, H Lu, M Buni, ...
Nature communications 13 (1), 1970 2022 - The vaccine-site microenvironment: impacts of antigen, adjuvant, and same-site vaccination on antigen presentation and immune signaling
MO Meneveau, P Kumar, KT Lynch, SP Patel, CL Slingluff
Journal for immunotherapy of cancer 10 (3), e003533 2022 - Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response
CN Spencer, JL McQuade, V Gopalakrishnan, JA McCulloch, M Vetizou, ...
Science 374 (6575), 1632-1640 2021 - Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade
MC Andrews, CPM Duong, V Gopalakrishnan, V Iebba, WS Chen, ...
Nature medicine 27 (8), 1432-1441 2021 - Worsening proteinuria and renal function after intravitreal vascular endothelial growth factor blockade for diabetic proliferative retinopathy
M Shye, RM Hanna, SS Patel, N Tram-Tran, J Hou, C Mccannel, M Khalid, ...
Clinical Kidney Journal 13 (6), 969-980 2020 - Immune profiling of uveal melanoma identifies a potential signature associated with response to immunotherapy
Y Qin, K Bollin, MP De MacEdo, F Carapeto, KB Kim, J Roszik, KM Wani, ...
Journal for immunotherapy of cancer 8 (2), e000960 2020 - Unicystic and Dysplastic Renal Anomalies in a Cadaver
MV Ravishankar, CS Vidya, PMC Sapna
Journal of Evolution of Medical and Dental Sciences 9 (43), 3268-3271 2020 - Thrombotic microangiopathy and acute kidney injury induced after intravitreal injection of vascular endothelial growth factor inhibitors VEGF blockade-related TMA after
RM Hanna, NT Tran, SS Patel, J Hou, KD Jhaveri, R Parikh, U Selamet, ...
Frontiers in Medicine 7, 579603 2020 - Profile of Congenital Cardiovascular Anomalies among Stillborns at a Tertiary Care Hospital.
SP Vinutha, D Narayanappa, GV Manjunath, MS SUJATHA, MCS PATEL, ...
Journal of Clinical & Diagnostic Research 14 (10) 2020 - The spectrum of congenital central nervous system anomalies among stillborn: an autopsy based study
SP Vinutha, D Narayanappa, GV Manjunath, MS Sujatha, ...
Annals of Neurosciences 27 (3-4), 224-231 2020 - Circulating tumor cells and early relapse in node-positive melanoma
A Lucci, CS Hall, SP Patel, B Narendran, JB Bauldry, RE Royal, ...
Clinical Cancer Research 26 (8), 1886-1895 2020
MOST CITED SCHOLAR PUBLICATIONS
- B cells and tertiary lymphoid structures promote immunotherapy response
BA Helmink, SM Reddy, J Gao, S Zhang, R Basar, R Thakur, K Yizhak, ...
Nature 577 (7791), 549-555 2020
Citations: 2147 - Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance
W Roh, PL Chen, A Reuben, CN Spencer, PA Prieto, JP Miller, ...
Science translational medicine 9 (379), eaah3560 2017
Citations: 830 - Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma
RN Amaria, SM Reddy, HA Tawbi, MA Davies, MI Ross, IC Glitza, ...
Nature medicine 24 (11), 1649-1654 2018
Citations: 794 - Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response
CN Spencer, JL McQuade, V Gopalakrishnan, JA McCulloch, M Vetizou, ...
Science 374 (6575), 1632-1640 2021
Citations: 610 - Neoadjuvant–adjuvant or adjuvant-only pembrolizumab in advanced melanoma
SP Patel, M Othus, Y Chen, GP Wright Jr, KJ Yost, JR Hyngstrom, ...
New England Journal of Medicine 388 (9), 813-823 2023
Citations: 533 - Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients
LG Radvanyi, C Bernatchez, M Zhang, PS Fox, P Miller, J Chacon, R Wu, ...
Clinical Cancer Research 18 (24), 6758-6770 2012
Citations: 497 - Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade
MC Andrews, CPM Duong, V Gopalakrishnan, V Iebba, WS Chen, ...
Nature medicine 27 (8), 1432-1441 2021
Citations: 323 - Neoadjuvant plus adjuvant dabrafenib and trametinib versus standard of care in patients with high-risk, surgically resectable melanoma: a single-centre, open-label, randomised
RN Amaria, PA Prieto, MT Tetzlaff, A Reuben, MC Andrews, MI Ross, ...
The lancet oncology 19 (2), 181-193 2018
Citations: 305 - Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses
K Robinson, R Kenefeck, EL Pidgeon, S Shakib, S Patel, RJ Polson, ...
Gut 57 (10), 1375-1385 2008
Citations: 295 - Neoadjuvant relatlimab and nivolumab in resectable melanoma
RN Amaria, M Postow, EM Burton, MT Tetzlaff, MI Ross, C Torres-Cabala, ...
Nature 611 (7934), 155-160 2022
Citations: 255 - Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome
A Torrelo, S Patel, I Colmenero, D Gurbindo, F Lendnez, A Hernndez, ...
Journal of the American Academy of Dermatology 62 (3), 489-495 2010
Citations: 235 - Hypoxia-driven immunosuppressive metabolites in the tumor microenvironment: new approaches for combinational immunotherapy
Y Li, SP Patel, J Roszik, Y Qin
Frontiers in immunology 9, 1591 2018
Citations: 191 - The tardigrade Hypsibius dujardini, a new model for studying the evolution of development
WN Gabriel, R McNuff, SK Patel, TR Gregory, WR Jeck, CD Jones, ...
Developmental biology 312 (2), 545-559 2007
Citations: 158 - First-in-human study of mivebresib (ABBV-075), an oral pan-inhibitor of bromodomain and extra terminal proteins, in patients with relapsed/refractory solid tumors
SA Piha-Paul, JC Sachdev, M Barve, P LoRusso, R Szmulewitz, SP Patel, ...
Clinical Cancer Research 25 (21), 6309-6319 2019
Citations: 149 - Advances in the clinical management of uveal melanoma
RD Carvajal, JJ Sacco, MJ Jager, DJ Eschelman, R Olofsson Bagge, ...
Nature reviews Clinical oncology 20 (2), 99-115 2023
Citations: 145 - Aloe–emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells
M Acevedo-Duncan, C Russell, S Patel, R Patel
International immunopharmacology 4 (14), 1775-1784 2004
Citations: 116 - Helicobacter pylori dupA Is Polymorphic, and Its Active Form Induces Proinflammatory Cytokine Secretion by Mononuclear Cells
NR Hussein, RH Argent, CK Marx, SR Patel, K Robinson, JC Atherton
The Journal of infectious diseases 202 (2), 261-269 2010
Citations: 95 - Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy
CP Vellano, MG White, MC Andrews, M Chelvanambi, RG Witt, ...
Nature 606 (7915), 797-803 2022
Citations: 88 - Effects of prophylactic antibiotics on colonic healing
HH LeVeen, S Wapnick, G Falk, O Olivas, D Bhat, M Gaurdre, M Patel
The American Journal of Surgery 131 (1), 47-53 1976
Citations: 86 - Ipilimumab with or without nivolumab in PD-1 or PD-L1 blockade refractory metastatic melanoma: a randomized phase 2 trial
A VanderWalde, SL Bellasea, KL Kendra, NI Khushalani, KM Campbell, ...
Nature medicine 29 (9), 2278-2285 2023
Citations: 84
Publications
57209192612, 3ChbaFIAAAAJ
Industry, Institute, or Organisation Collaboration
JAASAHER
INDUSTRY EXPERIENCE
18 YEARS